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Clindets

Category: Antibiotics

Description

Cleocin is used for treating serious infections caused by certain bacteria.

Active Ingredient: Clindamycin

Cleocin (Clindets) as known as: Acnestop, Agis, Aknet, Aknezel k, Albiotin, Anerocid, Aniclindan, Antirobe, Arfarel, Bactemicina, Basocin, Benzolac cl, Bexon, Bioclindax, Biodaclin, Biodasin, Borophen, Botamycin-n, Candid-cl, Clamine-t, Clendix, Cleorobe, Clidacin, Clidacin-t, Clidamacin, Clidan, Clidets, Climadan, Climadan acne, Clin, Clin-sanorania, Clinacin, Clinacnyl, Clinamicina, Clinaram, Clinbercin, Clinda, Clinda mip, Clinda-derm, Clinda-ipp, Clinda-saar, Clinda-t, Clindabeta, Clindabuc, Clindacin, Clindacne, Clindacutin, Clindacyl, Clindacyn, Clindagel, Clindahexal, Clindal, Clindalind, Clindamax, Clindamek, Clindamicin, Clindamicina, Clindamycine, Clindamycinum, Clindamyl, Clindana, Clindanil, Clindareach, Clindasol, Clindasome, Clindastad, Clindaval, Clindess, Clindesse, Clindets, Clindexcin, Clindobion, Clindopax, Clindoral, Clindox, Clinex, Clinfol, Clinidac, Clinika, Clinimycin, Clinium, Clinmas, Clinsol, Clintabs, Clintopic, Clinwas, Cliofar, Cliz, Cluvax, Comdasin, Cutaclin, Dacin, Daclin, Dalacin, Dalacine, Dalagis t, Dalcap, Damiciclin, Damicine, Damiclin, Dentomycin, Derma, Dermabel, Divanon, Edason, Eficline, Ethidan, Euroclin, Evoclin, Fouch, Handaramin, Indanox, Jutaclin, Klamoxyl, Klimicin, Klin-amsa, Klindacin, Klindagol, Klindamicin, Klindamycin, Klindan, Klindaver, Klinoksin, Klitopsin, Lanacine, Lexis, Lindacil, Lindacyn, Lindan, Lindasol, Lintacin s, Lisiken, Luoqing, Medacin, Mediklin, Meneklin, Midocin, Milorin, Myclin, Naxoclinda, Niladacin, Nufaclind, Opiclam, Panancocin s, Paradis, Permycin, Prolic, Ribomin, Rosil, Sobelin, Sotomycin, Tidact, Toliken, Topicil, Torgyn, Trexen, Turimycin, Upderm, Veldom, Velkaderm, Ygielle, Z-clindacin, Ziana, Zindaclin, Zindacline, Zumatic

Clindets Pledgets

Brand Name(s): C/T/S Topical Solution, Cleocin T Gel, Cleocin T Lotion, Cleocin T Pledgets, Cleocin T Topical Solution, Clinda-Derm Topical Solution, Clindagel Gel, Clindets Pledgets

Generic Name Clindamycin Topical

What is clindamycin skin lotion, solution or gel?

CLINDAMYCIN (Cleocin®) is an antibiotic or antiinfective. It is applied to the skin to stop the growth of certain bacteria that cause acne. Generic clindamycin skin lotion, solution and gel are available.

What should my health care professional know before I use clindamycin?

They need to know if you have any of these conditions:

  • diarrhea
  • inflammatory bowel disease
  • kidney disease
  • liver disease
  • ulcerative colitis
  • an unusual or allergic reaction to clindamycin, lincomycin, other medicines, foods, dyes or preservatives
  • pregnant or trying to get pregnant
  • breast-feeding
How should I use this medicine?

Clindamycin skin products are for external use only. Wash hands before and after use. Wash affected area and gently pat dry. Apply a thin layer of the gel or solution to the affected area as often as prescribed by your prescriber or health care professional. Do not use skin products near the eyes, nose, or mouth. It is important to use this medicine for the full course prescribed by your prescriber or health care professional, even if you think your condition is better. Do not stop using except on your prescriber's advice.

Contact your pediatrician or health care professional regarding the use of this medicine in children. Special care may be needed.

What if I miss a dose?

If you miss a dose, use it as soon as you can. If it is almost time for your next dose, use only that dose. Do not use double or extra doses.

What drug(s) may interact with clindamycin?
  • other acne products including benzoyl peroxide, salicylic acid, or tretinoin
  • skin cleansers or medicated soaps
  • medicated cosmetics, including cover-up preparations
  • shaving cream or lotion
  • after-shave lotion

Tell your prescriber or health care professional about all other skin products you are using.

What side effects may I notice from using clindamycin?

Side effects that you should report to your prescriber or health care professional as soon as possible:

  • contact dermatitis (rash, itching, swelling, redness)

Other serious side effects are unlikely from the use of skin products, but include:

  • diarrhea that is watery or severe
  • pain on swallowing
  • stomach pain or cramps
  • unusual bleeding or bruising

Side effects that usually do not require medical attention (report to your prescriber or health care professional if they continue or are bothersome):

What should I watch for while taking clindamycin?

Acne should begin to improve within about 6 weeks although complete improvement may take longer. Tell your prescriber or health care professional if you do not improve.

Your skin may get very dry and scale or peel. Let your prescriber or health care professional know if this happens and do not use any soothing cream or ointment without advice.

Keep clindamycin out of the eyes; if you do get any in your eyes rinse out with plenty of cool tap water.

After you wash or shave, wait for about 30 minutes before you apply the solution.

Clindamycin lotion contains alcohol and can catch fire. Keep away from lighted matches, cigarettes and other naked flames.

Where can I keep my medicine?

Keep out of the reach of children.

Store at room temperature between 15 and 30 °C (59 and 86 °F); do not freeze. Throw away any unused medicine after the expiration date.

Other articles

Clindets - Drug shopping offer for search

Clindets brands/generic - how/where to find for ordering at lowest prices a prescriptions free

Information on this site is provided for informational purposes and is not meant to substitute for the advice provided by your own physician or other medical professional. You should not use the information contained herein for diagnosing or treating a health problem or disease, or prescribing any medication incl Clindets. You should read carefully all product packaging. If you have or suspect that you have a medical problem, promptly contact your doctor.

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Clindets - drug review: dosage, side effects, action, buy Clindets

Clindets


Staphylococcus aureus has another medicament to worry about - Clindets. This antibiotic is one of the most effective without having to worry about hypersensitivity reactions. Though patients do have to learn proper use and observance of adverse effects.

Clindets is the generic name for the lincosamide antibiotic. It is used to treat infections caused by anaerobic bacteria and some protozoal diseases like malaria. Since it is highly effective against methicillin-resistant Staphylococcus aureus or MRSA infections, Clindets is used to treat acne. The medicament is available under the brand names Dalacin. Cleocin. Duac and Evoclin.

Clindets can be used to treat infections of the respiratory tract, pelvis, abdomen and vagina. peritonitis and septicemia. The medicament works well for patients with known hypersensitivity reactions to penicillins. Bone and joint infections from Staphylococcus aureus can also be treated with this medicament. The medicament is available in capsule form, taken orally. There are also lotions and gels applied topically for skin infections.

Serious side effects and allergic reactions include face and lip swelling. breathing difficulty, hives and rash, bloody or watery stool, fever. flu-like symptoms, body aches, nausea. vomiting. loss of appetite. jaundice, scanty or absent urine and headache. Mild or moderate side effects include mild nausea, stomachache, vaginal itching or discharge, throat irritation and mild skin itching or rash. Patients should immediately stop taking the medicament and seek immediate medical attention if they experience any symptoms of an allergic reaction. For mild to moderate side effects, patients may continue taking the medicament but everything should be reported to the physician.

Patients with hypersensitivity to Clindets or lincomycin should not take this medicament. This medicament is known to cause adverse reactions if it is taken with erythromycin. Patients with Crohns disease, asthma. eczema. allergies. colitis, intestinal disorder, kidney problem or liver disease should first consult their physician to ensure safety. Clindets is thought to have effects in-vitro so pregnant women, those planning to become pregnant and nursing mothers should seek their physician's advice before taking this medicament.

Clindets has a bacteriostatic effect meaning bacterial protein synthesis is interfered with through its binding action to bacterial ribosome particularly the 50S subunit. Since the medicament binds to the subunit, bacterial growth and spread is stopped. Clindets is absorbed from the gastrointestinal tract then delivered to various infection sites in the body.

In a study, 20 patients with Staphylococcus aureus skin infections were treated with 500 mg of Clindets every 6 hours for 2 weeks. After the first week, 14 participants exhibited a lot of improvement and by the end of the second week, 19 participants had improved conditions and 8 of the participants were fully recovered. Only 3 of the participants showed mild allergic side effects like skin itching and rash.

Clindets is an over-the-counter medicament, which can be bought at any pharmacy or drug store. The pills are available in 250 or 500 mg. Consumers should check the expiration date, manufacturer and brand name to ensure authenticity of the medicament. When buying generic brands, it is important to look for certified drug stores and online sites.

Clindets overdose is possible so patients should watch for signs and seek medical attention as soon as they notice any symptoms. If you miss a dose, take the missed dose as soon as remembered but skip it if it is almost time to take the next one. Store the medicament at room temperature free from direct sunlight and moisture. Follow the instructions from your physician, especially if the medicament is intended for vaginal use.

Clindets has the following structural formula:

• Molecular formula of clindets is C18H33ClN2O5S
• Chemical IUPAC Name is N-[2-chloro-1-(3,4,5-trihydroxy-6-methylsulfanyl-tetrahydropyran-2-yl)-propyl]- 1-methyl-4-propyl-pyrrolidine-2-carboxamide
• Molecular weight is 424.984 g/mol
Clindets available. 150mg capsules, 300mg capsules

Generic name:Clindamycin

Generic Clindets Pledget information

Generic Clindets Pledget information

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Clindets swab

Clindets swab

They rarely considered the possibility that hunger, satiety, and level of physical activity might be symptomatic of underlying physiological conditions. Imagine if diabetologists clindets swab had perceived the ravenous hunger that accompanies uncontrolled diabetes as a behavioral disorder, to be treated by years of psychotherapy or behavioral modification rather than injections of insulin. These researchers simply never confronted the possibility that the nutrient composition of the diet might have a fundamental effect on eating behavior and energy poly tussin dm expenditure, and thus on the long-term regulation of weight. There is one way to test this latter notion, and, in fact, such tests were clindets swab done from the 1930s onward.

Alter the proportion of fats and carbohydrates in experimental diets and see what happens. Test low-fat diets clindets swab versus low-carbohydrate diets, keeping in mind that a diet low in fat clindets swab must be high in carbohydrates and vice versa. This would test the notion that these nutrients have unique metabolic and hormonal effects that influence weight, hunger or satiety, and energy expenditure. Such trials provide the means of answering these fundamental questions: What happens when we eat a diet restricted in carbohydrates, but not calories? Are we as hungry as we are when calories are restricted? And what about when fat is restricted, but carbohydrates or calories are not?

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Clindets Swab - patient information, description, dosage and directions

Drugs Information Online
Drugs and diseases reference index
Drugs reference index «Clindets Swab » Clindets Swab

Generic Name:Clindamycin (KLIN-da-MYE-sin)Brand Name: Examples include Cleocin T and Clindets

Clindets Swab is used for:

Treating acne. It may also be used for other conditions as determined by your doctor.

Clindets Swab is a topical lincomycin antibiotic. It works by killing sensitive bacteria that cause acne and reducing the amount of free fatty acids that irritate the skin surface.

Do NOT use Clindets Swab if:
  • you are allergic to any ingredient in Clindets Swab or to lincomycin
  • you have Crohn disease, antibiotic-associated colitis, or ulcerative colitis

Contact your doctor or health care provider right away if any of these apply to you.

Before using Clindets Swab:

Some medical conditions may interact with Clindets Swab. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have gastrointestinal (bowel) disease or diarrhea

Some MEDICINES MAY INTERACT with Clindets Swab. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Nondepolarizing muscle relaxants (eg, vecuronium) or succinylcholine because their actions and the risk of their side effects may be increased by Clindets Swab
  • Erythromycin because it may decrease Clindets Swab's effectiveness

This may not be a complete list of all interactions that may occur. Ask your health care provider if Clindets Swab may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Clindets Swab:

Use Clindets Swab as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Clindets Swab is for topical use on the skin only.
  • Wash and completely dry the affected area.
  • Remove the pledget from the jar or foil wrapper just before use. Do not use a pledget from a foil wrapper that has a broken seal. With pledget, gently apply a thin film of medicine. You may use more than 1 pledget if necessary to completely cover the affected area. Wash your hands immediately after using Clindets Swab. Throw the pledget away after using.
  • Clindets Swab works best if it is used at the same time each day.
  • Continue to use Clindets Swab even if your condition improves. Do not miss any doses.
  • If you miss a dose of Clindets Swab, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.

Ask your health care provider any questions you may have about how to use Clindets Swab.

Important safety information:
  • Clindets Swab is for external use only. Avoid contact with the eyes because burning or irritation can occur. If contact occurs with the eyes or sensitive surfaces (eg, scraped skin, mucous membranes), wash the area with cool tap water.
  • Clindets Swab may cause harm if it is swallowed. If you may have taken it by mouth, contact your poison control center or emergency room right away.
  • Several weeks may pass before you see improvement in your acne. Continue using Clindets Swab for the full time recommended by your doctor.
  • Be sure to use Clindets Swab for the full course of treatment. If you do not, the medicine may not clear up your infection completely. The bacteria could also become less sensitive to this or other medicines. This could make the infection harder to treat in the future.
  • If severe diarrhea, stomach pain or cramping, or bloody stools develop during treatment or within several months after treatment with Clindets Swab, check with your doctor or pharmacist right away. Do not treat it without first checking with your doctor.
  • Clindets Swab should be used with extreme caution in CHILDREN younger than 12 years old; safety and effectiveness in these children have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Clindets Swab while you are pregnant. It is not known if Clindets Swab is found in breast milk. Do not breast-feed while using Clindets Swab.
Possible side effects of Clindets Swab:

All medicines may cause side effects, but many people have no, or minor side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Dry skin; mild stinging after applying.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); blood or mucus in stools; diarrhea; stomach pain; swelling, redness, burning, or peeling of the skin.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch .

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org ), or emergency room immediately. Clindets Swab may be harmful if swallowed.

Proper storage of Clindets Swab:

Store Clindets Swab at room temperature, between 68 to 77 degrees F (20 to 25 degrees C), in a tightly closed container. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Clindets Swab out of the reach of children and away from pets.

General information:
  • If you have any questions about Clindets Swab, please talk with your doctor, pharmacist, or other health care provider.
  • Clindets Swab is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Clindets Swab. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Clindets (Clindamycin Topical) - Drug Info, Side Effects, Research, Clinical Trials

Clindets (Clindamycin Phosphate Pledgets) - Summary CLINDETS SUMMARY

Clindets® (Clindamycin Phosphate Pledgets) contain clindamycin phosphate, USP at a concentration equivalent to 10 mg clindamycin per milliliter in a vehicle of isopropyl alcohol 52% v/v, propylene glycol and water. Each Clindets® pledget applicator contains approximately 1 mL of Clindamycin Phosphate Topical Solution. Clindamycin Phosphate Topical Solution has a pH range between 4.0 and 7.0.

Clindets are indicated in the treatment of acne vulgaris. In view of the potential for diarrhea, bloody diarrhea and pseudomembranous colitis, the physician should consider whether other agents are more appropriate. (See CONTRAINDICATIONS, WARNINGS, and ADVERSE REACTIONS.)

NEWS HIGHLIGHTS Media Articles Related to Clindets (Clindamycin Topical)

FDA Advisory Panel Backs OTC Adapalene Gel 0.1% for Acne
Source: Medscape Dermatology Headlines [2016.04.18]
An FDA panel voted to recommend over-the-counter marketing of adapalene gel 0.1% for persons aged 12 years or older with acne.
Medscape Medical News

Acne Drug: FDA Advisors Recommend OTC Adapalene
Source: MedPage Today Dermatology [2016.04.15]
(MedPage Today) -- Panel votes 16-0 that the drug is safe for use without a prescription.

Acne (Pimples) Quiz: Test Your Medical IQ
Source: MedicineNet Acne Specialty [2016.04.01]
Title: Acne (Pimples) Quiz: Test Your Medical IQ
Category: MedicineNet Quiz
Created: 2/28/2011 4:15:00 PM
Last Editorial Review: 4/1/2016 5:02:28 PM

Misconceptions About Acne Still Common
Source: MedicineNet Acne Specialty [2016.03.07]
Title: Misconceptions About Acne Still Common
Category: Health News
Created: 3/4/2016 12:00:00 AM
Last Editorial Review: 3/7/2016 12:00:00 AM

Cystic Acne
Source: MedicineNet Acne Specialty [2016.03.04]
Title: Cystic Acne
Category: Diseases and Conditions
Created: 3/4/2016 12:00:00 AM
Last Editorial Review: 3/4/2016 12:00:00 AM

Published Studies Related to Clindets (Clindamycin Topical)

Efficacy of clindamycin in reducing pain following tonsillectomy in adults: a double-blind, randomised trial. [2013]
reducing throat pain after tonsillectomy in adult patients. CONCLUSION: Topical clindamycin was not demonstrated to be more effective than

Topical 4% nicotinamide vs. 1% clindamycin in moderate inflammatory acne vulgaris. [2013]
Nicotinamide and clindamycin gels are two popular topical medications for acne vulgaris. Skin type is a significant factor in choosing between topical nicotinamide and clindamycin in patients with acne vulgaris.

Efficacy and safety of topical nadifloxacin and benzoyl peroxide versus clindamycin and benzoyl peroxide in acne vulgaris: A randomized controlled trial. [2011.11]
BACKGROUND: Topical therapy with comedolytics and antibiotics are often advocated for mild and moderate severity acne vulgaris. Nadifloxacin, a new fluoroquinolone with anti-Propionibacterium acnes activity and additional anti-inflammatory activity, is approved for use in acne. This randomized controlled assessor blind trial compared the clinical effectiveness and safety of eight weeks therapy of nadifloxacin 1% versus clindamycin 1% as add-on therapy to benzoyl peroxide (2.5%) in mild to moderate grade acne. CONCLUSIONS: Topical nadifloxacin, a new fluoroquinolone is effective, tolerable, and safe for mild o moderate facial acne. Its clinical effectiveness is comparable to clindamycin when used as add-on therapy to benzoyl peroxide.

Efficacy of topical combination of benzoyl peroxide 5% and clindamycin 1% for the treatment of progressive macular hypomelanosis: a randomized, doubleblind, placebo-controlled trial. [2011.02]
BACKGROUND: Progressive macular hypomelanosis is a dermatosis without definite etiology. There is no consensus or first-line therapy in the treatment of progressive macular hypomelanosis, and the treatment options used are very little effective. OBJECTIVE: To evaluate the therapeutic efficacy of the topical combination of benzoyl peroxide 5% and clindamycin 1% associated with sun exposure for the treatment of progressive macular hypomelanosis. CONCLUSION: The topical combination of benzoyl peroxide 5% and clindamycin 1% is effective in the treatment of progressive macular hypomelanosis.

Clinical Trials Related to Clindets (Clindamycin Topical)

Adherence to Study Medication Compared to Generic Topical Clindamycin Plus Generic Topical Tretinoin in Subjects With Mild to Moderate Acne Vulgaris [Completed]
The purpose of this research study is to evaluate the effectiveness of two different types of topical acne medication. This study will help to determine if one combined medication results in better acne improvement than two separate medications for acne.

Systemic and Topical Treatments for Rash Secondary to Erlotinib in Lung Cancer [Completed]
The purpose of this trial is to determine if rash caused by erlotinib can be successfully treated and if so to determine the optimal treatment approach. Hypothesis: Hypothesis 1: If the incidence of rash is 50% while on erlotinib, prophylactic monotherapy with minocycline can prevent occurrence in 50% of these patients. Hypothesis 2: Treatment of rash is successful in improving rash by at least one Grade in 80% of patients. Hypothesis 3: In patients with untreated rash, the rash will be self-limiting in 25% of patients, and 65% will be grade 1, 2A, and 2b. Ten percent will be grade 3 requiring treatment with monotherapy intervention.

Efficacy and Safety of a Preparation Containing an Antibiotic and Anti-Inflammatory Agent in Acne Vulgaris [Completed]
The concept behind our study was to combine an effect of antibiotic and anti-inflammatory agents for a more efficient acne therapy directed at the factors involved in the pathophysiology of the disease. For this purpose we evaluated a combination of clindamycin phosphate and salicylic acid in a non-irritating carrier.

Clindets diseases

clindamycin phosphate

Cleocin Phosphate, Cleocin T,Clindagel, ClindaMax, Clindesse,Clindets, Dalacin C Phosphate (CA),Dalacin T (CA) (UK), Evoclin, Zindaclin (UK)

Pharmacologic class . Lincosamide

Therapeutic class . Anti-infective

Pregnancy risk category B

FDA Box Warning

Clostridium difficile -associated diarrhea (CDAD) has been reported with use of nearly all antibacterial agents, including Cleocin. and may range in severity from mild diarrhea to fatal colitis. Treatment with antibacterial agents alters the normal flora of the colon, leading to overgrowth of C. difficile .

• Because Cleocin therapy has been associated with severe colitis that may be fatal, it should be reserved for serious infections for which less toxic antimicrobials are inappropriate. It shouldn't be used in patients with non-bacterial infections such as most upper respiratory tract infections.

C. difficile produces toxins A and B, which contribute to the development of CDAD. Hypertoxin-producing strains of C. difficile cause increased morbidity and mortality because these infections can be refractory to antimicrobial therapy and may require colectomy. CDAD must be considered in all patients who present with diarrhea following antibiotic use. Careful medical history is necessary because CDAD has occurred more than 2 months after administration of antibacterial agents.

• If CDAD is suspected or confirmed, ongoing antibiotic use not directed against C. difficile may need to be discontinued. Appropriate fluid and electrolyte management, protein supplementation, antibiotic treatment of C. difficile. and surgical evaluation should be instituted as clinically indicated.

Action

Inhibits protein synthesis in susceptible bacteria at level of 50S ribosome, thereby inhibiting peptide bond formation and causing cell death

Availability

Capsules. 75 mg, 150 mg, 300 mg

Granules for oral suspension. 75 mg/5 ml

Injection. 150 mg base/ml

Topical. 1% gel, lotion, single-use applicators, solution, and suspension

Vaginal cream. 2%

Vaginal suppositories (ovules). 100 mg

Indications and dosages

➣ Severe infections caused by sensitive organisms (such as Bacteroides fragilis, Clostridium perfringens, Fusobacterium. pneumococci, staphylococci, and streptococci)

Adults: 300 to 450 mg P.O. q 6 hours, or (for other than C. perfringens ) 1.2 to 2.7 g/day I.M. or I.V. in two to four equally divided doses

Children: 16 to 20 mg/kg/day P.O. (hydrochloride) in three to four equally divided doses, or 13 to 25 mg/kg/day P.O. (palmitate hydrochloride) in three to four equally divided doses

Neonates younger than 1 month: 15 to 20 mg/kg/day I.M. or I.V. in three to four equally divided doses

➣ Acute pelvic inflammatory disease

Adults: 900 mg I.V. q 8 hours (given with gentamicin)

➣ Acne vulgaris

Adults and children older than age 12:

Apply a thin film of topical gel, lotion, or solution locally to affected area b.i.d.

Off-label uses

• Bacterial vaginosis (phosphate)
Chlamydia trachomatis infection in females
• CNS toxoplasmosis in AIDS patients (given with pyrimethamine)
Pneumocystis jiroveci pneumonia (given with primaquine)
• Rosacea (lotion)

Contraindications

• Hypersensitivity to drug or lincomycin

Precautions

Use cautiously in:
• renal or hepatic impairment
• known alcohol intolerance
• pregnant patients
• neonates.

Administration

• Give oral doses with full glass of water, with or without food.

☞ Don't give as I.V. bolus injection.
• Dilute I.V. solution to a concentration of 18 mg/ml using normal saline solution, dextrose 5% in water, or lactated Ringer's solution. Infuse no faster than 30 mg/minute.
• Don't administer I.M. dosages above 600 mg.
• Inject I.M. doses deep into large muscle mass to prevent induration and sterile abscess.

Adverse reactions

GI: nausea, vomiting, diarrhea, abdominal pain, esophagitis, pseudomembranous colitis

Hematologic: neutropenia, leukopenia, agranulocytosis, thrombocytopenia purpura

Hepatic: jaundice, hepatic dysfunction

Skin: maculopapular rash, generalized morbilliform-like rash

Other: bitter taste (with I.V. use), phlebitis at I.V. site, induration and sterile abscess (with I.M. use), anaphylaxis

Interactions

Drug-drug.Erythromycin. antagonistic effect

Kaolin/pectin. decreased GI absorption of clindamycin

Hormonal contraceptives. decreased contraceptive efficacy

Neuromuscular blockers. enhanced neuromuscular blockade

Drug-diagnostic tests.Alanine aminotransferase, alkaline phosphatase, aspartate aminotransferase, bilirubin, creatine kinase. increased levels

Platelets, white blood cells. transient decrease in counts

Patient monitoring

• Monitor creatinine level closely in patients with renal insufficiency.
• Monitor hepatic enzyme levels in patients with hepatic disease.
• Assess for signs and symptoms of hypersensitivity reactions, including anaphylaxis.
• Assess for diarrhea and signs and symptoms of colitis.

Patient teaching

• Tell patient to take drug with food if it causes stomach upset.

☞ Urge patient to contact prescriber immediately if he develops rash, unusual fatigue, or yellowing of skin or eyes or if diarrhea occurs during or after treatment.
• Tell patient that I.V. use may cause bitter taste. Reassure him that this effect will resolve on its own.
• Caution patient not to rely on condoms or diaphragm for contraception for 72 hours after using vaginal preparation; drug may weaken latex products and cause breakage.
• Instruct patient taking hormonal contraceptives to use supplemental birth control method, such as condoms (unless she's using a vaginal preparation); drug may reduce hormonal contraceptive efficacy.
• As appropriate, review all other significant and life-threatening adverse reactions and interactions, especially those related to the drugs and tests mentioned above.

Link to this page:

Cleocin (Clindets) Delivery

You can order delivery of a Cleocin (Clindets) to the United Kingdom, Sweden, Norway or any other country in the world. Residents of the USA can order Cleocin (Clindets) to any city, to any address, for example to Chicago, Madison, or Houston.