Benadryl is an antihistamine. Diphenhydramine blocks the effects of the naturally occurring chemical histamine in the body. It is used to treat sneezing; runny nose; itching, watery eyes; hives; rashes; and other symptoms of allergies and the common cold.
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Benadryl is an antihistamine. Diphenhydramine blocks the effects of the naturally occurring chemical histamine in the body. It is used to treat sneezing; runny nose; itching, watery eyes; hives; rashes; and other symptoms of allergies and the common cold.
Active Ingredient: Diphenhydramine
Benadryl (Sedopretten) as known as: Adryl, Air salonpas, Aliserin, Allerdryl, Allergan, Allergina, Allerjin, Allernix, Antomin, Apap noc, Arcodryl, Asdrin, Azaron, Benaderma, Benalet, Benison, Benocten, Benylan, Benylin, Betadorm, Betadrin, Betasleep, Brudifen, Butix, Caladryl, Calmaben, Cerylana, Codilergi, Coldistan, Dermodrin, Desentol, Despa, Di-fedril, Dibondrin, Didryl, Difedrin, Difenhidramina, Difin, Dimedrol, Dimedrolum, Dimedrolum-darnitsa, Dimidril, Diphamine, Diphenhist, Diphenhydramin, Diphénhydramine, Diphenhydraminum, Diyenil, Dolestan, Dorenta, Dormital, Drafen, Dramalyn, Drogryl, Emesan, Expectalin, Exylin, Fabolergic, Fenotral, Genahist, Hemodorm, Hevert-dorm, Hiship s, Histaler, Histam, Histaxin, Histergan, Histodor, Indumir, Klonadryl, Miles, Moradorm, Nardyl, Nautamine, Neosayomol, Nervo opt, Nighlus, Noctor, Northicalm, Nuicalm, Nustasium, Nyflu, Nytol, Otede, Paxidorm, Pedeamin, Pediacare, Pedilar, Pedilin, Pediphen, Pektolin, Phenadryl, Pretniezes, Psilo, R calm, Reasec, Recodryl, Rescalmin, Resmin, Restamin, Rhinitin, Rhinocap retard, Salymetick, Scandin, Sediat, Sedopretten, Sleepinal, Snuzaid, Somnium, Somol, Soñodor, Stopkof, Tact, Therafilm, Travelmin, Twilite, Valdres, Vena, Venapas-a, Venasmin, Vicnite, Viscodril, Vivinox
If the grand jury finds no cause, lesser charges can be filed. They note that self-rated overall oral health Sedopretten 25 mg an independent risk factor for the infection, as the link did not vary regardless Sedopretten 25 mg whether the participant smoked or had multiple oral sex partners.
Amlodipine is also used to prevent certain types of chest pain (angina). This information does not assure that this product is safe, effective, or appropriate for you. Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products). The researchers conclude: "In this trial involving patients without knee osteoarthritis but with symptoms of a degenerative medial meniscus tear, the outcomes after arthroscopic partial meniscectomy were no better than those after a sham surgical procedure.
Increase your activity level slowly. The virus can cause genital warts - the most common sexually transmitted infection - and cause changes to cells in the cervix that can lead to cervical cancer. Some cases of industrial bronchitis go away without treatment. Becauseof such risks, antibody preparations derived from human donors (i.
Topics include the following: medicines, food and nutrition, medical devices, cosmetics, and animal health. It is a process that usually happens between ages 10 and 14 for girls and ages 12 and 16 for boys. Fluid and water retention.
Zinc acexamate vs famotidine in Sedopretten 25 mg treatment of acute duodenal ulcer. While giving an additional dose of polio vaccine may boost immunity in previously vaccinated children, the impact on the wider population and the cost-effectiveness of an extra dose remain uncertain, Kimberly Thompson, a professor at the University of Central Florida College of Medicine, wrote in an accompanying journal editorial.
The Australian researchers said the discovery may offer a potential therapy for treating stroke in the brain.
Use only if imprinted tape seals on top and bottom flaps are intact and clearly legible. Other institutions have adopted similar limits, and some specialty societies, including the American Board of Internal Medicine, have adopted guidelines.
By Pamela Lewis Dolan, amednews staff.
Your seizures may become worse when the drug is suddenly stopped. At over 8,800 meters high, Mount Everest is the highest mountain on Earth, with oxygen levels on the summit a third of those at sea level. A licensed physician should be consulted for diagnosis and treatment of any and all medical conditions. If medications and lifestyle changes are not effective in treating your symptoms, diagnostic tests may be performed to determine if surgery is necessary.
The researchers then administered the mice with sildenafil. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Call 911 for all medical emergencies. Some diseases make bones break easier, so use caution when assisting a person with fragile bones.Sedopretten 25 mg - Diphenhydramine
A physical exam for hiatal hernia is similar to that for heartburn, with two additions: X-rays may be ordered to show the hernia, and if anemia is a concern, a Sedopretten 25 mg sample may be taken to check your red blood cell count. Check each eye separately, first the right and then the left.
You may need another procedure to remove more breast tissue if tests show the cancer is too close to the edge of the tissue already removed. Drug-induced tremor is a simple nervous system and muscle response to certain medications.
Use a push mower instead of a riding mower. The risk of disease decreases as the weather becomes colder and mosquitoes die off. First, a person is exposed to an allergen by inhaling it, swallowing it, or getting it on Allergy Norway skin.
To identify these genes, Sukumar and colleagues scanned the genomes of patients in the early stages of breast cancer. Allergy Norway history of Dupuytrens contracture makes you more likely to develop this condition. A chest X-ray is a good test to diagnose pneumonia. In 2011, the Recovery from an osteotomy takes 6 to 12 months. Rest your ears for 24 hours after noise exposure to give them a chance to recover. As part of the study, the researchers divided individuals with prehypertension into two groups.
Obesity carries with it a multitude of health risks, but now a large study shows that obese adults who were obese as teens have a much greater risk of developing adverse health conditions, including abnormal kidney function, asthma and difficulty walking.
Use this drug for a condition that is listed in this section only if it has been so prescribed by your health care professional. Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects.
Cystic fibrosis (CF) is a genetic condition caused by a defect in the gene encoding the cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel. The Cystic Fibrosis Knowledge Centre provides healthcare professionals with access to disease awareness information, emerging and established treatment options and current best practice based on recently updated guidelines by the European Cystic Fibrosis Society (ECFS). A resources section contains external links to upcoming medical conferences and patient support groups.
This resource is developed by EPG Health Media for epgonline.org, supported by an independent educational grant from Vertex.
The Lysosomal Acid Lipase (LAL) Deficiency Knowledge Centre contains a range of accurate, informative clinical content for healthcare professionals. The disease awareness section presents epidemiology, pathophysiology and diagnosis information, among others. The treatment section details the drug characteristics, safety and efficacy of sebelipase alfa – the first and only licenced treatment for LAL deficiency. The resources section contains further clinical content including a video channel presenting expert opinions on diagnostic approach and current prognosis.
Developed by EPG Health Media (Europe) Ltd for epgonline.org, in collaboration and with content provided by Alexion Pharma GmbHSedopretten® Dosage Sedopretten® Adult Dosage
Lactose, Cellulosepulver, Povidon, hochdisperses Siliciumdioxid, Magnesiumstearat.
the liver, other drugs that affect hepatic
microsomal enzymes, and particularly the
cytochrome P-450 system, may influence the
circulating levels of cyclosporine.
Substances know to inhibit these enzymes will
increase cyclosporine levels, while
substances that are inducers of cytochrome
P-450 activity will increase hepatic
metabolism and thereby decrease cyclosporine
levels. Reduced clearance of prednisolone,
digoxin, and lovastatin has been observed
when these drugs are administered with
cyclosporine. Cyclosporine should not be used
with potassium-sparing diuretics because
hyperkalemia can occur. During treatment with
cyclosporine, vaccinations may be less
effective, and the use of live vaccines
should be avoided. [PDR 1997]
ADVERSE EFFECTS The principal adverse reactions to
cyclosporine therapy are renal dysfunction,
tremors, hirsutism, hypertension, and gum
hyperplasia. Hypomagnesemia has been reported
in some, but not all, patients exhibiting
convulsions while on cyclosporine therapy.
CONTRAINDICATIONS Risk-benefit of cyclosporine administration
should be considered when the following
medical conditions exist: chickenpox
(existing or recent), herpes zoster, hepatic
function impairment, hyperkalemia,
infections, malabsorption, renal function
impairment, sensitivity to cyclosporine. [USP
CHEMICAL/PHYSICAL DATA DRUG DESCRIPTION: Member of a group of
nonpolar cyclic oligopeptides with
immunosuppressant activity. Produced by
Tolypocladium inflatum Gams and other Fungi
imperfecti. [Merck Index 1996]
CHEMICAL/PHYSICAL DATA PHYSICAL DESCRIPTION: White prismatic needles
from acetone. [Merck Index 1996]
CHEMICAL/PHYSICAL DATA MOLECULAR FORMULA: C62H111N11O12 [USAN 1997]
CHEMICAL/PHYSICAL DATA MOLECULAR WEIGHT: 1202.64 [USAN 1997]
CHEMICAL/PHYSICAL DATA MELTING POINT: 148-151 C [Merck Index 1996]
CHEMICAL/PHYSICAL DATA SOLUBILITY: Relatively insoluble in water and
generally soluble in lipids and organic
solvents. [AHFS Drug Information 1997]
SUBSTANCE DELIVERY DATA DOSAGE FORM: Soft gelatine capsules (25 mg,
50 mg, or 100 mg); 50 mL bottles containing
100 mg of cyclosporine per mL; and for
intravenous infusion, 5 mL sterile ampules
containing 50 mg of cyclosporine per mL. [PDR
SUBSTANCE DELIVERY DATA MODE OF DELIVERY: Oral, or i.v. infusion.
SUBSTANCE DELIVERY DATA STORAGE INSTRUCTIONS: In the original
unit-dose containers at temperatures below 86
F (30 C). [PDR 1997]
MANUFACTURERS Novartis Pharmaceutical Corporation; 59 Route
10 / Building 419-2; East Hanover, NJ 07936
REFERENCES MED/97354217. St'astny M, Ulbrich K, Strohalm
J, Rossmann P, Rihova B. Abnormal
differentiation of thymocytes induced by free
cyclosporine is avoided when cyclosporine
bound to N-(2-hydroxypropyl)methacrylamide
copolymer carrier is used. Transplantation.
1997 Jun 27;63(12):1818-27.
REFERENCES MED/97331506. Lesnoni La Parola I, Masini C,
Nanni G, Diociaiuti A, Panocchia N, Cerimele
D. Kaposi's sarcoma in renal-transplant
recipients: experience at the Catholic
University in Rome, 1988-1996. Dermatology.
REFERENCES MED/97295475. Waldmann V, Kempf W, Burg G,
Dummer R. Kaposi sarcoma in cyclosporin A
therapy of actinic reticuloid. Hautarzt. 1997
REFERENCES MED/97184541. Braaten D, Ansari H, Luban J.
The hydrophobic pocket of cyclophilin is the
binding site for the human immunodeficiency
virus type 1 Gag polyprotein. J Virol. 1997
REFERENCES MED/97149469. Shapiro J, Lui H, Tron V, Ho V.
Systemic cyclosporine and low-dose prednisone
in the treatment of chronic severe alopecia
areata: a clinical and immunopathologic
evaluation. J Am Acad Dermatol. 1997
REFERENCES MED/97131728. Sun Y, Pinchuk LM, Agy MB,
Clark EA. Nuclear import of HIV-1 DNA in
resting CD4+ T cells requires a cyclosporin
A-sensitive pathway. J Immunol. 1997 Jan
REFERENCES MED/97152503. Briggs CJ, Tozser J, Oroszlan
S. Effect of cyclosporin A on the replication
cycle of human immunodeficiency virus type 1
derived from H9 and Molt-4 producer cells. J
Gen Virol. 1996 Dec;77(Pt 12):2963-7.
REFERENCES MED/96400134. Franke EK, Luban J. Inhibition
of HIV-1 replication by cyclosporine A or
related compounds correlates with the ability
to disrupt the Gag-cyclophilin A interaction.
Virology. 1996 Aug 1;222(1):279-82.
REFERENCES MED/96357041. Braaten D, Aberham C, Franke
EK, Yin L, Phares W, Luban J. Cyclosporine
A-resistant human immunodeficiency virus type
1 mutants demonstrate that Gag encodes the
functional target of cyclophilin A. J Virol.
REFERENCES MED/96433987. Andrada-Serpa MJ, Schor D,
Araujo AQ, Rumjanek VM. Immunolgical features
of HTLV-I myelopathy in Rio de Janeiro,
Brazil, and in vitro effects of cyclosporin
A. J Neurol Sci. 1996 Jul;139(1):7-14.
ENTRY MONTH 199707
LAST REVISION DATE 19971010
UNIQUE IDENTIFIER DRG-0274
NAME OF SUBSTANCE Infant Formula [ACTG 247]
PROTOCOL ID NUMBERS NIAID ACTG 247
DISEASES STUDIED/TREATED Under investigation as a caloric
supplementation to improve growth in
HIV-infected infants. [NIAID ACTG 247]
CLASSIFICATION CODE Nutritional support [ACTG 247]
CHEMICAL/PHYSICAL DATA DRUG PHYSICAL COMMENT: Concentrated 25.7
KCal/fluid oz formula. [NIAID ACTG 247]
SUBSTANCE DELIVERY DATA MODE OF DELIVERY: Oral administration. [NIAID
MANUFACTURERS Abbott Laboratories, Ross Products Division;
625 Cleveland Ave; Columbus, OH 43215
ENTRY MONTH 199707
LAST REVISION DATE 19980420
UNIQUE IDENTIFIER DRG-0273
NAME OF SUBSTANCE Diphenhydramine [NIAID ACTG 350]
REGISTRY NUMBER 147-24-0
STANDARD CHEMICAL NAME 2-(Diphenylmethoxy)-N,N-Dimethylethylamine
hydrochloride [USAN 1997]
SYNONYMS Benadryl [PDR 1998]
hydrochloride [Merck Index 1996]
hydrochloride [Merck Index 1996]
hydrochloride [USAN 1997]
SYNONYMS Alledryl [Merck Index 1996]
SYNONYMS Allergina [Merck Index 1996]
SYNONYMS Amidryl [Merck Index 1996]
SYNONYMS Bagodryl [Merck Index 1996]
SYNONYMS Bax [Merck Index 1996]
SYNONYMS Benocten [Merck Index 1996]
SYNONYMS Benodine [Merck Index 1996]
SYNONYMS Benzantin [Merck Index 1996]
SYNONYMS Dibondrin [Merck Index 1996]
SYNONYMS Dihydral [Merck Index 1996]
SYNONYMS Diphantine [Merck Index 1996]
SYNONYMS Dolestan [Merck Index 1996]
SYNONYMS Fenylhist [Merck Index 1996]
SYNONYMS Halbmond [Merck Index 1996]
SYNONYMS Histacyl [Merck Index 1996]
SYNONYMS Noctomin [Merck Index 1996]
SYNONYMS Sedopretten [Merck Index 1996]
SYNONYMS Sekundal-D [Merck Index 1996]
SYNONYMS Syntedril [Merck Index 1996]
SYNONYMS Wehydryl [Merck Index 1996]
SYNONYMS S 8 [Merck Index 1996]
PROTOCOL ID NUMBERS NIAID SPIRAT 3
PHARMACOLOGICAL ACTION MODE OF ACTION: Antihistamines act by
competing with histamine for H1-receptor
sites on effector cells. They thereby
prevent, but do not reverse, responses
mediated by histamine alone. They antagonize
the effects of histamine such as urticaria
and pruritus. The anticholinergic effects of
antihistamines provide a drying effect on the
nasal mucosa. Diphenyhdramine is well
absorbed following oral administration. It
undergoes first-pass metabolism through the
liver and only 40-60% of the oral dose
reaches systemic circulation. The drug
appears in plasma within 15 minutes.
Following single oral doses of 50 and 100 mg
in healthy adults, peak plasma concentrations
of 37-83 and 81-159 ng/mL respectively have
been reported. In vitro, diphenhydramine is
approximately 80-85% bound to plasma protein.
Terminal elimination half-life appears to be
2.4-9.3 hours in healthly adults. Following a
single 100-mg dose in healthy adults, about
50-70% is excreted in the urine within 4
days, almost completely as metabolites. [USP
DI 1997; AHFS Drug Information 1997]
CLASSIFICATION CODE Antihistamine [USAN 1997]
OTHER MAJOR USES For amelioration of allergic reactions;
temporary relief of cough caused by minor
throat and bronchial irritation; treatment of
nausea, vomiting, and/or vertigo associated
with motion sickness; short-term management
of insomnia. [AHFS Drug Information 1997]
SUBSTANCE INTERACTIONS Additive effects with alcohol and other CNS
depressants (hypnotics, sedatives,
tranquilizers, etc.). MAO inhibitors prolong
and intensify the anticholinergic effects of
antihistamines. [PDR 1998]
ADVERSE EFFECTS Adverse effects include the following,
general: drug rash, anaphylactic shock,
photosensitivity, excessive perspiration,
chills, and dryness of mouth, nose, and
throat; cardiovascular system: hypotension,
headache, palpitations, tachycardia, and
extrasystoles; hematologic system: hemolytic
anemia, thrombocytopenia, and
agranulocytosis; nervous system: sedation,
sleepiness, dizziness, disturbed
coordination, fatigue, confusion,
restlessness, excitation, nervousness,
tremor, irritability, insomnia, fatigue,
confusion, restlessness, excitation,
nervousness, tremor, irritability, insomania,
euphoria, paresthesia, blurred vision,
diplopia, vertigo, tinnitus, acute
labyrinthitis, neuritis, and convulsions; GI
system: epigastric distress anorexia, nausea,
vomiting, diarrhea, and constipation; GU
system: urinary frequency, difficult
urination, urinary retention, and early
menses; respiratory system: thickening of
bronchial secretions, tightness of chest or
throat and wheezing, and nasal stuffiness.
The most frequent adverse effects include
sedation, sleepiness, dizziness, disurbed
coordination, epigastric distress, and
thickening of bronchinal secretions. [PDR
CONTRAINDICATIONS Should not be used in neonates or premature
infants, nursing mothers, patients with
hypersensitivity to diphenhydramine
hydrochloride and other antihistamine of
similar chemical structure. Antihistamines
should be used with considerable caution in
patients with narrow-angle glaucoma,
stenosing peptic ulcers, pyloroduodenal
obstruction, sympotomatic prostatic
hypertrophy or bladder-neck obstruction. [PDR
CHEMICAL/PHYSICAL DATA DRUG DESCRIPTION: Antihistamine with
anticholinergic and sedative side effects.
CHEMICAL/PHYSICAL DATA PHYSICAL DESCRIPTION: White, odorless,
cyrstalline powder, slowly darken on exposure
to air. Bitter taste. [AHFS Drug Information
1997; Merck Index 1996]
CHEMICAL/PHYSICAL DATA MOLECULAR FORMULA: C17H21NO.HCL [Merck Index
CHEMICAL/PHYSICAL DATA MOLECULAR WEIGHT: 291.82 [PDR 1998]
CHEMICAL/PHYSICAL DATA MELTING POINT: 166-170 C [Merck Index 1996]
CHEMICAL/PHYSICAL DATA BOILING POINT: 150-165 C (free base) [Merck
CHEMICAL/PHYSICAL DATA SOLUBILITY: Soluble in Water, alcohol,
chloroform, and acetone. Very slightly
soluble in benzene, ether. [Merck Index 1996]
CHEMICAL/PHYSICAL DATA STABILITY: Slowly darkens when exposed to
light. [Merck Index 1996]
CHEMICAL/PHYSICAL DATA DRUG PHYSICAL COMMENT: pH of 1% aqueous
solution is about 5.5. [Merck Index 1996]
SUBSTANCE DELIVERY DATA DOSAGE FORM: 25 mg and 50 mg capsules or
tablets; 10mg/mL and 50mg/mL parenteral
injections, 12.5mg/5ml elixir, 1% or 2%
topical cream. [AHFS Drug Information 1997]
SUBSTANCE DELIVERY DATA MODE OF DELIVERY: Usually oral; when that is
not feasible, by deep IM, or preferably IV,
injection. [AHFS Drug Information 1997]
SUBSTANCE DELIVERY DATA STORAGE INSTRUCTIONS: Should be stored at
15-30 C (59-86 F) in light-resistant
containers and protected from moisture.
Freezing of liquid preparations should be
avoided. [AHFS Drug Information 1997]
MANUFACTURERS Drugs are provided by each participating unit
REFERENCES AIDS/95921074. Saavedra A, Rodriguez N,
Rivera-Vazquez CR, Ramirez-Ronda CH, Bermudez
RH. Trimethoprim-sulfamethoxazole (TMP-SMZ)
desensitization in patients (PTS) with HIV
infection who have non-life threatening
allergy to TMP-SMZ. Initial report. Natl Conf
Hum Retroviruses Relat Infect (1st). 1993 Dec
REFERENCES ICA9/93335041. Rich JD, Greineder D, Sullivan
TJ, Kazanjian PH. Successful oral
desensitization to TMP/SMX in persons with
HIV infection and prior hypersensitive
reactions. Int Conf AIDS. 1993 Jun
6-11;9(1):382 (abstract no.PO-B10-1482).
REFERENCES MED/93076569. Gearhart MO, Bhutani MS.
Intravenous pentamidine-induced bronchospasm.
Chest. 1992 Dec;102(6):1891-2.
REFERENCES MED/92016907. Toma E, Fournier S. Adverse
reactions to co-trimoxazole in HIV infection
[letter;comment]. Lancet. 1991 Oct
REFERENCES MED/85108363. Gibbons RB, Lindauer JA.
Successful treatment of Pneumocystis carinii
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Balanced load, under some conditions, spontaneously develop patchy hair loss that is associated with very mild pathological and immunopathological changes typical of LESSD.
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There is an additional general information about this medication active ingredient diphenhydramine:Pharmacological action
This is a blocker of histamine H1-receptors. It has antiallergic activity, has a local anesthetic, antispasmodic and mild ganglion blocking action.
When administered orally diphenhydramine has a sedative and hypnotic effects, has a moderate antiemetic effect and has a central holinoliticheskoy activity.
When applied externally it has antiallergic effect.
Rapidly absorbed from the gastrointestinal tract. Bioavailability is 50%. Cmax is achieved after 20-40 min (in the greatest concentration is determined in the lungs, spleen, kidneys, liver, brain and muscles). Binding to plasma proteins - 98-99%. Penetrates through the BBB. Metabolised mainly in the liver, partly - in the lungs and kidneys. T1/2 is 4-10 hours. Within one day completely removed kidneys as metabolites conjugated to glucuronic acid. Significant quantities are derived from milk and can cause sedation in infants (may be a paradoxical reaction characterized by hyperexcitability).Why is Sedopretten prescribed?
Allergic reactions (urticaria, hay fever, angioedema), allergic conjunctivitis, vasomotor rhinitis, Henoch-Schonlein purpura, serum sickness, itchy dermatitis, sleep disorders (monotherapy or in combination with drugs), chorea, sea and air sickness, vomiting in pregnancy, Meniere's syndrome, premedication.Dosage and administration
Oral, IV, IM, rectal, topical, intranasal, in the conjunctival sac. Oral for adults - at 30-50 mg 1-3 times / day. The treatment course is 10-15 days. As soporific - 50 mg at bedtime. IM in doses of 50-250 mg; IV in drip - 20-50 mg. When oral administered single dose for children under 1 year - 2-5 mg; from 2 to 5 years - 5-15 mg; of 6 to 12 years - 15-30 mg. Externally applied 1-2 times / day.Sedopretten side effects
Possible: a short-term numbness in the oral mucosa, drowsiness, weakness, decrease in psychomotor speed of reaction in children may be a paradoxical development of insomnia, irritability, and euphoria.
Rarely: dizziness, headache, dry mouth, nausea, photosensitivity, paresis of accommodation, poor coordination of movements, tremor.
Closure glaucoma, prostatic hypertrophy, stenosing peptic ulcer, stenosis of the bladder neck, bronchial asthma, epilepsy, hypersensitivity to diphenhydramine.Using during pregnancy and breastfeeding
During pregnancy and lactation (breastfeeding), diphenhydramine used with caution, according to strict indications, when the expected therapeutic effect for the mother outweighs the potential risk to the fetus or infant.Special instructions
With careful use diphenhydramine during pregnancy and lactation.
During the period of treatment should not be exposed to solar radiation should be avoided alcohol.
Used with caution in patients involved in potentially dangerous activities requiring attention and rapid psychomotor reactions.
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When applied simultaneously increases the effects of ethanol and drugs that depress the central nervous system.
With simultaneous use of MAO inhibitors increase the anticholinergic activity of diphenhydramine.
The antagonistic interaction observed with a joint appointment with psychostimulants.
Reduces the effectiveness of apomorphine as an emetic in the treatment of poisoning. Intensifies anticholinergic effects of drugs with anticholinergic activity.
Symptoms: dry mouth, difficulty breathing, persistent mydriasis, flushing, depression or excitement (more common in children), CNS confusion; children - the development of convulsions and death.
Treatment: induction of vomiting, gastric lavage, the prescription of activated charcoal, symptomatic and supportive therapy on a background of careful monitoring of respiration and blood pressure levels.
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