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Clinamicina

Category: Antibiotics

Description

Cleocin is used for treating serious infections caused by certain bacteria.

Active Ingredient: Clindamycin

Cleocin (Clinamicina) as known as: Acnestop, Agis, Aknet, Aknezel k, Albiotin, Anerocid, Aniclindan, Antirobe, Arfarel, Bactemicina, Basocin, Benzolac cl, Bexon, Bioclindax, Biodaclin, Biodasin, Borophen, Botamycin-n, Candid-cl, Clamine-t, Clendix, Cleorobe, Clidacin, Clidacin-t, Clidamacin, Clidan, Clidets, Climadan, Climadan acne, Clin, Clin-sanorania, Clinacin, Clinacnyl, Clinamicina, Clinaram, Clinbercin, Clinda, Clinda mip, Clinda-derm, Clinda-ipp, Clinda-saar, Clinda-t, Clindabeta, Clindabuc, Clindacin, Clindacne, Clindacutin, Clindacyl, Clindacyn, Clindagel, Clindahexal, Clindal, Clindalind, Clindamax, Clindamek, Clindamicin, Clindamicina, Clindamycine, Clindamycinum, Clindamyl, Clindana, Clindanil, Clindareach, Clindasol, Clindasome, Clindastad, Clindaval, Clindess, Clindesse, Clindets, Clindexcin, Clindobion, Clindopax, Clindoral, Clindox, Clinex, Clinfol, Clinidac, Clinika, Clinimycin, Clinium, Clinmas, Clinsol, Clintabs, Clintopic, Clinwas, Cliofar, Cliz, Cluvax, Comdasin, Cutaclin, Dacin, Daclin, Dalacin, Dalacine, Dalagis t, Dalcap, Damiciclin, Damicine, Damiclin, Dentomycin, Derma, Dermabel, Divanon, Edason, Eficline, Ethidan, Euroclin, Evoclin, Fouch, Handaramin, Indanox, Jutaclin, Klamoxyl, Klimicin, Klin-amsa, Klindacin, Klindagol, Klindamicin, Klindamycin, Klindan, Klindaver, Klinoksin, Klitopsin, Lanacine, Lexis, Lindacil, Lindacyn, Lindan, Lindasol, Lintacin s, Lisiken, Luoqing, Medacin, Mediklin, Meneklin, Midocin, Milorin, Myclin, Naxoclinda, Niladacin, Nufaclind, Opiclam, Panancocin s, Paradis, Permycin, Prolic, Ribomin, Rosil, Sobelin, Sotomycin, Tidact, Toliken, Topicil, Torgyn, Trexen, Turimycin, Upderm, Veldom, Velkaderm, Ygielle, Z-clindacin, Ziana, Zindaclin, Zindacline, Zumatic

Clindamycin vasculitis in patients with peripheral arterial vascular disease

First online: 15 July 2009

Clindamycin vasculitis in patients with peripheral arterial vascular disease
  • Jamil Al-Jamali Affiliated with Department of Plastic and Hand Surgery, University of Freiburg Medical Center Email author
  • . Gunther Felmerer Affiliated with Department of Plastic and Hand Surgery, University of Freiburg Medical Center
  • . Ahmed Kasem Affiliated with Department of Plastic and Hand Surgery, University of Freiburg Medical Center
  • . Khalid Al-awadi Affiliated with Department of Plastic and Hand Surgery, University of Freiburg Medical Center
  • . Ziad Kalash Affiliated with Department of Plastic and Hand Surgery, University of Freiburg Medical Center
  • . G. B. Stark Affiliated with Department of Plastic and Hand Surgery, University of Freiburg Medical Center

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Abstract

Clindamycin was first synthesized in 1966. It is a chemical derivative of lincomycin with activity against aerobic gram-positive and gram-negative bacteria. The side effects include diarrhea, pseudomembranous colitis, metallic taste in the mouth, transient elevation of transaminases, granulocytopenia, thrombocytopenia, and rash. The incidence of maculopapular rashes has been reported to be approximately 10%. Leukocytoclastic angitis or vasculitis induced by clindamycin has been reported (Lambert et al. Cutis 30:615–619, 1982 ) and this is a very serious complication in patients with peripheral arterial vascular diseases which may leads to severe and deep necrotizing vasculitis. We report two cases of necrotizing vasculitis due to clindamycin which was used for the treatment of chronic wounds in patients suffering of peripheral vascular disease.

Keywords

Chronic wounds Peripheral arterial vascular diseases Clindamycin vasculitis

Other articles

Does clindamycin treat pid

Does clindamycin treat pid

Our goal at Harel Chiropractic & Massage is to provide quality healthcare at affordable prices for the entire family. We aim to provide a complete wellness program. Pelvic inflammatory disease (PID), one of the most common infections in nonpregnant women of reproductive age, remains an important public health problem. It is. Memórias do Instituto Oswaldo Cruz On-line version ISSN 1678-8060 Mem. Inst. Oswaldo Cruz vol.104 no.2 Rio de Janeiro Mar. 2009. Pelvic inflammatory disease or pelvic inflammatory disorder (PID) is an infection of the upper part of the female reproductive system namely the uterus, fallopian. Pelvic inflammatory disease. In: Sexually transmitted diseases treatment guidelines, 2010. Clindamycin is the generic name of the prescription drug Cleocin, which is an antibiotic used to treat certain serious bacterial infections. Clindamycin belongs to a. Pelvic inflammatory disease (PID) comprises a spectrum of inflammatory disorders of the upper female genital tract, including any combination of endometritis. To offer recommendations on diagnosis, treatment regimens, and health promotion principles needed for the effective management of bacterial vaginosis (BV) covering. Pelvic Inflammatory Disease Definition Pelvic inflammatory disease (PID) is a term used to describe any infection in the lower female reproductive tract that spreads. We would like to show you a description here but the site won’t allow us.

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Clindamycin - drug review: dosage, side effects, action, buy Clindamycin

Clindamycin


Staphylococcus aureus has another great drug to worry about – clindamycin. This antibiotic is one of the most effective without patients having to worry much about hypersensitivity reactions. They do have to learn more about proper use and observance of adverse effects.

Clindamycin is the generic name of the lincosamide antibiotic. It is used for the treatment of infections caused by anaerobic bacteria as well as some protozoal disease like malaria. Since it is highly effective against methicillin-resistant Staphylococcus aureus or MRSA infections, clindamycin is also indicated for the treatment of acne. The drug also comes under the brand names Dalacin. Cleocin. Duac and Evoclin.

Clindamycin can also treat infections of the respiratory tract, pelvis, abdomen and vagina. peritonitis and septicemia. The drug is good for patients with known hypersensitivity reactions to penicillins. Bone and joint infections from Staphylococcus aureus can be treated as well. The medication comes in capsule form which should be taken orally. There are also lotions and gels to be applied topically for skin infections.

Various side effects have also been associated with the use of the medication. Examples of serious side effects are allergic reactions like face and lip swelling. breathing difficulty, hives and rash, bloody or watery stool, fever. flu-like symptoms, body aches, nausea. vomiting. loss of appetite. jaundice, scanty or absent urine and headache. Mild and moderate side effects include mild nausea, stomachache, vaginal itching or discharge, throat irritation and mild skin itching or rash. Patients should immediately stop taking the drug if allergic reactions occur. For less serious reactions, they may continue consumption but everything should be reported to the doctor.

Individuals with known hypersensitivity to clindamycin or lincomycin should not take the medication. The drug is also known to cause adverse reactions if it is taken together with erythromycin. People with history of Crohns disease, asthma. eczema. allergies. colitis, intestinal disorder, kidney problem or liver disease should first consult their doctor to ensure safety. Clindamycin is thought to have effects in-vitro so pregnant women, those trying to get pregnant as well as nursing mothers should seek consultation.

Clindamycin has a bacteriostatic effect in which bacterial protein synthesis is interfered through its binding action to bacterial ribosome particularly the 50S subunit. As the drug binds to the subunit, bacterial growth and spread is inhibited. Clindamycin is absorbed from the gastrointestinal tract after which it will be delivered to various infection sites in the body.

20 patients suffering from Staphylococcus aureus skin infection were treated with 500 mg of clindamycin every 6 hours for 2 weeks. After the first week, 14 patients exhibited a lot of improvement and by the end of the second week, 19 patients have improved conditions. 8 patients were fully recovered. Only 3 of the patients showed mild allergic side effects such as skin itching and rash.

Clindamycin is an over-the-counter or OTC drug which can be bought at any pharmacy or clinic. The tablets usually come in 250 or 500 mg. Consumers should check the expiry date, manufacturer as well as brand name to ensure authenticity. When buying generic brands, it is important to only look for certified drugstores and online sites.

Clindamycin overdose is also possible so patients should immediately watch for signs and find help as soon as they notice. Take the missed dose as soon as one remembers but skip the missed dose if it is almost time to take the next. Be sure to store the drug in room temperature free from direct sunlight and moisture. Follow the right instructions given by the physician if the drug is intended to be applied vaginally.

Clindamycin has the following structural formula:

• Molecular formula of clindamycin is C18H33ClN2O5S
• Chemical IUPAC Name is N-[2-chloro-1-(3,4,5-trihydroxy-6-methylsulfanyl-tetrahydropyran-2-yl)-propyl]- 1-methyl-4-propyl-pyrrolidine-2-carboxamide
• Molecular weight is 424.984 g/mol
Clindamycin available. 150mg capsules, 300mg capsules

Brand name(s): Chlolincocin. Cleocin. Clindagel. Clindamicina. Clindamycine. Clindamycinum. Clindesse. Clindets. Clinimycin. Dalacin. Evoclin. Sobelin

Clinamicina diseases

Clindamycin

Clindamycin rINN / k l ɪ n d ə ˈ m aɪ s ɨ n / is an antibiotic of the lincosamide class, which blocks the ribosomes of microorganisms. It is usually used to treat infections with anaerobic bacteria. but can also be used to treat protozoal diseases, such as malaria. It is a common topical treatment for acne and can be useful against some methicillin-resistant Staphylococcus aureus (MRSA) infections. [ 1 ]

The most severe common adverse effect of clindamycin is Clostridium difficile -associated diarrhea (the most frequent cause of pseudomembranous colitis ). Although this side effect occurs with almost all antibiotics, including beta-lactam antibiotics. it is classically linked to clindamycin use. [ 2 ]

Clindamycin is marketed as generic and under trade names including Cleocin HCl- (Pfizer). Dalacin. Lincocin (Bangladesh), and Dalacin. Clindacin. Combination products include Duac . BenzaClin. Clindoxyl and Acanya (in combination with benzoyl peroxide ), and Ziana (with tretinoin ). It is on the World Health Organization's List of Essential Medicines. a list of the most important medication needed in a basic health system. [ 3 ]

Medical uses

Clindamycin is used primarily to treat anaerobic infections caused by susceptible anaerobic bacteria. including dental infections, [ 4 ] and infections of the respiratory tract. skin, and soft tissue. and peritonitis. [ 5 ] In people with hypersensitivity to penicillins. clindamycin may be used to treat infections caused by susceptible aerobic bacteria, as well. It is also used to treat bone and joint infections, particularly those caused by Staphylococcus aureus . [ 5 ] [ 6 ] Topical application of clindamycin phosphate can be used to treat mild to moderate acne. [ 7 ]

Acne

The use of clindamycin in conjunction with benzoyl peroxide is more effective in the treatment of acne than the use of either product by itself. [ 8 ] [ 9 ] [ 10 ]

Clindamycin and adapalene in combination are also more effective than either drug alone, although adverse effects are more frequent. [ 11 ]

Susceptible bacteria

It is most effective against infections involving the following types of organisms:

The following represents MIC susceptibility data for a few medically significant pathogens.

  • Staphylococcus aureus. 0.016 μg/ml - >256 μg/ml
  • Streptococcus pneumoniae. 0.002 μg/ml - >256 μg/ml
  • Streptococcus pyogenes. <0.015 μg/ml - >64 μg/ml
D-Test

When testing a Gram-positive culture for sensitivity to clindamycin, it is common to perform a "D-Test" to determine if there is a macrolide -resistant subpopulation of bacteria present. This test is necessary because some bacteria express a phenotype known as MLSB. in which susceptibility tests will indicate the bacteria are susceptible to clindamycin, but in vitro the pathogen displays inducible resistance .

To perform a D-test, an agar plate is inoculated with the bacteria in question and two drug-impregnated disks (one with erythromycin. one with clindamycin) are placed 15–20 mm apart on the plate. If the area of inhibition around the clindamycin disk is "D" shaped, the test result is positive and clindamycin should not be used due to the possibility of resistant pathogens and therapy failure. If the area of inhibition around the clindamycin disk is circular, the test result is negative and clindamycin can be used. [ 17 ]

Malaria

Given with chloroquine or quinine. clindamycin is effective and well tolerated in treating Plasmodium falciparum malaria; the latter combination is particularly useful for children, and is the treatment of choice for pregnant women who become infected in areas where resistance to chloroquine is common. [ 18 ] [ 19 ] Clindamycin should not be used as an antimalarial by itself, although it appears to be very effective as such, because of its slow action. [ 18 ] [ 19 ] Patient-derived isolates of Plasmodium falciparum from the Peruvian Amazon have been reported to be resistant to clindamycin as evidenced by in vitro drug susceptibility testing. [ 20 ]

Other

Clindamycin may be useful in skin and soft tissue infections caused by methicillin-resistant Staphylococcus aureus (MRSA); [ 1 ] many strains of MRSA are still susceptible to clindamycin; however, in the United States spreading from the West Coast eastwards, MRSA is becoming increasingly resistant.

Clindamycin is used in cases of suspected toxic shock syndrome. [ 21 ] often in combination with a bactericidal agent such as vancomycin. The rationale for this approach is a presumed synergy between vancomycin, which causes the death of the bacteria by breakdown of the cell wall. and clindamycin, which is a powerful inhibitor of toxin synthesis. Both in vitro and in vivo studies have shown clindamycin reduces the production of exotoxins by staphylococci; [ 22 ] it may also induce changes in the surface structure of bacteria that make them more sensitive to immune system attack (opsonization and phagocytosis ). [ 23 ] [ 24 ]

Clindamycin has been proven to decrease the risk of premature births in women diagnosed with bacterial vaginosis during early pregnancy to about a third of the risk of untreated women. [ 25 ]

The combination of clindamycin and quinine is the standard treatment for severe babesiosis. [ 26 ]

Clindamycin may also be used to treat toxoplasmosis. [ 12 ] [ 27 ] [ 28 ] and, in combination with primaquine. is effective in treating mild to moderate Pneumocystis jirovecii pneumonia. [ 29 ]

Adverse effects

Common adverse drug reactions associated with systemic clindamycin therapy — found in over 1% of people — include: diarrhea, pseudomembranous colitis. nausea. vomiting. abdominal pain or cramps and/or rash. High doses (both intravenous and oral) may cause a metallic taste. Common adverse drug reactions associated with topical formulations - found in over 10% of people - include: dryness, burning, itching, scaliness, or peeling of skin (lotion, solution); erythema (foam, lotion, solution); oiliness (gel, lotion). Additional side effects include contact dermatitis. [ 30 ] [ 31 ] Common side effects - found in over 10% of people - in vaginal applications include fungal infection.

Pseudomembranous colitis is a potentially lethal condition commonly associated with clindamycin, but which occurs with other antibiotics, as well. [ 2 ] [ 32 ] Overgrowth of Clostridium difficile . which is inherently resistant to clindamycin, results in the production of a toxin that causes a range of adverse effects, from diarrhea to colitis and toxic megacolon. [ 30 ]

Chemistry

Clindamycin is a semisynthetic derivative of lincomycin. a natural antibiotic produced by the actinobacterium Streptomyces lincolnensis . It is obtained by 7(S )-chloro -substitution of the 7(R )-hydroxyl group of lincomycin. [ 33 ] [ 34 ] The synthesis of clindamycin was first announced by BJ Magerlein, RD Birkenmeyer, and F Kagan on the fifth Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC) in 1966. [ 35 ] It has been on the market since 1968. [ 31 ]

Mechanism of action

Clindamycin has a primarily bacteriostatic effect. It is a bacterial protein synthesis inhibitor by inhibiting ribosomal translocation, [ 36 ] in a similar way to macrolides. It does so by binding to the 50S rRNA of the large bacterial ribosome subunit. [ 12 ]

Interactions Available forms

Clindamycin preparations for oral administration include capsules (containing clindamycin hydrochloride ) and oral suspensions (containing clindamycin palmitate hydrochloride). [ 18 ] Oral suspension is not favored for administration of clindamycin to children, due to its extremely foul taste and odor. Clindamycin is formulated in a vaginal cream and as vaginal ovules for treatment of bacterial vaginosis. [ 25 ] It is also available for topical administration in gel form, as a lotion, and in a foam delivery system (each containing clindamycin phosphate ) and a solution in ethanol (containing clindamycin hydrochloride) and is used primarily as a prescription acne treatment. [ 8 ]

Several combination acne treatments containing clindamycin are also marketed, such as single-product formulations of clindamycin with benzoyl peroxide —sold as BenzaClin (Sanofi-Aventis ), Duac (a gel form made by Stiefel ), and Acanya, among other trade names—and, in the United States, a combination of clindamycin and tretinoin. sold as Ziana. [ 41 ] In India, vaginal suppositories containing clindamycin in combination with clotrimazole are manufactured by Olive Health Care and sold as Clinsup-V. In Egypt, vaginal cream containing clindamycin produced by Biopharmgroup sold as Vagiclind indicated for vaginosis.

Clindamycin is available as a generic drug. for both systemic (oral and intravenous) and topical use [ 18 ] (The exception is the vaginal suppository, which is not available as a generic in the USA). [ citation needed ]

Veterinary use

The veterinary uses of clindamycin are quite similar to its human indications, and include treatment of osteomyelitis. [ 42 ] skin infections, and toxoplasmosis. for which it is the preferred drug in dogs and cats. [ 43 ] Toxoplasmosis rarely causes symptoms in cats, but can do so in very young or immunocompromised kittens and cats.

References

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Clindamycin - Side Effects, Dosage, Interactions

Clindamycin

Clindamycin is the generic name of the prescription drug Cleocin, which is an antibiotic used to treat certain serious bacterial infections.

Clindamycin belongs to a group of medicines known as lincosamide or lincomycin antibiotics. It works by stopping bacteria from producing the protein they need to reproduce and spread infection in your body.

Clindamycin was first approved by the Food and Drug Administration (FDA) under the brand name Cleocin in 1970, and was manufactured by Pharmacia and Upjohn (now Pfizer).

Clindamycin comes in a number of different forms (capsules, creams, gels, solutions, injection, and more). It can be prescribed to treat or prevent many types of infections, such as:

  • Severe middle ear infections (acute otitis media)
  • Severe sinus infection caused by bacteria
  • Meningitis caused by Streptococcus bacteria
  • Bacterial community-acquired pneumonia (CAP)
  • Vaginal infection caused by bacteria
  • Pelvic inflammatory disease (PID)
  • Acne

Clindamycin might be used to prevent an infection in the heart before a dental procedure, too, especially for people who may be allergic to or unable to take penicillin.

It is also prescribed to treat babesiosis, an infection of the blood caused by ticks that have been infected with a specific parasite.

Clindamycin for Dogs and Cats

Veterinarians may prescribe clindamycin to treat the following conditions in dogs or cats when they are caused by dangerous bacteria:

  • Skin infections
  • Deep wounds
  • Abscesses
  • Tooth infections
  • A serious bone infection called osteomyelitis, to try to prevent bacteria from spreading into the bloodstream

Clindamycin prescriptions for dogs and cats normally come in liquid form to be given by mouth.

Clindamycin for Acne

Clindamycin can be applied to the skin to treat acne. It comes in lotion, cream, or gel form under the name Cleocin T or clindamycin phosphate.

For the best results, wait 30 minutes after washing your face or affected area before applying clindamycin to the skin. Your skin may become a little sensitive while using clindamycin, so be sure to use gentle cleansers and moisturizers that will not irritate it further.

Clindamycin Warnings

Clindamycin has a high-priority, FDA-issued warning about your risk of developing a dangerous, infectious and difficult-to-treat form of diarrhea.

Clindamycin changes the balance of microorganisms in your intestines, allowing growth of bacteria called Clostridium difficile (C. difficile). The bacteria produce toxins and inflammation that can cause diarrhea and damage your intestines.

After taking clindamycin, diarrhea can take months to develop, and can range from mild to severe. Symptoms include frequent diarrhea with loose, watery stool that has an extremely foul smell.

People who take clindamycin for long periods of time are at increased risk of developing C. difficile diarrhea. The infection is often picked up in hospitals or nursing homes, where there are also types of C. difficile that are resistant to treatment. Therefore, your doctor should only prescribe clindamycin for serious infections that other drugs won't treat.

If you are allergic to clindamycin or lincomycin, you should not take clindamycin.

Tell your doctor if you are taking erythromycin, because clindamycin and erythromycin should never be taken together.

Tell your doctor right away if you develop severe forms of any of the following symptoms that do not go away while taking clindamycin:

  • Rash
  • Painful joints
  • Any problems swallowing, including pain while swallowing
  • Other mouth or throat symptoms, such as white spots, redness, or discomfort in your mouth area; a sore throat; or cracks in the corners of your lips (an infection called thrush)
  • Genital-area problems, such as burning, itching, creamy discharge, or swelling in your vagina; red rash, itching or burning on your penis
  • Nausea
  • Vomiting
  • Heartburn

Before taking clindamycin, also let your doctor know if:

  • You are allergic to clindamycin, lincomycin, or any of these drugs' ingredients
  • You have Crohn's disease, ulcerative colitis, any other type of colitis, or any condition that affects your intestines
  • You have meningitis
Pregnancy and Clindamycin

Clindamycin falls under the FDA's Pregnancy Category B, because it has not been shown to harm a fetus. Regardless, you should tell your doctor if you are pregnant or plan to become pregnant before taking this medication.

Clindamycin is not recommended if you are breastfeeding. You should also alert your doctor before taking the drug if you are breastfeeding or plan to breastfeed.

Clindamycin (Cleocin) Side Effects Common Side Effects of Clindamycin

Tell your doctor or seek immediate medical help if any of the following common side effects of clindamycin do not go away or become severe:

  • Mild rash or itching
  • Stomach pain, nausea
Serious Side Effects and Reactions

Contact your doctor immediately or seek emergency medical care if you have any of the following while taking clindamycin:

  • Skin problems, such as hives, rash, red, shedding, or peeling skin
  • Yellow appearance of the skin, nails, or whites of the eyes (jaundice)
  • Vomiting, severe stomach pain, or diarrhea
  • Signs of low blood pressure, ranging from dizziness to fainting
  • Pain or difficulties when swallowing; pain behind the breastbone; newly developed heartburn or acid regurgitation (signs of inflammation in your esophagus)
  • Vein irritation (if you are receiving injections of clindamycin)
  • Fever or body aches

Blisters or swelling in your lips, mouth, eyes, ears, nose, or genital areas

  • Signs of abnormal bleeding caused by low blood-clotting cells (thrombocytopenia), such as: easy bruising, red pin-prick spots on the skin, gums bleeding when you brush your teeth
  • Abnormal high or low levels of certain white blood cells (eosinophils and granulocytes) showing up in blood tests

In rare cases, some people may actually experience their throat closing up and trouble breathing (anaphylaxis). These are life-threatening situations. If you are having these symptoms, you should immediately stop taking clindamycin and call 911.

Clindamycin (Cleocin) Interactions

It is always important to tell your doctor and pharmacist about all of your treatments. Not just your prescription drugs, but also things that may not seem like medication, such as: over-the-counter (OTC) medications; vitamins, nutritional shakes, protein powders, and other supplements; herbal treatments or other alternative medicines; and any illegal or recreational drugs.

The following drugs are known to interact with clindamycin:

  • Botulinum toxin A (Botox)
  • Many birth-control treatments, including ones that contain the following: desogestrel, dienogest, drospirenone, estradiol, ethynodiol, levonorgestrel, mestranol, norelgestromin, norgestimate, and norgestrel
  • Mycophenolate mofetil (Cellcept, Myfortic)
  • Many drugs that are used during surgery, such as the muscle-controlling drugs atracurium (Tacrum), cisatrcurium (Nimbex), pancuronium (Pavulon), rocuronium (Zemuron, Esmeron), and vecuronium (Norcuron)
  • Sodium picosulfate
Clindamycin and Grapefruit Juice

You should avoid eating grapefruit and drinking grapefruit juice while taking clindamycin.

Grapefruit juice decreases the body's ability to break down clindamycin, which could cause the drug to rise to dangerously high levels in your blood.

Clindamycin and Other Interactions

You should not take clindamycin if you are taking bacillus Calmette-Guerin (known as BCG, or Theracys), a treatment for tuberculosis, leprosy, bladder cancer and other conditions.

Clindamycin (Cleocin) Dosage

Clindamycin comes in 150 milligram (mg) and 300 mg capsules. You should receive no more than 4,800 mg of clindamycin in a day, and that dose is normally only for people receiving clindamycin via injection into the thigh.

You can take clindamycin with or without food, but always with a full glass of water to help prevent it from bothering your throat.

It's very important that you continue taking the medication as prescribed until you have finished it all, even if your symptoms improve and you start to feel better.

Clindamycin Overdose

If you suspect an overdose, you should contact a poison-control center or emergency room immediately. You can reach a poison-control center at (800) 222-1222.

Missed Dose of Clindamycin

If you miss a dose of clindamycin, try to take it as soon as you remember. If it is almost time for the next dose, skip the missed dose and take your next dose at the regular time.

Do not take two doses of the medication at the same time.

A: According to the prescribing information available, Cleocin (clindamycin), the brand name of clindamycin, does not interact with any blood tests. For more information regarding clindamycin, you may want to visit our website. http://www.everydayhealth.com/drugs/clindamycin Beth Isaac, PharmD

Q: The doctor put me on clindamycin for 10 days in case of a bacterial infection. The blood work results are not back yet. I am also experiencing an allergic reaction on my face from something. He suspected a strep infection of the skin. I have never heard of this. Will this medication cure it?

A: Streptococcus (strep) is a bacterium often found in the throat, respiratory tract and on the skin. When streptococci get under the skin, they can foster a common skin disease known as impetigo. Impetigo starts out as a little red pin-sized rash resembling tiny pimples. The treatment for impetigo is usually penicillins, but clindamycin is generally used in patients who are allergic to the penicillin group of medications. This is a common choice for skin infections, and is usually dosed three times a day for 10 days. Here is some information on clindamycin and impetigo: http://www.everydayhealth.com/drugs/clindamycin http://www.everydayhealth.com/health-information/impetigo-what-is-it.aspx Lori Poulin, PharmD

Q: My dentist prescribed clindamycin to me for an absessed tooth. Is there a reaction to sun exposure with this medicine?

A: Sun (photo) sensitivity is not a common or specific side effect associated with clindamycin (Cleocin). However a serious side effect associated with this antibiotic is red, swollen, blistered, or peeling skin, which is not necessarily a reaction from sun exposure. If you experience a serious skin-related side effect while taking Clindamycin, it is recommended that you contact your doctor or seek medical attention right away. You can also find helpful information on clindamycin and Cleocin at http://www.everydayhealth.com/drugs/clindamycin and http://www.drugs.com/cdi/cleocin.html. Leslie Ako-Mbo, PharmD

Q: Is there a remedy for the reaction I am having to clindamycin? I am using Lanacaine and CVS's Instant Relief Spray to no avail.

A: Cleocin (clindamycin) is an antibiotic that is used to treat a variety of infections. If you have a reaction to clindamycin which causes rash, it can be treated with Benadryl (diphenhydramine) which will help to reduce some of the itching. If the reaction consists of difficulty breathing, stop using the clindamycin and contact your physician as soon as possible. For more specific information, consult with your doctor or pharmacist for guidance based on your health status and current medications, particularly before taking any action. Megan Uehara, PharmD

Q: Is clindamycin a penicillin?

A: Cleocin (clindamycin) does not fall under penicillin-type antibiotics and should not pose any cross-sensitivity reactions if you are allergic to penicillin. It is always good to notify your doctor of any allergic reactions you have had to any medications. This way, they are aware of your allergies when they are prescribing medication for you. The clindamycin should not cause an allergic reaction, unless you are allergic to the clindamycin as well as penicillin. Megan Uehara, PharmD

Q: How are the side effects of clindamycin treated?

A: Clindamycin is an antibiotic that is used to treat serious infections caused by bacteria. Common side effects of clindamycin include changes in bowel habits, nausea, vomiting, stomach pain, joint pain, rash, and itching. Clindamycin can also cause a more serious side effect called pseudomembranous colitis, which is an infection of the large intestine that can range in severity from mild to life-threatening. Patients who develop diarrhea while taking clindamycin or any other antibiotic should be evaluated by their healthcare provider for appropriate treatment. It is also important to understand that although you may feel better quickly, clindamycin should be taken as directed for as long as directed. Skipping doses or not completing the full course of therapy may not fully treat the infection and it could come back and be harder to treat. Michelle McDermott, PharmD

Q: What infections does clindamycin treat?

A: Cleocin (clindamycin) is an antibiotic that fights bacteria in the body. It is used to treat serious infections caused by bacteria, including skin infections, acne, pelvic inflammatory disease, bacterial vaginosis, respiratory infections, abdominal infections, ear infections, bone and joint infections, Strep throat, and periodontitis (infection of the gums). Clindamycin may be used to treat other infections not mentioned here. Consult your doctor for information about the specific infection you may have. Common side effects of clindamycin include change in bowel habits, nausea, vomiting, stomach pain, joint pain, and throat irritation. This is not a complete list of the side effects associated with clindamycin. To reduce the development of drug-resistant bacteria and maintain the effectiveness of clindamycin and other antibacterial drugs, clindamycin should be used only to treat or prevent infections that are proven or strongly suspected to be caused by bacteria. Sarah Lewis, PharmD

Q: What is the shelf life of clindamycin?

A: Clindamycin is in a drug class called lincomycin antibiotics. Clindamycin is used to treat certain serious bacterial infections -- when infections cannot be treated by certain other antibiotics. Clindamycin is used to treat serious: respiratory tract infections; skin infections; blood infections; infections of female reproductive organs or other organs. Clindamycin works by preventing or slowing the growth of bacteria. Clindamycin does not kill viruses; thus, it is not effective for treating colds, flu, or infections not associated with bacteria. When clindamycin is prescribed to treat a bacterial infection, it may be common to feel better early in the course of therapy; however, clindamycin should be taken exactly as directed. Skipping doses or not completing the full course of therapy may (1) decrease the effectiveness of the immediate treatment and (2) increase the likelihood that bacteria will develop resistance and will not be treatable by clindamycin or other antibiotics in the future. Prescription medications are required by law in the United States to have expiration dates. The expiration date on a prescription drug, including clindamycin, is the last date the manufacturer can ensure the full potency and safety of the medication. Medications can lose their potency and effectiveness as time passes. There have been reports of medication being harmful after its expiration date. The expiration date is the date the medication should be discarded, according to the Institute for Safe Medication Practices (ISMP). For prescription medications, the expiration date may be on the prescription label. If a medication comes without a documented expiration date, the pharmacy where the medication was dispensed may be able to provide the expiration date. According to ISMP, if the expiration date is unknown, and it has been more than one year since the medication has been dispensed from the pharmacy, the medication should be discarded. Additionally, if the medication has been stored outside of recommended conditions (e.g. extreme temperatures, direct sunlight), the integrity of the medication may be compromised. Clindamycin capsules should be stored at room temperature -- 68 - 77°F, according to prescribing information. Clindamycin should be only be taken as prescribed and under the supervision of a healthcare provider. Derek Dore, PharmD

By Frieda Wiley, PharmD | Medically Reviewed by Robert Jasmer, MD

Latest Update: 2014-12-17
Copyright © 2014 Everyday Health Media, LLC

Clindamycin, Oral (Cleocin): Drug Side Effects, Dosage

Omudhome Ogbru, PharmD

Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

Medical and Pharmacy Editor:

Jay W. Marks, MD

Jay W. Marks, MD, is a board-certified internist and gastroenterologist. He graduated from Yale University School of Medicine and trained in internal medicine and gastroenterology at UCLA/Cedars-Sinai Medical Center in Los Angeles.

GENERIC NAME: clindamycin oral BRAND NAME: Cleocin DISCONTINUED: Cleocin capsules have been discontinued.

DRUG CLASS AND MECHANISM: Clindamycin is an antibiotic used for treating serious infections. It is effective again several types of bacteria such as Staphylococcus aureus . Streptococcus pneumoniae. Staphylococcus epidermidis. and Propionibacterium acnes. It reduces growth of bacteria by interfering with their ability to make proteins. The FDA approved clindamycin in February 1970.

PRESCRIBED FOR: Clindamycin is used for treatment of serious infections caused by susceptible bacteria. It is most often used for treating penicillin-allergic patients or in other situations where penicillin or other alternative antibiotics cannot be used.

Some examples of infections that are treated with clindamycin include serious respiratory tract infections (for example, empyema, pneumonitis, and lung abscess ); serious skin and soft tissue infections; female pelvic and genital tract infections (for example, endometritis ); and ovarian abscess).

Medically Reviewed by a Doctor on 2/20/2015

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Cleocin (Clinamicina) Delivery

Residents of the USA can order Cleocin (Clinamicina) to any city, to any address, for example to Los Angeles, Atlanta, Mesa or Chicago. You can order delivery of a Cleocin (Clinamicina) to the United States, Japan, United Kingdom or any other country in the world.