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Clinda

Category: Antibiotics

Description

Cleocin is used for treating serious infections caused by certain bacteria.

Active Ingredient: Clindamycin

Cleocin (Clinda) as known as: Acnestop, Agis, Aknet, Aknezel k, Albiotin, Anerocid, Aniclindan, Antirobe, Arfarel, Bactemicina, Basocin, Benzolac cl, Bexon, Bioclindax, Biodaclin, Biodasin, Borophen, Botamycin-n, Candid-cl, Clamine-t, Clendix, Cleorobe, Clidacin, Clidacin-t, Clidamacin, Clidan, Clidets, Climadan, Climadan acne, Clin, Clin-sanorania, Clinacin, Clinacnyl, Clinamicina, Clinaram, Clinbercin, Clinda, Clinda mip, Clinda-derm, Clinda-ipp, Clinda-saar, Clinda-t, Clindabeta, Clindabuc, Clindacin, Clindacne, Clindacutin, Clindacyl, Clindacyn, Clindagel, Clindahexal, Clindal, Clindalind, Clindamax, Clindamek, Clindamicin, Clindamicina, Clindamycine, Clindamycinum, Clindamyl, Clindana, Clindanil, Clindareach, Clindasol, Clindasome, Clindastad, Clindaval, Clindess, Clindesse, Clindets, Clindexcin, Clindobion, Clindopax, Clindoral, Clindox, Clinex, Clinfol, Clinidac, Clinika, Clinimycin, Clinium, Clinmas, Clinsol, Clintabs, Clintopic, Clinwas, Cliofar, Cliz, Cluvax, Comdasin, Cutaclin, Dacin, Daclin, Dalacin, Dalacine, Dalagis t, Dalcap, Damiciclin, Damicine, Damiclin, Dentomycin, Derma, Dermabel, Divanon, Edason, Eficline, Ethidan, Euroclin, Evoclin, Fouch, Handaramin, Indanox, Jutaclin, Klamoxyl, Klimicin, Klin-amsa, Klindacin, Klindagol, Klindamicin, Klindamycin, Klindan, Klindaver, Klinoksin, Klitopsin, Lanacine, Lexis, Lindacil, Lindacyn, Lindan, Lindasol, Lintacin s, Lisiken, Luoqing, Medacin, Mediklin, Meneklin, Midocin, Milorin, Myclin, Naxoclinda, Niladacin, Nufaclind, Opiclam, Panancocin s, Paradis, Permycin, Prolic, Ribomin, Rosil, Sobelin, Sotomycin, Tidact, Toliken, Topicil, Torgyn, Trexen, Turimycin, Upderm, Veldom, Velkaderm, Ygielle, Z-clindacin, Ziana, Zindaclin, Zindacline, Zumatic

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Clinda-Derm Topical Advanced Patient Information

Clinda-Derm (Topical)
  • Cleocin T
  • Clindacin ETZ
  • Clindacin P
  • Clindacin Pac
  • Clinda-Derm
  • Clindagel
  • ClindaMax
  • ClindaReach
  • Clindets
  • Evoclin
  • Z-Clinz

Available Dosage Forms:

Therapeutic Class: Antiacne

Chemical Class: Lincosamide

Uses For Clinda-Derm

Clindamycin belongs to the family of medicines called antibiotics. Topical clindamycin is used to help control acne. It may be used alone or with one or more other medicines that are used on the skin or taken by mouth for acne. Topical clindamycin may also be used for other problems as determined by your doctor.

Clindamycin is available only with your doctor's prescription.

Before Using Clinda-Derm

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Studies on this medicine have been done only in adult patients, and there is no specific information comparing use of this medicine in children up to 12 years of age with use in other age groups.

Geriatric

Many medicines have not been studied specifically in older people. Therefore, it may not be known whether they work exactly the same way they do in younger adults. Although there is no specific information comparing use of this medicine in the elderly with use in other age groups, this medicine is not expected to cause different side effects or problems in older people than it does in younger adults.

Pregnancy

Animal studies have revealed no evidence of harm to the fetus, however, there are no adequate studies in pregnant women OR animal studies have shown an adverse effect, but adequate studies in pregnant women have failed to demonstrate a risk to the fetus.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

  • History of stomach or intestinal disease (especially colitis, including colitis caused by antibiotics, or enteritis)—These conditions may increase the chance of side effects that affect the stomach and intestines
Proper Use of clindamycin

This section provides information on the proper use of a number of products that contain clindamycin. It may not be specific to Clinda-Derm. Please read with care.

Before applying this medicine, thoroughly wash the affected areas with warm water and soap, rinse well, and pat dry.

When applying the medicine, use enough to cover the affected area lightly. You should apply the medicine to the whole area usually affected by acne, not just to the pimples themselves. This will help keep new pimples from breaking out.

You should avoid washing the acne-affected areas too often. This may dry your skin and make your acne worse. Washing with a mild, bland soap 2 or 3 times a day should be enough, unless you have oily skin. If you have any questions about this, check with your doctor.

Topical clindamycin will not cure your acne. However, to help keep your acne under control, keep using this medicine for the full time of treatment, even if your symptoms begin to clear up after a few days. You may have to continue using this medicine every day for months or even longer in some cases. If you stop using this medicine too soon, your symptoms may return. It is important that you do not miss any doses.

For patients using the topical foam form of clindamycin:

  • After washing or shaving, it is best to wait 30 minutes before applying this medicine. The alcohol in it may irritate freshly washed or shaved skin.
  • This medicine contains alcohol and is flammable. Do not use near heat, near open flame, or while smoking.
  • To apply this medicine:
    • Do not dispense clindamycin topical foam directly onto your hands because the foam will begin to melt on contact with warm skin.
    • Remove the clear cap. Align the black mark with the nozzle of the actuator.
    • Hold the can upright and press firmly to dispense. Dispense amount that will cover the affected area(s) directly into the cap or onto a cool surface.
    • The can may be placed under cold running water if the can seems warm or the foam seems runny.
    • A small amount of topical foam should be picked up with your fingertips and massaged gently into the affected areas until the foam disappears.
    • Unused medicine that was removed from the can should be throw away.
    • Since this medicine contains alcohol, it will sting or burn. In addition, it has an unpleasant taste if it gets on the mouth or lips. Therefore, do not get this medicine in the eyes, nose, or mouth, or on other mucous membranes. Spread the medicine away from these areas when applying. If this medicine does get in the eyes, wash them out immediately, but carefully, with large amounts of cool tap water. If your eyes still burn or are painful, check with your doctor.
  • It is important that you do not use this medicine more often than your doctor ordered. It may cause your skin to become too dry or irritated.

For patients using the topical solution form of clindamycin:

  • After washing or shaving, it is best to wait 30 minutes before applying this medicine. The alcohol in it may irritate freshly washed or shaved skin.
  • This medicine contains alcohol and is flammable. Do not use near heat, near open flame, or while smoking.
  • To apply this medicine:
    • This medicine comes in a bottle with an applicator tip, which may be used to apply the medicine directly to the skin. Use the applicator with a dabbing motion instead of a rolling motion (not like a roll-on deodorant, for example). Tilt the bottle and press the tip firmly against your skin. If needed, you can make the medicine flow faster from the applicator tip by slightly increasing the pressure against the skin. If the medicine flows too fast, use less pressure. If the applicator tip becomes dry, turn the bottle upside down and press the tip several times to moisten it.
    • Since this medicine contains alcohol, it will sting or burn. In addition, it has an unpleasant taste if it gets on the mouth or lips. Therefore, do not get this medicine in the eyes, nose, or mouth, or on other mucous membranes. Spread the medicine away from these areas when applying. If this medicine does get in the eyes, wash them out immediately, but carefully, with large amounts of cool tap water. If your eyes still burn or are painful, check with your doctor.
  • It is important that you do not use this medicine more often than your doctor ordered. It may cause your skin to become too dry or irritated.

For patients using the topical suspension form of clindamycin:

  • Shake well before applying.
Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

  • For topical dosage form (foam):
    • For acne:
      • Adults and children 12 years of age and over—Apply once a day to areas affected by acne.
      • Infants and children up to 12 years of age—Use and dose must be determined by your doctor.
  • For topical dosage forms (gel, solution, and suspension):
    • For acne:
      • Adults and children 12 years of age and over—Apply two times a day to areas affected by acne.
      • Infants and children up to 12 years of age—Use and dose must be determined by your doctor.
Missed Dose

If you miss a dose of this medicine, apply it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Precautions While Using Clinda-Derm

If your acne does not improve within about 6 weeks, or if it becomes worse, check with your health care professional. However, treatment of acne may take up to 8 to 12 weeks before full improvement is seen.

If your doctor has ordered another medicine to be applied to the skin along with this medicine, it is best to apply them at different times. This may help keep your skin from becoming too irritated. Also, if the medicines are used at or near the same time, they may not work properly.

For patients using the topical solution form of clindamycin:

  • This medicine may cause the skin to become unusually dry, even with normal use. If this occurs, check with your doctor.

In some patients, clindamycin may cause diarrhea.

  • Severe diarrhea may be a sign of a serious side effect. Do not take any diarrhea medicine without first checking with your doctor. Diarrhea medicines may make your diarrhea worse or make it last longer.
  • For mild diarrhea, only diarrhea medicine containing attapulgite (e.g. Kaopectate, Diasorb) may be taken. Other kinds of diarrhea medicine (e.g. Imodium A.D. or Lomotil) should not be taken. They may make your condition worse or make it last longer.
  • If you have any questions about this or if mild diarrhea continues or gets worse, check with your health care professional.

You may continue to use cosmetics (make-up) while you are using this medicine for acne. However, it is best to use only “water-base” cosmetics. Also, it is best not to use cosmetics too heavily or too often. They may make your acne worse. If you have any questions about this, check with your doctor.

Clinda-Derm Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Rare
  • Abdominal or stomach cramps, pain, and bloating (severe)
  • diarrhea (watery and severe), which may also be bloody
  • fever
  • increased thirst
  • nausea or vomiting
  • unusual tiredness or weakness
  • weight loss (unusual)—these side effects may also occur up to several weeks after you stop using this medicine

Check with your doctor as soon as possible if any of the following side effects occur:

Less common
  • Skin rash, itching, redness, swelling, or other sign of irritation not present before use of this medicine

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
  • Dryness, scaliness, or peeling of skin (for the topical solution)
Less common
  • Abdominal pain
  • diarrhea (mild)
  • headache
  • irritation or oiliness of skin
  • stinging or burning feeling of skin

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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Clinical Cases and Images: Empiric Treatment of Common Infections

Routine Inpatient: Levaquin alone, 3* Ceph + Z-max (B-lac = Ceph, PCN, Imipenem)

IC (Immunocompromised) / HA (Hosp. acquired), sick patients:
B-lac + Z-max
If vent > 7 d -> Pseudomonas, MRSA -> B-lac + Tobra + Vanco

ABx choice in HA pneumonia is hospital dependent -> depends on the local bug (check local bacterial resistance reports, e.g. in Meditech).
Use the "Hit them hard at the beginning approach".

Soft Tissue Infections
Outpatient: Cefazolin, Unasyn, Nafcillin

Routine inpatient:
DM --> GNB
If ulcer drains --> Anaerobes !
Imipenem, Ertapenem, Zosyn, Aztreonam + Clinda

B-lac allergy? --> Clinda + Z-max, Clinda + Cipro, Clinda + Aztreonam

If MRSA risk --> Vanco

PCN allergy suspected, and yet it needs Zosyn?
Skin test --> if negative--> OK
Skin test--> if positive--> Desensitize x 6 hr, PO protocol every 15 min x 6 hr - call Pharmacy dept
(ID does it on average every 2 mo for a Pt)

UTI
Check UA:
-if Nitrite+ UA --> E.coli or Klebsiella
-if Nitrite- UA --> Pseudomonas, Enterococci (Zosyn)

Outpatient: Levaquin or Cipro

Except NH patients who often already treated w Leva + E.coli resistance
(No quinolone)
NH Patients: empiric B-lac + Tobra

Always ask about previous ABx therapy.
You can use 2 GNB ABx = Aztr + Tobra
+/- Diflucan

Sepsis
No focus (no CAP, no MG, abdomen is OK, no UTI). Many times source obvious within 2 d. & it's abdomen.
PMH: ABx? How long TLC? Hospital stay?

Vanco + Zosyn + Tobra (1 dose)
No Diflucan at the beginning.
You will get Cx results back in 2 d.

Get Cortisol level. Start Hydrocortisone + Fludrocortisone

If PCN allergy --> Clinda + Levaq + Flagyl + Aztreonam?
vs. Zyvox + Aztreonam
"Hit them hard at the beginning" approach.

If patient was on Vanco (LTAC, chronic trach/vent), suspect VRE --> use Zyvox, SE: platelets drop.

Intra-abdominal Sepsis - GNB + Anaerobes
SBP - E. coli, Klebsiella, Strep --> Cefotaxime, Levaq
Enterococci less likely - no need for initial coverage

Diverticulitis - cover Enterococci. -> Imipenem.
Levaq + Flagyl. Zosyn

Below diaphragm - never use Clinda --> C.diff. risk
Always use Flagyl for anaerobes below diaphragm.

TLC, Line Sepsis
Cut 1 cm TLC tip --> Cx.
Staph. epi / Staph. aureus - Vanco +/- GNB coverage (if groin TLC or IJ TLC & sputum GNB).
ABx Tx - at least for 3 wk.

Every time MSSA/MRSA bacteremia - suspect endocarditis. -> 2D Echo vs. TEE esp. if fever persists

Meningitis - Vanco + Ceftriax / Cefotaxime
Patient > 50 yo - Ampicillin to cover Listeria .
Aminoglycosides - not used - don't cross BBB.
Past - intrathecal injection, not anymore.

GPB - ABx CHOICE - Dr.Chmielewski

PSSA (rare, community)
MSSA--> Naf/Oxacillin, Cefazolin, Unasyn, Zosyn; Vanco, Zyvox, Synercid
MRSA--> Vanco (no B-lactams), Bactrim, Zyvox PO, Cubicin new, ID-Eli Lylli old)
VISA (slow)/VRSA (rapid, chromosome piece from VREF)

CNS (coagulase Neg.)--> like MRSA ABx
MRCNS-hosp. bug

Entercocc. fec (past-Strept.fec)--> Amp, PCN, Vanco
VREF-> Zyvox, Synercid

Strep A, B, G--> B-lactams, if PCN R--> Vanco, no tetracycl or macrolides

Pneumo-coccus (Diplo-coccus PN)--> removed from Strep group now, different bug from Strep
Diplocc-->
S--> PCN, Ceph
I--> Zyvox, Vanco, Quinilone, Macrolide, 3* Ceph.
R--> 3* Ceph + Vanco, always both in meningitis or bacteremia (just in case)

Listeria--> Amp
Corynebact--> Vanco
Bacillus antrax--> Vanco, although Cipro recommended

Zosyn OK for almost any GNB but Acitenobacter and Legionella
Most problematic - Acetinobacter & Pseudomonas

E. coli--> no Amp. NH resident + UTI--> 30% E.coli resistant to Levaquin (Leva was already used at NH)
They come w UTI--> give Zosyn + Aminogl, 3* Cephs
DDx: effect- Genta 80% vs. Tobra 90%

E.coli - Amp. effective 30-40% only

ESBL = Extended Spectrum Beta Lactamase
E.coli, Klebsiella, Acitenobacter - inactivates most b-lactam ABx
You can use 2-3 ABx only (no Zosyn) --> Imipenem.

Klebsiella - always resistant to Unasyn, Zosyn OK = empiric Tx, 1* Cephs OK but not empiric Tx

Enterobacter - Zosyn, Cefepime

Proteus - Zosyn, even Unasyn OK; easy bug to treat in general

Pseudomonas - difficult to treat, even Zosyn OK only 80%.
Zosyn 80%, Cefepime 75% (high risk for C.diff), Imipenem 60% only, Leva 70%, Bactrim 0%
Resistant to Genta, Amikacin is better than Tobra but higher dose (3 x)
Amika 15 mg/kg
Tobra 5 mg/kg

Pseudomonas - most problematic bug (after Acitenobacter)
Zosyn effective 80% only
You have to cover w 2-3 ABx = Zosyn + Imipenem + Tobra
Within 24 hr you have S/I/R Cx & can drop 1-2 ABx

Pseudomonas pneumonia mortality > 50%

Acinetobacter- NE US Hosp
Timentin (Ticarcillin) only +/- Imipenem/Bactrim
Zosyn 0%
Worse than Pseudomonas

H.flu - Zosyn, 3* Cephs

HACEK - Zosyn, 3* Cephs, Amp + Genta (= for Endocarditis +/- Vanco)

Neisseria MG - PCN, Ceftriaxone = 3* Cephs -> if B-lactam allergy - Imipenem

References:
Practice Guidelines by Topic from the Infectious Diseases Society of America (IDSA)

Created: 2004
Updated: 2004

Clinda-Derm topical: Uses, Side Effects, Interactions, Pictures, Warnings - Dosing

Clinda-Derm topical Uses

This medication is used to treat acne. It helps to decrease the number of acne lesions. Clindamycin is an antibiotic which works by stopping the growth of bacteria.

How to use Clinda-Derm topical

Use this medication only on the skin. Clean and dry the affected area first. Follow all directions on the product package, or use as directed by your doctor.

If you are using the lotion, shake the bottle well before using. Apply a thin layer of medication usually twice a day or as directed by your doctor.

If you are using the medicated pad or swab, apply to the the affected area gently with it, then discard. Depending on the size of the area to be treated, more than one pad or swab may be necessary.

If you are using the foam, apply it once daily to the affected areas. Use enough to cover the entire affected area. Do not spray the foam directly onto your hands or face, because the foam will begin to melt on contact with warm skin. Instead spray the amount needed directly into the cap or onto a cool surface such as a counter top. If the can seems warm or the foam seems runny, run the can under cold water. Please read the patient information leaflet available from your pharmacist for specific instructions on how to use the foam, and ask about any information that is unclear.

Avoid contact with your eyes. nose, mouth or any areas of broken skin. If you accidentally get medication in these areas, rinse well with plenty of cool water.

It may take between 2-6 weeks to notice an improvement in your condition, and up to 12 weeks to see the full benefit.

Inform your doctor if your condition does not improve or worsens.

Side Effects

Burning, itching. dryness, redness, oily skin or skin peeling may occur. If any of these effects persist or worsen, notify your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

A small amount of this medication may be absorbed into your bloodstream and may rarely cause a severe intestinal condition (Clostridium difficile -associated diarrhea ) due to a resistant bacteria. This condition may occur while receiving treatment or even weeks to months after treatment has stopped. Do not use anti-diarrhea products or narcotic pain medications if you have the following symptoms because these products may make them worse. Tell your doctor right away if you develop persistent diarrhea, abdominal or stomach pain /cramping, or blood /mucus in your stool.

A very serious allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of a serious allergic reaction may include: rash. itching /swelling (especially of the face/tongue /throat), severe dizziness. trouble breathing .

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Precautions

Before using clindamycin, tell your doctor or pharmacist if you are allergic to it; or to lincomycin; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: chronic asthma or hay fever (atopic conditions), intestinal diseases (such as ulcerative colitis. enteritis, Clostridium difficile-associated diarrhea).

Tell your doctor if you are pregnant before using this medication.

It is not known if the medication in this product passes into breast milk. While there have been no reports of harm to nursing infants, consult your doctor before breast -feeding.

Interactions

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.

Some products that may interact with this drug include: other acne skin treatments.

Overdose

If overdose is suspected, contact a poison control center or emergency room right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center. This medication may be harmful if swallowed.

Notes

Do not share this medication with others.

Missed Dose

If you miss a dose, apply it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.

Storage

Storage instructions vary depending on the product. Check the product package for instructions on how to store your product, or ask your pharmacist. Do not freeze or store in the bathroom. Keep all medicines away from children and pets.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.

Information last revised October 2015. Copyright(c) 2015 First Databank, Inc.

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Clinda vag cream

clindamycin-Najo 2% Vaginal Cream

INDICATIONS: Antibiotic for the treatment of bacterial vaginosis.

DOSAGE AND ADMINISTRATION: One applicator full (approximately 5 grams) intravaginally at bedtime for 7 consecutive days. In patients in whom a shorter treatment course is desirable, a 3 day regimen has been shown to be effective.

Children and the elderly: No clinical studies have been conducted in populations younger than 15 or older than 60. Clindamycin-Najo Vaginal Cream is not recommended in children under 12 years of age.

Clindamycin is an antimicrobial agent which has been shown to be effective in the treatment of infection caused by susceptible anaerobic bacteria or susceptible strains of Gram positive aerobic bacteria. It has been shown to have in-vitro activity against the following organisms which are associated with bacterial vaginosis: Gardnerella vaginalis; Mobiluncus spp; Bacteroides spp; Mycoplasma hominis; Peptostreptococcus spp.

In women with bacterial vaginosis, the amount of clindamycin absorbed following vaginal administration of 100 mg of Clindamycin-Najo Cream (20 mg/g) is 4% (range 0.8-8%), which is approximately the same as in normal women.

CONTRAINDICATIONS: Clindamycin-Najo vaginal cream is contra-indicated in patients previously found to be hypersensitive to preparations containing clindamycin or any of the components of the cream base. Although cross-sensitisation to lincomycin has not been demonstrated, it is recommended that Clindamycin vaginal cream should not be used in patients who have demonstrated lincomycin sensitivity. Clindamycin vaginal cream 2% is also contraindicated individuals with a history of inflammatory bowel disease or a history of antibiotic-associated colitis.

Pregnancy: pregnancy category B.There are no adequate and well-controlled studies in pregnant women during their first trimester, and because animal reproduction studies are not always predictive of human response, this drug should be used during the first trimester of pregnancy only if clearly needed and careful risk-benefit assessment should take place beforehand.

Nursing Mothers: It is not known if clindamycin is excreted in breast milk following the use of vaginally administered clindamycin phosphate. Therefore, a full assessment of benefit-risk should be made when consideration is given to using vaginal clindamycin phosphate in a nursing mother.

The use of clindamycin may result in the overgrowth of non-susceptible organisms, particularly yeasts.

Virtually all antibiotics have been associated with diarrhea and in some cases pseudomembranous colitis. Therefore, even though only a minimal amount of drug is absorbed, if significant diarrhea occurs, the drug should be discontinued and appropriate diagnostic procedures and treatment provided as necessary.

Clindamycin vaginal cream contains oil-based components. Some of these have been shown to weaken the rubber of condoms and diaphragms and make them less effective as a barrier method of contraception or as protection from sexually transmitted disease, including AIDS. Do not rely on condoms and diaphragms when using Clindamycin vagina cream.

SIDE EFFECTS: More common, important: cervisitis, vaginitis, vulvuvaginal pruritis. Less common, important: CNS effects, GI disturbance. Rare, important: hypersensitivity.

DRUG INTERACTION: Clindamycin has been shown to have neuromuscular blocking properties that may enhance the action of other neuromuscular blocking agents. Therefore, it should be used with caution in patients receiving such agents. No information is available on concomitant use with other intravaginal products, which is not recommended.

How Supplied: Each package contains one tube … grams of Clindamycin-Najo 2% vaginal cream.

storage: Store below 30°C.

For more information please refer to:

USPDI for Professional Health Care, 2007, page: 843.

Martindale 35 ed page: 225.

IRAN NAJO PHARMACEUTICAL COMPANY

www.irannajo.com
Address: No. 153, West Hoveiseh, Sabounchi St. Sohrevardi Ave. Tehran 1533693317, Iran
Tel: +9821-88747363 Fax: +9821-88740644 info@irannajo.com

Clinda-Derm Topical Solution

Brand Name(s): C/T/S Topical Solution, Cleocin T Gel, Cleocin T Lotion, Cleocin T Pledgets, Cleocin T Topical Solution, Clinda-Derm Topical Solution, Clindagel Gel, Clindets Pledgets

Generic Name Clindamycin Topical

What is clindamycin skin lotion, solution or gel?

CLINDAMYCIN (Cleocin®) is an antibiotic or antiinfective. It is applied to the skin to stop the growth of certain bacteria that cause acne. Generic clindamycin skin lotion, solution and gel are available.

What should my health care professional know before I use clindamycin?

They need to know if you have any of these conditions:

  • diarrhea
  • inflammatory bowel disease
  • kidney disease
  • liver disease
  • ulcerative colitis
  • an unusual or allergic reaction to clindamycin, lincomycin, other medicines, foods, dyes or preservatives
  • pregnant or trying to get pregnant
  • breast-feeding
How should I use this medicine?

Clindamycin skin products are for external use only. Wash hands before and after use. Wash affected area and gently pat dry. Apply a thin layer of the gel or solution to the affected area as often as prescribed by your prescriber or health care professional. Do not use skin products near the eyes, nose, or mouth. It is important to use this medicine for the full course prescribed by your prescriber or health care professional, even if you think your condition is better. Do not stop using except on your prescriber's advice.

Contact your pediatrician or health care professional regarding the use of this medicine in children. Special care may be needed.

What if I miss a dose?

If you miss a dose, use it as soon as you can. If it is almost time for your next dose, use only that dose. Do not use double or extra doses.

What drug(s) may interact with clindamycin?
  • other acne products including benzoyl peroxide, salicylic acid, or tretinoin
  • skin cleansers or medicated soaps
  • medicated cosmetics, including cover-up preparations
  • shaving cream or lotion
  • after-shave lotion

Tell your prescriber or health care professional about all other skin products you are using.

What side effects may I notice from using clindamycin?

Side effects that you should report to your prescriber or health care professional as soon as possible:

  • contact dermatitis (rash, itching, swelling, redness)

Other serious side effects are unlikely from the use of skin products, but include:

  • diarrhea that is watery or severe
  • pain on swallowing
  • stomach pain or cramps
  • unusual bleeding or bruising

Side effects that usually do not require medical attention (report to your prescriber or health care professional if they continue or are bothersome):

What should I watch for while taking clindamycin?

Acne should begin to improve within about 6 weeks although complete improvement may take longer. Tell your prescriber or health care professional if you do not improve.

Your skin may get very dry and scale or peel. Let your prescriber or health care professional know if this happens and do not use any soothing cream or ointment without advice.

Keep clindamycin out of the eyes; if you do get any in your eyes rinse out with plenty of cool tap water.

After you wash or shave, wait for about 30 minutes before you apply the solution.

Clindamycin lotion contains alcohol and can catch fire. Keep away from lighted matches, cigarettes and other naked flames.

Where can I keep my medicine?

Keep out of the reach of children.

Store at room temperature between 15 and 30 °C (59 and 86 °F); do not freeze. Throw away any unused medicine after the expiration date.

Cleocin (Clinda) Delivery

You can order delivery of a Cleocin (Clinda) to the France, Austria, Switzerland or any other country in the world. Residents of the USA can order Cleocin (Clinda) to any city, to any address, for example to San Antonio, El Paso, San Jose or Cleveland.