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Dueva

Category: Woman's Health

Description

Lynoral (Ethinyl Estradiol) is a synthetic estrogen that is used to prevent pregnancy.

Active Ingredient: Ethinylestradiol

Lynoral (Dueva) as known as: Aethinyloestradiolum, Aida, Aliane, Apri, Aranelle, Arianna, Balanca, Balziva, Belara, Belarina, Bellgyn ratiopharm, Bellissima, Bellune, Bemasive, Binovum, Biviol, Brenda-35 ed, Brevinor, Careza, Carlin, Chariva, Chloe, Ciclidon, Ciclomex, Cileste, Clairette, Claudia, Clevia, Conceplan, Cryselle, Cycléane, Cyclen, Cyclessa, Cypestra-35, Cyprelle, Cyprene-35 ed, Cyprest, Cyproderm, Cyprodiol, Cypromix, Cyproteron, Cyprotérone, Cyproterone-apc, Daphne, Demulen, Desmin, Désobel, Desolett, Desorelle, Desoren, Diacare, Diane mite, Diane-35, Dianette, Dianova mite, Dileva, Diva-35, Dixi 35, Docdonna, Drina, Drosperin, Dueva, Duofem, Duoluton, Edelsin, Edulen, Efézial, Elisamylan, Elleacnelle, Elleogest, Enriqa, Ergalea, Estelle-35, Estinette, Estinyl, Estraceptin, Estrostep, Ethinyl estradiol, Ethinylestradiolum, Ethinyloestradiol, Etinilestradiol, Etinilestradiolo, Eufem, Eugynon, Evalon, Evépar, Evra, Facetix, Fedra, Felixita, Femcon, Femelle, Femhrt, Femiane, Femigen, Femina, Feminac 35, Feminil, Femodeen, Femoden, Femodene, Femodette, Femovan, Gestinyl, Gestodelle, Gestodette, Gestodiol, Gestofeme, Gestonette, Ginera, Ginette, Ginoden, Gracial, Gratiella, Gynelle, Gyneplen, Gynera, Gynofen, Gynovin, Gyselle, Harmonet, Harmonette, Holgyeme, Hormofen, Improvil, Jasminelle, Jeanine, Jenetten, Jennifer, Juliette, Kariva, Katya, Kelnor, Kipling, Lamuna, Laurina, Leena, Libeli, Liberel, Lilia, Lindynette, Linessa, Liofora, Logest, Lovelle, Low-ogestrel, Lucille, Ludeal, Lumalia, Lybella, Mamineurine, Masbell, Meliane, Melodene, Melodia, Microdiol, Microfollin, Microgestin, Midane, Milligest, Milvane, Minero, Minerva, Minesse, Minigeste, Miniphase, Ministat, Minulet, Minulette, Miravelle, Mirelle, Modina, Mona hexal, Moneva, Mononessa, Morea, Myralon, Myvlar, Necon, Nelova, Neo-eunomin, Neocon, Non-ovlon, Norimin, Norinyl, Nortrel, Norvetal, Novial, Novynette, Nuvaring, Ocella, Ogestrel, Oilezz, Ortho, Orthonett novum, Ortrel, Ovcon, Ovestin, Ovidol, Ovral, Perléane, Phaeva, Planak, Planovar, Planum, Practil 21, Pramino, Prefest, Previfem, Primosiston, Progynon c, Prosexol, Prostarin, Ratiopharmeva, Reclipsen, Reginon, Regulon, Remexin, Restovar, Securgin, Suavuret, Sunya, Sylgestrel, Sylvan, Sylvie, Syndi, Synfase, Synphase, Synphasec, Taril, Tri-gynera, Tri-legest, Tri-minulet, Tri-sprintec, Triadene, Triafemi, Tricilest, Triella, Trigynovin, Triminulet, Trimiron, Trinessa, Trinovum, Triodeen, Triodena, Triodene, Trisequens, Valette, Varnoline, Velivet, Visofid, Vivelle, Vreya, Xylia, Yadine, Yarina, Yasminelle, Yax, Yaz, Yira, Yris, Zenchent, Zovia, Zyrona

Interaction with the Mother in Children Born as a Result of in Vitro Fertilization (IVF): Attachment and Parenting Style Features

Psychological Science and Education psyedu.ru
2014. Vol. 6, No. 2.
ISSN: 2074-5885 (online)

Interaction with the Mother in Children Born as a Result of in Vitro Fertilization (IVF): Attachment and Parenting Style Features

Dueva A.A. Post-graduate Student, Chair of Development Psychology, Department of Educational Psychology, Moscow State University of Psychology & Education, Moscow, Russia, a_gusarova@bk.ru

The article is devoted to the social and emotional development of children. We tested and partially confirmed the hypothesis that children born as a result of reproductive technology, less often show reliable attachment type than the naturally born children. Such a pattern may emerge because of the behavior of IVF mothers. The present study involved 11 children aged from 5 years to 6 years 11 months, born as a result of IVF, and 10 control children conceived naturally, as well as their mothers. To collect anamnesis, we used: survey of parents with Child-parent emotional interaction questionnaire, and techniques Analysis of family education, projective drawing techniques Nest drawing and Drawing dialogue aimed at identifying the quality of the child's attachment to his mother and interaction in the dyad, as well as Kaplan method for determining the type of attachment.

Keywords: socio- emotional development of children, child's attachment to his mother, parent-child relationships, in vitro fertilization, parenting styles, projective drawing techniques

References
  1. Abramian L.A. Emotsional'noe samochuvstvie rebenka v protsesse vzaimodeistviia s mater'iu [Emotional well-being of the child in the process of interaction with the mother]. Problemy gumanizatsii vospitatel'no-obrazovatel'nogo protsessa v detskom sadu [Problems of humanisation of upbringing and education in kindergarten]. Perm': PGPI, 1993, pp. 14–18.
  2. Bowlby G. Priviazannost' [Attachment]. Moscow: Gardariki, 2003. 477 p.
  3. Burmenskaia G.V. Metodiki diagnostiki priviazannosti k materi rebenka doshkol'nogo i mladshego shkol'nogo vozrasta [Diagnostic methods of attachment to the mother in preschool and primary school age children]. Psikhologicheskaia diagnostika [Psychological diagnostics]. 2005, no 4, pp. 5–44.
  4. Vozrastno-psikhologicheskii podkhod v konsul'tirovanii detei i podrostkov [Developmental-psychological approach to counseling children and adolescents]. Burmenskaia G.V. eds. 2-e izd. rasshirennoe. Moscow: MPSI, 2007. 480 p.
  5. Gusarova A.A. Diagnostika priviazannosti doshkol'nikov i mladshikh shkol'nikov k materi na osnove proektivnykh metodik i osobennostei detsko-roditel'skikh vzaimootnoshenii [Attachment diagnostics in preschool and primary school children to the mother on the basis of projective techniques and characteristics of parent-child relationships]. Materialy Mezhdunarodnogo molodezhnogo nauchnogo foruma “LOMONOSOV-2011” [Proceedings of International youth scientific forum “Lomonosov-2011” ]. Andreev A.I. eds. 1 elektronnyi opticheskii disk (DVD-ROM). Moscow: MAKS Press, 2011. Available at: http://lomonosov-msu.ru/archive/Lomonosov_2011/1456/24115_9140.pdf (Accessed: 27.02.2014)
  6. Zakharova E.I. Issledovanie osobennostei emotsional'noi storony detsko-roditel'skogo vzaimodeistviia [A study of features of the emotional side of parent-child interaction]. Zhurnal prakticheskogo psikhologa [Journal of practical psychology ], 1996, no 6, pp. 96–104.
  7. Zakharova E.I. Karabanova O.A. Diagnostika kharaktera detsko-roditel'skikh otnoshenii v probe na sovmestnuiu deiatel'nost' [Diagnostics of parent-child relationship via joint activity trials]. Psikholog v detskom sadu [Psychology in kindergarten]. 2002, no 1, pp. 23–31.
  8. Lantsburg M.E. Solov'eva E.V. Sravnitel'noe issledovanie materinskogo otnosheniia k detiam rannego vozrasta, zachatym pri pomoshchi EKO i spontanno [Comparative study of maternal attitude to young children conceived through IVF and spontaneously]. U istokov razvitiia. Sbornik tezisov uchastnikov Chetvertoi vserossiiskoi nauchno-prakticheskoi konferentsii po psikhologii razvitiia [At the root of development. Abstracts of the participants of the Fourth All-Russian scientific-practical conference on developmental psychology]. Moscow: GBOU VPO MGPPU, 2013, pp. 40–43.
  9. Eidemiller E.G. Iustitskis V. Psikhologiia i psikhoterapiia sem'i [Family psychology and psychotherapy]. 4-e izd. St. Petersburg: Piter, 2008. 672 p.
  10. Colpin H. Demyttenaere K. Vandemeulebroecke L. New reproductive technology and the family: The parent–child relationship following in vitro fertilization. Journal of Child Psychology and Psychiatry. 1995, no. 36, pp. 1429–1441.
  11. Colpin H. Soenen S. Parenting and psychosocial development of IVF children: a follow-up study. Hum. Reprod. 2002, vol.17, no. 4, pp. 1116–1123.
  12. Gibson F.L. Ungerer J.A. McMahon C.A. et al. The Mother–Child Relationship Following In Vitro Fertilisation (IVF): Infant Attachment, Responsivity, and Maternal Sensitivity. J. Child Psychol. Psychiat. 2000, vol. 41, no. 8, pp. 1015–1023.
  13. Golombok S. Brewaeys A. Cook R. et al. The European study of assisted reproduction families: family functioning and child development. Hum. Reprod. 1996, vol.11, no.10, pp. 2324–2331.
  14. Hvidtjørn D. Jacobsson B. Cerebral palsy, autism spectrum disorders, and developmental delay in children born after assisted conception: A systematic review and meta-analysis. Arch. Pediatr. Adolesc. Med.. 2009, vol. 163, no. 1, pp. 72–83.
  15. Levy-Shiff R. Vakil E. Dimitrovsky L. et al. Medical, cognitive, emotional, and behavioral outcomes in school-age children conceived by in-vitro fertilization. J. Clin. Child. Psychol. 1998, vol. 27, no. 3, pp. 320–329.
  16. Sheller S. Understanding Insecure Attachment: A Study Using Children's Bird Nest Imagery. Journal of the American Art Therapy Association. 2007, vol. 24, no. 3, pp. 119–127.
  17. Van Balen F. Children born following in vitro fertilization. Zeitschrift fur Erziehungswissenschaft, 1999, no. 2, pp. 31–44.
See also

Other articles

Olga Dueva-Koganov, White Plains US - Patent applications

Olga Dueva-Koganov, White Plains US

Sunless tanning composition and method of sunless tanning - A sunless tanning composition having dihydroacetone and an amphoglycinate (amphoacetate) in an amount effective for sunless tanning is provided. Also provided is a method of sunless tanning having the step of topically applying to the skin an effective amount of a sunless tanning composition having dihydroacetone and an amphoglycinate.

Sunless tanning compositions comprising certain substituted polyamine compounds and methods of use - The present invention is directed to cosmetic and/or dermatological compositions for enhancing the rate of tanning human skin with sunless tanning compositions and providing the added benefit of simultaneously providing protection from ultraviolet light radiation. More particularly, the present invention is directed to a sunless tanning composition comprising a sunless tanning agent, a substituted polyamine compound and a cosmetically acceptable adjuvant. Methods of use of the instant compositions are disclosed as well.

BIOACTIVE FRACTIONS FROM STRESS-INDUCED PHOTOSYNTHETIC ORGANISMS AND METHODS OF THEIR MANUFACTURE AND USE - The present invention relates to bioactive fractions isolated from stress-induced photosynthetic organisms. The present invention also relates to methods of producing stress-induced photosynthetic organisms suitable for isolating altered bioactive fractions. The present invention further relates to bioactive compositions, bioactive topical formulations, and methods of their use.

COMPOSITIONS AND METHODS FOR TREATING SKIN - The present invention relates to skin care compositions comprising blends of

COMPOSITIONS AND METHODS FOR IMPROVING THE APPEARANCE OF AGING HAIR - A hair care composition and method of using the composition is provided that can increase the appearance of thicker and/or fuller hair and/or delay the appearance of gray hair to provide healthy and younger looking hair.

COMPOSITION COMPRISING BANYAN TREE, LOTUS, AND CLOVER SERUM FRACTIONS (AGING) - The present invention relates to compositions comprising banyan tree, lotus, and clover serum fractions. A method of improving the appearance of aging skin may comprise the step of applying a composition comprising an effective amount of banyan tree serum fraction, lotus serum fraction, and clover serum fraction to a sign of aging on a skin surface, wherein the composition is applied for a period of time sufficient to improve the appearance of the aging skin. The method may include the step of identifying a sign of aging on a facial skin surface.

COMPOSITION COMPRISING BANYAN TREE, LOTUS, AND CLOVER SERUM FRACTIONS (HYPERPIGMENTATION) - The present invention relates to compositions comprising banyan tree, lotus, and clover serum fractions. A method of improving the appearance of a hyperpigmented spot may comprise the step of applying a composition comprising an effective amount of banyan tree serum fraction, lotus serum fraction, and clover serum fraction to a hyperpigmented spot on a skin surface, wherein the composition is applied for a period of time sufficient to improve the appearance of the hyperpigmented spot. The method may include the step of identifying a hyperpigmented spot on a facial skin surface. Other methods as disclosed include a method for improving the appearance of post-inflammatory hyperpigmentation.

BIOACTIVE COMPOSITIONS FROM THEACEA PLANTS AND USE THEREOF IN BEVERAGES, FUNCTIONAL FOODS, NUTRICEUTICALS, SUPPLEMENTS AND THE LIKE - The present invention relates to isolated bioactive compositions containing bioactive fractions derived from Theacea plants. The present invention also relates to bioactive topical formulations containing the bioactive compositions. The present invention further relates to methods of using the bioactive compositions of the present invention, including, for example, methods for inhibiting inflammatory activity in skin tissue of a mammal, for protecting skin tissue of a mammal from ultraviolet light-induced damage, and for normalizing skin disorders in skin tissue of a mammal. The present invention also relates to methods for isolating bioactive fractions derived from cell juice or a cell walls component a Theacea plant. The bioactive compositions are suitable for use in, inter alia, beverages, functional foods, nutriceuticals, supplements, and the like.

Patent applications by Olga Dueva-Koganov, White Plains, NY US

Interaction of Flaviviruses with Reproduction Inhibitors Binding in - OG Pocket: Insights from Molecular Dynamics Simulations - Dueva - 2014 - Molecul

Interaction of Flaviviruses with Reproduction Inhibitors Binding in β-OG Pocket: Insights from Molecular Dynamics Simulations How to Cite

Dueva, E. V. Osolodkin, D. I. Kozlovskaya, L. I. Palyulin, V. A. Pentkovski, V. M. and Zefirov, N. S. (2014), Interaction of Flaviviruses with Reproduction Inhibitors Binding in β-OG Pocket: Insights from Molecular Dynamics Simulations. Mol. Inf. 33: 695–708. doi: 10.1002/minf.201300185

Author Information

Department of Chemistry, Lomonosov Moscow State University, Moscow 119991, Russia phone: +7-495-939-39-69, fax: +7-495-939-02-90

Chumakov Institute of Poliomyelitis and Viral Encephalitides, Moscow 142782, Russia

iScalare Laboratory, Moscow Institute of Physics and Technology, Dolgoprudny 141700, Russia

Email: Vladimir A. Palyulin (vap@qsar.chem.msu.ru)

* Department of Chemistry, Lomonosov Moscow State University, Moscow 119991, Russia phone: +7-495-939-39-69, fax: +7-495-939-02-90

Publication History
  1. Issue published online: 8 OCT 2014
  2. Article first published online: 26 SEP 2014
Funded by
  • OpenEye Scientific Software, Inc.
  • Russian Foundation for Basic Research. Grant Numbers: 14-03-00851, 14-03-31566
  • iScalare laboratory at MIPT
  • Government of the Russian Federation (Decree 220 of 09.04.2010)
  • Lomonosov Moscow State University
ARTICLE TOOLS Keywords:
  • Powassan virus;
  • Flavivirus;
  • Antivirals;
  • Envelope proteins;
  • Molecular dynamics
Abstract

Flaviviral diseases, including dengue fever, West Nile fever, yellow fever, tick-borne encephalitis, Omsk haemorrhagic fever, and Powassan encephalitis, threaten human health all over the world. Lack of effective antivirals targeting replication cycle of flaviviruses makes the search of such compounds a challenging task. Recently we have identified a reproduction inhibitor effective against tick-borne encephalitis virus and Powassan virus (POWV) (ACS Med. Chem. Lett.. 2013. 4. 869–874). To enable using this inhibitor as a template for 3D pharmacophore search, a biologically active conformation of this molecule should have been established. Here we performed molecular dynamics simulations of the complexes between the different enantiomers of the inhibitor and POWV envelope (E) proteins, putative targets of the inhibitor, in the different protonation states corresponding to the different stages of membrane fusion process. Several stable conformations of the inhibitor were identified, opening routes for further design of more advanced molecules.

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Toxicity of isonicotinic acid

Toxicity of isonicotinic acid

N. N. Nemchinov, Ref. Informatsiya, TSBNTI Medproma. Ser. Khim. Farm. Prom. No. 6 (1975), pp. 17–20.

Temporary Methodological Instructions for Investigations to Substantiate Maximum Permissible Concentrations of Toxic Substances in the Air of Working Zone (Rotaprint, Institute of Labor Hygiene and Occupational Diseases, Academy of Medical Sciences of the USSR) [in Russian], Moscow (1969).

O. G. Alekseev and A. I. Petkevich, Gig. San. No. 3, 64 (1972).

A. S. Raben, O. G. Alekseeva, and L. A. Dueva, Experimental Allergic Dermatitis [in Russian], Moscow (1970).

S. D. Zaugol'nikov, A. O. Loit, and A. M. Ivanitskii, in: General Problems of Industrial Toxicology. Materials of the First All-Union Conference (ed. by A. V. Roshchin and I. V. Sanotskii) [in Russian], Moscow (1967), pp. 46–49.

R. K. Lim, K. G. Rink, H. G. Glass, et al. Arch. Int. Pharmacodyn. 130. 336 (1961).

A. L. Germanova, “Experimental determination of the threshold of the acute action of irritating substances as a basis for the establishment of their MPC,” Author's Abstract of Candidate's Dissertation, Moscow (1971).

G. G. Maksimov, “Substantiation of the hygienic limitation of the content of industrial poisons in the air of workrooms according to irritating properties,” Author's Abstract of Candidate's Dissertation, Moscow (1969).

Патент US20060008427 - Sunscreen compositions with SPF enhancer - Google Патенты

Sunscreen compositions with SPF enhancer
US 20060008427 A1

The present invention provides a photo-protective composition that has a synergistic combination of at least one sunscreen agent and at least one carotenoid, which results in a composition with an increased SPF compared to a composition without the synergistic combination. Preferably, the composition also has at least one of the following additional components: emulsifier, emollient, skin-feel additive, moisturizing agent, film former/waterproofing agent, pH adjuster/chelating agent, preservative, or any combinations thereof.

1. A photo-protective composition comprising:

a synergistic combination of at least one sunscreen agent and at least one carotenoid, wherein said synergistic combination results in said photo-protective composition having a higher SPF than a photo-protective composition without said synergistic combination.

2. The photo-protective composition according to claim 1. wherein said at least one sunscreen agent is selected from the group consisting of para-aminobenzoic acid (PABA), butyl methoxydibenzoylmethane (avobenzone), benzophenone-1, benzophenone-2, benzophenone-3, benzophenone-4, benzophenone-6, benzophenone-8, benzophenone-12, methoxycinnamate, ethyl dihydroxypropyl-PABA, glyceryl PABA, homosalate, methyl anthranilate, octocrylene, octyl dimethyl PABA, octyl methoxycinnamate, octyl salicylate, PABA, 2-phenylbenzimidazole-5-sulphonic acid, triethanolamine salicylate, 3-(4-methylbenzylidene)-camphor, red petrolatum, zinc oxide, titanium dioxide, 3-(4-methylbenzyldine)boran-2-one(methylbenzindinecamphor), benzotriazole, phenylbenzimidazole-5-sulfonic acid, methylene bis-benzotrizolyl tetramethylbutyl phenol, and any combinations thereof.

3. The photo-protective composition according to claim 1. wherein said at least one sunscreen agent is selected from the group consisting of avobenzone, benzophenone-3, octyl methoxycinnamate, octyl salicylate, homosalate, and any combinations thereof.

4. The photo-protective composition according to claim 1. wherein said at least one sunscreen agent is present in an amount about 1 wt. % to about 40 wt. %, based on the total weight of said composition.

5. The photo-protective composition according to claim 1. wherein said at least one sunscreen agent is present in an amount about 4 wt. % to about 35 wt. %, based on the total weight of said composition.

6. The photo-protective composition according to claim 1. wherein said photo-protective composition has a SPF about 2 to about 50.

7. The photo-protective composition according to claim 1. wherein said at least one carotenoid is selected from the group consisting of lutein, lutein ester, xanthophyll, alpha-carotene, beta-carotene, gamma-carotene, lycopene, zeaxanthin, isozeaxanthin, astaxanthin, canthaxanthin, tanaxanthin, cryptoxanthin, rhodoxanthin, capxanthin, and any combinations thereof.

8. The photo-protective composition according to claim 1. wherein said at least one carotenoid is selected from the group consisting of lutein, lutein ester, and any combinations thereof.

9. The photo-protective composition according to claim 1. wherein said at least one carotenoid is present in an amount about 0.00001 wt. % to about 0.011 wt. %, based on the total weight of said composition.

10. The photo-protective composition according to claim 1. further comprising one or more components selected from the group consisting of pharmaceutically acceptable carrier, emulsifier, emollient, skin-feel additive, moisturizing agent, film former/waterproofing agent, pH adjuster/chelating agent, preservative, and any combinations thereof.

11. The photo-protective composition according to claim 1. wherein said composition has a pH about 3 to about 9.

12. The photo-protective composition of claim 1. further comprising one or more optional additives selected from the group consisting of fragrances, colorants, plant extracts, absorbents, thickeners, salicylic acid, alpha hydroxy acid, beta hydroxy acid, vitamin, and any combinations thereof.

13. The photo-protective composition of claim 1. wherein said composition is an oil-in-water emulsion.

14. A photo-protective composition comprising:

a synergistic combination of at least one sunscreen agent and a carotenoid selected from the group consisting of lutein, lutein ester, and any combination thereof,

wherein said synergistic combination results in said photo-protective composition having a higher SPF than a photo-protective composition without said synergistic combination.

15. The photo-protective composition of claim 14. wherein said at least one sunscreen agent is selected from the group consisting of octyl methoxycinnamate, octyl salicylate, butyl methoxydibenzoylmethane, benzophenone-3, and any combinations thereof.

16. The photo-protective composition of claim 14. wherein said at least one sunscreen agent is present in an amount about 12 wt. % to about 20 wt. %, based on a total weight of said composition.

17. The photo-protective composition of claim 14. wherein said carotenoid is present in an amount about 0.00001 wt. % to about 0.011 wt. %, based on a total weight of said composition.

18. A method for enhancing a SPF of a photo-protective composition comprising the step of incorporating a synergistic combination of at least one sunscreen agent and at least one carotenoid in said photo-protective composition.

19. The photo-protective composition according to claim 18. wherein said at least one sunscreen agent is selected from the group consisting of para-aminobenzoic acid (PABA), butyl methoxydibenzoylmethane (avobenzone), benzophenone-1, benzophenone-2, benzophenone-3, benzophenone-4, benzophenone-6, benzophenone-8, benzophenone-12, methoxycinnamate, ethyl dihydroxypropyl-PABA, glyceryl PABA, homosalate, methyl anthranilate, octocrylene, octyl dimethyl PABA, octyl methoxycinnamate, octyl salicylate, PABA, 2-phenylbenzimidazole-5-sulphonic acid, triethanolamine salicylate, 3-(4-methylbenzylidene)-camphor, red petrolatum, zinc oxide, titanium dioxide, 3-(4-methylbenzyld ine)boran-2-one(methylbenzindinecamphor), benzotriazole, phenylbenzimidazole-5-sulfonic acid, methylene bis-benzotrizolyl tetramethylbutyl phenol, and any combinations thereof.

20. The photo-protective composition according to claim 18. wherein said at least one sunscreen agent is selected from the group consisting of avobenzone, benzophenone-3, octyl methoxycinnamate, octyl salicylate, homosalate, and any combinations thereof.

21. The photo-protective composition according to claim 18. wherein said at least one sunscreen agent is present in an amount about 1 wt. % to about 40 wt. %, based on the total weight of said composition.

22. The photo-protective composition according to claim 18. wherein said at least one carotenoid is selected from the group consisting of lutein, lutein ester, xanthophyll, alpha-carotene, beta-carotene, gamma-carotene, lycopene, zeaxanthin, isozeaxanthin, astaxanthin, canthaxanthin, tanaxanthin, cryptoxanthin, rhodoxanthin, capxanthin, and any combinations thereof.

23. The photo-protective composition according to claim 18. wherein said at least one carotenoid is selected from the group consisting of lutein, lutein ester, and any combinations thereof.

24. The photo-protective composition according to claim 18. wherein said at least one carotenoid is present in an amount about 0.00001 wt. % to about 0.011 wt. %, based on the total weight of said composition.

This patent application claims priority to pending Provisional Patent Application Ser. No. 60/559,858, filed on Apr. 6, 2004.

BACKGROUND OF THE INVENTION
  • 1. Field of the Invention

    The present invention relates to photo-protective compositions. More particularly, the present invention relates to photo-protective compositions that have a synergistic combination of sunscreen agent and carotenoid resulting in a SPF increase or boost to the composition, without the need for additional sunscreen agent.

    2. Description of Related Art

    Photo-protective compositions, such as sunscreen compositions, are applied to the skin to protect the skin from the sun's ultraviolet rays that can lead to erythema, a reddening of the skin also known as sunburn. Sunlight or ultraviolet radiation in the UV-B range has a wavelength of 290 nm to 320 nm and is known to be the primary cause of sunburn. Ultraviolet rays at a wavelength of 320 nm to 400 nm, known as UV-A radiation, produces tanning of the skin. However, in the process of doing so, the UV-A rays can damage or harm the skin.

    Besides the immediate malady of sunburn, excessive sunlight exposure can lead to skin disorders. For instance, prolonged and constant exposure to the sun may lead to actinic keratoses and carcinomas. Another long-term effect is premature aging of the skin. This condition is characterized by skin that is wrinkled, cracked and has lost its elasticity.

    As stated above, sunscreens are typically formulated with the goal of inhibiting skin damage from the sun's rays. The sunscreen composition filters or blocks the harmful UV-A and UV-B rays that can damage and harm the skin. It is believed that sunscreen agents accomplish this by absorbing the UV-A and/or UV-B rays. Sunscreen compositions are typically formulated with one or more sunscreen active agents, which absorb and/or block the UVA and UVB radiation. The SPF of the composition is usually controlled by the amount of sunscreen active present in the composition. Generally, the more sunscreen active included in the composition, the higher the SPF.

    While compositions with sunscreen agents are effective at blocking and/or absorbing UV light, it is difficult to eliminate all of the impact of UV irradiation on the skin. Sunscreen agents alone are unable to repair the damage to the skin resulting from UV irradiation. As such, the use of carotenoids in skin care compositions to treat skin maladies that result from UV light exposure is found in the prior art. See, for example, U.S. Pat. No. 6,433,025 B1; U.S. Pat. No. 6,348,200 B1; U.S. Pat. No. 6,316,012 B1; U.S. Pat. No. 6,296,880 B1; U.S. Pat. Nos. 6,110,478; 6,071,541; and 5,712,311, all of which are incorporated by reference herein.

    However, what is clearly not appreciated in the prior art, yet is unexpectedly achieved by the present invention, is a photo-protective composition having a synergistic combination of sunscreen agent and carotenoid such that a SPF increase or boost is observed in the composition as compared to a photo-protective composition without carotenoid.

    SUMMARY OF THE INVENTION
  • It is an object of the present invention to provide a composition that has enhanced photo-protective properties achieved without the inclusion of additional sunscreen agent.

    It is another object of the present invention to provide such a composition that has a synergistic combination of sunscreen agent and carotenoid.

    It is still another object of the present invention to provide such a composition wherein the carotenoid in the presence of sunscreen agent synergistically increases the SPF of the composition compared to a composition without carotenoid.

    To accomplish the foregoing objects and advantages, the present invention, in brief summary, is a photo-protective composition that has a synergistic combination of at least one sunscreen agent and at least one carotenoid, which results in a composition with an increased SPF over a composition without carotenoid. Preferably, the composition also has at least one of the following additional components: emulsifier, emollient, skin-feel additive, moisturizing agent, film former/waterproofing agent, pH adjuster/chelating agent, preservative, or any combinations thereof.

    DETAILED DESCRIPTION OF THE INVENTION
  • The present invention is a photo-protective composition that includes a synergistic combination of at least one sunscreen agent and at least one carotenoid.

    Contrary to conventional formulating of photo-protective compositions, which call for increasing the amount of sunscreen agent to achieve increased SPF in the composition, it has been unexpectedly found that by including a synergistically effective amount of one or more carotenoids to a composition having one or more sunscreen agents, an increase in the SPF of the composition is observed over those compositions having only sunscreen agent and no carotenoid. As a result, higher SPF can be achieved without the inclusion of additional sunscreen agent to the composition.

    The fact that additional sunscreen agent is not required to boost the SPF of the composition is important in lieu of the fact that sunscreen agents that are commonly used in sunscreen compositions are regulated by the FDA. As a result of these regulations, namely the FDA Final Monograph, numerous sunscreen agents have are limited as to the maximum amount that can be included in a composition. Due to these limits, it can be difficult to formulate increased SPF compositions, since the SPF is typically related to the amount of sunscreen included in the composition. The compositions of the present invention with the one or more carotenoids overcome this problem or limitation.

    The one or more sunscreen agents that can be used in the present invention must be capable of absorbing or blocking the harmful effects of ultraviolet radiation. In addition, they must be non-toxic and non-irritating when applied to the skin. Suitable sunscreen agents that may be used in the sunscreen composition include, but are not limited to, para-aminobenzoic acid (PABA), butyl methoxydibenzoylmethane (avobenzone), benzophenone-1, benzophenone-2, benzophenone-3, benzophenone4, benzophenone-6, benzophenone-8, benzophenone-12, methoxycinnamate, ethyl dihydroxypropyl-PABA, glyceryl PABA, homosalate, methyl anthranilate, octocrylene, octyl dimethyl PABA, octyl methoxycinnamate, octyl salicylate, PABA, 2-phenylbenzimidazole-5-sulphonic acid, triethanolam ine salicylate, 3-(4-methylbenzylidene)-camphor, red petrolatum, zinc oxide, titanium dioxide, 3-(4-methylbenzyldine)boran-2-one(methylbenzindinecamphor), benzotriazole, phenylbenzimidazole-5-sulfonic acid, methylene bis-benzotrizolyl tetramethylbutyl phenol, or any combinations thereof.

    The preferred sunscreen agents are avobenzone, benzophenone-3, octyl methoxycinnamate, octyl salicylate, homosalate, or any combinations thereof.

    The one or more sunscreen agents are included in the present composition in an amount about 1 weight percent (wt. %) to about 40 wt. %, based on the total weight of the composition. Preferably, the one or more sunscreen agents are included in an amount about 4 wt. % to about 35 wt. % to achieve a SPF of about 2 to about 50.

    An important aspect of the present invention is the inclusion of one or more carotenoids in combination with the one or more sunscreen agents in the photo-protective compositions of the present invention. It has been unexpectedly found that the inclusion of small amounts of one or more carotenoids in the compositions of the present invention result in a SPF increase or boost to the composition, as compared to a composition with equal amounts of sunscreen agent and no carotenoid.

    Carotenoids suitable for use in the present invention include, but are not limited to, one or more lutein, lutein esters, xanthophylls, alpha-carotene, beta-carotene, gamma-carotene, lycopene, zeaxanthin, isozeaxanthin, astaxanthin, canthaxanthin, tanaxanthin, cryptoxanthin, rhodoxanthin, capxanthin, or any combinations thereof. Preferably, the one or more carotenoids are one or more lutein, lutein esters, or any combinations thereof.

    As noted above, only a small amount of carotenoid is required to be included in the compositions of the present invention to achieve the unexpected SPF boost in the composition. Carotenoid in an amount about 0.00001 wt. % to about 0.03 wt. % can be included in the composition to synergistically boost the final SPF of the composition. Preferably, the carotenoid is present in an amount about 0.00001 wt. % to about 0.02 wt. %, and more preferably in an amount about 0.00001 wt. % to about 0.011 wt. %.

    The need for only a small amount of carotenoid to synergistically achieve the SPF boost with the sunscreen agent results in a cost reduction when formulating the composition and does not require significant formulation modifications to incorporate it into the composition.

    In addition, it has been found that the amount of carotenoid to be used in the compositions must be carefully selected. By way of example, it has been found that the use of lutein in amounts greater than about 0.011 wt. % may color the composition excessively, which may result in the undesirable staining of the skin and fabric. In addition, it is believed that lutein at concentrations below 0.00001 wt. % does not have any biological effects on the skin.

    Preferably, the composition also has one or more of the following additional components: pharmaceutically acceptable carrier, emulsifier, emollient, skin-feel additive, moisturizing agent, film former/waterproofing agent, pH adjuster/chelating agent, preservative, or any combinations thereof.

    Suitable emulsifiers that may be used in the compositions of the present invention include, but are not limited to, butylated PVP, cetyl alcohol, sodium acrylate/sodium acryloyldimethyltaurate copolymer, diethylhexyl napthalate, sorbitan oleate, sorbitan sesquioleate, sorbitan isostearate, sorbitan trioleate, polyglyceryl-3-diisostearate, polyglycerol esters of oleic/isostearic acid, polyglyceryl-6 hexaricinolate, polyglyceryl-4-oleate, polyglyceryl-4 oleate/PEG-8 propylene glycol cocoate, oleamide DEA, sodium glyceryl oleate phosphate, hydrogenated vegetable glycerides phosphate, cetearyl glucoside, cocoyl glucoside, cocoyl ethyl glucoside, disodium coco-glucoside citrate, disodium coco-glucoside sulfosuccinate, lauroyl ethyl glucoside, myristoyl ethyl glucoside, octyl dimethicone ethoxy glucoside, oleoyl ethyl glucoside, sodium coco-glucoside tartrate, or any combinations thereof.

    The amount of emulsifier present in the sunscreen compositions of the present invention is about 1 wt. % to about 15 wt. % of the total weight of the composition. Preferably, the emulsifier is present in an amount about 2.5 wt. % to about 7.5 wt. % of the total weight of the composition.

    The compositions of the present invention also include water. Water is present in an amount about 45 wt. % to about 75 wt. %, and preferably about 50 wt. % to about 65 wt. %, of the total weight of the sunscreen composition.

    The present composition may include one or more emollients. An emollient provides a softening or soothing effect on the skin surface and is generally considered safe for topical use. It also helps control the rate of evaporation and the tackiness of the sunscreen composition.

    Suitable emollients include, but are not limited to, cyclomethicone, dimethicone, dicapryl maleate, caprylic/capric triglyceride, mineral oil, lanolin oil, coconut oil, cocoa butter, olive oil, aloe extracts such as aloe vera, jojoba oil, castor oil, fatty acid such as oleic and stearic, fatty alcohol such as cetyl and hexadecyl (ENJAY), diisopropyl adipate, hydroxybenzoate esters, benzoic acid esters of C9 -C15 alcohols, isononyl iso-nonanoate, alkanes such as mineral oil, silicone such as dimethyl polysiloxane, ether such as polyoxypropylene butyl ether and polyoxypropylene cetyl ether, C12 -C15 alkyl benzoate, or any combinations thereof.

    The preferred emollients are cyclomethicone, dimethicone, dicapryl maleate, caprylic/capric triglyceride, aloe vera, or any combinations thereof.

    The total amount of emollient present in the sunscreen composition is typically about 0.10 wt. % to about 30 wt. %, based on the total weight of the composition. The preferred amount of emollient is about 1 wt. % to about 20 wt. %.

    The feel of the sunscreen composition upon application to the skin may be a consideration of a consumer when purchasing a sunscreen. Moreover, a smooth, silky sunscreen composition may be more uniformly applied over the skin. To further enhance the feel of the sunscreen compositions of the present invention when applied to the skin, a skin-feel additive may be included. Suitable skin-feel additives include, but are not limited to, synthetic polymers, silicones, esters, particulates, or any combinations thereof.

    Preferably, the skin-feel additive is present in the sunscreen composition in an amount about 0.10 wt. % to about 5 wt. %, based on the total weight of the composition. More preferably, it is present in an amount about 0.30 wt. % to about 0.70 wt. % of the total weight of the composition.

    The pH of the compositions of the present invention may be adjusted by one or more basic pH adjusters and/or chelating agents. For example, sodium hydroxide, triethanolamine, trisodium ethylenediaminetetraacetic acid, or any combinations thereof are suitable pH adjusters/chelating agents that may be included in the sunscreen compositions of the present invention.

    An effective amount of a pH adjuster and/or chelating agent that may be included to adjust the pH of the final composition to about 3 to about 9. Preferably, the pH is adjusted to about 6 to about 8.

    A moisturizing agent, such as a humectant, may be used in the compositions of the present invention. Suitable humectants include, but are not limited to, glycerin, polyethylene glycol, polypropylene glycol, pentylene glycol, caprylyl glycol, sorbitol, PEG-4, PEG-8, or any combinations thereof.

    One or more moisturizing agents are optionally included in the compositions of the present invention in an amount about 0.1 wt. % to about 2 wt. % of the total weight of the composition. Preferably, about 0.25 wt. % to about 0.75 wt. % of one or more moisturizing agents may be used in the composition.

    Another component that may be used in a sunscreen composition of the present invention is a film former/waterproofing agent. The film former/waterproofing agent is a hydrophobic material that imparts film forming and waterproofing characteristics to the emulsion. One such agent is polyethylene, which is available from New Phase Technologies as PERFORMALENE® 400, a polyethylene having a molecular weight of 400. Another suitable water-proofing agent is polyethylene 2000 (molecular weight of 2000), which is available from New Phase Technologies as PERFORMALENE® 2000. Yet, another suitable film former/waterproofing agent is synthetic wax, also available from New Phase Technologies as PERFORMA® V-825. One or more film formers/waterproofing agents may be present in a composition of the present invention in an amount about 0.1 wt. % to about 5 wt. %, based on the total weight of the composition.

    Optionally, one or more preservatives may be included in a composition of the present invention. The preservative protects the composition from microbial contamination and/or oxidation. As such, the preservative can include an antioxidant. Preservatives, such as diazolidinyl urea, iodopropynyl butylcarbamate, chloromethylisotiazolinone, methylisothiazolinone, vitamin E and its derivatives including vitamin E acetate, vitamin C, butylated hydroxytoluene, methylparaben, or any combinations thereof, may be included as a preservative in a composition of the present invention.

    About 0.01 wt. % to about 1 wt. % of preservative may be included in a composition of the present invention. Preferably, one or more preservatives total about 0.05 wt. % to about 0.50 wt. %, based on the total weight of the composition.

    The sunscreen compositions of the present invention may also have other optional additives. For instance, one or more fragrances, colorants, plant extracts, absorbents, thickeners, salicylic acid, alpha and beta hydroxy acids, vitamins including vitamins A, C, and E, retinol, retinol palmitate, vitamin E acetate, tocopherol, vitamin A palmitate, vitamin E palmitate, or any mixtures thereof, may be included in the sunscreen compositions.

    The components of the present invention may be combined to form a stable oil-in-water emulsion. The sunscreen is incorporated into the oil phase and later combined with water with the help of the one or more emulsifiers. The process used to manufacture the composition of the present invention must be capable of forming a homogeneous composition that can be spread into a film.

    In one preferred embodiment of the present invention, the sunscreen composition includes about 12 wt. % to about 20 wt. % of one or more sunscreen agents selected from the group consisting of: octyl methoxycinnamate, octyl salicylate, butyl methoxydibenzoylmethane, benzophenone-3, or any combinations thereof; and about 0.00001 wt. % to about 0.011 wt. % of lutein.

    This unexpected benefit of including one or more carotenoids in the compositions of the present invention is demonstrated in the Example below.

    Two compositions were prepared and subsequently tested for SPF. The first composition (Composition 1) included about 16 wt. % sunscreen agents and about 0.011% lutein where the second, comparative composition (Composition 2) contained about 16 wt. % sunscreen agents and no lutein. Concurrent with the testing of the above compositions, a standard sunscreen preparation of 8% homosalate with a mean SPF value of 4.47+/−1.28 was tested. As set forth below in Table 1, overall, Composition 1 had an average measured average SPF of 31.50 where the comparative Composition 2, absent lutein, only had an average measured SPF of 29.65, demonstrating that the composition with lutein has almost 2 SPF units more than that composition without lutein.

    The test procedure was based on the method outlined in the FDA Final Monograph for sunscreen testing published in the Federal Register, Vol. 64, No. 98, May 21, 1999. Further testing parameters were are follows:

    • a) At least twenty (20) but not more than twenty-five (25) healthy male or female volunteers of skin types I-III as described below:
      • I Always burns easily, never tans (sensitive)
      • II Always burns easily; tans minimally (sensitive)
      • III Burns moderately; tans gradually (light brown) (normal)
      • IV Burns minimally; always tans well (moderate brown) (normal)
      • V Rarely burns; tans profusely (dark brown) (insensitive)
      • VI Never burns; deeply pigmented (insensitive)
    • b) Ages 18-65 years old.
    • c) Absence of any visible skin disease which might be confused with a skin reaction from the Test Material;
    • d) Completion of a Medical History Form and the understanding and signing of a legally effective Informed Consent Form; and
    • e) Considered dependable and capable of following directions.
      Exclusion Criteria:
    • a) Subjects with a history of abnormal response to sunlight or those taking medication which might produce an abnormal response to sunlight;
    • b) Subjects exhibiting current sunburn, suntan, or uneven skin tone or visible skin disease, which might interfere with evaluation of test, results;
    • c) Presence of nevi, blemishes, or moles which, in the Investigator's judgement, would interfere with the study results. Excess hair on the back would be accepted if hair is clipped or shaved;
    • d) Subjects with a history of lupus, erythematosis, or skin cancer; and
    • e) Females who are pregnant or lactating.
      Test Method

    Seven (7) subjects who met the inclusion criteria were selected for participation.

    Light Source—A Xenon Arc Solar Simulator (150 w) was used as the source of ultraviolet light irradiation (Solar Light Company, Philadelphia, P A). This instrument, described in detail in J. Invest. Dermatol. 53, 192 (1969), provides a spectral output in the ultraviolet range comparable to that of natural sunlight. The WG-320 and VG-II filters were used to provide a basic UV-A and UV-B wavelength spectrum, with wavelength ranges of 290-400 nm. The lamp output was measured with a UV intensity meter (Model PMA2100, Solar Light Company, Philadelphia, Pa.) before and after the test period.

    Determination of Minimal Erythemal Dose (MED)—An MED is defined as the lowest time interval or dosage of UV light irradiation sufficient to produce defined erythema on designated test sites. Prior to the product testing phase, the MED of the unprotected skin of each subject was determined by a progressive sequence of timed UV light exposures, graduated incrementally by 25% over that of the previous exposure. The sites were evaluated for erythema according to the following scoring system:

    Determination of Static SPF Values—A sufficient number of 50 square centimeter test site areas were outlined with a surgical marking pen on the subject's back between the scapulae and the beltline, lateral to the midline. These areas were designated for applications of the Test Material and Standard, with an adjacent site designated for a concurrent MED determination (unprotected control).

    A 2 mg/cm 2 portion of the Test Material and of the Standard was applied to the appropriate designated test site and spread evenly over the site using a fingercot. After product application, each test area was subdivided into sites, which were used for defined serial UV light exposures. Irradiation of the sites was begun no less than 15 minutes after application.

    Exposure times were selected for each site in treated areas based upon the previously determined MED of unprotected skin and the expected SPF of the Test Material and the HMS Standard. After irradiation was completed for each area, responses for tanning, reddening, and heat response were recorded as absent (O) or present (1).

    Evaluation of Test Sites—All test sites were evaluated 22 to 24 hours after irradiation to determine minimal erythemal response of all sites. The MED evaluator did not apply or irradiate the test material.

    SPF Determination—The SPF is defined as the ratio of the amount of energy or time required to produce an MED on protected skin (treated with Test Material(s) or Standard) to the amount of energy or time needed to produce an MED on untreated skin and is calculated as follows: SPF = MED ⁢ ⁢ Test ⁢ ⁢ Material ⁢ ⁢ or ⁢ ⁢ Standard MED ⁢ ⁢ Unprotected ⁢ ⁢ Control

    Again, as demonstrated by the data summarized in Table 1, Composition 1, which included lutein according to the present invention had a SPF value almost 2 SPF units higher than Composition 2, which did not include lutein. Therefore, an SPF boost is observed without the inclusion of additional sunscreen agent.

    The sunscreen compositions of the present invention may be prepared by using techniques and methods well known in the art. In general, ingredients are incorporated by mixing and applying heat if necessary, until the composition is uniform and homogeneous. The composition may be homogenized to ensure homogeneity and to build the proper viscosity. The sunscreen compositions of the present invention are then packaged as a lotion in any package or container suitable for a sunscreen composition.

    Having thus described the present invention with particular reference to preferred embodiments thereof, it will be apparent that various changes and modifications may be made therein without departing from the spirit and scope of the present invention as defined in the appended claims.

  • Lynoral (Dueva) Delivery

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