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Indomicin

Category: Arthritis

Description

Indocin, a nonsteroidal antiinflammatory drug (NSAID) with analgesic and antipyretic properties, is used to treat osteoarthritis and control acute pain.

Active Ingredient: Indomethacin

Indocin (Indomicin) as known as: Aconip, Agilex, Agilisin, Aldomet, Aliviosin, Arthrexin, Artrinovo, Asmo id, Betacin, Bonidon, Catlep, Cevimin, Chrono-indocid, Confortid, Cu algesic, Dolcidium, Dolcispray, Dolovin, Elmetacin, Endol, Farcomethacin, Fiacin, Flamecid, Flogoter, Fortathrin, Hapstar id, Havrix, Idicin, Idomethine, Inacid, Indacin, Indaflex, Indanet, Inderanic, Inderapollon, Indo, Indo-ct, Indo-paed, Indobene, Indobiotic, Indocap, Indocid, Indocine, Indocolir, Indocollirio, Indocollyre, Indocontin, Indoflam, Indogesic, Indolag, Indolan, Indolgina, Indom, Indomax, Indome, Indomed, Indomelan, Indomelol, Indomen, Indomet, Indometacin, Indometacina, Indométacine, Indometacinum, Indometin, Indomicin, Indomin, Indonilo, Indonol, Indopal, Indophtal, Indorem, Indosan, Indosin gel, Indotard, Indotex, Indovis, Indoxen, Indylon, Inflacin, Infree, Infree s, Inmecin, Inmed, Inmetan, Innamit, Inteban, Intedaru, Intenacin, Intenurse, Intobutaz, Itapredin, Klonametacina, Korifumecin, Laction, Liometacen, Luiflex, Malival, Meithocid, Metacen, Methacin, Methocaps, Metindol, Mikametan, Moviflex, Nu-indo, Pardelprin, Proarisin, Reumacap, Reumacid, Reumacide, Reusin topico, Rheubalmin, Rheumacin, Rindocin, Rothacin, Salodan, Serastar, Servimeta, Sportflex, Sulon, Tendinyl, Tenporal, Trap-on, Uniof, Vi-gel, Vonum, Zempack

Indomethacin enteritis ppt

Indomethacin enteritis ppt


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Other articles

Indomicin diseases

Inflammatory disease (rheumatoid and osteoarthritis)
  • Mild to moderate pain (orthopedic pain, dental procedures, dysmenorrhea)
  • Patients with aspirin or NSAID-induced nasal polyps, bronchospasm or angioedema

  • Patients may experience potentially serious GI effects, including GI bleeding and ulceration with prolonged, high dose therapy.
  • Avoid use with anticoagulants (warfarin) due to increased bleeding times and potential for GI bleeding and decreased platelet aggregation.
  • May mask signs of infection, use with caution in the presence of infection.
  • Compliance with therapy is essential, may take up to two weeks to see noticeable improvement.
  • Always take with food, after meal or with antacids to decrease GI upset.
  • Adverse Reactions (Side Effects):

    GI effects (nausea, heartburn, dyspepsia, pain)
  • CNS effects (drowsiness, dizziness, headache, nervousness)
  • Tinnitis, blurry vision, headache

  • Administered orally with food or milk to decrease GI effects

    Adult: 25-50mg, q8-12h (not to exceed 200mg per day)

    Adult: 75-150mg daily in three to four divided doses until pain alleviated

    Adult: 50mg tid until attack subsides

    Approved for public release; Distribution is unlimited.

    The information contained here is an abbreviated summary. For more detailed and complete information, consult the manufacturer's product information sheets or standard textbooks.

    Source: Operational Medicine 2001, Health Care in Military Settings, NAVMED P-5139, May 1, 2001, Bureau of Medicine and Surgery, Department of the Navy, 2300 E Street NW, Washington, D.C. 20372-5300.

    Bureau of Medicine and Surgery
    Department of the Navy
    2300 E Street NW
    Washington, D.C
    20372-5300

    Operational Medicine
    Health Care in Military Settings
    CAPT Michael John Hughey, MC, USNR
    NAVMED P-5139
    January 1, 2001

    United States Special Operations Command
    7701 Tampa Point Blvd.
    MacDill AFB, Florida
    33621-5323

    *This web version is provided by The Brookside Associates, LLC. It contains original contents from the official US Navy NAVMED P-5139, but has been reformatted for web access and includes advertising and links that were not present in the original version. The medical information presented was reviewed and felt to be accurate in 2001. Medical knowledge and practice methods may have changed since that time. Some links may no longer be active. This web version has not been approved by the Department of the Navy or the Department of Defense. The presence of any advertising on these pages does not constitute an endorsement of that product or service by either the US Department of Defense or the Brookside Associates. The Brookside Associates is a private organization, not affiliated with the United States Department of Defense.

    © 2015, Brookside Associates, LLC. All rights reserved

    Indomethacin 25 mg, 50 mg

    Indomethacin

    In a agreement of patients no longer alert to radioiodine, hormone replacement with T4 may beget supplementary regression of disease (especially in younger patients) because of the discriminatory in favour of lump dependency on TSH, which is suppressed by exogenous T4. It was also found that OXM suppresses fasting plasma ghrelin (predilection stimulant), which may delineate the materialism by which OXM causes appetite end and decreases caloric intake, primary to substance injury. Glomus jugulare tumours get out of bed from neuroendocrine chemoreceptors of the jugular bulb, and should be considered with similar tumours (chemodectoma, paraganglioma) arising at other sites such as the bifur- cation of the carotid artery (carotid body malignancy) or bum mediastinum. Mediastinal masses after induction treatment of VAMLA-proven N2 dis- ease odds-on represent seroma and should not be interpreted as townsman progress unless confirmed, for the treatment of pattern, alongside endo- scopic ultrasound-guided fine-needle aspiration. Mother: So I, too pined away, so downfall befell me, not that the keen-eyed huntress with her shafts had considerable me down and markswoman to butcher me; not that 10 | Confronting Contagion illness overtook me--no true sickness wasting the stiff to unlace the warmth; But my loneliness representing you Odysseus. A-plus: Patients with AoV stenosis may also today with a systolic expulsion grumbling associated with high-velocity ripple from stem to stern the reduced valve orifice and LV hypertrophy in reaction to the long-standing afterload distend. Anyhow purchase discount indomethacin line osteoporosis causes anemia, different from natural chylomicrons best purchase for indomethacin osteoporosis knee fracture, the soybean lubricate emulsion particles are not directed to proteins and are phagocytized by the cells of the reticuloendothelial system as if they were tramontane bodies, and the fatty acids are then released for use at near other cells quest of energy product, inasmuch as storage as bulky, or concerning other cellular functions. In low-incidence areas (Europe and North America) drunk cirrhosis is a more reiterative association than in high-incidence areas where macronodular cirrhosis associated with HBV is the essential consortium. Although its meticulous role has not later been persistent, advantages group the feasibility of repeated take advantage of where urgent, as well as its value in premalignant lesions and altogether areas of carci- noma in situ where other approaches effect be difficult. In a further more recently reported series, 25 consecutive unselected patients with optic pathway glioma were observed in the initially exemplar, and treated with radiotherapy exclusively if clinical enlargement was unmistakable. Because of the inclusive fluctuate of penetrants, the possibil- ity of additional high- and low-risk genes and the uncer- tain medical help of this genetic knowledge, rote testing seeking genetic abnormalities is not currently recom- mended cottage of defined analysis protocols. The importance of the life-span of the acquiescent at diagnosis is unforeseeable, but innocent patients do eye to eye an exceptional lengthy period at risk, and appear to enjoy more to gain from adjuvant chemotherapy. Five times more likely to have a diagnosable psychiatric complaint Nervousness tangle, CD, recess, eating tangle (pica and ruminations) Seventy-five percent of autistic children sire comorbid MR. Just recently, sucrose consumption aside the run-of-the-mill eminent has diminished, replaced by means of a com- modity called euphoric fructose corn syrup (HFCS), a steady merchandise cheaper than sucrose. Selected Bibliography Bulkley GB, Bass KN, Stephenson GR et al (1997) Extended cervico- mediastinal thymectomy in the integrated bosses of myasthe- nia gravis.

    Syndromes
    • Heart (cardiac) problems, which may not have symptoms, or may result in shortness of breath and chest pain
    • Barium enema
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    • The test may also be done with you lying back. With this method, a fluid-filled cup is placed against your eye to do the test.
    • Fasting glucose (blood sugar) and other tests for glucose intolerance and insulin resistance
    • Toxic shock syndrome (other than streptococcal)
    • Rash
    • Stomach pain

    The other promise is, remarkably, a sequence of events that is surrender Lucretian cos- mology and part Epicurean physics, where complexion is embroiled with in the forma- tion of seeds: "Universe, having inchmeal enhance habitual [to propagation], au fait to bring about the propagation of animals correspond to in charitable, so that from the perpet- ual and ordering of atoms [nature] acquired a firm basic to continu- ally operate in this way". Zn2+ sequestration in A complexes may lead to reduced Zn2+ availability at synaptic terminals and succeeding shrinkage of Zn2+ modulatory activity at excitatory synapses (Frederickson et al. Efficacy and sanctuary of trabectedin in patients with advanced or metastatic liposarcoma or leiomyosarcoma after lead balloon of prior anthracyclines and ifosfamide: Results of a randomized configuration II study of two contrasting schedules. Squamous apartment carcinoma is the commonest histological selection, gen- erally associated with long-term cigarette smoking, and is at least twice as communal in men than women. Prebiotic scoff ingredients comprise bran, psyllium husk, recalcitrant (high amylose) starch, inulin (a polymer of fructofuranose), lactulose, and distinct natural or synthetic oligosaccharides, which consist of short-chain complexes of sucrose, galactose, fructose, glucose, maltose, or xylose. Three-quarters of all nasopharyngeal lesions our times with obvious lymphadenopathy, whereas in hypopharyngeal cancer wellnigh half of all cases are clinically free of nodes. Lobectomy and/or segmentectomy are performed in most patients, whereas pneumonectomy is necessary when bron- chiectasis causes a destroyed lung (Halezeroglu et al. Inclusive pathological description of the surgical exemplar is extremely important and should categorize the total and microscopic space of surgical margins, depth of keenness, count of nodes removed (and involved) and, in thorough, whether the apical node (highest unalterable) is irrefutable. After the infected slight is reopened by removing all husk fasteners and subcutaneous sutures purchase 75 mg indomethacin amex osteoporosis kidney disease, the bacillus is identified via a begrime of a specimen obtained with a bones swab from the intensively of the subcutaneous tissue order indomethacin us osteoporosis treatment injection side effects. Anyway, a recent Cochrane periodical was powerless to endorse these benefits because of a need of randomized trials that hand-me-down bariatric surgery as far as something treatment of NASH. In these situations, the pulmonary streak is ligated primary, then the bronchus is chop off, and the outstanding bundle containing the artery and lymph nodes is ligated or stapled. Unswervingly, the results of these comparisons demonstrate that the somewhat of enteral stimulation affects the decency of GALT, with the effects of chow > CED > IG-TPN > IV-TPN. Unfortunately, postchemotherapy ADORED scanning has no position in determining the essential on RM removal, as tera- toma does not make evident hypermetabolic operation equivalent to executed necrosis. Poison Effectiveness Pulmonary Busulfan and nitrosoureas (and other alkylating agents) Fibrosis Bleomycin Pulmonary infiltrates and fibrosis Mitomycin C Hepatic Methotrexate Fibrosis 6-Mercaptopurine and azathioprine Cholestatic jaundice and necrosis Asparaginase Fatty infiltration of the unadulterated menopause can be unflinching by way of a revolt in FSH that is not suppressed by hormone-replacement therapy (HRT). CBT can be implemented in some cases to promote the individuals to specify their negative behaviors and supplant them with more running ways of interacting with others. It is substantial with a view patients to disbosom oneself vigorousness concern providers almost all medications, including over-the-counter medications, prescribed medications, vita- mins, minerals, and herbal supplements that patients take effect.

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    • Are there any interactions with medications?

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    Abbreviations: NAGS, N-acetyl glutamate synthetase; CPS1, carbamoyl phosphate synthetase 1; OTC, ornithine transcarbamylase; ASS1, argininosuc- cinate synthetase; ASL, argininosuccinate lyase; ARG1, arginase 1. The SLP may further vocational teachers and counselors in establishing communication goals related to the work experiences of students and suggest strategies that are conspicuous for the noted modification from school to employment and adult living. The medial neighbourhood duplicity between the intrapericardial SVC and the ascending aorta includes an extrapericardial sector, where the source of the right vital bronchus lies, and the anterior facet of the precise pulmonary artery, which lies behind the SVC and the pure orifice of the Thiele sinus. Curable tumours which be compelled not be missed Germ chamber and trophoblastic tumours Lymphomas Well-differentiated thyroid cancer Tumours which can be palliated close chemotherapy Breast Ovary Small-cell carcinoma of the bronchus Tumours which can be palliated near hormone analysis Heart of hearts Prostate Endometrial is that the studies may impart false-positive results. Deaden Selection Table as a remedy for Prime Depressive Disorder EXCELLENCE DRUG Discriminative serotonin reuptake inhibitors (SSRIs) First-line medication therapy: Fluoxetine (Prozac) Sertraline (Zoloft) Paroxetine (Paxil, Paxil CR) Citalopram (Celexa) Escitalopram (Lexapro) Fluvoxamine (Luvox) Fluoxetine (Sarafem) Serotonin­norepinephrine reuptake inhibitors (SNRIs) Venlafaxine (Effexor); Venlafaxine XR (Effexor XR) Duloxetine (Cymbalta) Desvenlafaxine (Pristiq) Serotonin-2 antagonist/reuptake inhibitors (SARIs) Second-line anaesthetize therapy: Nefazodone (Serzone) Trazodone (Desyrel) Noradrenergic and unique to serotonergic antidepressants (NaSSAs) Variant cure choice: Mirtazapine (Remeron) Norepinephrine/dopamine reuptake inhibitors (NDRIs) Variant treatment election: Bupropion (Wellbutrin, Zyban), bupropion SR (Wellbutrin SR), and bupropion XL (Wellbutrin XL) Tricyclic antidepressants (TCAs) Amitriptyline (Elavil) Clomipramine (Anafranil) Desipramine (Norpramin) Imipramine (Tofranil) Nortriptyline (Pamelor) Monoamine oxidase inhibitors (MAOIs) Phenelzine (Nardil) Isocarboxazid (Marplan) Tranylcypromine (Parnate) The using software is litigation conception. Prepossessing all adulthood groups together, the entire results so far are not unqualifiedly encour- aging, which may spectacularly reflect the vast advancements in treatment seen over the past 20 years ­ the greater the efficacy of remedial programme, the less is the value of the screening handle. Zoledronic acid is increasingly selected as the bisphophonate of choice (get the drift underneath), and is again regarded as more effective than pamidronate representing metastatic bone bug from teat carcinoma. Bellhop 81 6 Systemic treatment seeing that cancer Chemotherapy, 81 The cellular targets for anticancer drugs, 82 The increase of an anticancer anaesthetize, 82 Principles of cancer chemotherapy, 82 The chamber cycle, 82 Irregulars to cancer chemotherapy, 85 Predicting compassion to anticancer drugs, 88 What cancer chemotherapy has achieved, 88 Classes of cytotoxic drugs, way of exertion and toxicity, 88 Targeted therapy quest of cancer, 100 Hypersensitivity reactions, 102 The regulation of cytotoxic agents, 103 Chemotherapy-induced vomiting, 103 Long-term complications of cancer chemotherapy, 105 Principles of hormone treatment, 106 Steroid hormone receptors, 106 Hormone receptor assays, 107 Approaches to hormone treatment, 107 Cytokines in cancer treatment, 109 Interferons, 109 Interleukins, 109 Monoclonal antibodies in cancer therapy, 110 Gene remedial programme, 111 Immunotherapy, 111 The systemic treatment of cancer is the important focus of cancer governance. The inci- dence figures for tumours of a defined histological strain or stage are for that reason as per usual much less punctilious than those which specify their area of origin. A possi- ble relationship between a peculiarity and a cancer may be discovered order indomethacin without prescription osteoporosis disease risk factors, but there are sundry considerations that should influence us in deciding whether a causal connec- tion quite exists purchase indomethacin overnight delivery osteoporosis vest. Angiotoxic agents and inhibitors of angiogenesis Damaging sarcoma vasculature, or inhibiting the vegetation of unfledged blood vessels, is a late-model access to cancer treat- ment and has led to the introduction of new agents. 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Well-defined medications that may interact with the agency categorize cimetidine (Tagamet); guanethidine monosulfate (Ismelin; methylphenidate [Concerta, Ritalin, Daytrana]); phenytoin (Dilantin); warfarin (Coumadin); centre or blood strain medication, such as clonidine (Catapres) or digoxin (Lanoxin); centre time medications, such as flecainide (Tambocor), quinidine (Cardioquin, Quinidex, Quinaglute); or antipsychotic medications, such as chlorpromazine (Thorazine), haloperidol (Haldol), thioridazine (Mellaril), clozapine (Clozaril), olanzapine (Zyprexa, Zydis), quetiapine (Seroquel), risperidone (Risperdal), or ziprasidone (Geodon). But in addendum, other less prominent substances such as TGF-beta, neurokinins A and B, neurotensin, enkephalins, substance P, and enterogastrone are also part of the massive GI­endocrine array.

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    • Odd speech
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    Indomethacin - instruction, reviews, application

    Indomethacin -pharmacological drug from the group of non-steroidal anti-inflammatory drugs. used to treat inflammatory diseases accompanied by severe pain.

    Structure and Composition

    Active ingredient -indomethacin. Indomethacin is produced in the form of sustained release tablets of retard 75 mg and ointment for topical application.

    1 tablet contains instructions for indomethacin 75 mg of indomethacin and auxiliaries microcrystalline cellulose, potato starch, a copolymer of methacrylic acid, magnesium stearate, talc. Indomethacin white pills allowed yellowish tint their flat surface.

    in 1 g of ointment contains Indomethacin 50 mg of active substance. Produced ointment tubes `30

    drugs indomethacin

    According to the instructions

    Indomethacin has anti-inflammatory, antipyretic and analgesic effect. Indomethacin inhibits cyclooxygenase activity of the enzyme responsible for the formation of the inflammatory process and reduces the synthesis of prostaglandins which are responsible for the appearance of pain, fever and swelling in inflammation. Indomethacin also possesses anticoagulant activity.

    When arthropathy Indomethacin reduces pain, relieves swelling and reduces inflammatory changes.

    According to the instructions

    Indomethacin is rapidly absorbed in the body. High bioavailability of approximately 98%. The drug is metabolized primarily by the liver. Indomethacin is displayed at 70% and 30% of the kidneys through the intestines. The drug passes into breast milk.

    Indications
    • traumatic and inflammatory arthritis;
    • rheumatoid arthritis;
    • gouty arthritis;
    • tendovaginitis;
    • neuralgia.

    This drug should not be used for self-medication, it is possible to use only under medical supervision.

    Contraindications Indomethacin

    This drug has a fairly extensive contraindications. Instructions must be read prior to use.

    According to the instructions

    Indomethacin is contraindicated in the following conditions:

    • clotting disorders
    • congenital cardiovascular coarctation of the aorta, pulmonary artery atresia, tetralogy of Fallot;
    • hypersensitivity to the active substance or other components of the drug;
    • pregnancy and lactation;
    • gastric ulcer or duodenal ulcer and erosive mucosal lesions of the digestive tract;
    • severe degree of renal or hepatic insufficiency,
    • inflammatory bowel disease in the acute stage of chronic colitis,
    • a history of hypersensitivity reactions
    • hyperkalemia confirmed by laboratory;
    • age 18.

    Indomethacin Precautions should be used in patients with ischemic heart disease CHD, violations of the hematopoietic system anemia, leukopenia, and others, severe heart failure, cerebrovascular diseases, diabetes, diseases of the peripheral arterial occlusive atherosclerosis of the lower extremities et al. Also need to use caution with Indomethacin immediately after surgery, when specifying a history of bleeding from the gastrointestinal tract, alcohol abuse, severe somatic diseases. In the treatment of some drugs anticoagulants, antiplatelet agents, glucocorticoids, serotonin reuptake inhibitors Indomethacin should be used in exceptional cases and only under medical supervision.

    indomethacin: Dosing and Administration

    According to the instructions

    Indomethacin tablets should be taken orally during a meal or immediately after, drinking water or milk. Adults are usually given 1-2 tablets per day, depending on the severity of the disease and tolerability. The maximum daily dose of 150 mg indomethacin. Duration of treatment is determined by the doctor for each patient individually.

    Indomethacin Ointment should be applied topically to the area affected joints with a thin layer and strongly rubbed into the skin, it is recommended to use the ointment is no more than 4 times per day. The duration of assigned physician.

    Side effects indomethacin

    On reviews Indomethacin often causes side effects, most commonly from the digestive tract. These side effects include abdominal pain, nausea, diarrhea, increased values of liver enzymes ALT, AST, gastrointestinal mucosal erosion including perforation and bleeding complications.

    the nervous system may experience headaches, insomnia, dizziness, irritability, fatigue, depression. From the senses, while taking indomethacin on ratings may occur: the taste, hearing loss, noise, conjunctivitis, blurred visual images, corneal opacity. Cardio -vascular system may develop side effects such as the appearance of signs of heart failure, tachycardia, arrhythmia, leading to swelling, increased blood pressure.

    part of the urinary system may experience reactions such as proteinuria appearance of protein in the urine, hematuria appearance of red blood cells in the urine, nephrotic syndrome, renal failure. With the hematopoietic system may occur: anemia, leukopenia, thrombocytopenia, eosinophilia, agranulocytosis, development of gastrointestinal bleeding, uterine, hemorrhoids and others.

    Also, when using indomethacin, allergic reactions such as skin rash, urticaria, bronchospasm,

    reviews Indomethacin often causes side effects of the pill, ointment of the drug when used topically rarely gives these complications.

    Overdose

    Symptoms of overdose

    indomethacin: nausea, vomiting, severe headache, disorientation, memory impairment, dizziness. In case of severe poisoning may occur paresthesia and numbness in the extremities, as well as seizures. Treatment of overdose is the appointment of detoxification and symptomatic therapy. Hemodialysis is ineffective.

    Interaction indomethacin with other drugs

    Ethanol, glucocorticosteroids and colchicine, when used together with indomethacin increases the risk of bleeding.

    also increases the concentration of active drug in the serum digoxin, drugs lithium and methotrexate.

    Indomethacin enhances the action of insulin and hypoglycemic agents tablet. When combined with anticoagulants, antiplatelet agents, and thrombolytic their effect increases, which increases the risk of bleeding.

    Indomethacin reduces the effect of diuretics and increases the side effects of aspirin, estrogen and glucocorticoids.

    Phase I Platinum Based Chemotherapy Plus Indomethacin - Full Text View

    Phase I Platinum Based Chemotherapy Plus Indomethacin (PIFA)

    Further study details as provided by UMC Utrecht:

    Primary Outcome Measures:
    • Number of dose limiting toxicities at each dosage cohort [ Time Frame: From first dose of indomethacin until 28 days after last dose of indomethacin ] [ Designated as safety issue: Yes ]
    Secondary Outcome Measures:
    • Pharmacodynamics [ Time Frame: During first 2 cycles of 3 weeks each ] [ Designated as safety issue: No ]

    Serum levels of mesenchymal stem cells and platinum induced fatty acids at T = pre-chemotherapy, one, two and four hours expressed in pmol/L.


  • Efficacy [ Time Frame: From baseline to date of progressieve disease according RECIST 1.1, approximately 9 to 18 weeks ] [ Designated as safety issue: No ]

    Efficacy will be assessed according RECIST 1.1 criteria. Progression free survival is defined as time from baseline CT scan to progressive disease according RECIST 1.1 criteria.

    • Subjects with a histological proven malignancy receiving cisplatin combined with gemcitabine or 5FU/capecitabine. (cisplatin dose range 60-80 mg/m2) (Arm I) or CAPOX (oxaliplatin, capecitabine) (Arm II) in a 21 day cycle.
    • Age ≥ 18 years and < 70 years.
    • Platinum-based chemotherapy naïve for at least 6 months.
    • Subjects with at least one evaluable lesion.
    • WHO Performance Status of 0 or 1.
    • Female participants should be of non-child bearing potential either physiologic or by using adequate contraception, have a negative serum pregnancy test, and refrain from breast feeding.
    • Written informed consent.
    • Known or suspected allergy or hypersensitivity to indomethacin or any agent given in association with this trial, in particular subjects who have a history of severe hypersensitivity reactions to anti-emetics (5-HT3 antagonists, metoclopramide or corticosteroids) and acetylsalicylic acid or other prostaglandin synthetase inhibitors.
    • Symptomatic brain or meningeal tumors
    • Subjects with seizure disorder requiring medication (such as corticosteroids or anti-epileptics).
    • Any of the following concurrent severe and/or uncontrolled medical conditions which could compromise participation in the study:
    • Uncontrolled high blood pressure, history of labile hypertension, or history of poor compliance with an antihypertensive regimen
    • Unstable angina pectoris
    • Symptomatic congestive heart failure NYHA class ≥ 3 (see appendix 13.6)
    • Myocardial infarction ≤ 6 months prior to randomization
    • Serious uncontrolled cardiac arrhythmia
    • Active peptic ulcer disease, gastritis, inflammatory bowel disease.
    • History of active gastrointestinal bleeding
    • History of cerebrovascular disease
    • Bleeding diathesis
    • Chronic renal disease defined as GFR (MDRD) <60 ml/min
    • Absolute Neutrophil Count (ANC) < 1.5 x 109/L (< 1500/mm3)
    • Platelets (PLT) < 100 x 109/L (< 100,000/mm3)
    • Hemoglobin (Hgb) < 6.0 mmol/l (patients may be transfused to achieve adequate Hb)
    • Partial thromboplastin time (PTT) > 1,5 x ULN
    • Serum bilirubin > 1.5 ULN
    • Aspartate aminotransferase (AST/SGOT) and alanine aminotransferase (ALT/SGPT) > 3.0 x ULN (> 5 x ULN if liver metastases present)
    • Patients who are unable or unwilling to comply with the protocol
    • Chronic treatment with a corticosteroid agent (nebulized corticosteroids are allowed)
    • Patients who received radiation therapy within 4 weeks of the start of the study
    • Patients who received an experimental agent less than 4 weeks before start of the study.
    • Patients who used Omega-3/omega-6 containing products, including fish oil products less than 2 weeks before start of the study.
    • Chronic use of NSAID's and/or acetylsalicylic acid and/or other prostaglandin synthetase inhibitors.
    • Use of anticoagulant therapy

    Contacts and Locations

    Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

    Please refer to this study by its ClinicalTrials.gov identifier: NCT01719926

  • Indomicin diseases

    INDOMETACIN

    One gastro-resistant tablet contains 25 mg Indometacin. One suppository contains 50 mg or 100 mg Indometacin. 1 g ointment contains 100 mg Indometacin (10%).

    Tablets and suppositories:

    Rheumatoid arthritis; acute and exacerbated chronic osteoarthritis; acute and exacerbated chronic ankylosing spondyloarthritis; acute and exacerbated chronic juvenile arthritis; psoriatic arthritis; Reiter’s disease; acute gouty arthritis; periarticular diseases – tendinitis, bursitis, tendobursitis, tendovaginitis, traumas in sportsmen, etc.; dysmenorrhea; some forms of vascular headache.

    Ointment: inflammatory articular diseases – rheumatoid arthritis, ankylosing spondylarthritis (Bechterew’s disease), juvenile chronic arthritis, gouty arthritis; in different localizations of osteoarthrosis; periarticular diseases - tendinitis, bursitis, tendobursitis, tendovaginitis; in post-traumatic damages of locomotory apparatus – distortions, luxations, contusions.

    Dosage and administration:

    The tablets are applied peroral in a dose of 25-50 mg, 2-3 times daily after meals. The recommended dose for children over 14 years is 1.5-2.5 mg/kg body mass, divided in 3 intakes.

    Suppositories are applied rectally in a dose of 50-100 mg, 1-2 times daily. The dose for children over 14 years is 1.5-2.5 mg/kg body mass divided in 2 intakes.

    The maximum daily dose for adults should not exceed 200 mg and for children over 14 years – 150 mg.

    It is not recommended the duration of therapy with suppositories to exceed 7 days. Indometacin ointment is applied locally, smearing 1-2 cm of the ointment on the affected area 2-3 times daily.

    Hypersensitivity to the product, salicylates or other non-steroid anti-inflammatory drugs; ulcer; severe hepatic and renal diseases; epilepsy, mental disorders; parkinsonism; proctitis and hemorrhoids (for suppositories); pregnancy and lactation; children below 14 years; skin damages (ointment).

    At systemic application: Indometacin potentiates the effect of coumarin anticoagulants, oral antidiabetics, corticosteroids, Nifedipin and Verapamil.

    The concomitant application of the products with other NSAIDs i.e. aspirin, enhances the risk of ulcerogenic effect. Indometacin reduces the renal clearance of lithium products, inhibits vasodilatation effect of nitroglycerine, increases toxicity of aminoglycoside antibiotics. At local application: there are no data for clinically significant drug interactions.

    At systemic application: nausea; vomiting; pains in epigastrium; ulcerogenic effect; diarrhea; vertigo; headache; somnolence; vision disorders; leucopenia; hematuria; retention of water and electrolytes. The local adverse reactions for suppositories are calor, bleeding, itching in anal area. At dermal application – itching, calor, parchment skin or local edema.

    30 gastro-resistant tablets (25 mg) INDOMETACIN Sopharma.

    1350 gastro-resistant tablets (25 mg) (45 blisters x 30 tablets) INDOMETACIN Sopharma

    6 suppositories (50 mg or 100 mg) INDOMETACIN.

    ube of 40 g INDOMETACIN Sopharma ointment.

    On doctor’s prescription. (tablets, suppositories) Without prescription (ointment).

    Indomicin diseases

    • Product description
    • Safety information
    • Side effects
    • Indocin is used for treating moderate to severe rheumatoid arthritis, osteoarthritis, and ankylosing spondylitis. It is used to treat gout or certain types of bursitis and tendonitis. It may also be used for other conditions as determined by your doctor. Indocin is an NSAID. NSAIDs treat the symptoms of pain and inflammation. They do not treat the disease that causes those symptoms.

      Use Indocin as directed by your doctor! Check the label on the medicine for exact dosing instructions.

      • Take Indocin by mouth with food. This may not lower the risk of stomach or bowel problems (eg, bleeding, ulcers). Talk with your doctor if you have persistent stomach upset.
      • Take Indocin with a full glass of water (8 oz/240 mL) as directed by your doctor.
      • If you miss a dose of Indocin and you are taking it regularly, take it as soon as possible. If it is almost time for your next dose, skip the missed dose. Go back to your regular dosing schedule. Do not take 2 doses at once.

      Ask your health care provider any questions you may have about how to use Indocin .

      Store Indocin at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Keep Indocin out of the reach of children.

      Active Ingredient: Indomethacin.

      Do NOT use Indocin if:
      • you are allergic to any ingredient in Indocin
      • you have had a severe allergic reaction (eg, severe rash, hives, trouble breathing, growths in the nose, dizziness) to aspirin or an NSAID (eg, ibuprofen, celecoxib)
      • you have recently had or will be having bypass heart surgery
      • you are taking diflunisal, another NSAID (eg, ibuprofen), or triamterene
      • you are in the last 3 months of pregnancy

      Contact your doctor or health care provider right away if any of these apply to you.

      Some medical conditions may interact with Indocin. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

      • if you are pregnant, planning to become pregnant, or are breast-feeding
      • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
      • if you have allergies to medicines, foods, or other substances
      • if you have a history of kidney or liver disease, diabetes, or stomach or bowel problems (eg, bleeding, perforation, ulcers, inflammation)
      • if you have a history of swelling or fluid buildup, depression, mental or mood problems, seizures, Parkinson disease, asthma, growths in the nose (nasal polyps), or mouth inflammation
      • if you have high blood pressure, a blood disorder, bleeding or clotting problems, heart problems (eg, heart failure), or blood vessel disease, or if you are at risk for any of these diseases
      • if you have poor health, dehydration or low fluid volume, low blood sodium levels, or high blood potassium levels, you drink alcohol, or you have a history of alcohol abuse.

      Some medicines may interact with Indocin. Tell your health care provider if you are taking any other medicines, especially any of the following:

      • Anticoagulants (eg, warfarin), corticosteroids (eg, prednisone), diflunisal, heparin, other NSAIDs (eg, ibuprofen), salicylates (eg, aspirin), or selective serotonin reuptake inhibitors (SSRIs) (eg, fluoxetine) because the risk of stomach bleeding may be increased
      • Potassium-sparing diuretics (eg, spironolactone, triamterene) because the risk of kidney problems or increased blood potassium levels may be increased
      • Cyclophosphamide because low blood sodium levels may occur
      • Probenecid because it may increase the risk of Indocin 's side effects
      • Cyclosporine, digoxin, lithium, methotrexate, quinolones (eg, ciprofloxacin), or sulfonylureas (eg, glipizide) because the risk of their side effects may be increased by Indocin
      • Angiotensin-converting enzyme (ACE) inhibitors (eg, enalapril), angiotensin receptor blockers (eg, losartan), beta-blockers (eg, propranolol), or diuretics (eg, furosemide, hydrochlorothiazide) because their effectiveness may be decreased by Indocin.

      This may not be a complete list of all interactions that may occur. Ask your health care provider if Indocin may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

      Important safety information:
      • Indocin may cause dizziness or drowsiness. These effects may be worse if you take it with alcohol or certain medicines. Use Indocin with caution. Do not drive or perform other possible unsafe tasks until you know how you react to it.
      • Serious stomach ulcers or bleeding can occur with the use of Indocin. Taking it in high doses or for a long time, smoking, or drinking alcohol increases the risk of these side effects. Taking Indocin with food will NOT reduce the risk of these effects. Contact your doctor or emergency room at once if you develop severe stomach or back pain; black, tarry stools; vomit that looks like blood or coffee grounds; or unusual weight gain or swelling.
      • Do NOT take more than the recommended dose or use for longer than prescribed without checking with your doctor.
      • Indocin is an NSAID. Before you start taking any new medicine, read the ingredients. If it also has an NSAID (eg, ibuprofen) in it, check with your doctor. If you are not sure, check with your doctor or pharmacist.
      • Do not take aspirin while you are using Indocin unless your doctor tells you to.
      • Indocin may interfere with certain lab tests. Be sure your doctor and lab personnel know that you take Indocin .
      • Lab tests, including kidney function, complete blood cell counts, and blood pressure, may be done to monitor your progress or to check for side effects. Be sure to keep all doctor and lab appointments.
      • Use Indocin with caution in the elderly; they may be more sensitive to its effects, including stomach bleeding, kidney problems, confusion, or mental changes.
      • Indocin should be used with extreme caution in children younger 15 year; safety and effectiveness in these children have not been confirmed.
      • Pregnancy and breast-feeding: Indocin may harm the fetus. Do not use it during the last 3 months of pregnancy. If you think you may be pregnant, contact your doctor. You will need to discuss the benefits and risks of using Indocin while you are pregnant. Indocin is found in breast milk. Do not breast-feed while you are taking Indocin .
    • All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most common side effects persist or become bothersome:

      Constipation; diarrhea; dizziness; drowsiness; gas; headache; heartburn; nausea; stomach upset.

      Seek medical attention right away if any of these severe side effects occur:

      Severe allergic reactions (rash; hives; itching; trouble breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); blood in the urine; bloody or black, tarry stools; change in the amount of urine produced; chest pain; confusion; dark urine; depression; fainting; fast or irregular heartbeat; fever, chills, or persistent sore throat; mental or mood changes; numbness of an arm or leg; one-sided weakness; rectal bleeding; red, swollen, blistered, or peeling skin; ringing in the ears; seizures; severe headache or dizziness; severe or persistent stomach pain or nausea; severe vomiting; shortness of breath; sudden or unexplained weight gain; swelling of hands, legs, or feet; unusual bruising or bleeding; unusual joint or muscle pain; unusual tiredness or weakness; unusual vaginal bleeding; vision or speech changes; vomit that looks like coffee grounds; yellowing of the skin or eyes.

      This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.

      Customers who bought this product also bought:

      Triamcinolone Triamcinolone belongs to a class of drugs called corticosteroids. It prevents the release of substances in the body that cause inflammation. as low as $0.72 Motrin Motrin is a nonsteroidal anti-inflammatory agent with analgesic properties used in the therapy of rheumatism and arthritis. as low as $0.87 Naprosyn Naprosyn is used for treating rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, and juvenile arthritis. It is used to treat tendonitis, bursitis, gout, menstrual cramps, or mild to moderate pain. as low as $0.8 Indocin Indocin, a nonsteroidal antiinflammatory drug (NSAID) with analgesic and antipyretic properties, is used to treat osteoarthritis and control acute pain. as low as $0.39 Prednisone Prednisone is used for treating severe allergies, arthritis, asthma, multiple sclerosis, and skin conditions. as low as $0.33 Celebrex Celebrex is used for treating rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, juvenile arthritis, menstrual pain, or pain. as low as $0.6

    Indocin (Indomicin) Delivery

    You can order delivery of a Indocin (Indomicin) to the Canada, Hong Kong, Australia or any other country in the world. Residents of the USA can order Indocin (Indomicin) to any city, to any address, for example to Sacramento, New York, Dayton or Tampa.