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Nizoral is used for treating fungal infections.
Active Ingredient: ketoconazole
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Nizoral is used for treating fungal infections. Nizoral is an azole antifungal. It kills sensitive fungi by interfering with the formation of the fungal cell membrane.
Use Nizoral as directed by your doctor!
Ask your health care provider any questions you may have about how to use Nizoral.
Store Nizoral between 59 and 77 degrees F (15 and 25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Nizoral out of the reach of children and away from pets.
Active Ingredient: Ketoconazole.
Do NOT use Nizoral if:
Contact your doctor or health care provider right away if any of these apply to you.
Some medical conditions may interact with Nizoral. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
Some medicines may interact with Nizoral. Tell your health care provider if you are taking any other medicines, especially any of the following:
This may not be a complete list of all interactions that may occur. Ask your health care provider if Nizoral may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.Important safety information:
All medicines may cause side effects, but many people have no, or minor, side effects.
Check with your doctor if any of these most common side effects persist or become bothersome:
Nausea; stomach pain or upset.
Seek medical attention right away if any of these severe side effects occur:
Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); bloating; dark urine; decreased sexual ability; depression; irregular heartbeat; fever, chills, or persistent sore throat; loss of appetite; numbness or tingling of the hands or feet; pale stools; severe or persistent nausea or stomach pain; swollen or tender abdomen; thoughts of suicide; unusual bruising or bleeding; unusual tiredness or fatigue; vision changes; vomiting; yellowing of the skin or eyes.
This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.
Read code: y00UU [Gynaecological Use]; y08DN [Infections]; y0132 [Skin]; y02UM
European Pharmacopoeia, 6th ed. (Ketoconazole ). A white or almost white powder. Practically insoluble in water sparingly soluble in alcohol freely soluble in dichloromethane soluble in methyl alcohol. Protect from light.Read indications for use if you want to order Ketoconazole online Adverse Effects
Gastrointestinal disturbances are the most frequently reported adverse effect after the oral use of ketoconazole. Nausea and vomiting have been reported in about 3% of patients, and abdominal pain in about 1%. These adverse effects are dose-related and may be minimised by giving ketoconazole with food. Asymptomatic, transient elevations in serum concentrations of liver enzymes may occur in about 10% of patients. Hepatitis has been reported and the risk appears to increase if treatment with ketoconazole is continued for longer than 2 weeks it is usually reversible on stopping ketoconazole but fatalities have occurred. Ketoconazole interferes with steroid biosynthesis and adverse endocrine effects include gynaecomastia, oligospermia, menstrual irregularities, and adrenal cortex suppression, especially at high doses.
Other adverse effects include allergic reactions such as urticaria and angioedema, and rare cases of anaphylax-is after the first dose have been reported. Pruritus, rash, alopecia, headache, dizziness, impotence, and somnolence may also occur. Thrombocytopenia, paraesthe-sia, raised intracranial pressure, and photophobia have been reported rarely.
After topical use of ketoconazole. irritation, dermatitis, or a burning sensation has occurred.
Effects on the blood. A case of fatal aplastic anaemia was reported in a 23-year-old woman who had taken ketoconazole for 4 days for the treatment of vaginal discharge.
Effects on endocrine function. Oral ketoconazole blocks testosterone synthesis and adrenal response to corticotropin, resulting in azospermia and oligospermia, gynaecomastia, impotence and decreased libido, and adrenal insufficiency. As an inhibitor of steroid production, ketoconazole is valuable in controlling hypercortisolism and is used therapeutically in some endocrine disorders and prostatic cancer. For further discussion see under Uses and Administration, below.
Effects on the liver. Hepatic adverse reactions to oral ketoconazole are well known. Transient minor elevations of liver enzymes without clinical signs or symptoms of hepatic disease occur in about 10% of patients and may occur at any stage of treatment. Although this reaction is not usually clinically important it may signal the onset of more serious hepatic injury and indicates the need for close monitoring of liver function. Symptomatic hepatic reactions are much rarer (less than 0.1% of patients) but are potentially fatal. There is usually a hepatocellular pattern of damage and sometimes cholestasis. Patients at increased risk of hepatic injury include those with a history of liver disease, those aged over 50, especially women, and those requiring prolonged treatment. It is important to monitor liver function during treatment as well as to limit the length of treatment. if liver enzyme values continue to rise or jaundice or hepatitis occur, ketoconazole should be withdrawn immediately since fatalities have occurred in patients who continued treatment after signs of hepatic injury developed.Precautions Before buy Ketoconazole online, read information about the drug
Since ketoconazole has been reported to cause hepatotoxicity it should not be given to patients with pre-existing liver disease. Patients given ketoconazole should be monitored for symptoms of hepatitis also, liver function tests should be performed before starting oral treatment with ketoconazole lasting for more than 14 days and then at least monthly throughout therapy. Ketoconazole has been shown to be teratogenic in animal studies and its use is generally not recommended during pregnancy. For a discussion of the caution needed when using azole antifungals during pregnancy, see under Pregnancy in Precautions of Fluconazole. Hypochlorhydria, which may be present in patients with AIDS, can reduce absorption of ketoconazole. In this case absorption may be improved by giving ketoconazole with an acidic drink, such as a cola beverage.
Breast feeding. Ketoconazole is excreted in breast milk and licensed product information states that oral use should be avoided during breast feeding. However, no adverse effects were seen in a breast-fed infant whose mother was receiving ketoconazole it was calculated that the infant was exposed to about 0.4%) of the usual therapeutic dose of ketoconazole for this age group. The American Academy of Pediatrics considers that use of ketoconazole is therefore usually compatible with breast feeding.
Porphyria. Ketoconazole is considered to be unsafe in patients with porphyria because it has been shown to be porphyrinogenic in in-vitro systems.Interactions When you buy cheap Ketoconazole you must know how to use it
Use of drugs that reduce stomach acidity, such as an-timuscarinics, antacids, histamine H2 -antagonists, and proton pump inhibitors, may reduce the absorption of ketoconazole. Absorption of ketoconazole may also be reduced by sucralfate. Enzyme-inducing drugs such as rifampicin, isoniazid. efavirenz. nevirapine. or phenytoin may reduce plasma-ketoconazole concentrations. Concentrations of isoniazid and rifampicin may also be reduced by ketoconazole .
Ketoconazole inhibits certain hepatic oxidase enzymes, especially the cytochrome P450 isoenzyme CYP3A4, in a similar way to itraconazole and similar care should be taken to avoid adverse effects due to increased plasma concentrations of the interacting drugs.
A disulfiram-like reaction may occur in patients taking ketoconazole after drinking alcohol. The efficacy of oral contraceptives may be reduced.Antimicrobial Action
Ketoconazole is an imidazole antifungal that interferes with ergosterol synthesis and therefore alters the permeability of the cell membrane of sensitive fungi. It is reported to be fiingistatic at concentrations achieved clinically. Ketoconazole has a wide spectrum of antimicrobial activity including activity against Blastomyces dermatitidis, Candida spp. Coccidioides immitis, Epidermophyton floccosum, Histoplasma capsulatum. Malassezia spp. Microsporum canis, Paracoccidioides brasiliensis, Trichophyton mentagrophytes, and T. rubrum. Some strains of‘Aspergillus spp. Cryptococcus neoformans, and Sporothrix schenckii are sensitive.
Ketoconazole has activity against some Gram-positive bacteria and some antiprotozoal activity against Leishmania spp.
There are rare reports of Candida albicans acquiring resistance to ketoconazole .
Microbiological interactions. For the effect of imidazoles and amphotericin B on each other’s antimicrobial activity, see Amphotericin B .
Resistance. For a discussion of increasing resistance of Candida spp. to azoles see Fluconazole. Antimicrobial Action.Pharmacokinetics
The absorption of ketoconazole from the gastrointestinal tract is variable and increases with decreasing stomach pH. Mean peak plasma concentrations of about 3.5 micrograms/mL have been obtained 2 hours after an oral dose of 200 mg. Systemic absorption after topical or vaginal application in healthy subjects is minimal. Ketoconazole is more than 90% bound to plasma proteins, mainly albumin. It is widely distributed and appears in breast milk. Penetration into the CSF is poor. The elimination of ketoconazole is reported to be biphasic, with an initial half-life of 2 hours and a terminal half-life of about 8 hours. Ketoconazole is metabolised in the liver to inactive metabolites. It is excreted as metabolites and unchanged drug chiefly in the faeces some is excreted in the urine.Uses and Administration Buy Ketoconazole without prescription
Ketoconazole is an imidazole antifungal used topically or orally. It is given orally in chronic mucocutaneous or vaginal candidiasis. in fungal infections of the gastrointestinal tract, in dermatophyte infections of the skin and fingernails not responding to topical treatment, and in systemic infections including blastomycosis. candidiasis. coccidioidomycosis. histoplasmosis. and paracoccidioidomycosis. It has been given for the prophylaxis of fungal infections in immunocom-promised patients, although fluconazole or itraconazole are usually preferred. It has been recommended that, because of its erratic absorption and slow therapeutic response, ketoconazole should not be used for the treatment of life-threatening fungal infections. including fungal meningitis. or for severe infections in immunocompromised patients. Also, because of the risk of hepatotoxicity the use of ketoconazole in nonsystemic fungal infections tends to be restricted to serious infections resistant to other treatment. The place of ketoconazole in the treatment of fungal infections is discussed in the various sections under Choice of Antifungal.
The usual oral dose for treatment and prophylaxis of fungal infections is 200 mg once daily taken with food. This may be increased to 400 mg daily if an adequate response is not obtained in some infections even higher doses have been used. Children may be given about 3 mg/kg daily, or 50 mg for those aged 1 to 4 years and 100 mg for children aged 5 to 12 years. Treatment should usually be continued for 14 days and for at least one week after symptoms have cleared and cultures have become negative. Some infections may require several months of treatment and giving ketoconazole for such prolonged periods may increase the risk of hepatotoxicity.
A dose of 400 mg once daily for 5 days is used for the treatment of chronic vaginal candidiasis .
Ketoconazole is applied topically as a 2% cream in the treatment of candidal or dermatophyte infections of the skin, or in the treatment of pityriasis versicolor. It is used once or twice daily and continued for at least a few days after the disappearance of symptoms. A foam containing 2% ketoconazole applied twice daily for 4 weeks may be used in the treatment of seborrhoeic dermatitis. A shampoo containing 1 or 2% ketoconazole is also used it is applied twice weekly for 2 to 4 weeks (or occasionally longer) in the treatment of dandruf for seborrhoeic dermatitis. The 2% shampoo is used once daily for up to 5 days in pityriasis versicolor. For prophylaxis of seborrhoeic dermatitis the 2% shampoo is used once every 1 to 2 weeks for prophylaxis of pityriasis versicolor it may be used once daily for a maximum of 3 days before exposure to sunshine.
Acanthamoeba infections . Although there is currently no established treatment for granulomatous amoebic encephalitis. ketoconazole may have some activity against the Acanthamoeba spp. responsible for this infection and has been applied topically to skin lesions. Ketoconazole has also been suggested for Acanthamoeba keratitis, when it has been given orally with topical miconazole .
Acute respiratory distress syndrome. In two small double-blind, controlled trials, the development of acute respiratory distress syndrome (ARDS) and mortality rates were lower in high-risk patients given ketoconazole than in those given placebo. An accompanying editorial commented that adequate blood concentrations appeared to be essential. The mode of action could be associated with inhibition of leukotriene and thromboxane synthesis. Nevertheless, in a study in 234 patients, ketoconazole failed to reduce mortality or improve clinical outcomes when given early in the course of ARDS. Some centres have developed guidelines for ketoconazole prophylaxis in patients at risk of ARDS.
Blastomycosis . Ketoconazole has largely been replaced by itraconazole as the azole of choice in the treatment of blastomycosis because of its higher incidence of adverse effects, and lower efficacy. if used as an alternative it is given in doses of 400 to 800 mg daily.
Endocrine disorders and malignant neoplasms. Ketoconazole has been reported to impair steroid hormone synthesisand to blunt the response of cortisone to adrenocorticotrophic hormone (ACTH) and has been tried in the management of a number of endocrine disorders.
In Cushing’s syndrome. ketoconazole in doses of up to 1200 mg daily has been used successfully as an alternative or adjuvant to definitive therapies such as surgery or radiotherapy.Treatment of hirsutism is usually with an anti-androgen (see under Cyproterone), but ketoconazole has been tried in small numbers of women at a dose of 300 mg daily or 400 mg daily, with variable results.
Ketoconazole has been reported to produce a beneficial response in some forms of precocious puberty thatdo not generally respond to gonadorelin analogues cessation of menstruation and regression of pubertal signs in girls and reduced testosterone secretion and increase in adult height in boys” has been noted in small numbers of patients studied. The anti-androgenic effects of ketoconazole have also been found useful in the management of prostatic cancer in selected patients, although there have been some concerns about its tolerability, and it is not generally used as a first-line treatment.
Ketoconazole was ineffective in suppressing postoperative erection in patients undergoing penile reconstructive surgery.
Hypercalcaemia. Ketoconazole has been used’ in the treatment of hypercalcaemia. It acts to reduce 1,25-dihy-droxycholecalciferol concentrations by inhibiting cytochrome P450-dependent 1α-hydroxylation of vitamin D.
Leishmaniasis. As discussed, ketoconazole has been tried as an alternative to conventional first- and second-line therapy for visceral leishmaniasis, although reports of treatment have not all been favourable.
It has also been tried in cutaneous leishmaniasis. A cure rate of 70% was reported in over 100 patients with Leishmania major infections treated with oral ketoconazole 200 to 400 mg daily for 4 to 6 weeks. Ketoconazole was not considered to be effective in infections due to L. tropica, L. aethiopica, or L. guyanensis Ketoconazole 600 mg daily for 28 days has produced similar results to sodium stibogluconate intramuscularly for 20 days in patients with cutaneous leishmaniasis due to L. panamensis. A further comparative study of 96 patients being treated for cutaneous leishmaniasis, caused mainly by L. major or L.tropica, found ketoconazole given in doses of 600 mg in adults or 10 mg/kg in children for 30 days to be more effective than 6 to 8 bi-weekly intralesional injections of meglumine antimonate. In another study, ketoconazole was less effective than sodium stibogluconate when cutaneous leishmaniasis was due to L. braziliensis, but more effective when L. mexicana was the cause.Read side effects if you want cheap Ketoconazole no prescription Preparations
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Nizoral is an antifungal antibiotic used to treat serious fungal or yeast infections, such as candidiasis, blastomycosis, coccidioidomycosis, histoplasmosis, chromoblastomycosis, or paracoccidioidomycosis. Nizoral kills sensitive fungi by interfering with the formation of the fungal cell membrane. Also Nizoral is used to treat parasitic fungal infections on the skin that cannot be treated with topical medicine or griseofulvin, or for patients who cannot take griseofulvin.
Dosage and direction
Take it orally with food or milk at the same time each day.
The recommended starting dose for adults is 200 mg once a day.
Dosage for 2-year-old children is based on body weight. A single daily dose varies from 3.3 to 6.6 mg/kg. Do not use it without doctor's permission and dose has to be prescribed just after consulting your doctor.
For children under the age of 2, use it just after doctor's permission and dose has to be prescribed after consulting your doctor.
Note: this instruction presented here just for review. It's very necessary to consult your doctor before using.
Liver problems may occur while you are taking this medicine. If you experience one of this symptoms as dark urine; abdominal pain or tenderness; clay-colored stools; nausea and vomiting; decreased appetite; skin rash; fever; headache; itching; loss of appetite; swelling of the feet or lower legs; unusual tiredness or weakness; or yellow eyes or skin call your doctor immediately. Nizoral should not be used during pregnancy, becoming pregnant or lactating without doctor's advice. Do not use this drug before breast-feeding without doctor's permission.
Nizoral is not allowed to people who are hypersensitive to any components of this medication. Also it is contraindicated with terfenadine, astemizole, triazolam, cisapride.
Possible side effect
They may include an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Also the most possible side effects include:
dizziness, fainting, fast or pounding heartbeat;
easy bruising or bleeding, unusual weakness;
numbness or tingly feeling;
severe depression, confusion, or thoughts of hurting yourself; or
nausea, stomach pain, low fever, loss of appetite, weakness, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).
Less serious include:
mild nausea, vomiting, or stomach pain;
mild itching or skin rash;
breast swelling; or
impotence or loss of interest in sex.
If you experience one of them stop using Nizoral and tell your doctor as soon as possible. Also consult with your doctor about any side effect that seems unusual.
Nizoral interact with follow list of drugs: acetaminophen (Tylenol); cyclosporine (Gengraf, Sandimmune, Neoral); digoxin (digitalis, Lanoxin); tacrolimus ((Prograf); loratadine (Alavert, Claritin, Tavist ND); methylprednisolone (Medrol); phenytoin (Dilantin); rifampin (Rifadin, Rifater, Rifamate, Rimactane); diabetes medication you take by mouth; a sedative such as midazolam (Versed); a blood thinner such as warfarin (Coumadin); cancer medications; birth control pills or hormone replacement therapy; methotrexate (Rheumatrex, Trexall); cholesterol medications such as niacin (Advicor), atorvastatin (Lipitor), lovastatin (Altocor, Mevacor), simvastatin (Zocor), and others; or medications to treat HIV or AIDS. Also note that interaction between two medications does not always mean that you must stop taking one of them. As usual it affects the the effect of drugs, so consult with your doctor about how it interactions are being managed or should be managed.
If you forgot to take your dose in time, please do it as soon as you remember. But do not take if it is too late or almost time for your next dose. Do not take double or extra doses. Take your usually dose next day in the same regularly time.
Symptoms of Nizoral overdose are not known well, but if you experience any unusual symptoms call your doctor immediately. Also in the event of accidental over-dosage, supportive measures, including gastric lavage with sodium bicarbonate, should be employed.
Store at room temperature between 59-77 degrees F (15-25 degrees C) away from light and moisture, kids and pets. Do not use after expiration term.
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