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Ralovera

Category: Woman's Health

Description

Provera is used for treating certain menstrual problems or uterine problems (eg, abnormal bleeding, endometrial hyperplasia).

Active Ingredient: Medroxyprogesterone

Provera (Ralovera) as known as: Amen, Apo-medroxy, Aragest, Ciclotal, Climanor, Contracep, Curretab, Cycrin, Depo-clinovir, Depo-prodasone, Depo-progevera, Depo-provera, Depocon, Depotrust, Deviry, Dugen, Duova, Enaf, Farlutal, Farlutale, Femihexal, Gestapuran, Gestomikron, Hexal-mpa, Hysron, Livomedrox, Lunelle, Lutoral, Lyndavel, Medkiron, Medroplex, Medrosterona, Medroxiprogesterona, Medroxyhexal, Medroxyprogesteron, Medroxyprogesteronacetat, Medroxyprogesteronum, Megestron, Mepastat, Meprate, Mepro, Methypregnone, Metigesterona, Modus, Mpa-beta, Nerfin, Non-preg, Novo-medrone, Perlutex, Petogen, Petogen-fresenius, Planibu, Prodafem, Prodasone, Progeron, Progestagen, Progevera, Ralovera, Roxyprog, Sayana, Veraplex

Swollen belly

Swollen belly Detailed list of causes of Swollen belly How Common are these Causes of Swollen belly? This information refers to the general prevalence and incidence of these diseases, not to how likely they are to be the actual cause of Swollen belly. Of the 111 causes of Swollen belly that we have listed, we have the following prevalence/incidence information:
  • 5 causes are "very common" diseases
  • 9 causes are "common" diseases
  • 2 causes are "uncommon" diseases
  • 1 causes are "rare" diseases
  • 10 causes are "very rare" diseases
  • 98 causes have no prevalence information.
Conditions listing medical symptoms: Swollen belly:

The following list of conditions have 'Swollen belly ' or similar listed as a symptom in our database. This computer-generated list may be inaccurate or incomplete. Always seek prompt professional medical advice about the cause of any symptom.

Select from the following alphabetical view of conditions which include a symptom of Swollen belly or choose View All.

A C D W Conditions listing medical complications: Swollen belly:

The following list of medical conditions have Swollen belly or similar listed as a medical complication in our database. The distinction between a symptom and complication is not always clear, and conditions mentioning this symptom as a complication may also be relevant. This computer-generated list may be inaccurate or incomplete. Always seek prompt professional medical advice about the cause of any symptom.

G Join in at the forums Causes of Swollen belly Based on Risk Factors Classifications of Swollen belly:

Medical Conditions associated with Swollen belly:

Symptoms related to Swollen belly:

Medical articles on signs and symptoms: Medical News summaries about Swollen belly Evidence Based Medicine Research for Swollen belly

Other articles

A Phase 3, Multi-Center, Open-Label Study of a Levonorgestrel-Releasing Intrauterine System for Long-Term, Reversible Contraception

A Phase 3, Multi-Center, Open-Label Study of a Levonorgestrel-Releasing Intrauterine System for Long-Term, Reversible Contraception Brief Summary

The levonorgestrel IUS (LNG20) that Medicines360 proposes to develop consists of a T-shaped polyethylene frame (T-body) with a steroid reservoir around the vertical stem. The steroid reservoir is covered with a polydimethylsiloxane membrane which controls the release rate of levonorgestrel from the reservoir. The LNG20 reservoir contains 52 mg levonorgestrel; providing an initial release rate of 20 mcg/day. A polypropylene monofilament blue thread is attached to the end of the vertical stem. Please refer to the Investigator’s Brochure for full details on the components of LNG20.

LNG20 is currently being investigated in a multi-center, single-blind randomized trial in Europe to assess the therapeutic equivalence in terms of efficacy and safety compared to Mirena in patients with menorrhagia. Enrollment of 280 subjects was completed in January, 2009 and 50% were randomized to LNG20. Serious Adverse Events collected during the reporting period did not reveal any new safety concerns and did not change the overall risk-benefit evaluation for LNG20. To date, adverse event-related removals of the IUS have occurred in five women (three LNG20, two Mirena). The three LNG20 removals were related to ovarian cysts (one of these three subjects required hospitalization). The two Mirena removals followed development of abdominal and peripheral edema in one subject, and reported nervousness, chest tension, abdominal pain, and hypertension in a second subject. Expulsion of the IUS has been reported in a total of 10 subjects (five LNG20, five Mirena). No deaths occurred in this reporting period. An interim review of all safety data reported as of December 2008 supports that LNG20 was generally well tolerated in female subjects with menorrhagia.

This study is being performed to evaluate the Medicines360 levonorgestrel-releasing IUS, LNG20. LNG20 is expected to provide safe and effective contraception for up to 7 years.

The primary objective of this study is to assess the efficacy of a levonorgestrel-releasing intrauterine system (LNG20) in nulliparous and parous females of child-bearing potential who request long-term, reversible contraception.

The secondary objectives of this study are to assess:

• The safety, tolerability, bleeding patterns, and continuation rates of LNG20

• The occurrence of menses and return to fertility after IUS discontinuation

• The plasma pharmacokinetics of levonorgestrel in a subset of 80 subjects (40 for each IUS) with serial sampling over the duration of use

• Plasma levonorgestrel levels in a subset of approximately 60 subjects (LNG20 arm only) following IUS removal at 85 months of use with sampling at various timepoints up to 14 days post-IUS removal

• Plasma levonorgestrel levels for all subjects at each visit starting with Month 36 to support a decision for extended duration of use of LNG20 beyond Month 60

• Analysis of an appropriate sampling of IUSs that are removed and, when available, expelled during the study

• The safety and tolerability of LNG20 in a small cohort of women between ages 36 and 45 years

• Endometrial thickness in a subset of 60 subjects at 1, 5 and 7 years of LNG20 use


The Utah study site has been selected to participate in the PK Treatment substudy.

• Levonorgestrel PK data will be generated in a subset of 80 subjects, (approximately 40 subjects per study arm). Blood samples will be obtained at the Enrollment Visit (pre-IUS insertion), Weeks 1 and 2, and Months 1, 3, 6, 9, 12, 18, 24 and 30 after IUS insertion.

Contact Information
  1. Signed informed consent
  2. Healthy females 16-45 years old inclusive at the time of enrollment
  3. Sexually active and in a mutually monogamous relationship at study entry
  4. Willing to rely on the IUS as the primary method of contraception during study participation
  5. History of regular menstrual cycles defined as occurring every 21-35 days when not using hormones and with a variation of typical cycle length of no more than 5 days
  6. Willing to comply with study visit schedule and assessments, including diary completion requirements

Treatment PK Substudy

In addition to meeting all entry criteria for the primary study, subjects desiring to enter the PK substudy must meet all of the following criteria:

  • be 16-35 years old at the time of enrollment in the primary study.
  • have signed informed consent for the PK sampling prior to collection of the blood sample on Day 1.
  • Have venous access adequate for multiple blood draws
  • have not received hormonal contraception within 7 days of enrollment

Subjects meeting any of the following criteria will be ineligible for study entry:

  1. Currently pregnant
  2. Pregnant within 4 weeks prior to study entry
  3. Planning pregnancy within 24 months of study entry
  4. Currently breastfeeding
  5. History of ectopic pregnancy without a subsequent intrauterine pregnancy
  6. History of trophoblastic disease (benign or malignant gestational) without a subsequent non-trophoblastic intrauterine pregnancy
  7. Acute pelvic inflammatory disease or a history of pelvic inflammatory disease without subsequent intrauterine pregnancy
  8. Known to be HIV positive or have a partner who is known to be HIV positive
  9. History of cervical or vaginal infection (unless successfully treated and considered clinically cured for at least 7 days prior to study entry)
  10. Postpartum or post-abortion endometritis unless symptoms resolved at least 4 weeks prior to study entry
  11. Current persistent, abnormal vaginal bleeding
  12. Abnormal Pap smear based on the following criteria:

•Pap smear in the past 18 months with ASC-US unless:


oLess than 21 years of age

oa repeat Pap smear at least 6 months later was normal;

oreflex HPV testing was performed and was negative for high-risk HPV; or

oreflex HPV testing was performed and was positive for high-risk HPV, and colposcopy (with or without biopsy) found no evidence of dysplasia requiring treatment or treatment was performed and follow-up at least six months after the treatment showed no evidence of the disease;

•Pap smear in the past 18 montsh with LSIL unless:

oLess than 21 years of age; or

oA coloposcopy (with or without biopsy) found no evidence of dysplasia requiring treatment or treatment was performed and follow-up at least six months after the treatment showed no evidence of disease;

•Pap smear in the past 18 months with ASC-H, atypical glandular cells, LSIL, or HSIL unless colposcopy and/or treatment was performed and follow-up at least 6 months after the colposcopy and/or treatment showed no evidence of disease;

•Pap smear in the past 18 months with malignant cells

13. History of malignancy of the genital tract (e.g. cervical cancer, ovarian cancer, endometrial cancer)

14. History of breast cancer, or suspicion of breast cancer until proven otherwise

15. History of bicornuate uterus or any other abnormality of the uterus resulting in distortion of the uterine cavity or cervical canal incompatible with insertion

16. Known or suspected allergy to levonorgestrel or hypersensitivity to any component of the product

17. Bleeding diathesis (inherited or acquired)

18. Use of anticoagulants within 30 days prior to study entry

19. Body habitus or history of lower genital tract abnormalities or prior surgeries which may prohibit proper visualization of the cervix or not allow the uterus to be appropriately instrumented [Note: any women who may meet this criteria should have a pelvic examination prior to randomization to confirm that the cervix cannot be properly visualized for IUS insertion]

20. Current or history of alcohol or illicit drug abuse within 12 months prior to study entry

21. Current use of hormonal contraception for cycle control

22. DMPA (Depo-Provera®/Depo-Ralovera®) injection:

• within the past 9 months, OR

• within the past 6 months, if subject has also had two spontaneous menstrual cycles (requires minimum of 3 menses) that meet criteria for normal menstrual cycles

23. Current use of non-contraceptive estrogen, progesterone, or testosterone

24. Use of an experimental medication or receipt of an experimental treatment for any condition within 30 days of study entry

25. Study staff or a member of the immediate family of a study staff

26. Any condition that, in the opinion of the investigator, would constitute contraindications to participation in the study or would compromise ability to comply with the study protocol

The University of Utah Health Sciences Center
50 North Medical Drive
Salt Lake City, Utah 84132

Depo-ralovera Side Effects

Depo-ralovera Side Effects

Your Depo-ralovera Side Effect submission can play a very important role. Reporting your experience could help identify an unknown risk and inform other patients and health care professionals.

List of Depo-ralovera Adverse Effects reported to US Food and Drug Administration (FDA) Contusion, Erythema, Injection Site Induration, Injection Site Pain, Injection Site Pruritus, Vasculitis (6936221-3)
on Aug 13, 2010 Female patient from AUSTRALIA. 25 years of age, weighting 253.5 lb, was diagnosed with
  • contraception
and was treated with Depo-ralovera. Patient experienced the following unwanted or unexpected effects: contusion, erythema, injection site induration, injection site pain, injection site pruritus, vasculitis. Depo-ralovera dosage: 150 Mg, Every 3 Months. Chest Pain (4770757-9)
Patient was taking Depo-ralovera (medroxyprogesterone Acetate). Patient had the following side effects: chest pain on Sep 05, 2005 from AUSTRALIA Additional patient health information: Female patient. 21 years of age, was diagnosed with
  • ill-defined disorder
and. Depo-ralovera (medroxyprogesterone Acetate) dosage: N/A. Patient was hospitalized. Anxiety, Breast Pain, Swelling (4614098-9)
Adverse event was reported on Mar 01, 2005 by a Female patient taking Depo-ralovera (medroxyprogesterone Acetate) (Dosage: 150 Mg (150 Mg, Every Threemonths, First Injection), Intramuscular) was diagnosed with
  • contraception
and. Location. 25 years of age, weighting 152.1 lb, After Depo-ralovera was administered, patient had the following side effects: anxiety, breast pain, swelling.

Did You Have a Depo-ralovera Side Effect?

Ralovera diseases

The Injection

Depo-Provera or Depo Ralovera (Depot Medroxyprogesterone Acetate) is a contraceptive injection of a chemical similar to the hormone progesterone which your ovaries produce. The three monthly injection protects you from pregnancy for 12 weeks by stopping the release of an egg from your ovaries. However if you delay having your next injection for over two weeks there is a small risk of pregnancy

It is a very effective contraceptive. If 1000 women were each to use it for a year only four or five may become pregnant. There are fewer accidental pregnancies with the injection than with the oral contraceptive pill.

If you want to use the three monthly injection you should tell your doctor if:

you could be pregnant
you have unusual or irregular vaginal bleeding.

You should also tell your doctor if you have had any of the following health problems:

cancer of the breast or genitals
a history of severe depression
disease of the heart, liver or kidneys
a history of blood clots

The drugs is injected into the muscle of your upper arm every twelve weeks. The first injection should be given during the first five days of your menstrual cycle (the first day of bleeding is day one). In this way you are protected from pregnancy immediately. If you have the injection on the same day as an abortion it will be effective immediately.

If you have irregular cycles or aren’t getting periods (eg breast feeding) it can be given at any time as long as you aren’t pregnant. Abstain from sex for two weeks or use condoms. A urine pregnancy test should show positive if a pregnancy has occurred over 14 days before. A negative test and it’s okay to have it but it will take 7 days before it is effective, (use condoms or abstain for this time).

It can be injected at the time of a surgical or medical termination and will be effective immediately. If it is given at a post termination check up it is important that there has either been no sex, or careful condom use, and it will take seven days to begin work.

The injection changes your periods. They often become irregular and may last longer. Bleeding is usually light and may be continual. This can be treated. After several injections your periods may stop altogether. This is normal and does not harm you. After 14 weeks from the last injection, there is a chance that you may start ovulating again.

It also reduces the incidence of monilia (thrush/candida).When you stop the injections your periods will return to normal although for some women, this may take up to 18 months. Some women have weight gain, headaches or depression and side effects can last for three months or longer.

Some studies have shown that there can be a loss of bone density (bone thinning). This can increase the chance of osteoporosis after menopause. Young women (under 18) are more at risk of this.

Most women find that it takes about 10 months after the last injection to become pregnant. Sometimes it takes longer but the number of injections you have does not affect this.Some women conceive when they are only a few weeks late having the injection. If you stop the injections and do not want to become pregnant you must use another form of contraception.

Depo Ralovera

Generic Name: Medroxyprogesterone acetate
Product Name: Depo Ralovera

Indication

Depo-Ralovera can be used in the palliative treatment of recurrent and/or metastatic breast, renal cell or endometrial cancer.

It can also be used in the treatment of visually proven endometriosis when pregnancy is the desired treatment outcome, or when surgery is contraindicated or has been unsuccessful.

Due to its ovulation-suppressing effects, a high dose of Medroxyprogesterone is also useful as a contraceptive agent. Depo-Ralovera can be administered every three months for this purpose.

Action

Many cancers rely on supplies of specific sex hormones, such as oestrogen, to grow. Cancer cells have proteins called receptors on their surface which the sex hormones attach to. The easiest way to understand the significance of these receptors is to compare the process to that of a lock and key. Under normal circumstances, when the sex hormones come into contact with the receptors they fit into the lock and activate the cancer cells to divide, and the tumour grows.

Medroxyprogesterone acetate disrupts this process in some way. It may be that it prevents the cancer cells from maintaining the receptors on their surface, effectively removing the lock. Or it may have a more direct means of destroying cancer cells that has not, as yet, been identified. Medroxyprogesterone acetate is a hormonal agent that supports pregnancy. It transforms the endometrium (lining of the uterus) into the kind that supports pregnancy, it maintains pregnancy, delays labour/birth and suppresses ovulation. At high doses Depo-Ralovera can be used to treat certain cancers, where it has corticoid-like activity.

Dose advice

Inoperable/recurrent/metastatic renal cell and endometrial cancer

  • Initially 600-1200mg weekly
  • 450-600mg every 1-4 weeks for maintenance
  • 500mg daily by IM injection
  • treat for at least 6 months
  • 50mg weekly or 100mg every 2 weeks by IM injection
  • treat for at least 6 months
  • 150mg every three months by deep IM injection
  • give first injection within 5 days of normal menstrual period
  • if the period between injections is greater than 14 weeks, pregnancy needs to be excluded before the next injection
  • the 50mg/1ml preparation is NOT to be used for contraception, the 150mg1/ml vial should be used
  • if volumes larger than 2.5ml are to be injected, the dose should be divided and multiple sites used, as gluteal infiltration and abscess formation may occur with large doses- long term use of cyclical oestrogens with Depo-Ralovera is not recommended
Schedule Common side effects
  • Prolonged bleeding, spotting, cessation of periods, depression, weight gain, moderate increase in blood pressure, decreased glucose tolerance.
  • The most commonly reported side effect is an increase in appetite, causing some people to put on weight.

Nausea and indigestion:

  • Occasionally nausea is are present for the first few weeks of taking medroxyprogesterone acetate, but often the nausea then disappears. It can usually be relieved by taking the tablets with food and milk.
  • Some people have experienced mild ankle swelling caused by fluid retention. This is not harmful but can be uncomfortable.

Vaginal bleeding (in women):

  • Occasionally women may have some light vaginal bleeding (spotting) while having treatment with medroxyprogesterone acetate.
Uncommon side effects
  • Nausea
  • Vomiting
  • Headache
  • Dizziness
  • Lethargy
  • Breast discomfort
  • Decreased libido
  • Acne
  • Backache
  • Leg cramps
  • Decreased hair growth/hair loss
  • Bloating
  • Hot flushes
  • Nervousness
  • Insomnia
  • Fatigue
  • Tremor
  • Hives
  • Itching
  • Injection site reactions
  • Fever
  • Changes in vaginal and cervical secretions

For further information talk to your doctor.

Ralovera diseases

Generic Name: Medroxyprogesterone acetate
Product Name: Ralovera

Indication

Ralovera can be used in the palliative treatment of recurrent and/or metastatic breast, renal cell or endometrial cancer.

It can also be used in the treatment of visually proven endometriosis when pregnancy is the desired treatment outcome, or when surgery is contraindicated or has been unsuccessful.

Due to its ovulation-suppressing effects, a high dose of Medroxyprogesterone is also useful as a contraceptive agent. Ralovera can be administered every three months for this purpose.

Action

Many cancers rely on supplies of specific sex hormones, such as oestrogen, to grow. Cancer cells have proteins called receptors on their surface which the sex hormones attach to. The easiest way to understand the significance of these receptors is to compare the process to that of a lock and key. Under normal circumstances, when the sex hormones come into contact with the receptors they fit into the lock and activate the cancer cells to divide, and the tumour grows.

Medroxyprogesterone acetate disrupts this process in some way. It may be that it prevents the cancer cells from maintaining the receptors on their surface, effectively removing the lock. Or it may have a more direct means of destroying cancer cells that has not, as yet, been identified. Medroxyprogesterone acetate is a hormonal agent that supports pregnancy. It transforms the endometrium (lining of the uterus) into the kind that supports pregnancy, it maintains pregnancy, delays labour/birth and suppresses ovulation. At high doses Ralovera can be used to treat certain cancers, where it has corticoid-like activity.

Dose advice

Inoperable/recurrent/metastatic renal cell and endometrial cancer

  • initially 600-1200mg weekly
  • 450-600mg every 1-4 weeks for maintenance
  • 500mg daily by IM injection
  • treat for at least 6 months
  • 50mg weekly or 100mg every 2 weeks by IM injection
  • treat for at least 6 months
  • 150mg every three months by deep IM injection
  • give first injection within 5 days of normal menstrual period
  • if the period between injections is greater than 14 weeks, pregnancy needs to be excluded before the next injection
  • the 50mg/1ml preparation is NOT to be used for contraception, the 150mg1/ml vial should be used
  • if volumes larger than 2.5ml are to be injected, the dose should be divided and multiple sites used, as gluteal infiltration and abscess formation may occur with large doses
  • long term use of cyclical oestrogens with Ralovera is not recommended
Schedule Common side effects
  • prolonged bleeding
  • spotting
  • cessation of periods
  • depression
  • weight gain
  • moderate increase in blood pressure
  • decreased glucose tolerance
  • The most commonly reported side effect is an increase in appetite, causing some people to put on weight.

Nausea and indigestion:

  • Occasionally nausea is are present for the first few weeks of taking medroxyprogesterone acetate, but often the nausea then disappears. It can usually be relieved by taking the tablets with food and milk.
  • Some people have experienced mild ankle swelling caused by fluid retention. This is not harmful but can be uncomfortable.

Vaginal bleeding (in women):

  • Occasionally women may have some light vaginal bleeding (spotting) while having treatment with medroxyprogesterone acetate.
Uncommon side effects
  • Nausea
  • Vomiting
  • Headache
  • Dizziness
  • Lethargy
  • Breast discomfort
  • Decreased libido
  • Acne
  • Backache
  • Leg cramps
  • Decreased hair growth/hair loss
  • Bloating
  • Hot flushes
  • Nervousness
  • Insomnia
  • Fatigue
  • Tremor
  • Hives
  • Itching
  • Injection site reactions
  • Fever
  • Changes in vaginal and cervical secretions

For further information talk to your doctor.

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They usually work the identical hours because the pharmacist, since the pharmacy technician works under close supervision of the pharmacist. Let me start out by stating that regardless of what area you pursue (institutional or retail) for that most part, you is going to be involved in a fast paced environment. Nonetheless, this is a cheaper option than all kinds of other online pharmacy technician schools and may be suited to those on a tight budget.

In order to qualify for federal loans a Free Application for Federal Student Aid (FAFSA) have to be completed and aid is granted dependant on student need, tuition rates on the college, as well as other factors. I must add, I have never had just about any emotional disorder during my life and am a skeptic of anti-depressants. You should find these records somewhere in the "Contact Us" section from the website.

I come with an even deeper reply to this newest pharmacy tragedy. This triggered various senior medical companies to come up with online pharmacy locators that enable older folks to receive their medications without the need to leave their homes. Their recommendations about medicines and dosages needs to get adopted on, they need to get acquainted with medicines and that is certainly consequences.

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