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Category: Allergies


Benadryl is an antihistamine. Diphenhydramine blocks the effects of the naturally occurring chemical histamine in the body. It is used to treat sneezing; runny nose; itching, watery eyes; hives; rashes; and other symptoms of allergies and the common cold.

Active Ingredient: Diphenhydramine

Benadryl (Sedopretten) as known as: Adryl, Air salonpas, Aliserin, Allerdryl, Allergan, Allergina, Allerjin, Allernix, Antomin, Apap noc, Arcodryl, Asdrin, Azaron, Benaderma, Benalet, Benison, Benocten, Benylan, Benylin, Betadorm, Betadrin, Betasleep, Brudifen, Butix, Caladryl, Calmaben, Cerylana, Codilergi, Coldistan, Dermodrin, Desentol, Despa, Di-fedril, Dibondrin, Didryl, Difedrin, Difenhidramina, Difin, Dimedrol, Dimedrolum, Dimedrolum-darnitsa, Dimidril, Diphamine, Diphenhist, Diphenhydramin, Diphénhydramine, Diphenhydraminum, Diyenil, Dolestan, Dorenta, Dormital, Drafen, Dramalyn, Drogryl, Emesan, Expectalin, Exylin, Fabolergic, Fenotral, Genahist, Hemodorm, Hevert-dorm, Hiship s, Histaler, Histam, Histaxin, Histergan, Histodor, Indumir, Klonadryl, Miles, Moradorm, Nardyl, Nautamine, Neosayomol, Nervo opt, Nighlus, Noctor, Northicalm, Nuicalm, Nustasium, Nyflu, Nytol, Otede, Paxidorm, Pedeamin, Pediacare, Pedilar, Pedilin, Pediphen, Pektolin, Phenadryl, Pretniezes, Psilo, R calm, Reasec, Recodryl, Rescalmin, Resmin, Restamin, Rhinitin, Rhinocap retard, Salymetick, Scandin, Sediat, Sedopretten, Sleepinal, Snuzaid, Somnium, Somol, Soñodor, Stopkof, Tact, Therafilm, Travelmin, Twilite, Valdres, Vena, Venapas-a, Venasmin, Vicnite, Viscodril, Vivinox

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If the grand jury finds no cause, lesser charges can be filed. They note that self-rated overall oral health Sedopretten 25 mg an independent risk factor for the infection, as the link did not vary regardless Sedopretten 25 mg whether the participant smoked or had multiple oral sex partners.

Amlodipine is also used to prevent certain types of chest pain (angina). This information does not assure that this product is safe, effective, or appropriate for you. Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products). The researchers conclude: "In this trial involving patients without knee osteoarthritis but with symptoms of a degenerative medial meniscus tear, the outcomes after arthroscopic partial meniscectomy were no better than those after a sham surgical procedure.

Increase your activity level slowly. The virus can cause genital warts - the most common sexually transmitted infection - and cause changes to cells in the cervix that can lead to cervical cancer. Some cases of industrial bronchitis go away without treatment. Becauseof such risks, antibody preparations derived from human donors (i.

Topics include the following: medicines, food and nutrition, medical devices, cosmetics, and animal health. It is a process that usually happens between ages 10 and 14 for girls and ages 12 and 16 for boys. Fluid and water retention.

Zinc acexamate vs famotidine in Sedopretten 25 mg treatment of acute duodenal ulcer. While giving an additional dose of polio vaccine may boost immunity in previously vaccinated children, the impact on the wider population and the cost-effectiveness of an extra dose remain uncertain, Kimberly Thompson, a professor at the University of Central Florida College of Medicine, wrote in an accompanying journal editorial.

The Australian researchers said the discovery may offer a potential therapy for treating stroke in the brain.

Use only if imprinted tape seals on top and bottom flaps are intact and clearly legible. Other institutions have adopted similar limits, and some specialty societies, including the American Board of Internal Medicine, have adopted guidelines.

By Pamela Lewis Dolan, amednews staff.

Your seizures may become worse when the drug is suddenly stopped. At over 8,800 meters high, Mount Everest is the highest mountain on Earth, with oxygen levels on the summit a third of those at sea level. A licensed physician should be consulted for diagnosis and treatment of any and all medical conditions. If medications and lifestyle changes are not effective in treating your symptoms, diagnostic tests may be performed to determine if surgery is necessary.

The researchers then administered the mice with sildenafil. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Call 911 for all medical emergencies. Some diseases make bones break easier, so use caution when assisting a person with fragile bones.

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A physical exam for hiatal hernia is similar to that for heartburn, with two additions: X-rays may be ordered to show the hernia, and if anemia is a concern, a Sedopretten 25 mg sample may be taken to check your red blood cell count. Check each eye separately, first the right and then the left.

You may need another procedure to remove more breast tissue if tests show the cancer is too close to the edge of the tissue already removed. Drug-induced tremor is a simple nervous system and muscle response to certain medications.

  • Of these people, 42 percent had more than one animal. As well as this, the bacterium is proving increasingly stubborn to shift: antibacterial drugs are often no longer strong enough to eradicate it completely, so it goes into persistent mode, leading to chronic infection with no symptoms.
  • Check your blood pressure regularly while taking this medication. Lectins bind to epithelialsurfaces via specific receptors.
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Use a push mower instead of a riding mower. The risk of disease decreases as the weather becomes colder and mosquitoes die off. First, a person is exposed to an allergen by inhaling it, swallowing it, or getting it on Allergy Norway skin.

To identify these genes, Sukumar and colleagues scanned the genomes of patients in the early stages of breast cancer. Allergy Norway history of Dupuytrens contracture makes you more likely to develop this condition. A chest X-ray is a good test to diagnose pneumonia. In 2011, the Recovery from an osteotomy takes 6 to 12 months. Rest your ears for 24 hours after noise exposure to give them a chance to recover. As part of the study, the researchers divided individuals with prehypertension into two groups.

Obesity carries with it a multitude of health risks, but now a large study shows that obese adults who were obese as teens have a much greater risk of developing adverse health conditions, including abnormal kidney function, asthma and difficulty walking.

Use this drug for a condition that is listed in this section only if it has been so prescribed by your health care professional. Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects.

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Cystic fibrosis (CF) is a genetic condition caused by a defect in the gene encoding the cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel. The Cystic Fibrosis Knowledge Centre provides healthcare professionals with access to disease awareness information, emerging and established treatment options and current best practice based on recently updated guidelines by the European Cystic Fibrosis Society (ECFS). A resources section contains external links to upcoming medical conferences and patient support groups.

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The Lysosomal Acid Lipase (LAL) Deficiency Knowledge Centre contains a range of accurate, informative clinical content for healthcare professionals. The disease awareness section presents epidemiology, pathophysiology and diagnosis information, among others. The treatment section details the drug characteristics, safety and efficacy of sebelipase alfa – the first and only licenced treatment for LAL deficiency. The resources section contains further clinical content including a video channel presenting expert opinions on diagnostic approach and current prognosis.

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Sedopretten® Dosage Sedopretten® Adult Dosage

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Unique identifier drg-0310 - страница 11

the liver, other drugs that affect hepatic

microsomal enzymes, and particularly the

cytochrome P-450 system, may influence the

circulating levels of cyclosporine.

Substances know to inhibit these enzymes will

increase cyclosporine levels, while

substances that are inducers of cytochrome

P-450 activity will increase hepatic

metabolism and thereby decrease cyclosporine

levels. Reduced clearance of prednisolone,

digoxin, and lovastatin has been observed

when these drugs are administered with

cyclosporine. Cyclosporine should not be used

with potassium-sparing diuretics because

hyperkalemia can occur. During treatment with

cyclosporine, vaccinations may be less

effective, and the use of live vaccines

should be avoided. [PDR 1997]

ADVERSE EFFECTS The principal adverse reactions to

cyclosporine therapy are renal dysfunction,

tremors, hirsutism, hypertension, and gum

hyperplasia. Hypomagnesemia has been reported

in some, but not all, patients exhibiting

convulsions while on cyclosporine therapy.

CONTRAINDICATIONS Risk-benefit of cyclosporine administration

should be considered when the following

medical conditions exist: chickenpox

(existing or recent), herpes zoster, hepatic

function impairment, hyperkalemia,

infections, malabsorption, renal function

impairment, sensitivity to cyclosporine. [USP


nonpolar cyclic oligopeptides with

immunosuppressant activity. Produced by

Tolypocladium inflatum Gams and other Fungi

imperfecti. [Merck Index 1996]


from acetone. [Merck Index 1996]




CHEMICAL/PHYSICAL DATA SOLUBILITY: Relatively insoluble in water and

generally soluble in lipids and organic

solvents. [AHFS Drug Information 1997]

SUBSTANCE DELIVERY DATA DOSAGE FORM: Soft gelatine capsules (25 mg,

50 mg, or 100 mg); 50 mL bottles containing

100 mg of cyclosporine per mL; and for

intravenous infusion, 5 mL sterile ampules

containing 50 mg of cyclosporine per mL. [PDR



unit-dose containers at temperatures below 86

F (30 C). [PDR 1997]

MANUFACTURERS Novartis Pharmaceutical Corporation; 59 Route

10 / Building 419-2; East Hanover, NJ 07936

REFERENCES MED/97354217. St'astny M, Ulbrich K, Strohalm

J, Rossmann P, Rihova B. Abnormal

differentiation of thymocytes induced by free

cyclosporine is avoided when cyclosporine

bound to N-(2-hydroxypropyl)methacrylamide

copolymer carrier is used. Transplantation.

1997 Jun 27;63(12):1818-27.

REFERENCES MED/97331506. Lesnoni La Parola I, Masini C,

Nanni G, Diociaiuti A, Panocchia N, Cerimele

D. Kaposi's sarcoma in renal-transplant

recipients: experience at the Catholic

University in Rome, 1988-1996. Dermatology.

REFERENCES MED/97295475. Waldmann V, Kempf W, Burg G,

Dummer R. Kaposi sarcoma in cyclosporin A

therapy of actinic reticuloid. Hautarzt. 1997

REFERENCES MED/97184541. Braaten D, Ansari H, Luban J.

The hydrophobic pocket of cyclophilin is the

binding site for the human immunodeficiency

virus type 1 Gag polyprotein. J Virol. 1997

REFERENCES MED/97149469. Shapiro J, Lui H, Tron V, Ho V.

Systemic cyclosporine and low-dose prednisone

in the treatment of chronic severe alopecia

areata: a clinical and immunopathologic

evaluation. J Am Acad Dermatol. 1997

REFERENCES MED/97131728. Sun Y, Pinchuk LM, Agy MB,

Clark EA. Nuclear import of HIV-1 DNA in

resting CD4+ T cells requires a cyclosporin

A-sensitive pathway. J Immunol. 1997 Jan

REFERENCES MED/97152503. Briggs CJ, Tozser J, Oroszlan

S. Effect of cyclosporin A on the replication

cycle of human immunodeficiency virus type 1

derived from H9 and Molt-4 producer cells. J

Gen Virol. 1996 Dec;77(Pt 12):2963-7.

REFERENCES MED/96400134. Franke EK, Luban J. Inhibition

of HIV-1 replication by cyclosporine A or

related compounds correlates with the ability

to disrupt the Gag-cyclophilin A interaction.

Virology. 1996 Aug 1;222(1):279-82.

REFERENCES MED/96357041. Braaten D, Aberham C, Franke

EK, Yin L, Phares W, Luban J. Cyclosporine

A-resistant human immunodeficiency virus type

1 mutants demonstrate that Gag encodes the

functional target of cyclophilin A. J Virol.

REFERENCES MED/96433987. Andrada-Serpa MJ, Schor D,

Araujo AQ, Rumjanek VM. Immunolgical features

of HTLV-I myelopathy in Rio de Janeiro,

Brazil, and in vitro effects of cyclosporin

A. J Neurol Sci. 1996 Jul;139(1):7-14.




NAME OF SUBSTANCE Infant Formula [ACTG 247]


DISEASES STUDIED/TREATED Under investigation as a caloric

supplementation to improve growth in

HIV-infected infants. [NIAID ACTG 247]

CLASSIFICATION CODE Nutritional support [ACTG 247]


KCal/fluid oz formula. [NIAID ACTG 247]


MANUFACTURERS Abbott Laboratories, Ross Products Division;

625 Cleveland Ave; Columbus, OH 43215




NAME OF SUBSTANCE Diphenhydramine [NIAID ACTG 350]


STANDARD CHEMICAL NAME 2-(Diphenylmethoxy)-N,N-Dimethylethylamine

hydrochloride [USAN 1997]

SYNONYMS Benadryl [PDR 1998]

hydrochloride [Merck Index 1996]

hydrochloride [Merck Index 1996]

hydrochloride [USAN 1997]

SYNONYMS Alledryl [Merck Index 1996]

SYNONYMS Allergina [Merck Index 1996]

SYNONYMS Amidryl [Merck Index 1996]

SYNONYMS Bagodryl [Merck Index 1996]

SYNONYMS Bax [Merck Index 1996]

SYNONYMS Benocten [Merck Index 1996]

SYNONYMS Benodine [Merck Index 1996]

SYNONYMS Benzantin [Merck Index 1996]

SYNONYMS Dibondrin [Merck Index 1996]

SYNONYMS Dihydral [Merck Index 1996]

SYNONYMS Diphantine [Merck Index 1996]

SYNONYMS Dolestan [Merck Index 1996]

SYNONYMS Fenylhist [Merck Index 1996]

SYNONYMS Halbmond [Merck Index 1996]

SYNONYMS Histacyl [Merck Index 1996]

SYNONYMS Noctomin [Merck Index 1996]

SYNONYMS Sedopretten [Merck Index 1996]

SYNONYMS Sekundal-D [Merck Index 1996]

SYNONYMS Syntedril [Merck Index 1996]

SYNONYMS Wehydryl [Merck Index 1996]

SYNONYMS S 8 [Merck Index 1996]



competing with histamine for H1-receptor

sites on effector cells. They thereby

prevent, but do not reverse, responses

mediated by histamine alone. They antagonize

the effects of histamine such as urticaria

and pruritus. The anticholinergic effects of

antihistamines provide a drying effect on the

nasal mucosa. Diphenyhdramine is well

absorbed following oral administration. It

undergoes first-pass metabolism through the

liver and only 40-60% of the oral dose

reaches systemic circulation. The drug

appears in plasma within 15 minutes.

Following single oral doses of 50 and 100 mg

in healthy adults, peak plasma concentrations

of 37-83 and 81-159 ng/mL respectively have

been reported. In vitro, diphenhydramine is

approximately 80-85% bound to plasma protein.

Terminal elimination half-life appears to be

2.4-9.3 hours in healthly adults. Following a

single 100-mg dose in healthy adults, about

50-70% is excreted in the urine within 4

days, almost completely as metabolites. [USP

DI 1997; AHFS Drug Information 1997]


OTHER MAJOR USES For amelioration of allergic reactions;

temporary relief of cough caused by minor

throat and bronchial irritation; treatment of

nausea, vomiting, and/or vertigo associated

with motion sickness; short-term management

of insomnia. [AHFS Drug Information 1997]

SUBSTANCE INTERACTIONS Additive effects with alcohol and other CNS

depressants (hypnotics, sedatives,

tranquilizers, etc.). MAO inhibitors prolong

and intensify the anticholinergic effects of

antihistamines. [PDR 1998]

ADVERSE EFFECTS Adverse effects include the following,

general: drug rash, anaphylactic shock,

photosensitivity, excessive perspiration,

chills, and dryness of mouth, nose, and

throat; cardiovascular system: hypotension,

headache, palpitations, tachycardia, and

extrasystoles; hematologic system: hemolytic

anemia, thrombocytopenia, and

agranulocytosis; nervous system: sedation,

sleepiness, dizziness, disturbed

coordination, fatigue, confusion,

restlessness, excitation, nervousness,

tremor, irritability, insomnia, fatigue,

confusion, restlessness, excitation,

nervousness, tremor, irritability, insomania,

euphoria, paresthesia, blurred vision,

diplopia, vertigo, tinnitus, acute

labyrinthitis, neuritis, and convulsions; GI

system: epigastric distress anorexia, nausea,

vomiting, diarrhea, and constipation; GU

system: urinary frequency, difficult

urination, urinary retention, and early

menses; respiratory system: thickening of

bronchial secretions, tightness of chest or

throat and wheezing, and nasal stuffiness.

The most frequent adverse effects include

sedation, sleepiness, dizziness, disurbed

coordination, epigastric distress, and

thickening of bronchinal secretions. [PDR

CONTRAINDICATIONS Should not be used in neonates or premature

infants, nursing mothers, patients with

hypersensitivity to diphenhydramine

hydrochloride and other antihistamine of

similar chemical structure. Antihistamines

should be used with considerable caution in

patients with narrow-angle glaucoma,

stenosing peptic ulcers, pyloroduodenal

obstruction, sympotomatic prostatic

hypertrophy or bladder-neck obstruction. [PDR


anticholinergic and sedative side effects.


cyrstalline powder, slowly darken on exposure

to air. Bitter taste. [AHFS Drug Information

1997; Merck Index 1996]






chloroform, and acetone. Very slightly

soluble in benzene, ether. [Merck Index 1996]

CHEMICAL/PHYSICAL DATA STABILITY: Slowly darkens when exposed to

light. [Merck Index 1996]


solution is about 5.5. [Merck Index 1996]

SUBSTANCE DELIVERY DATA DOSAGE FORM: 25 mg and 50 mg capsules or

tablets; 10mg/mL and 50mg/mL parenteral

injections, 12.5mg/5ml elixir, 1% or 2%

topical cream. [AHFS Drug Information 1997]


not feasible, by deep IM, or preferably IV,

injection. [AHFS Drug Information 1997]


15-30 C (59-86 F) in light-resistant

containers and protected from moisture.

Freezing of liquid preparations should be

avoided. [AHFS Drug Information 1997]

MANUFACTURERS Drugs are provided by each participating unit

REFERENCES AIDS/95921074. Saavedra A, Rodriguez N,

Rivera-Vazquez CR, Ramirez-Ronda CH, Bermudez

RH. Trimethoprim-sulfamethoxazole (TMP-SMZ)

desensitization in patients (PTS) with HIV

infection who have non-life threatening

allergy to TMP-SMZ. Initial report. Natl Conf

Hum Retroviruses Relat Infect (1st). 1993 Dec

REFERENCES ICA9/93335041. Rich JD, Greineder D, Sullivan

TJ, Kazanjian PH. Successful oral

desensitization to TMP/SMX in persons with

HIV infection and prior hypersensitive

reactions. Int Conf AIDS. 1993 Jun

6-11;9(1):382 (abstract no.PO-B10-1482).

REFERENCES MED/93076569. Gearhart MO, Bhutani MS.

Intravenous pentamidine-induced bronchospasm.

Chest. 1992 Dec;102(6):1891-2.

REFERENCES MED/92016907. Toma E, Fournier S. Adverse

reactions to co-trimoxazole in HIV infection

[letter;comment]. Lancet. 1991 Oct

REFERENCES MED/85108363. Gibbons RB, Lindauer JA.

Successful treatment of Pneumocystis carinii

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Sedopretten Drug Information, Indications - Other Medicaments on

Sedopretten Drug Information Sedopretten forms, composition and dosages:
  • Tablet; Oral; Diphenhydramine Hydrochloride
Indications, usages and classification codes:

There is an additional general information about this medication active ingredient diphenhydramine:

Pharmacological action

This is a blocker of histamine H1-receptors. It has antiallergic activity, has a local anesthetic, antispasmodic and mild ganglion blocking action.
When administered orally diphenhydramine has a sedative and hypnotic effects, has a moderate antiemetic effect and has a central holinoliticheskoy activity.
When applied externally it has antiallergic effect.


Rapidly absorbed from the gastrointestinal tract. Bioavailability is 50%. Cmax is achieved after 20-40 min (in the greatest concentration is determined in the lungs, spleen, kidneys, liver, brain and muscles). Binding to plasma proteins - 98-99%. Penetrates through the BBB. Metabolised mainly in the liver, partly - in the lungs and kidneys. T1/2 is 4-10 hours. Within one day completely removed kidneys as metabolites conjugated to glucuronic acid. Significant quantities are derived from milk and can cause sedation in infants (may be a paradoxical reaction characterized by hyperexcitability).

Why is Sedopretten prescribed?

Allergic reactions (urticaria, hay fever, angioedema), allergic conjunctivitis, vasomotor rhinitis, Henoch-Schonlein purpura, serum sickness, itchy dermatitis, sleep disorders (monotherapy or in combination with drugs), chorea, sea and air sickness, vomiting in pregnancy, Meniere's syndrome, premedication.

Dosage and administration

Oral, IV, IM, rectal, topical, intranasal, in the conjunctival sac. Oral for adults - at 30-50 mg 1-3 times / day. The treatment course is 10-15 days. As soporific - 50 mg at bedtime. IM in doses of 50-250 mg; IV in drip - 20-50 mg. When oral administered single dose for children under 1 year - 2-5 mg; from 2 to 5 years - 5-15 mg; of 6 to 12 years - 15-30 mg. Externally applied 1-2 times / day.

Sedopretten side effects

Possible: a short-term numbness in the oral mucosa, drowsiness, weakness, decrease in psychomotor speed of reaction in children may be a paradoxical development of insomnia, irritability, and euphoria.
Rarely: dizziness, headache, dry mouth, nausea, photosensitivity, paresis of accommodation, poor coordination of movements, tremor.


Closure glaucoma, prostatic hypertrophy, stenosing peptic ulcer, stenosis of the bladder neck, bronchial asthma, epilepsy, hypersensitivity to diphenhydramine.

Using during pregnancy and breastfeeding

During pregnancy and lactation (breastfeeding), diphenhydramine used with caution, according to strict indications, when the expected therapeutic effect for the mother outweighs the potential risk to the fetus or infant.

Special instructions

With careful use diphenhydramine during pregnancy and lactation.
During the period of treatment should not be exposed to solar radiation should be avoided alcohol.
Used with caution in patients involved in potentially dangerous activities requiring attention and rapid psychomotor reactions.

Precautionary measures

Not recommended for SC injection. Since diphenhydramine has atropinopodobnym action should be cautious in its use: patients with recent respiratory infection in history (including asthma), increased intraocular pressure in hyperthyroidism, cardiovascular system, hypotension. Antihistamines drugs can reduce mental alertness as well as in adults and children and also cause agitation and hallucinations, convulsions and death in infants and children, especially in overdose. Precautions apply at age 60 and older because more likely to develop dizziness, sedation and hypotension. During treatment with diphenhydramine should avoid sun exposure. Should not be used during the drivers of vehicles and people, trade is connected with increased concentration. In the period of treatment should avoid drinking alcoholic beverages.

Sedopretten drug interactions

When applied simultaneously increases the effects of ethanol and drugs that depress the central nervous system.
With simultaneous use of MAO inhibitors increase the anticholinergic activity of diphenhydramine.
The antagonistic interaction observed with a joint appointment with psychostimulants.
Reduces the effectiveness of apomorphine as an emetic in the treatment of poisoning. Intensifies anticholinergic effects of drugs with anticholinergic activity.

Sedopretten in case of emergency / overdose

Symptoms: dry mouth, difficulty breathing, persistent mydriasis, flushing, depression or excitement (more common in children), CNS confusion; children - the development of convulsions and death.
Treatment: induction of vomiting, gastric lavage, the prescription of activated charcoal, symptomatic and supportive therapy on a background of careful monitoring of respiration and blood pressure levels.


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