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John P

John P. Merrill

John Putnam Merrill (March 10, 1917 – April 14, 1984) was an American physician and medical researcher. He led the team which performed the world's first successful kidney transplant. [ 1 ] He generally credited as the "father of nephrology" [ 2 ] or "the founder of nephrology," which is the scientific study of the kidney and its diseases. [ 1 ]

Early life

Merrill was born in 1917 in Hartford, Connecticut. After graduating from Dartmouth College in 1938, he attended the Harvard Medical School. He graduated in 1942; and he was an intern at the Peter Bent Brigham Hospital. [ 2 ]

During World War II, he served for four years in the Air Force. Two years were spent on Kwajalein Island in the Pacific with "Operation Crossroads ." [ 2 ]


Merrill's entire career was spent in Boston at Peter Bent Brigham Hospital. now known as Brigham and Women's Hospital. His work as a medical researcher began in 1947. As a resident in medicine, he was assigned to head the team which developed an artificial kidney (the Brigham-Kolff dialyzers) for use in the treatment of acute and chronic renal failure. [ 2 ]

With our tradition of kidney disease research, we felt we should sponsor the so-called artificial kidney. But who could take on this complex—and risky—research project? My choice was John P. Merrill. With his excellent medical background. four years as a flight surgeon. interest in cardiorenal disease. and the intellectual curiosity that characterizes a born researcher. he was ideally suited.

— Dr. George W. Thorn, Physician in chief, Peter Bent Brigham Hospital, 1942–1972. [ 3 ]

In 1954, Merrill headed the multidisciplinary team that performed the first successful transplant of a kidney between identical twin brothers. [ 2 ]

Merrill was made a full professor at Harvard Medical School in 1970. [ 1 ] His legacy is found in his students and in those doctors he mentored. [ 4 ]


Merrill's career was cut short when he died on April 14, 1984, in a boating accident while vacationing in the Bahamas. [ 1 ]

Selected works

In a statistical overview derived from writings by and about John Merrill, OCLC /WorldCat encompasses roughly 20+ works in 30+ publications in 3 languages and 400+ library holdings. [ 6 ]

This is an incomplete list that may never be able to satisfy particular standards for completeness. You can help by expanding it with reliably sourced entries.

  • 1980 – The role of the kidney in human hypertension.
  • 1980 – Factors Influencing Renal Vasculature During Anesthesia, Trauma, and Oliguric Renal Failure States in Man
  • 1977 – Electrolyte Imbalance
  • 1974 – Present Status of Kidney Transplantation
  • 1973 – Topics in Nephrology
  • 1973 – Squirrel Island, Maine: the First Hundred Years
  • 1971 – Uremia; Progress in Pathophysiology and Treatment
  • 1971 – Artificial Organs and Cardiopulmonary Support Systems
  • 1969 – Treatment of acute renal failure
  • 1967 – Il trattamento dell'insufficienza renale
  • 1963 – Reversible Renal Failure
  • 1959 – Die Behandlung der Niereninsuffizienz therapeutische Grundlagen der Behandlung akuter und chronischer Urämie unter besonderer Berücksichtigung des Elektrolythaushaltes
  • 1959 – Die Behandlung der Niereninsuffienz (The Treatment of Renal Failure)
  • 1955 – The Treatment of Renal Failure; Therapeutic Principles in the Management of Acute and Chronic Uremia
Honors Notes References
  • Fenster, Julie M. (2003). Mavericks, Miracles, and Medicine: The Pioneers Who Risked Their Lives to Bring Medicine Into the Modern Age. New York: Carroll & Graf Publishers. ISBN 9780786712366 ; ISBN 9780786714155 ; OCLC 52825127
  • Friedman, Eli A. (1978). The John P. Merrill Festschrift: nephrological research papers by past and present members of the Merrill School of Nephrology. New York: Karger. OCLC 10230217
  • Thorn, George W. (1973). Essays in Medicine: Topics in Nephrology. New York: Medcom Communications Group.

Other articles

Wiley: Introduction to Syndemics: A Critical Systems Approach to Public and Community Health - Merrill Singer

Introduction to Syndemics: A Critical Systems Approach to Public and Community Health



On Not Planting Cut Flowers: The Weight of History.

Germ Theory and the Biomedical Conception of Disease.

Revolutions in Biomedical Realities.

Problems with Postulates.

Toward Syndemic Reconceptualization.

Connections: Human and Nonhuman.

Questions for Discussion.



The Term Syndemic.

The SAVA Syndemic.

SAVA Among Victims of Domestic Violence.

SAVA Among Street Drug Users.

SAVA Among Commercial Sex Workers.

SAVA and Public Health.

Questions for Discussion.


Syllables in the Biological Message.

Varieties of Microlevel Disease Interaction.

SARS–Chronic Disease Syndemic.

Asthma-Infl uenza Syndemic.

Questions for Discussion.


Assessing the HIV/AIDS Syndemics.

Opportunistic Infections and HIV/AIDS.

Sexually Transmitted Disease Syndemics.

Hepatitis and HIV/AIDS Syndemic.

Tuberculosis and HIV/AIDS Syndemic

Malaria and HIV/AIDS Syndemic

VL and HIV/AIDS Syndemic.

Helminths and HIV/AIDS Syndemic.

Questions for Discussion.


An Aging Epidemic.

Infectious and Chronic Disease Connections.

Kidney Disease and HIV.

Food Insuffi ciency and HIV.

Cardiovascular Diseases and HIV/AIDS.

Emotional and Cognitive Health and HIV/AIDS.

Questions for Discussion.



Disease in the Time of Disparity.

The Making Social of Disease.

Health and Human Rights.

Questions for Discussion.


Irish Famine Syndemic of 1741.

Gibraltar Cholera Syndemic of 1865.

Massachusetts Scarlet Fever Syndemic of the 1800s.

Global Influenza Syndemic of 1918.

Syndemics Among Native Americans on the American Frontier.

Syndemics of the Mormon Migration.

Syndemics of War.

Questions for Discussion.


Emergent Syndemics of a Troubled World.

From Emergent Infection to Emergent Syndemic.

Reemergent Diseases and Emergent Syndemics.

Superinfection: Intragenus Syndemics.

Ecosyndemics and the Anthropocene.

Questions for Discussion.



Why Study Syndemics?

Public Health and Syndemic Prevention.

Medical Treatment of Syndemics.

Questions for Discussion.

Merrill Singer, a cultural and medical anthropologist who earned his PhD degree from the University of Utah, holds a dual appointment as senior research scientist at the Center for Health, Intervention, and Prevention and professor of anthropology at the University of Connecticut. Additionally, he is affi liated with the Center for Interdisciplinary Research on AIDS (CIRA) at Yale University. He has authored, coauthored, or edited twenty books and over two hundred articles and book chapters on health and social issues. Active in the building of social science of health theory, the development of methods in qualitative health research, and the use of research in the development of community - based health promotion and intervention, he has been the recipient of the Rudolph Virchow Award from the Critical Anthropology of Health Caucus of the Society for Medical Anthropology, the George Foster Practicing Medical Anthropology Award from the Society for Medical Anthropology, the AIDS and Anthropology Prize Paper award from the AIDS and Anthropology Research Group, and the Prize for Distinguished Achievement in the Critical Study of North America from the Society for the Anthropology of North America. Since 1984 he has been the principal investigator on a continuous series of basic and applied federally funded health studies, and he has carried out health research in the United States, Brazil, China, and Haiti.

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Important Ophthalmology Books of the 20th Century - Thompson - Blanchard

One Hundred
Important Ophthalmology Books
of the 20 th Century

H. Stanley Thompson M.D. & Donald L. Blanchard M.D.

Table of Contents

One hundred 20 th century ophthalmic books arranged chronologically within each subspecialty area. The subspecialty areas themselves are arranged roughly in anatomical order from the front of the eye to the back of the eye.
Click on any of these titles to go to the appropriate part of the main text below.
Scroll down to reach the alphabetic checklist. and scroll further down to reach the main text.

Norris and Oliver. System of Diseases of Eye. 1897-1900

Wood. Casey, The American Encyclopedia of Ophthalmology. 1913–1921

Berens. Conrad, The Eye and its Diseases. 1936-1949

Duke-Elder. Sir Stewart, Textbook and System of Ophthalmology, 1941-‘72

Adler. Francis Heed, Physiology of the Eye: Clinical Applications. 1933-1992

May. Charles Henry, Manual of Disease of Eye. 1900-‘73

Vaughan & Asbury. General Ophthalmology. 1958-1999

AAO. Basic and Clinical Science Course. 1940-2000

Grant. Morton, Toxicology of the Eye. 1962

Duane. Thomas, Clinical Ophthalmology. 1976

Fraunfelder and Roy. Current Ocular Therapy. 1980

Spalton , Hitchings, Hunter. Atlas of Ophthalmology. 1984

Albert & Jacobiec. Principles & Practice of Ophthalmology. 1994

Smith. Henry, The Treatment of Cataract. 1910

Arruga. H. Cirugia ocular. 1946

Kirby. Daniel B. Surgery of Cataract. 1950

Kelman. Charles, Phacoemulsificationand Aspiration: the Kelman Technique. 1975

Jaffe. Norman, Cataract Surgery and its Complic ations, 1972-97

Axenfeld. Theo, The Bacteriology of the Eye. 1908

Vogt. Alfred, Slit Lamp Microscopy of the Living Eye. 1921

Berliner. M. L. Biomicroscopy of the Eye. 1943-49

Castroviejo. Ramon, Keratectomy and Keratoplasty. 1964

Donaldson. David, Atlas External Diseases of Eye. 1966

Fedukowicz. Helena B. External Infections of Eye. 1963

Grayson. Merrill, Diseases of the Cornea. 1979

Krachmer. Mannis & Holland, Cornea. 1997

Elliot. Robert, Treatise on Glaucoma. 1922

Uribe-Troncoso, M. A Treatise on Gonioscopy. 1947

Sugar. H. Saul, The Glaucomas. 1951

Becker & Shaffer. Diagnosis and Therapy of Glaucomas. 1961

Ascher. Karl, The Aqueous Veins. 1961

Chandler & Grant. Lectures on Glaucoma. 1965

Shields. M. Bruce, Textbook of Glaucoma. 1982

Anderson. Douglas, Testing the Field of Vision. 1982

Alward. Wallace L. Color Atlas of Gonioscopy. 1994

Wilbrand & Saenge r, Die Neurologie des Auges: ein Handbuch. 1900-1922

Posey & Spiller. The Eye and Nervous System. 1906

Traquair. Harry, An Introduction to Clinical Perimetry. 1927

Cogan. David G, The Neurology of Ocular Muscles. 1945

Walsh. Frank, Clinical Neuro-ophthalmology. 1947

Bender. Morris, The Oculomotor System, 1964

Hoyt & Beeston , Ocular Fundus in Neurolologic Disease, 1966

Smith & GlaserUniversity of Miami Neuro-ophthalmology Symposia, 1965-1980

Leigh & Zee. The Neurology of Eye Movement, 1983

Loewenfeld. Irene E. The Pupil, 1993

Jackson. Edward, Skiascopy and its Practical Applications, 1895

Gullstrand. Allvar, Monochromatische Aberrationen. 1900

Obrig. Theo, Contact Lenses, 1942

Mandell. Robert, Contact Lens Practice, 1965

Milder & Rubin. The Fine Art Prescribing Glasses Without Making a Spectacle of Yourself 1979

Maddox. Ernest, Tests & Studies of Ocular Muscles, 1898-1935

Worth. Claud, Squint, 1903-1936

Howe. Lucien, The Muscles of the Eye. 1907-1908

Peter. Luther C. The Extra-Ocular Muscles, 1927

Bielschowsky. Alfred, Lectures on Motor Anomalies, 1940

Scobee. Richard, The Oculorotary Muscles, 1947

Burian & von Noorden. Binocular Vision and Ocular Motility, 1974

Ishihara. Shinobu, Ishihara Charts for Color Blindness, 1917

Waardenburg. PJ, Das menschlichen Auge und seine Erbanlagen, 1932

Krill. Alex, Hereditary Retinal and Choroidal Diseases, 1972

Ramon y Cajal. Santiago, Die Retina der Wirbelthiere, 1894-1933

Woods. Alan C. Endogenous Uveitis, 1956

Meyer-Schwickerath. Gerd, Lichtkoagulation. 1959

Schepens. Charles, Retinal Detachment & Allied Dis., 1983

Cibis. Paul, Vitreoretinal Pathology and Surgery in Retinal Detachment, 1965

Gass. J.D. Stereoscopic Atlas of Macular Disease, 1970

Shields. Jerry, Intraocular Tumors, 1983

Ryan. Stephen J. Retina, 1989

Meller. Josef, Ophthalmic Surgery, 1908

Whitnall. S. Ernest, Anatomy of the Human Orbit, 1921

Sheehan. J. Eastman, Plastic Surgery of the Orbit, 1927

Wheeler. John Martin, The Collected Papers of JMW., 1939

Spaeth. Edmund, New Meth of Ophthal Plastic Surg., 1925

Hughes. W. L. Reconstructive Surgery of the Eyelids. 1943

Stallard. H. B. Eye Surgery, 1946

Fox. Sidney A. Ophthalmic Plastic Surgery, 1952

Beard. Crowell, Ptosis, 1969

Jones & Wobig. Surgery of Eyelids & Lacrim. Syst., 1976

Henderson. John W. Orbital Tumors, 1973

Dutton. Jonathan, Atlas Clin. & Surg. Orbit Anat., 1994

Fuchs. Ernst, Lehrbuch der Augenheilkunde, 1889–1945

Parsons. J. Herbert, The Pathology of the Eye. 1904-1908

Salzmann. Maximilian, Anat. & Histo. des Auges, 1912

Fuchs. Adalbert, Atlas of the Histopathology of Eye, 1924

Mann. Ida Caroline, Development of the Human Eye. 1928

Collins & Mayou. Pathol. & Bacteriology of the Eye, 1918

Wessely. Karl, Auge,(Henke–Lubarsch), 1928-1937

Wolff. Eugene, The Anatomy of the Eye and Orbit, 1933

Reese. Algernon, Tumors of the Eye. 1951

Friedenwald. Jonas et al. Ophthalmic Pathology, 1952

Hogan and Zimmerman. Pathology of the Eye. 1962

Hogan. Alvarado & Weddell, Histology of the Eye, 1971

Spencer. William, Ophthalmic Pathology, 1985

Check List

One hundred 20 th Century ophthalmic books, arranged alphabetically by first author.
Click on any of these titles to go to the appropriate part of the main text below.
Scroll down to reach the alphabetic checklist. and scroll further down to reach the main text.

AAO. Basic and Clinical Science Course. 1940-2000

Adler. Francis Heed, Physiology of the Eye: Clinical Applications. 1933-1992

Albert & Jacobiec. Principles & Practice of Ophthalmology. 1994

Alward. Wallace L. Color Atlas of Gonioscopy. 1994

Anderson. Douglas, Testing the Field of Vision. 1982

Arruga. H Cirugia ocular. 1946

Ascher. Karl, The Aqueous Veins. 1961

Axenfeld. Theo, The Bacteriology of the Eye. 1908

Beard. Crowell, Ptosis, 1969

Becker & Shaffer. Diagnosis and Therapy of the Glaucomas. 1961

Bender. Morris, The Oculomotor System, 1964

Berens. Conrad, The Eye and its Diseases. 1936-1949

Berliner. M. L. Biomicroscopy of the Eye. 1943-49

Bielschowsky. Alfred, Lectures on Motor Anomalies, 1940

Burian & von Noorden. Binocular Vision and Ocular Motility, 1974

Castroviejo. Ramon, Keratectomy & Keratoplasty. 1964

Chandler & Grant. Lectures on Glaucoma. 1965

Cibis. Paul, Vitreoretinal Pathology and Surgery in Retinal Detachment, 1965

Cogan. David G, The Neurology of Ocular Muscles. 1945

Collins & Mayou. Patholology and Bacteriology of the Eye, 1918

Donaldson. David, Atlas of External Diseases of the Eye. 1966

Duane. Thomas Clinical Ophthalmology. 1976

Duke-Elder. Sir Stewart, Textbook and System of Ophth almology, 1941-‘72

Dutton. Jonathan, Atlas of Clinical and Surgical Orbital Anatomy., 1994

Elliot. Robert, Treatise on Glaucoma. 1922

Fedukowicz. Helena B. External Infections of Eye. 1963

Fox. Sidney A. Ophthalmic Plastic Surgery, 1952

Fraunfelder & Roy. Current Ocular Therapy. 1980

Friedenwald. Jonas et al. Ophthalmic Pathology, 1952

Fuchs. Adalbert, Atlas of the Histopathology of Eye, 1924

Fuchs. Ernst, Lehrbuch der Augenheilkunde, 1889–1945

Gass. J.D. Stereoscopic Atlas of Macular Disease, 1970

Grant. Morton, Toxicology of the Eye. 1962

Grayson, Merrill, Diseases of the Cornea, 1979

Gullstrand. Allvar, Allgemeine Theorie der Monochromatische Aberrationen. 1900

Henderson. John W. Orbital Tumors, 1973

Hogan and Zimmerman. The Pathology of the Eye. 1962

Hogan, Alvarado & Weddell. The Histology of the Eye, 1971

Howe. Lucien, The Muscles of the Eye. 1907-1908

Hoyt & Beeston. The Ocular Fundus in Neurologic Disease, 1966

Hughes. W. L. Reconstructive Surgery of the Eyelids. 1943

Ishihara. Shinobu, Ishihara Charts for Color Blindness, 1917

Jackson. Edward, Skiascopy and its practical applications, 1895

Jaffe. Norman, Cataract Surgery and its Complications, 1972-97

Jones & Wobig, Surgery of the Eyelids and the Lacrimal System, 1976

Kelman. Charles, Phacoemulsification and Aspiration: the Kelman Technique of Cataract Removal. 1975

Kirby. Daniel B, Surgery of Cataract. 1950

Krachmer. Mannis & Holland, Cornea. 1997

Krill. Alex, Hereditary Retinal and Choroidal Diseases, 1972

Leigh & Zee. The Neurology of Eye Movement, 1983

Loewenfeld. Irene E. The Pupil,Anatomy, Physiology, and Clinical Applications ,1993

Maddox. Ernest, Tests and Studies of Ocular Muscles, 1898-1935

Mandell. Robert, Contact Lens Practice, 1965

Mann. Ida Caroline, The Development of the Human Eye. 1928

May. Charles Henry, Manual of Disease of Eye. 1900-‘73

Meller. Josef, Ophthalmic Surgery, 1908

Meyer-Schwickerath. G. Lichtkoagulation. 1959

Milder & Rubin. The Fine Art Prescribing Glasses Without Making a Spectacle of Yourself, 1979

Norris and Oliver. System of Diseases of Eye. 1897-1900

Obrig. Theo, Contact Lenses, 1942

Parsons. J. Herbert, The Pathology of the Eye. 1904-1908

Peter. Luther C. The Extra-Ocular Muscles, 1927

Posey & Spiller. The Eye and Nervous System. 1906

Ramon y Cajal. Santiago, Structure of Retina, 1894-1933

Reese. Algernon, Tumors of the Eye. 1951

Ryan. Stephen J. Retina, 1989

Salzmann, Maximilian, Anatomie und Histologie des Auges, 1912

Schepens. Charles, Retinal Detachment and Allied Diseases, 1983

Scobee. Richard, The Oculorotary Muscles, 1947

Sheehan. J. Eastman, Plastic Surgery of the Orbit, 1927

Shields. Jerry, Intraocular Tumors, 1983

Shields. M. Bruce, Textbook of Glaucoma. 1982

Smith & Glaser. Neuro-ophth. Symp., 1965-1980

Smith. Henry, The Treatment of Cataract. 1910

Spaeth. Edmund, New Meth of Ophthal Plastic Surg., 1925

Spalton. Hitchings, Hunter, Atlas of Ophthalmology. 1984

Spencer. William, OphthalmicPathology, 1985

Stallard. H. B. Eye Surgery, 1946

Sugar. H. Saul, The Glaucomas. 1951

Traquair. Harry, An Introduction to Clinical Perimetry. 1927

Uribe-Troncoso. M. A Treatise on Gonioscopy. 1947

Vaughan & Asbury. General Ophthalmology. 1958-1999

Vogt. Alfred, Atlas of the Slit Lamp. 1921

Waardenburg. PJ, Das menschlichen Auge etc., 1932

Walsh. Frank, Clinical Neuro-ophthalmology. 1947

Wessely. Karl, Auge,(Henke–Lubarsch), 1928-1937

Wheeler. John Martin, The Collected Papers of JMW., 1939

Whitnall. S. Ernest, Anatomy of the Human Orbit, 1921

Wilbrand & Saenger. Die Neurologie des Auges., 1900-1922

Wolff. Eugene, The Anatomy of the Eye and Orbit, 1933

Wood. Casey, The American. Encyclopedia of Ophth.. 1913–1921

Woods. Alan C. Endogenous Uveitis, 1956

Worth. Claud, Squint, 1903-1936

General Texts and Encyclopedias Norris, Wm. F. & Oliver, Chas. A. A System of Diseases of the Eye. Philadelphia, J.P. Lippincott, 1897-‘00.

This massive four-volume work was a multi-authored compendium edited by Norris and Oliver. There were many illustrious contributions, including a large chapter by Hermann Wilbrand on perimetry, summarizing 19 th century advances in the anatomy of the visual pathways and the intracranial lesions that produced visual field defects; and a lengthy section on glaucoma by Priestley Smith. This four volume “System”, which was seen as an American version of the famous French text by deWecker and Landoldt, grew out of the very popular single volume “Text-Book of Ophthalmology” by the same authors (Philadelphia, Lea Brothers, 1893). Their decision to switch to a multi-authored, multi-volume version promptly made their “Textbook” obsolete, even though it had already been translated into Chinese. Since Norris died just a few years later, the “System” was never revised. Their original “Textbook” had appeared in 1893 on the heels of two remarkable one-volume ophthalmology texts: Alexander Duane’s translation of Ernst Fuchs’ Lehrbuch in 1892, and George DeSchweinitz’s 1892 “Diseases of the Eye”. Both of these texts stuck to the one-volume format and persisted through 10 editions in English.

Wood, Casey A. (ed). The American Encyclopedia and Dictionary of Ophthalmology. Chicago, Cleveland Press, 1913-1921 (18 vols).

More than 100 ophthalmologists contributed to this work, with Thomas Hall Shastid writing about 10% of the entire set - including 3000 biographical sketches and a 375 page history of ophthalmology (Newell). This massive set of books underlined for the public and for the medical profession that ophthalmology, even though it dealt with a small organ, had considerable content that required many years of concentrated study and practice to master. At approximately the same time (1916-17), the first voluntary medical specialty certifying board in America was founded: the American Board of Ophthalmology.

Berens, Conrad. The Eye and its Diseases. by 82 international authorities. Philadelphia, W B Saunders, 1936.

This book was exceedingly popular, and after the war, in 1949, a second edition was put together, still in one volume, with contributions by even more international authorities. Berens must have been a persuasive man and a skillful editor because the book runs smoothly along with succinct summaries of knowledge by various well-known authors.

Duke-Elder, Sir Stewart 1. Textbook of Ophthalmology. (7 volumes, 1941-1954) 2. System of Ophthalmology. (19 volumes, 1958-1972) UK editions, London, H. Kimpton; US editions, St Louis, Mosby.

The “Textbook of Ophthalmology” began in the late 1930s, and was just getting going when the world war started. The second half of the set was written after the war. This delay made the first volumes seem old, and rather than do them over again, Duke-Elder undertook to edit a much more comprehensive, multi-authored “System of Ophthalmology”. Duke-Elder’s “System” was sold all over the world as the ultimate compendium of ophthalmic knowledge, although it was deliberately short on surgical procedure. Duke-Elder felt that surgical technique was a fleeting skill, a slave to fashion, and a mere technical servant of the art and science of ophthalmology. This attitude may have served as a subtle damper on innovation and progress in ophthalmic surgery. Duke-Elder’s special talent was in summarizing a great jumble of information into a single smoothly written, helpful paragraph; his astonishingly retentive memory and his encyclopedic output allowed him to stand like a Colossus astride the middle 40 years of the ophthalmic century. The System of Ophthalmology was highly valued: a young American ophthalmologist who collected the entire 19 volumes in the 1960s may have paid 5% of one year’s income for the set. Like most sets of books that take more than a decade to complete, the System was barely finished before it was seen as getting a little long in the tooth. None of the great surgical advances of the last generation can be found in this set, but it is still a gold mine of information on the ophthalmic basic sciences and it will always have value because of the author’s fascination with the history of his specialty.

Adler, Francis Heed. Physiology of the Eye. Clinical Application. St Louis, Mosby, 1992.

The first edition of this book appeared in 1950; 2 nd edition, 1953; 3rd edition, 1959; 4 th edition, 1965; 5 th edition, a multi-authored volume edited and in part re-written by Robert Moses, was published in 1970; 6 th edition, Moses, 1975; 7 th edition, Moses, 1981; 8 th edition, Moses & W.M. Hart, 1987; 9 th edition, Hart, 1992.

This famous text had its start in 1933 with a book by Adler called Clinical Physiology of the Eye. New York, The Macmillan Company, 1933. The book was appreciated and admired and it filled a void, but physiology is a moving target, and Adler admitted that he had limited himself to those aspects of ocular physiology that sparked his interest. Almost twenty years went by before Adler attempted an update, and this time the book was more ambitious and had a new publisher. As the new title suggests, he still wanted to discuss ocular physiology in the context of a related clinical problem. “Adler’s Physiology of the Eye” has become a highly respected textbook of almost 900 pages, used throughout the world in the training of ophthalmologists; it is the envy of other medical specialties.

May, Charles Henry. Manual of Diseases of the Eye. New York, William Wood, 1900.

Dr. May graduated near the top of his Columbia medical school class at age 22 and after 2 years as a junior assistant at Mt Sinai Hospital began a medical practice. He was influenced by Cornelius Agnew, his professor of ophthalmology at Columbia, to take up the study of the eye, and undertook to spend 14 months in Europe. Upon returning to New York he received appointments at many hospitals and eventually directed the ophthalmology service at Bellevue. At age 39 he not only introduced a new double disc ophthalmoscope, but also published this little book addressed to medical students and general practitioners. Both were very popular. The book contained 22 colored plates, most of them fundus drawings, all of them done by Dr. May. He worked hard at keeping the book up to date. By 1917 there had already been 18 printings of the first 8 U.S. editions and the ninth edition had arrived. The book had been translated into seven different languages and a British edition had been supervised by Mr. Claud Worth. When Dr. May died in 1943 the book had gone through 18 U.S. editions and had been translated into 10 languages. For many years almost every medical student bought a copy. The book continued as “May's Manual” for another 30 years under the editorship first of Dr. Charles Perera, and then Dr. James H. Allen. All told, there were about 80 editions of this book published in various languages over the years, and many of them were reprinted more than once.

Vaughan, Daniel & Asbury, Taylor. General Ophthalmology. Los Altos, CA. Lange Medical Publications, 1958. (15 th edition 1999, with Riordan-Eva, P. Appleton, Lange)

This is another book about ophthalmology that is not intended for ophthalmologists. It has always been in a modest, yellow, soft cover. In the 1960s it challenged Charles May's Manual of Diseases of the Eye and soon took over as the most popular summary of ophthalmology for medical students and general practitioners. It was translated into several languages and has served many doctors as an introduction to modern ophthalmology. It offers just what the general medical practitioner needs to know about ophthalmology: a basic understanding of the problem and a sense of when to refer the patient to a specialist.

American Academy of Ophthalmology. Basic and Clinical Science Course. San Francisco, CA A.A.O. 1940-2000.

In 1938, Dr Harry Gradle of Chicago proposed that the American Academy of Ophthalmology start a Home Study Course for ophthalmologists in training. When it got rolling in 1940 - again because of Dr. Gradle's energetic support - far more practitioners than residents signed up, but after the war the residents began signing up in droves. Booklets that surveyed a subspecialty area were written by well-known ophthalmologists (for example, Saul Sugar, Wilbur Rucker, Bruce Fralick), and a "faculty" of volunteer Academy members compiled reading lists, prepared questions and individually graded the written examinations.

In 1970 the course was restructured and its name was changed to the Basic and Clinical Science Course, or "BCSC" for short. By 1975 it was clearly aimed at both ophthalmologists in training and at ophthalmologists in practice. Every year a set of about 10 volumes was published, each volume devoted to a particular "section" of ophthalmic knowledge.

The set has now grown to 12 substantial books with readable text (rather than bare outlines) and with color photos throughout, plus an index volume; and plans are being made for a 13 th volume. Each year three of these books are rewritten from the ground up by a fresh subcommittee, while the rest are edited lightly every year by the same team that put them together. Thus the entire set is rewritten about every four years.

The American Academy of Ophthalmology, through the "BCSC", has been distributing fresh ophthalmic knowledge throughout the world for the last 60 years. The complete set now runs to 4200 printed pages, and about 1350 of these sets are sold every year (25% of them overseas). The total press run is in the neighborhood of 26,000 volumes each year - and every year any left over books are sent free to needy ophthalmology training institutions around the world. This massive project has been of incalculable benefit to the quality of ophthalmic care in this century.

Grant, Morton. Toxicology of the Eye. Charles C. Thomas, Springfield, IL, 1962 (2nd ed. 1974; 3rd ed.1986; 4th ed. with Joel Schuman, 1993) .

This office reference work has been nurtured along through several editions by Dr. Grant, the pioneering Boston glaucomatologist. The book is a fat, but readily accessible, clinical work with clear descriptions and good documentation. It is the book to turn to when considering the ocular toxic side effects of various drugs and preparations. The listing of both generic and trade names of medicines makes this especially helpful in practice. Lately the text has benefited greatly from Dr. F. Fraunfelder's National Drug Registry to keep up-to-date on new patterns of toxicity emerge.

Duane, Thomas. Clinical Ophthalmology. New York, Harper and Row, 1976.

This innovative text was designed to be always up-to-date. It was bound in a set of six sturdy 3 ring binders and it was hoped that every owner would become a subscriber. Revised chapters were sent by mail to replace the old chapters (a plan reminiscent of the Academy of Ophthalmology’s Basic and Clinical Sciences Course). Every year a few chapters were redone, so that in 4 or 5 years the whole set of volumes would be revised. The set is now called "Duane's Clinical Ophthalmology". For more than 20 years it has been a very influential textbook.

Dr. Duane was Professor of Ophthalmology at Jefferson Medical College and Ophthalmologist-in-Chief at Wills Eye Hospital in Philadelphia. He was a lifetime teacher and he was interested in helping the practicing ophthalmologist to make informed judgments about a patient’s diseases and treatments in the midst of a busy schedule. He was also addressing doctors who were in the process of Board Certification and licensing. Duane recruited the first group of section editors and many contributors then helped to prepare concise chapters. Dr. Duane died in 1993 and his associate editors Edward Jaeger and William Tasman have kept the project going. In 1982 a parallel set of loose-leaf books was started emphasizing the basic sciences of Ophthalmology; it was called "Duane's Foundations of Clinical Ophthalmology". The updates for both sets, under the same editorship, are now supplied by Lippincott-Williams and Wilkins.

Fraunfelder, F. & Roy, F. H. Current Ocular Therapy. Philadelphia, Saunders 1980 (5th ed. 2000).

The entries in this book are by various authors and they cover almost every disease a practicing ophthalmologist might encounter. Each entry offers a brief description of how the diagnosis is confirmed and then summarizes current treatment. Some ophthalmologists see this book as merely a condensed version of material that can be found in instructive detail elsewhere, however a great many ophthalmologists have found this book very useful and comforting; they have a copy to help them through a busy day at the office and an extra copy at home.

Spalton, D. J. Hitchings, R.A. Hunter, P.A. Atlas of Clinical Ophthalmology. London, Gower Medical Publishing, 1984, and in US, Philadelphia, Lippincott, 1984. (2nd ed. Wolfe/Mosby/ Yearbook, 1994).

This is a masterpiece of medical book design: it is a large book (a double page spread is 12" by 20") with two columns per page. The photos throughout are clean, and uncluttered by arrows and letters. Each has a matching, adjacent, computer-generated line diagram with arrows identifying the important parts. All the graphs and charts have been re-drawn with the same pastel palette of pale green, blue or yellow so that they don't jar the page. Any ophthalmologist riffling through the enlarged 2nd edition will be dazzled by 537 pages of irresistible visual delights. It is not surprising that this book has been such a popular and effective teaching tool.

Albert, D.M. & Jacobiec, F.A. Principles and Practice of Ophthalmology. Philadelphia, W.B. Saunders, 1994 (2nd edition 2000).

This work was started while both the authors were at the Massachusetts Eye and Ear Infirmary. Both are ophthalmic pathologists. Jacobiec is chair at MEEI, and Albert is now chair at the University of Wisconsin. This book was begun as a Harvard project, but quickly outgrew this focus as they recruited experts across the country as contributors. This set of 6 books is one of the best single summaries of ophthalmic knowledge since Duke-Elder, and might well be a modern clinical ophthalmologist's "desert island" choice.

Cataract Surgery

At the beginning of the century Hermann Knapp of New York was strongly recommending taking the entire cataractous lens out of the eye with its capsule intact. He liked to tumble the lens on its way out. In 1917 Ignacio Barraquer of Barcelona invented a little suction cup that he called an erysophake. With this suction he could grip the lens firmly and remove it without tearing the capsule. In 1949 Harold Ridley of London boldly tried to replace the cataractous crystalline lens with an intraocular acrylic lens. He had trouble securing the lens in the posterior chamber so he tried fixating the lenses in the anterior chamber angle. Most of these patients ended up witha cloudy cornea and glaucoma and had to have theplastic lenses removed. Joaquin Barraquer tried Ridley’s lenses with similar bad results and ended up in 1958 offering a way of dissolving the supporting zonules with an enzyme (“alpha-chymotrypsin zonulolysis”) thus contributing to the continuing popularity of intracapsular surgery. Binkhorst, despite Ridley’s failure, had the courage in 1958 to try a 4-loop iris-clip plastic intraocular lens, and then offered a 2-loop iridocapsular lens in 1965. Krasner suggested sponging up the anterior vitreous. Cryoextraction of the lens was introduced by Krawicz in 1961. Kelman introduced phacoemulsification in 1967, and gradually the advantages of the small incisions, extracapsular extraction and the new posterior chamber lenses won over the profession.

Smith, Henry. The Treatment of Cataract. Calcutta, Thacker, Spink & Co, 1910.

Lt.-Colonel Smith of the Indian Medical Service, who was famous for his ever-present cigar, had done over 24,000 cataract extractions in northern India when he wrote this book. He liked to slip the entire lens out of the eye through a Graefe knife incision, with a curved spatula under the lens and a bulbous-tipped lens hook pressing the cornea against the lower half of the lens. The on-the-spot pen and ink sketches of every step by Derrick T. Vail and the huge experience of Colonel Smith served to popularize intracapsular cataract extraction by the “Smith-Indian” technique.

Arruga, Hermengildo. Cirugia ocular. Barcelona, Salvat Editores, 1946 (The 3 rd edition was translated into English as Ocular Surgery by Hogan & Chapparo, NY, McGraw-Hill, 1952; There were 5 Spanish editions and translations into 3 languages).

Arruga (1886-1972 ) was the brilliant son of a Barcelona ophthalmologist who began his medical studies at age 16. At 21 he was studying ophthalmology in France and Germany with Landolt, de Lapersonne and Hirschberg. He later embraced Gonin’s new treatment for retinal detachment. He lived a long and admirably full life. This well-made and handsomely illustrated volume was an important source of instruction for 20 years.

Kirby, Daniel B. Surgery of Cataract. Philadelphia, J.B. Lippincott, 1950.

This book, assembled with great care, appeared at the peak of the popularity of intracapsular cataract extraction. It is printed on high quality paper and has 339 in-text figures and 21 color plates, each with 2 or 3 paintings by Gus Bethke. At every opportunity Kirby emphasizes the history of cataract surgery, often illustrating his point with a vignette or comment from the old literature. Every student of modern cataract surgery ought to read this book. The technical aspects may already be 50 years behind the times but the patients and their cataracts are the same, and Kirby’s knowledge, experience and humanity come through. Kirby’s follow-up book ( Advanced Surgery of Cataract. 1955) lays out his own preferred techniques and addresses the management of complications. It is clearly just an appendix to his 1950 book.

Kelman, Charles. Phacoemulsification and Aspiration: the Kelman Technique of Cataract Removal. Birmingham, Ala. Aesculapius Pub. Co. 1975.

Kelman was as innovative to cataract surgery in the 20th century as Daviel was in the 18th. In 1967 he introduced phacoemulsification. He entered the eye through a small incision, removed the anterior capsule of the lens, and then using an ultrasound probe he fragmented the clouded lens and removed every scrap of it by suction, leaving the posterior capsule suspended by the intact zonules as a hammock for the plastic replacement lens. The response was prompt and mostly negative as outlined in his auto-biography, (Through My Eyes: The Story of a Surgeon Who Dared to Take on the Medical World. New York, Crown,1985). The procedure has of course been modified a great deal in the last generation, but Kelman’s phaco-emulsification has become the standard cataract procedure throughout the world, and today we expect cataract surgery to have a minimal recuperation time, and each year we expect ever more flexible and forgiving posterior chamber lenses. (See also: The History of Modern Cataract Surgery by Charles Kelman and Marvin Kwitko, Kugler Publications, 1998)

Jaffe, Norman S. Cataract Surgery and its Complications. St Louis, C V Mosby, 1972.

When this book first appeared it came across as a lone, thoughtful voice in an exciting new field. It is now in its 6 th edition (1997) with younger Jaffes as co-authors. This series has kept up with cataract surgery during the period of greatest innovation and change since Daviel by serving up to a generation of surgeons a dependable and nourishing diet of instruction on new tricks and techniques, garnished with cautionary notes and supported by the steadying voice of experience.

Eisner teaches ophthalmology at the University of Bern. A book like this is just what every teacher of ophthalmic surgery needs to help answer questions, and what every would-be eye surgeon needs to own and study. Instead of merely mimicking his master, the student can find in this book a lucid explanation of why the knife should be held just so, and the knot tied left over right, etc. It has many helpful, easy-to-understand, two-color diagrams by Peter Schneider, diagrams that no doubt helped the 1973 edition to be named as one of the “Fifty Most Beautiful German Books of the Year” by the Book Art Foundation of the Association of the German Book Trade.

Cornea and External Disease Axenfeld, K. Theodor P. P. Die Bakteriologie in der Augenheilkunde. Jena. Gustav Fischer, 1907. Vogt, Alfred (1879-1943). Lehrbuch und Atlas der Spaltlampen-mikroskopie des lebenden Auges. 2 nd edition. Begun by Springer Verlag, Berlin in 1930-31, and completed in Stuttgart by Ferdinand Enke in 1942.

The first version of this amazing three-volume atlas appeared in 1921 as a single slim volume dedicated to Allvar Gullstrand, the inventor of the slit-lamp (Atlas der Spaltlampen-mikroskopie des lebenden Auges, Berlin, Springer, 1921). An English version of the first edition (153 pages) also appeared at the same time, translated by Robert von der Heydt of Chicago, and also printed by Brockhaus in Leipzig (Atlas of the Slit Lamp-Microscopy of the Living Eye Berlin, Julius Springer, 1921).

These are all well described in his text, but it is the illustrations by Jakob Iseli that leap off the page and still bring gasps of admiration from modern ophthalmologists because of the exquisite attention that was paid to the minutest details. It is obvious from the drawings that Iseli was facile with the instrument and understood what he was seeing: his paintings are often composites of what could be seen at different planes of focus, and in those first slit lamps the center of rotation of the lamp and the microscope were not co-axial. And imagine the work of keeping a hot, smoking, sparking and sighing arc lamp constantly tuned up while he was drawing.

Berliner, M. L. Biomicroscopy of the Eye. New York, Paul B. Hoeber, 1943-1949. Vol. 1 appeared in 1943 and was reprinted in 1949 when the second volume came out.

Berliner taught slit lamp biomicroscopy at various New York hospitals, and these volumes are a spare-no-expense effort to put these clever techniques and beautiful images between the covers of a book. Zeiss slit lamps were used and it seems that the electric bulbs suffused these images with a warmth that was not present in Iseli’s arc-lamp drawings. The paintings by J. McGuiness Myers in Berliner’s book also have a style that differs from those in Vogt’s atlas. Iseli’s paintings suggest the notes of a meticulous explorer, scrupulously accurate, recording every detail no matter how trivial; but there is a teacher looking over McGuiness Myers’ shoulder, asking for emphasis where it is clinically important. This gives the Berliner/Myers pictures a confident air of certainty that makes them better teaching instruments.

Castroviejo (1904-1987) was born in northern Spain, the son of an ophthalmologist. At age 24, having completed medical school and ophthalmic training, he accepted a position as an assistant at the Chicago Eye & Ear Hospital. The next year he was working at experimental corneal transplantation under Dr Benedict at the Mayo Clinic, and the following year (1931) he was invited by Dr Maynard Wheeler to New York’s Columbia Presbyterian. Within a few years Castroviejo was making successful square corneal grafts in humans. The square graft remained his signature procedure until the early 1950s. He opened his own eye hospital in New York in the 1940s, and patients were sent to him from all over the world. Castroviejo was a pioneer of corneal transplantation and he trained many corneal surgeons. It was his drive and energy that produced the techniques and the instruments that made corneal grafting a successful operation. His book summarized his work and the latest technology of the day.

Donaldson, David D. Atlas of External Diseases of the Eye. Vol 1 Congenital anomalies and systemic diseases. St Louis, C V Mosby, 1966.

(Vol 2, Orbit, lacrimal apparatus, eyelids and conjunctiva, 1968. Vol 3, Cornea and Sclera, 1971. Vol 4, Anterior Chamber Iris, and Ciliary Body, 1973. Vol 5, The Crystalline Lens, 1976)

This thorough collection of color stereo-photographs, extending over 5 volumes and supported by text and B&W photos, were all taken with the “Donaldson camera”. The vivid 3-D photos brought diseases of the external eye to life, and served to extend the visual experience of many ophthalmologists in training.

Fedukowicz, Helena B. External Infections of the Eye. bacterial, viral and mycotic. NY, Appleton Century Crofts 1963.

Helena Biantovskava Fedukowicz (1900-1998) was born in the Ukraine and educated in the Soviet Union, where she eventually became a professor of Ophthalmology at Vinniza with an interest in infectious disease. She arrived in the US in 1949. After some English lessons, she got a job, through the efforts of Dr George Wise, running an ophthalmic bacteriology laboratory at New York University supported by the NYU chairman, Dr. Alson E. Braley. Her book, on the clinical bacteriology of the eye was the first written in English and the first since Axenfeld’s book. Beatrice Glover had drawn an excellent series of color plates, but the publisher refused to use them saying that color would be too expensive. Fedukowicz insisted that color was essential. This impasse was broken when an anonymous donor paid the cost of the plates. The book became very popular and was used widely in teaching institutions; subsequent co-authored editions appeared in 1978 and 1985, with a Spanish edition in 1987. Fedukowicz was elected an Honorary Fellow of the American Academy of Ophthalmology in 1982. Later it came out that the anonymous donor was Dr. George Wise. (see: Baum, Jules. Helena B. Fedukowicz, Documenta Ophthalmologica 99:215-218, 1999

Grayson, Merrill. Diseases of the Cornea. St Louis, C.V.Mosby, 1979. (2nd ed. 1983; 3rd ed. by R. Arffa, 1991; 4th ed. by R. Arffa, 1997).

This one volume introduced the ophthalmologist in training to corneal disease. It was thorough, well organized and richly illustrated with color photographs that seemed unusually clear and expressive. It proved to be very popular.

Krachmer, J. H. Mannis, M. & Holland, E. Cornea. St Louis, C.V.Mosby, 1997.

The medical illustrator involved with this project was Martin Finch. It started with a spectacular atlas (Krachmer, Jay H. and Palay, David, Color Atlas of the cornea. Mosby, 1995) and went on to a three volume text (Vol 1: Fundamentals; Vol 2: Diagnosis and Management; Vol 3: Surgery). With 250 contributors it must have been a staggering editorial job, but there is no doubt that it is now the most complete compendium available on the subject.


In 1857 von Graefe found that taking out a large piece of the iris seemed to help many patients with glaucoma (Graefe’s Archiv 3:456, 1857, and then 4:127, 1858; 8:242, 1862; and 15:108, 1859). Graefe’s early work on this subject was translated into English and published by the New Sydenham Society in 1859). Eserine eye drops, made from the Calabar bean, were used before iridectomy to produce a miosis so that the iridectomy could be made peripherally in the iris. It was soon noticed that occasionally the glaucoma seemed better after the eserine so that the surgery was no longer needed. Graefe also suggested that a visual field examination could, and should be done in the office (Graefe’s Archiv 2:258, 1856). Towards the end of the 19 th century glaucoma was considered to be identical to elevated intraocular pressure (and vice versa). “Low-tension glaucoma” by definition, did not exist. The English language glaucoma expert was Priestley Smith.

Elliot, Robert Henry. Treatise on Glaucoma. London, Henry Frowde and Hodder & Stoughton, 1922. (US edition, Paul B. Hoeber in New York).

Iridencleisis was dropped for fear of sympathetic ophthalmia, and the post-operative complications of cyclodialysis made it fall from favor. Variations of Elliot’s trephination are still in use: Scheie’s thermal sclerectomy was popular for a while, and Cairns’ 1968 trabeculectomy turned out to be another external filtering operation that worked quite well.

Uribe-Troncoso, Manuel. A Treatise on Gonioscopy. Philadelphia, F.A.Davis, 1947.

Gonioscopy had a long history before 1947, but this book brought the test into the ophthalmologist’s office. For a review of the history of gonioscopy (Trantas, Salzmann, Koeppe, Barkan) see Dellaporta, Survey Ophthalmology 20: 137-149, 1975. Uribe-Troncoso’s (1869-1959) 1947 book was the first comprehensive book on gonioscopy. Trantas’ word ‘gonioscopy’ was in the title and was used throughout the book. Color paintings by Gus Bethke were the best then available. The anatomic landmarks of the chamber angle as seen with the gonioscope were named and clarified in this book. Examination of the chamber angle now had a familiar name, familiar landmarks and there were clinical indications for its use in the ophthalmologist’s office, but it was still an awkward procedure: the patient was lying down, and a large, bulbus, limbus to limbus Koeppe lens was used to view the angle directly. The internal curvature of the lens vaulted over the cornea and this space had to be filled with water. The lens was then pressed to the patient’s eye while the patient was turned on his back so that a suspended microscope and illuminator could be brought up for viewing. The water would often leak out, allowing air to bubble up and spoil the view. Nevertheless Troncoso’s book marked the elevation of gonioscopy to an important clinical test, in part because Sugar, Gradle and Kronfeld were verifying the value of Barkan’s classification of the glaucomas by the appearance of the chamber angle.

Goldmann’s major contribution to gonioscopy was the Haag-Streit 900 slit lamp. This was an instrument in which the microscope and the light beam and the attached camera were always in focus together no matter what angle separated them, because they all moved together when the joy stick was moved. The joy-stick could be operated with one hand, leaving the other free to hold Goldmann’s mirrored lens against the eye.

Sugar. H. Saul. The Glaucomas. New York, Hoeber - Harper, 1951 (2 nd edition 1957).

Dr. Sugar (1912-1993) was a thoughtful ophthalmologist who made many contributions to the literature, including some of the early work on pigmentary glaucoma. He was in private practice in Detroit and, in addition to being the Head of the Department of Ophthalmology at Detroit’s Sinai Hospital, he was a professor at Wayne State University Medical School, and head of the glaucoma service there. His 1951 book was the first American textbook on Glaucoma and it was based largely on his own considerable experience and knowledge. He was interested in gonioscopy (see Sugar’s chapter in vol. 2 of Berliner’s 1949 Biomicroscopy text). Gonioscopy was used by Barkan not only for surgical goniotomy but also to differentiate one kind of glaucoma from another (note Sugar’s use of the plural in his title). This text encouraged many others to tackle some of the unsolved problems in the glaucomas.

Becker, B. & Shaffer, R.N. Diagnosis and Therapy of the Glaucomas. St Louis, C.V. Mosby, 1961. (Through seven editions there have been many co-authors and editors including Kolker, A.; Hetherington, J. Jr.; Hoskins, H. D.; Stamper, R.; Lieberman, M.; Drake, M and Kass, M).

Dr. Becker was Chairman of the Department of Ophthalmology at Washington University in St. Louis for 35 years (1953-88), he established a glaucoma research center, and was the founding editor of "Investigative Ophthalmology". His brilliance and erudition are legendary. He was an enthusiastic collector of old ophthalmic books and eventually gave his entire collection to the Medical Library at Washington University. His energetic fund raising for that library resulted in it being named “The Bernard Becker Medical Library”.

Dr Shaffer was active in California for most of his clinical years. He produced a stereo atlas of gonioscopy and was a leading expert in gonioscopic surgery in infants. He also did work on malignant glaucoma and the vitreous diversion syndrome, and served for many years as the Executive Director of the American Board of Ophthalmology.

This text, designed for students of ophthalmology, was very clear and definite about the mechanisms at work in glaucoma and what should be done about it. It began in 1961 with the goal of making available the current thinking about pathogenesis, diagnosis, and management of the glaucomas in a single volume, and it did it remarkably well. If it can be said that "Lectures on Glaucoma " by Chandler and Grant was the definitive glaucoma textbook on the East Coast, especially in New England, then Becker and Shaffer's book was certainly the glaucoma bible of the West Coast. Different treatments were recommended, and they even used opposite numbering systems for openness of the angle. These differences have softened as the new editors have worked on the text and brought diverse backgrounds to the work. The importance of pressure elevation with steroid administration was stressed, and impressive efforts have been made in later editions to keep the therapy up to date.

Ascher, Karl W. The Aqueous Veins. Springfield, Charles C. Thomas, 1961.

Dr. Ascher was originally from Prague where he had a special interest in keratoplasty. Because of the war he came to the US in 1939 and worked at the University of Cincinnati College of Medicine with Derrick Vail. Having studied with Alfred Vogt, Ascher was an expert with the slit lamp and detected and recognized the importance of aqueous veins. These are transparent vessels which transport aqueous from Schlemm's canal into the conjunctival or episcleral veins. This discovery settled three debates that were active at the time. First whether the aqueous fluid was a stagnant system, second whether primary open angle glaucoma was a problem of retention or of over-production of fluid, and third whether Schlemm's canal was normally a non-functioning space, which was only active in glaucomatous conditions with raised intraocular pressure. The working out of these questions also helped lead to the popularity of tonography in the middle part of the century.

Chandler, Paul A. & Grant, W. Morton. Lectures on Glaucoma. Philadelphia, Lea & Febiger, 1965 (2 nd edition, 1968; 3 rd edition 1986. A fourth edition 1996 was made available as Chandler and Grant's Glaucoma edited by David Epstein, Rand Allingham, and Joel Schuman.)

Chandler and Grant worked at the Massachusetts Eye and Ear Infirmary and gave a series of clinical lectures on glaucoma there. These lectures were primarily to "provide a practical guide for recognition and modern treatment of the various forms of glaucoma and for the solution of problems encountered clinically." They brought these lectures together for publication, deliberately avoiding the research aspects of glaucoma and the details of surgical techniques. For years this book was carefully studied and mined sentence by sentence for its nuggets of clinical wisdom. It has grown and broadened in the last generation, surgical teaching has been included and many new ideas have been introduced. It is still a clinician’s guide but it has become far more than a set of Boston lectures.

Shields, M. Bruce. Textbook of Glaucoma. Baltimore, Williams and Wilkins, 1982.

This much admired text grew along a well-trodden path: first the author put together A Study Guide for Glaucoma (Baltimore, Williams & Wilkins 1982) for his students. This was very popular so he expanded it in 1987 into a Textbook of Glaucoma, which was even more popular. This was followed by 3 rd (1992) and 4 th (1998) editions, with contributions by other authors. Great care was taken to keep the book up to date: for example, sections on. nerve thickness and the modulation of wound healing were expanded. Dr. Shields was professor of ophthalmology and director of the glaucoma service at Duke University when this work was done.

Anderson, Douglas R. Testing the Field of Vision. St Louis, C.V. Mosby, 1982.

This was the first of an important series of books about visual field testing. The second book (1987) was called "Perimetry with and without Automation". This grew into a 3 rd book (1992) called. "Automated Static Perimetry". The 4 th edition was co-authored with Patella, V. in 1999. Dr.Anderson is a professor of ophthalmology at the Bascom Palmer Eye Institute in Miami. He directs the glaucoma service, so it is natural that his books emphasize glaucomatous field loss rather than defects of neurologic origin. The general shift from kinetic perimetry to automated static perimetry can be seen in this series of books. This in turn is a reflection of the success of the Humphrey Visual Field Analyser with its various new models, strategies and programs for getting the most accurate representation of the visual field. These new programs require a text such as Anderson and Patella’s to explain how best to do and interpret the fields. It was at first hoped that automated visual field testing would provide a purely objective result. But it soon became obvious that without supervision and encouragement by an experienced perimetrist the test could turn out entirely untrustworthy results. The book faces up to this problem and offers an excellent guide for the perimetrist on how to oversee the testing moment by moment, how to change the strategy as needed and how to explain to the patient the purpose and technique of the testing to get the best results.

Alward, Wallace L. Color Atlas of Gonioscopy. Wolfe Publishing, Mosby-Yearbook, 1994.

This book, illustrated by Lee Allen, is not a glaucoma text, it is a slim guide to gonioscopy for the fledgling ophthalmologist. In the early 1940s Lee Allen, in Iowa City, made a direct goniolens so light in weight that it could be held on the cornea by the eyelids and capillary attraction alone. An improved version was equipped with an internally reflecting surface built into the plastic; this gonioprism was held against the cornea and manipulated with a thumb guide. The patient could then be seated and examined at a slit lamp. The Allen-Thorpe version was provided with 4 mirrors so it didn’t have to be rotated all the way around. However after only a decade or so of use this handy gonioprism was replaced by Goldmann’s lens. Lee Allen’s drawings of the chamber angle using his gonioprism, made in the late 1940s and early 1950s are outstanding, and remain unsurpassed in clarity. Their publication here in Alward’s instructional book is a winning combination that is much prized as a teaching tool.


Having done chapters for other texts, Wilbrand started on his own work in 1899, in collaboration with Alfred Saenger. It was called “The Neurology of the Eye: a handbook for neurologists and ophth-almologists”. There were to be nine volumes in the set, and they were published over a considerable period of time and were not completed until 1922. These volumes offered a detailed summary of the contributions to German neuro-ophthalmology over the last half of the 19 th century. This exhaustive set, together with the endless Graefe-Saemisch (neither of them ever translated into English) were the origin of the statement that “The ‘Laurels of Originality’ often celebrate nothing more than an ignorance of the old German literature.”

Posey, William Campbell and Spiller, William G. The Eye and Nervous System, their diagnostic relations by various authors. Phila. J.P. Lippincott, 1906.

The anatomists of the late 19 th century had identified the visual pathways in the brain all the way to the occipital cortex, (see Polyak’s masterful review: especially Chaps. 4 & 12 of The Vertebrate Visual System, Univ Chicago Press, 1957) and Wilbrand and then Henschen had laid out the expected visual field loss associated with various cerebral lesions. A few focal injuries to the brain were needed to confirm the facts in humans. During and after Japan’s war with Russia (1904-1905 ), Inouye was able to test the visual fields in wounded soldiers for insurance purposes and realized the importance of his observations. A few years later, during World War I, the London neurologist Gordon Holmes. examining soldiers with shrapnel injuries to the brain, began to sort out the exact representation of the retina in the visual pathways and cortex (Brain,1916, 39:34; BJO,1918, 2:353). On the German side Wilhelm Uhthoff was making similar observations; he may have had fewer occipital injuries to work with because of the shape of the German helmet. For 75 years Holmes’ map was the best available. In 1991 Horton and Hoyt (Arch Ophth. 109: 816-824) were able to make a small improvement on Holmes’ map of the representation of the visual field in the human occipital cortex.

Traquair, Harry Moss (1876-1954). An Introduction to Clinical Perimetry. London, Henry Kimpton 1927, and St Louis, C V Mosby (6th ed. 1949). Cogan, David G. The Neurology of the Ocular Muscles. Springfield, Charles C. Thomas, 1945 (published simultaneously in UK by Blackwell, Oxford, and in Canada by the Ryerson Press, Toronto).

Cogan’s small but fully referenced book was written in a very economical style so that one could pick up several important points in a single paragraph. Many of the brainstem syndromes that disturbed eye movements mentioned by Bielschowsky were brought into sharper focus. No better description of the cranial nerves serving the eye muscles could be found.

Walsh, Frank Burton. Clinical Neuro-ophthalmology. Baltimore, Williams & Wilkins, 1947.

Walsh (1895-1978) was a Canadian from Saskatchewan who had served in World War I. He received his medical degree from the University of Manitoba in 1921, interned in Winnipeg, and began to practice general medicine. After seven years he decided he wanted to specialize and began a residency at Johns Hopkins in 1930 with Dr Wilmer as his chief. Walsh was particularly influenced by Frank Ford, the pediatric neurologist, who was working on a book called “Diseases of the Nervous System in Infancy, Childhood and Adolescence” (Springfield, Charles C. Thomas 1937). Walsh’s 1947 book, “Clinical Neuro-ophthalmology”, was so impressive and so popular that he soon started working on the second edition and this came out in 1957; it had three columns instead of two and was altogether a very impressive compendium of neuro-ophthalmic knowledge. The third edition was the product of a collaboration between Dr Walsh and his 1958 fellow William F. Hoyt of San Francisco. It appeared in 1969. The fourth edition of “Walsh and Hoyt” came out in the 80’s revised and greatly enlarged by Neil Miller, Walsh’s successor at the Wilmer Institute. For the fifth edition of “Walsh & Hoyt”, Miller and his co-editor Nancy Newman solicited chapters from many neuro-ophthalmologists. The dramatic increase in the size of this book through its five editions is an indicator of the geometric expansion of neuro-ophthalmic knowledge in the 2 nd half of the 20 th century.

Bender, Morris B. The Oculomotor System. NY, Hoeber, 1964.

In 1961 Dr. Bender put together a symposium on eye movement control at the Mt Sinai Hospital Department of Neurology in New York, and this book was the result. The symposium attracted investigators from all over the world, and since that time, these workers and their successors have met repeatedly to compare notes, (see the work of Daroff, Dell’Osso, Robinson, Leigh, Zee, Baloh, Sharpe, Halmagyi, Paige and others). This has led to significant new understanding of eye movement control.

Hoyt, William Fletcher & Beeston, Diane. The Ocular Fundus in Neurologic Disease: a Diagnostic Manual and Stereo Atlas. St Louis, CV Mosby, 1966.

In the 1870s and 1880s many voices had strongly urged that the ophthalmoscope by used by all physicians to examine the retina and the optic nerve head (see especially Eduard Jaeger, Hughlings Jackson, Clifford Allbutt, and William Gowers). This book, by a neuro-ophthalmologist (Hoyt) and a photographer (Beeston), follows in the same tradition. There are 14 viewmaster reels and a fold-up viewer at the back. The book sold out almost immediately and was never reprinted. A generation of neuro-ophthalmologists used this book, if they could find a copy, to teach a generation of ophthalmologists about the differential diagnosis of the elevated optic nerve head.

Smith, J. Lawton & Glaser, Joel S. Neuro-ophthalmology – University of Miami Symposia, Vol 1. Springfield, Charles Thomas, 1964. Vols 2-4, 6-10, St Louis, C.V Mosby,1965-1980. Vol 5, Hallandale, FL, Huffman, 1971.

These were the years of spectacular growth of the subspecialty of neuro-ophthalmology, and Lawton Smith was a major player: he was guru, enthusiast, teacher, catalyst and salesman. In the mid 1960s his “Miami Symposium” was the only annual meeting for neuro-ophthalmologists. In this series of ten books Smith and Glaser manage to convey the bubbling and uneven quality of the new subspecialty, and the excitement of learning something new every day. It was this sense of immediacy that Smith later transferred to his role as founding editor of the Journal of Clinical Neuro-ophthalmology.

Leigh, John & Zee, David S. The Neurology of Eye Movement. Philadelphia, F.A. Davis Co, 1983, 281 pp. (2 nd edit. 561 pp, 1991; 3 rd edit. 646 pp. 1999).

These two clinicians wrote their book for ophthalmologists, neurologists and neurosurgeons who in turn continue to find it of value in recognizing and understanding clinical problems. The peg-board upon which various eye movement abnormalities have been hung up and sorted out is that of control systems analysis and modeling as recommended by the neurophysiologist David A. Robinson. This technique has helped to answer many difficult questions about the pathophysiology of human eye movements.

Loewenfeld, Irene E. The Pupil: Anatomy, Physiology and Clinical Applications. Ames, Iowa State University Press, 1993, 2223 pages, (2 nd printing Butterworth & Heinemann, 1999). Optics and Refraction Jackson, Edward. Skiascopy and its practical application. Philadelphia, The Edwards & Docker Co. 1895.

This book was a deliberate (and successful) effort to popularize the test that had been called “the shadow test” (Cuignet, 1875) and is now called “retinoscopy”(Thorington, 1897). The book was frequently reprinted in the first decades of the century. This technique used the doctor’s observations rather than the patient’s responses and it became an almost universal first step in estimating refractive error. Jackson encouraged full correction of ametropia. In 1887 Jackson had recommended a cross cylinder for estimating cylinder strength and only later did he realize how quickly and effectively the cross cylinder could be used to determine cylinder axis. In 1907 at the Colorado Ophthalmological Society, Jackson began to give instruction on the use of the cross cylinder, a handy test that made it possible, in the course of a simple examination, to measure the power and the axis of the total astigmatism both corneal and lenticular. In some clinics automated refractometers are beginning to replace retinoscopy as a way to find a starting place for a refraction.

This book introduced Gullstrand’s work in optics to ophthalmology and helped establish him as the 20th century's worthy successor to Helmholtz. Gullstrand (1862-1930) was Professor of Ophthalmology at the University of Upsala from 1894 until 1914. During this time he was an active surgical ophthalmologist and teacher. In 1914 a special post of Professor of Optics was created for him there, so that he could pursue his primary interest in physiological optics. He is known for his work on the third edition of Helmholtz's "Treatise on Physiological Optics" published 1909-1911 and translated into English in 1924. In this work Gullstrand edited and annotated the work of Helmholtz with a pious respect for the original text. He then added a series of lengthy appendices of his own work, which brought the area of optics up to date especially in regard to the field of ophthalmology. He confirmed Helmholtz’s ideas about the mechanism of accommodation by describing the intracapsular lens changes, and he showed how the shape of the cornea could be mapped with reflections. At the turn of the century unwanted reflections were troublesome in the examination of the fundus. Gullstrand worked first on the theoretic aspects of the problem, and then produced a working, stand-mounted reflex-free ophthalmoscope.

Gullstrand introduced aspheric lenses to ophthalmology. Even more importantly he developed a slit beam for lateral illumination, leading the way to the Zeiss slit lamp. His contributions in the area of dioptrics led to a Nobel Prize in 1911. Gullstrand’s original work is still under-appreciated by most English speaking ophthalmologists, perhaps because of the complex geometric formulas used in his German texts. His influence on 20 th century ophthalmology was immense, and it can be seen today in the optics of the slit lamps that are now casually used in every eye examination.

Obrig, Theo. E. A.B. Contact Lenses. Philadelphia, Chilton, 1942.

This book records the history of a hundred years of attempts to fit a lens in direct contact with the eye. Obrig did pioneering work with plastic “scleral contact lenses”. He made a cast of the front of the globe, as others had done, and then molded a plastic shell to conform to the shape of cornea and sclera. Refraction was repeated over the shell, and zones of poor scleral fit were marked on the shell. The lens was then sent away to have the optics installed and the shell modified for a uniform tight fit. The technique was tricky and the lens uncomfortable, but it actually worked and was used for special circumstances.

Mandell, Robert. Contact Lens Practice. Springfield, Charles C. Thomas 1965. (Fourth edition 1988).

Dr. Mandell was active as a professor at the University of California, College of Optometry, Berkeley while these books were coming out. Dr. Mandell was very influential in establishing fitting patterns for hard corneal contact lenses that were easy on the cornea. The trend at first was to fit the lens to the flattest axis of the cornea. and this led to chronic epithelial stippling and a tendency for the lens to flip out with a firm blink. This accounted for the peculiar head back posture of early contact lens wearers. In his book Mandell emphasized the need for a vaulted lens and proper centering, always with consideration for the oxygen needs and health of the corneal epithelium. As the wide variety of soft contacts and then rigid gas permeable lens became available, Mandell kept pace and provided fitting guides with illustrations in the later editions.

Bifocal contact lenses were tried, and some patient’s were happy to have one eye corrected for distance vision leaving the other eye focused for reading. This was referred to as “monovision”.

Milder, Benjamin & Rubin, Melvin L. The Fine Art of Prescribing Glasses Without Making a Spectacle of Yourself. Gainesville, Triad Scientific Publications, 1979.

Refraction is all too often taught to residents by bored junior instructors who only manage to convey their unhappiness with the job. Milder and Rubin accepted the serious challenge of teaching an important subject to reluctant would-be ophthalmologists, and they have succeeded brilliantly, and produced this smoothly written and light-hearted book. An enlarged second edition appeared in 1991, and it is still heavily used by ophthalmology residents.

Pediatric Ophthalmology Maddox, Ernest Edmund (1863-1933). Tests and Studies of the Ocular Muscles. Bristol, John Wright, 1898.

This book reviewed the details and summarized the examination of the alignment of the eyes. It started with a little book called The Clinical Use of Prisms and the Decentering of Lenses. 1889, which was revised and enlarged in a second edition in 1893 when Maddox was 30 years old. In the first quarter of the 20 th century ophthalmologists everywhere had learned to use his tools and devices to estimate and measure ocular deviations: the Maddox Rod, the Maddox Wing, the Maddox Double Prism.

Worth, Claud Alley. Squint, its Causes, Pathology and Treatment. London, John Bale and Danielsson, 1903 (and in U S. Philadelphia, P. Blakiston's Son & Co, 1903).

What was it about Claud Worth (1869-1936) that made the publishers cling to his name 33 years after his death. Worth was born into a well-to-do English farming family, and quite against his father's wishes, developed a passion for sailing that stuck with him all his life. He is now perhaps better known to sailing enthusiasts than to ophthalmologists ("Worth's chain pawl"; "Yacht Cruising ", 1910; “Yacht Navigation". 1927). After training in ophthalmology he was able to concentrate on one area - strabismus - and he developed an unusual expertise. He started the first Orthoptic Clinic at Moorfields and set about systematically examining children with comitant squint and recording every detail. He invented the amblyopscope and began trying to train the fusion sense in children. His book was based on 2337 such cases seen between 1893 and 1903. This kind of monograph may not seem unusual today, but at the turn of the century it was sensational, it was " a beautiful demonstration of the value of that somewhat rare gift - the capacity for undertaking, with sustained interest, laborious and honest observation in the elucidation of clinical problems." (Duke-Elder)

Howe, Lucien. The Muscles of the Eye. New York, G.P.Putnam’s Sons, 2 volumes, 1907-1908.

Dr Howe (1848-1928) was a prominent American ophthalmologist who attended many European meetings. In 1884, at age 36 he wrote to the American Journal of Ophthalmology from Heidelberg about the demonstration he had just witnessed of the use of a cocaine solution as a local anesthetic. At 40 he agitated for control of ophthalmia neonatorum by placing prophylactic drops in the eyes of every newborn, and was instrumental in getting “The Howe Bill” through the New York legislature in 1890. At 60 he published his magnum opus - an influential 2 volume text on ocular motility that was 900 pages long, with 2000 references and 356 in-text figures and various appendices and indices. It was clearly the most thorough book on the subject in English, and it was much admired and was dubbed “a classic” even before the second volume was available. He lived another 20 years and did some important philanthropy.

Peter, Luther C. The Extra-ocular Muscles; a clinical study of normal and abnormal ocular motility. Philadelphia. Lea & Febiger, 1927, 294 pages. (2nd edition, 1936, 351 pages. 3rd edition 1941, 368 pages).

Luther Peter (1869-1942), at the University of Pennsylvania, who had written a very successful book on perimetry in 4 editions (1916-1938), put out this book on eye movement problems, using the same publisher, and it served a generation of American students of ophthalmology. Taken together the three editions provide a fascinating review of "pre-Scobee orthoptics", and of the parade of ingenious instruments and devices offered for the diagnosis and treatment of eye movement problems.

Bielschowsky, Alfred. Lectures on Motor Anomalies. Hanover, Dartmouth College Publications, 1940. softcover, 128pp.

Bielschowsky (1871-1940), was a well established German professor of Ophthalmology, who in 1935 accepted an invitation from Adelbert Ames to join the Dartmouth Eye Institute. He practiced there for five years and lectured widely on eye movements. These lectures were given at the Research Study Club of Los Angeles in 1938, and were then published in the American Journal of Ophthalmology (1938-39). They were to be part of a major textbook in English on this subject, but he died suddenly on Jan 5 th 1940 on a trip to Manhattan and was buried in Hanover, NH.

Scobee, Richard G. The Oculorotary Muscles. St Louis, C. V. Mosby, 1947.

Scobee (1914-1952) was an energetic and cheerful young man at Washington University in St Louis with a passionate interest in straightening children’s eyes. (“Strabismus is not only my work, it is my hobby” he said). In a decade he wrote 70 papers on the topic. He summarized what he was learning in this book and it had an energizing effect on the new subspecialty of pediatric ophthalmology and on orthoptic training. His tragic death at age 38 was from coronary artery disease. All who knew him seem to remember him with warmth and admiration.

Burian, Hermann & von Noorden, Gunther K. Binocular Vision and Ocular Motility. St Louis, C.V. Mosby, 1974, (5 th edition 1996).

Dr. Burian (1906-1974) worked in Goldmann’s lab in Berne and with Tschermak in Prague before joining Bielschowsky at the Dartmouth Eye Institute in 1935. At the close of the Institute in 1945, Burian practiced in Boston and then went to Iowa City in 1951, where he was active in ocular motility research and practice and in electrophysiology. He died in 1974 just before the book came out.

Dr. von Noorden did his medical training in Germany and his ophthalmology training in Iowa while Burian was there, and he remained on the Iowa faculty for a year before moving to the Wilmer Institute. He has been active at Baylor in Houston, emphasizing strabismus and amblyopia.

Burian wrote the chapters in the book on physiology, perception, examination, and neuromuscular control, while von Noorden emphasized the clinical aspects of eye deviation and therapy. The revising and updating for subsequent editions, have been done by von Noorden alone. This book encourages the reader to want to understand the mechanisms at work in ocular motility. The authors set out to explain these things thoughtfully, with the practicing ophthalmologist in mind, and with language that is crisp and clear.

Hereditary Ocular Diseases Ishihara, Shinobu Test for Colour-Blindness. Tokyo, Handaya Company, 1917.

Ishihara (1879-1963) attended medical school at Tokyo University with a military scholarship and an obligation to serve in the Army upon graduation in 1905. He then studied Ophthalmology at Tokyo University under Prof. J. Komoto. He went to Germany in 1912 and learned more ophthalmology with Prof. W. Stock in Jena. When the war began in 1914 he returned home to Tokyo and worked as an instructor in the Military Medical School. During this time he was asked to devise a test to screen recruits for abnormalities of color vision. His adjutant (also a physician) was color blind and helped by testing the test plates. At first the charts were not for sale and were used exclusively by the Army. Some of these first plates used the cursive Japanese phonetic script (‘hiragana’) and some asked the subject to trace a tortuous line across the plate.

In May 1916, Ishihara received his Doctor of Medical Sciences from Tokyo University (Thesis: “The Cause of Idiopathic Night-Blindness and Conjunctivitis Sicca”). Later that same year he made a set of plates using the ‘kanji’-based Japanese phonetic script (‘katakana’). He personally painted all the dots for his charts with watercolors. His contribution was in designing new plates that used several different stratagems to bring out anomalies in color vision. The original hand-painted charts are still at the University of Tokyo.

Ishihara was not the first to use pseudo-isochromatic plates; Jakob Stilling had published a set of 8 such plates in 1877 and 1883. Oguchi and then Fuminori Ita had produced some color charts in Japan in 1913. Ishihara’s plates were evidently superior: they seemed to give more dependable results and were easier to interpret. In 1917 he first considered that the plates might be valuable elsewhere in the world and made a set of charts using Arabic numerals, which he called the “International Edition”, but he could find no one to publish the plates. Finally, in late 1917, he had 600 copies printed by the Handaya Company at his own expense with instructions in English. The title was “Test for Colour-Blindness”, and very few copies were sold.

In 1921 Ishihara sent 90 copies off to Universities and ophthalmologists around the world. In 1923 Meisling evaluated the plates and gave them his enthusiastic support and, as a result, the International Edition was accepted as the preferred color vision test for seamen and railroad employees in Scandinavia. This created a new demand for the booklet and, in 1925, the Kanehara Co. took up the job of marketing and distributing the International Edition (Ishihara Pseudoisochromatic Charts for Color Blindness, Tokyo, Kanehara & Co, 1925). This was referred to as the 5 th edition; the previous 4 having come from Handaya Co. Both companies still exist and have kept to their agreement for 75 years: Handaya handles the Japanese versions and Kanehara the overseas versions.

At the 13 th International Congress of Ophthalmology at Amsterdam/The Hague in 1929 the plates were recommended for testing naval personnel and air force pilots. Ishihara’s charts were then used throughout the world for many decades and they are still considered the best screening test for congenital color blindness.

In 1922 Ishihara succeeded Professor Komoto as Chair of Ophthalmology. In 1937 he served as Dean of the Faculty of Medicine. In 1940 he retired and became professor emeritus. In 1925 Prof. Ishihara wrote a textbook called "Concise Ophthalmology" which was exceedingly popular in Japan and went through 22 editions He donated the royalties from his color vision test to establish a foundation that still provides research grants for color vision studies. In 1963 the Japanese Government named him as a National Treasure.

Waardenburg, P.J. Das menschlichen Auge und seine Erbanlangen. 's-Gravenhage, Martinus Nijhoff, 1932. Franceschetti, Adolphe, François, J. and Babel, J. Les Hérédo-dégéneresences Chorio-rétiniennes. Société Française d’Ophtalmologie, Paris, Masson, 1963. (An English translation, sponsored by the Excerpta Medica Foundation and called Chorioretinal Heredo-degenerations. was published by Charles C. Thomas, Springfield, Illinois in 1974.

These publications by Waardenburg and by François and by Franceschetti (see above) were full of case histories and family trees and together they added greatly to the understanding of the heredity of eye diseases - at a time when Watson and Crick had just cracked open the door that would eventually lead to molecular biology in genetics. No doubt, when the gene abnormalities causing these conditions are fully understood, there will be some re-classifying of these conditions.

Krill, Alex E. Hereditary Retinal and Choroidal Diseases Vol 1. Evaluation. Vol 2, (Krill & Archer) Clinical Characteristics. New York, Harper & Row, 1972.

Krill (1928-1972) was a professor of ophthalmology at the University of Chicago, Pritzker School of Medicine and editor of "Ophthalmology Digest". His main research interest was in the influence of the retinal pigment epithelium in chorio-retinal disease. He studied this through genetics, fluorescein angiography, and electrophysiology. This knowledge helped him with the taxonomy of retinal diseases; he was able to step past the renaming of diseases based on reports of certain familial occurrences, and try to categorize them by fluorescein appearance and by function. The first volume summarizes the tests then available to help sort out different chorio-retinal diseases. Volume two was incomplete at the time of his death in an airplane crash. Drs. Archer, Deutman, and Newell and many other contributors worked together to complete Krill’s book – a book that seemed to bring some functional order to a group of uncommon and hard to grasp diseases. August F. Deutman’s “ The hereditary dys-trophies of the posterior pole of the eye” ( Assen, Van Gorcum, 1971) provided a brilliant follow up to Krill’s work.

Retina and Vitreous Ramon y Cajal, Santiago. Die Retina der Wirbelthiere. Wiesbaden, J.F. Bergmann, 1894. Woods, Alan C. Endogenous Inflammations of the Uveal Tract. Baltimore, Williams & Wilkins, 1956-1961.

This book was the last of a series of works by Dr. Woods during his lifelong effort to understand ocular inflammations. During the war years of 1916-1918 he wrote a series of 5 articles about Ocular Anaphylaxis. His 1933 book “Allergy and Immunology in Ophthalmology” summarized knowledge of ocular tuberculosis and the concept of ocular inflammations induced by focal infections elsewhere in the body. In 1934 when Wilmer retired, Woods became professor and Director of the Wilmer Institute. In 1956 he wrote a book called “Endogenous Uveitis” with some excellent illustrations by Annette Burgess. Then in 1960 he became persuaded that previous exposure to histoplasmosis was a contributing factor in certain macular lesions (AJO 49:205). Evidence supporting this idea was summarized in 1961, in the second edition of “Endogenous Uveitis” (called “Endogenous Inflammations of the Uveal Tract”). Books by Ted Schlaegel of Indianapolis and Ronald Smith & Robert Nozik of California built on Dr Woods’ work and addressed the subject of uveitis for the next generation of ophthalmologists.

Gonin (1870 -1935) spent the entire second half of his life wrestling with the problems of retinal detachment. By 1918 he had become convinced that Theodor Leber was right when he suggested in 1882 that tiny adhesions between the vitreous gel and the adjacent retina – for the most part ophthalmoscopically invisible – could contract and tear a hole in the retina; and that the retina then became detached when fluid from the vitreous got through the hole and worked its way between the retina and the choroid. Gonin then emphasized the importance of sealing the hole. Gradually a technique was worked out that involved draining the fluid and using diathermy through the sclera to stir up a local inflammatory response in the choroid to plug the hole. This book summarizes his pioneering work on understanding and treating detachments of the retina.

Meyer-Schwickerath, G. Lichtkoagulation. Stuttgart, Ferdinand Enke, 1959, (also appeared in Suppl. 33, Klin. Mbl. Augenheilk.)

This monograph reviews the history of the author’s pioneering work with photocoagulation of the retina, from using the sun as a source of light, then a carbon arc lamp, and finally the xenon lamp. It appeared in English, translated by Stephen Drance, as Light Coagulation St Louis, C.V. Mosby,1960.

Schepens, Charles L. Retinal Detachment and Allied Diseases (2 vols). Philadelphia, Saunders, 1983 (2 nd edition with Mary E. Hartnett and Tatuo Hirose. Boston, Butterworth Heinemann, 2000).

Schepens mounted the indirect ophthalmoscope on the doctor’s head and this made it possible to indent the sclera to see the peripheral retina, and this helped to localize the retinal hole that was causing the detachment. The draining of the fluid could then be done in the right location and the encircling band and buckle could be made to apply pressure in the right place. Schepens and his group had a major influence on retinal detachment surgery through the entire last half of the century.

Cibis, Paul. Vitreoretinal Pathology and Surgery in Retinal Detachment. CV Mosby, St Louis, 1965.

Old retinal detachments have a way of scarring and stretching the retina and they have always been difficult to treat. In this book Dr. Cibis (1911-1965) summarizes his work on surgically releasing pre-retinal membranes and using silicone as an artificial vitreous. Dr. Cibis died soon after the completion of this text leaving a strong family of ophthalmologists including his wife, son and daughter. His work has continued in St. Louis and for a time vitreous surgery was the most active area of advancement in clinical ophthalmology. This was largely due to Cibis’s early work on "hopeless" cases of retinal detachment.

Gass, J. Donald M. Stereoscopic Atlas of Macular Disease. St Louis, CV Mosby, 1970 (2 nd edition, 1977, in one volume with 951 in text illustrations and 133 stereoviews on 19 ViewMaster reels ; 3 rd edition 1987 ; 4th edit. in 2 volumes, 1997)

Dr. Gass spent his entire academic career as an expert on macular disease, and his name will probably still come up when macular problems are discussed at the turn of the next century. This book remains the definitive work on the subject and the color photos are of the finest quality. Each new edition has kept up with recently recognized clinical entities and sorts out various conditions that had previously been wrongly lumped together.

Shields, Jerry. Diagnosis and Management of Orbital Tumors. Philadelphia, Saunders, 1983. 2 nd edition, 1989; 3 rd edition Intraocular Tumors rewritten and revised by Shields, J. and Shields, C. 1992; 4 th edition, Lippincott-Williams and Wilkins, 1999

Dr. Jerry Shields has been the Director of the Ocular Oncology Unit at Wills Eye Hospital for some years and has enormous clinical experience, especially in uveal melanomas. The latest edition of this text was done in collaboration with his wife, Dr. Carol Shields - also at Wills Eye Hospital - and their Oncology fellows. It is rare for one department, in one hospital to have such an active subspecialty practice, and perhaps rarer for one such unit to be able to produce a world class text for 2 decades without recruiting expertise from all over the country. Uveal melanomas and retinoblastomas get most attention, followed by phakomatoses, epithelial tumors, and lymphoid and leukemic processes in the eye. It is a worthy successor to Reese’s book of the previous generation.

Ryan, Stephen J. Retina. St Louis, Mosby, 1989. With associate editors: T. Ogden, A. Schachat, R. Murphy, B. Glaser, and their 164 contributors. The 2725 illustrations were supervised by Timothy Hengst. A 2 nd edit. appeared in 1994 (188 contributors, 3573 illustrations), and a 3 rd edit. in 2000.

This 3 volume, multi-authored work, under the general editorship of Dr Ryan was immediately recognized as an authoritative standard text for vitreo-retinal specialists.

Oculoplastic Surgery

Three generations before World War I stimulated a general interest in facial and ophthalmic plastic surgery Johann Friederich Dieffenbach (1792-1847) was working in Berlin and Friedrich August von Ammon (1799-1861) in Dresden, laying the foundations of modern plastic surgery.

Meller, Josef. Ophthalmic Surgery. Philadelphia, Blakiston’s Son & Co, 1908. (translation reviewed by Walter L. Pyle).

In 1908 Meller was Privatdocent at the 2nd Eye Clinic in Vienna. So many Americans were going to this Clinic in Vienna to hear Fuchs’ lectures that there was a demand for a small surgical text in English designed for ophthalmologists in training in America. Meller’s book is well laid out and the rules are made clear (“Never draw the Graefe knife backwards, don’t even bring it to a standstill”) and the illustrations are of exemplary clarity. A 2nd edition in English, (edited by William M. Sweet. Philadelphia, Blakiston’s Son & Co) appeared in 1913 at about the time that Meller became professor of Ophthalmology at the University of Innsbruck. Meller became professor at the First Eye Clinic in Vienna in 1918, and in that same year the first edition of this book in German appeared in Vienna (Augenärtzliche Eingriffe: ein kurzes Handbuch für angehende Augenärtzte). A 3rd US edition came out in 1923, and a sixth edition, revised by Böck (who was Meller’s successor as Professor at the 1st Eye Clinic) appeared in 1953.

Whitnall, Samuel Ernest. The Anatomy of the Human Orbit and Accessory Organs of Vision. London, Henry Froude, Hodder & Stoughton, 1921.

Whitnall was an Englishman (Oxford and St. Thomas’) who emigrated to Canada in 1919 to become professor of Anatomy at McGill University. Whitnall carefully dissected the human orbit and described the distribution of the levator aponeurosis, the superior transverse ligament (“Whitnall’s ligament”) and the insertion of the lateral canthal tendon, all of which was a great help to ophthalmic plastic surgeons.

Sheehan, J. Eastman. Plastic Surgery of the Orbit. New York, Macmillan, 1927

Dr Sheehan was a New York facial plastic surgeon with many interests, who wrote a book about plastic surgery of the nose in 1925. This is a very handsomely put together book with many well-made drawings and photographs and is dedicated to Harold Delf Gillies the English plastic surgeon.

Wheeler, John Martin. The Collected Papers of John Martin Wheeler, M.D. on Ophthalmic Subjects. Institute of Ophthalmology, Columbia-Presbyterian Medical Center, 1939

Dr Wheeler (1879-1938) trained in New York and served at Fort McHenry, Maryland in World War I and developed a great interest in ophthalmic plastic surgery. He took over the directorship of the Bellevue ophthalmology service from C.H. May in 1925, and in 1928 he resigned to become the first director of the new Institute of Ophthalmology at the Presbyterian Hospital. His papers were usually on surgical subjects and they were admirably short and clearly stated. This book contains 30 papers on oculoplastic and orbital problems, many of them influential. They reveal that he was a modest man and a caring physician. His student Wendell Hughes stayed at Bellevue to found an oculoplastics service and went on to teach other well-known ophthalmic plastic surgeons, among them Alston Callahan and Byron C. Smith.

Spaeth, Edmund Benjamin. Newer Methods of Ophthalmic Plastic Surgery. Philadelphia, P. Blakiston's Sons, 1925.

This was the first book in English devoted to oculoplastic surgery. In 1939 Dr. Spaeth (1890-1976) incorporated much of this book into a new text called Principles and Practice of Ophthalmic Surgery (Philadelphia, Lea & Febiger).

This popular book quickly went through several editions: 2nd,1941; 3 rd 1944; 4 th ,1948. Edmund Spaeth’s interest in ophthalmic plastic surgery began in World War I. His large private practice in Philadelphia reflected his expertise in these problems, and for many years the residents at Wills Eye Hospital learned from him the basics and the fine points of the then new field of ocular plastic and reconstructive surgery.

Hughes, Wendell L. Reconstructive Surgery of the Eyelids. St Louis, C V Mosby, 1943

The detailed review of the history of eyelid surgery in the first chapters of this book was originally prepared as a thesis for Hughes’s 1941 application for membership in the American Ophthalmological Society, but because of its length (94 figures and 331 references) it was not printed in the Transactions of the AOS. The American Ophthalmic Plastic and Reconstructive Surgery Society was founded chiefly by former Hughes fellows, and this may account for that Society’s unusual interest in the history of their subspecialty.

Stallard, H. B. Eye Surgery. Bristol, John Wright and Sons, 1946 (1st US edition with same pages, Baltimore, Williams and Wilkins, 1946; 2 nd editions 1950; 3 rd editions, 1958; 4th editions, 1965; 5th editions 1973; 6th edition 1978 and 7th edition 1988 by Roper-Hall.)

Stallard gave a prominent place to oculoplastic surgery (35%, 34% and 27% of the pages in each of the first 3 editions respectively). His book was a worldwide standard text in ophthalmic surgery for more than 30 years.

Fox, Sidney. Ophthalmic Plastic Surgery. New York, Grune and Stratton, 1952. ( 2nd edition 1958, 3rd edition 1963, fourth edition 1970, 5th edit. 1976).

Dr. Fox had a large clinical practice in New York, and was on the staff of many hospitals including New York University. His popular text was concerned with the surgical problems of the lids and conjunctiva. He believed that there were too many procedures, and that most general ophthalmologists never got a chance to sort them out and master a few of them. He set out to correct this situation with a straightforward, declarative style and simple clear illustrations – the same confident style that he had used in 1944 in a small book called “Your Eyes’’ addressed to the general reader. In Ophthalmic Plastic Surgery he was openly opinionated and didn’t hesitate to throw some procedures on the trash heap that were quite popular at the time. His later book "Surgery of Ptosis" appeared in 1968, before Beard's work, and was the first major textbook concerned only with the surgery of eyelid ptosis. Once again, he was impressed with how many ways there were to fix these things, and with the difficulty that most general ophthalmologists had in mastering the surgical principles involved. There were, naturally quite a few objections, to which he responded in subsequent editions by reorganizing and clarifying. His books are a rich source of older techniques because he was interested in the history of the way things had been done. He readily admitted that in surgical techniques, as in life, "we live and learn -and change”.

Beard, Crowell. Ptosis. St Louis, Mosby, 1969 Illustrated by Joan Esperson.

As soon as this book appeared Dr Beard became the world’s expert on the repair of ptosis of the eyelids; the book seemed to offer clinical insights and clear step by step instruction unavailable elsewhere. Beard was very explicit about the anatomical rationale for his procedure, depending on the type of ptosis. In its subsequent editions this book remained the standard work on ptosis. Dr Beard spent most of his academic career at the University of California San Francisco. There he was a greatly sought after consultant and teacher. Doctors crowded into his operating room to watch his surgery. A video of Dr Beard’s surgery was offered by the American Academy of Ophthalm-ology in 1976. A text by Beard and Quickert, M. Anatomy of the Orbit is a good supplement to this study. A fourth edition, called Beard's Ptosis was co-authored by M. Callahan (Birmingham, Aesculapius, 1990) in which the text was expanded and revised but Beard’s basics were left untouched.

Jones, Lester T. and Wobig, J.L. Surgery of the Eyelids and Lacrimal System. Birmingham, AL, Aesculapius, 1976.

Dr. Jones trained as an Eye, Ear, Nose, and Throat surgeon. To further his knowledge of anatomy he did minute dissections of the human orbit under water. This allowed visualization of tiny strands from major muscles and tendons that made interlacing attachments throughout the orbit. With this special expertise he helped write a series of booklets for the American Academy of Ophthalmology on anatomy. He applied this understanding of the orbit to devising surgical techniques with a rational anatomical basis. This resulted in some dramatic improvements in lacrimal and eyelid surgery.

Henderson, John W. with George M. Farrow and others. Orbital Tumors. Philadelphia, Saunders, 1973 (2 nd edition with Dr. George Farrow, New York, Brian C. Decker, 1980. 3 rd edition with Jean Campbell, George Farrow and James Garrity, New York, Raven Press, 1993)

In this book an ophthalmologist orbital surgeon gives practical, articulate advice and thereby contributes to the transfer of the care and management of orbital tumors from the neurosurgeon to the ophthalmologist. Walter E. Dandy’s book. “Orbital Tumors”, (NY, Oskar Piest, 1941) summarized the 1 st half of the century on this subject at a time when it was clear that taking out an orbital tumor was often a neurosurgeon’s job.

Dutton, Jonathan J. Atlas of Clinical and Surgical Orbital Anatomy. Phila. Saunders, 1994

This atlas is a virtuoso display of orbital and periorbital anatomy. Histologic sections of the orbit that have been turned into layers of crisp instructional paintings by the medical illustrator Thomas G. Waldrop. There are also sections on the eyelids and the lacrimal system. Somewhere, at this very moment, these images are probably being scanned into Powerpoint slides for teaching purposes.

Ocular Anatomy and Pathology Fuchs, Ernst. Lehrbuch der Augenheilkunde. Leipzig und Wien, F. Deuticke, 1889.

Ernst Fuchs (1851-1930) who had trained in Vienna under Arlt and was Professor of Ophthalmology in Liege from 1881-1885, wrote a prize winning essay in 1884 on the causes and prevention of blindness and became the Professor at the second Eye Clinic in Vienna in 1885. There he undertook to write this book, a textbook of only one volume that summarized the material covered in his lectures. The book was quickly translated by Alexander Duane of New York and published in 1892 by the D. Appleton Company as “Textbook of Ophthalmology”. It was an exceedingly popular text during the first half of the 20 th Century: there were 18 editions in German, and most of the 10 editions in English (1892-1933) were closely monitored by Dr. Duane, and it became increasingly difficult to stick to the one volume format. In the first edition there are only 17 figures showing what might be called microscopic anatomy, but Fuchs clearly believed that understanding the microscopic details of eye diseases would lead to effective treatment. An entire generation of ophthalmologists in the first quarter of the 20 th Century came to Vienna to hear him lecture, and they took home this book and the message that the microscope was the key to new knowledge.

Parsons, J. Herbert. (1868-1957) The Pathology of the Eye. 4 vols. London, Hodder & Stoughton, 1904-1908 (1 st US ed - New York, G P Putnam’s Sons, 1904-1908).

Parsons acknowledged the previous work of Greef (1902-06) and Ginsberg (1903) of Berlin and then produced this classic set of volumes. This book helped to make ophthalmic pathology into a recognized field of specialization, and for decades remained the standard English reference work on this subject.

Salzmann, Maximillian. Anatomie und Histologie des menschlichen Augapfels im Normalzustande, seine Entwicklung und sein Altern. Leipzig und Wien, F. Deuticke, 1912. Fuchs, Adalbert. Atlas der Histopathologie des Auges. Leipzig & Vienna, Franz Deuticke, Vol 1, 1923; Vol 2, 1927. Vol 1 was translated into English as Atlas of the Histopathology of the Eye with help from Drs Cottle, Horner and Barkan, and published by Deuticke in 1924.

Adalbert Fuchs was the son of Ernst Fuchs and an excellent ophthalmic pathologist. This atlas, the first ever with color plates (44 of them in volume 1, and 32 further plates in Vol 2), was produced in response to a demand from Ernst Fuchs’ students. Its purpose was to help the ophthalmologist to "attain a better anatomical foundation for his clinical knowledge". The plates were carefully drawn by R. Keilitz from microscopic sections.

Mann, Ida Caroline. Development of the Human Eye. Cambridge, The University Press. 1928, (2 nd edition, London,1949, New York, Grune and Stratton, 1950; 3 rd updated edition 1964).

Ida Mann (1893-1983) was the first woman ophthalmic surgeon at Moorfields Eye Hospital. She had access to a large human embryology specimen collection at the Institute of Pathology, St Mary’s Hospital, London and undertook a comprehensive study of the embryology of the eye. Building on the work of Bach and Seefelder (Atlas zur Entwicklungsgeschichte des menschlichen Auges. Leipzig, 1911-14), she made many major contributions to the subject and using her own illustrations, put them together in this book, the first comprehensive monograph devoted to the subject. The companion volume "Developmental Abnormalities of the Eye" came out in 1937 and was reprinted in 1957.

Collins, E. Treacher & Mayou, M.S. Pathology and Bacteriology of the Eye. Philadelphia, Blakiston, 1918.

This second edition was the first as a free standing text. It covers aberrations in development, neoplasms, injuries, infections, parasitic diseases and inflammation. The first edition (1911) was one of the volumes of a “System of Ophthalmic Practice” edited by the industrious Walter L. Pyle.

Wessely, Karl. Auge. Volume 11, in three parts of 1024, 534 and 641 pages, respectively, Berlin, Julius Springer, 1928-1937. Wolff, Eugene. The Anatomy of the Eye and Orbit. Philadelphia, Blakiston,1933 (4 th ed. 1954; 5 th ed. Phila, Saunders,1961, edited by Raymond Jack Last; 6 th ed. 1968, R.J. Last; 7 th ed. London, H.K. Lewis, 1976, edited by Roger Warwick; 8 th ed. London, Chapman Hall, 1997 edited by Anthony Bron, Ramesh C.Tripathi and Brenda J.Tripathi.)

Wolff (1896-1954) an English ophthalmologist, produced a book which became the standard anatomy text for ophthalmologists in training for the entire last two thirds of the century. He also wrote A Pathology of the Eye (Blakiston, 1935-1951) based on a series of lectures and demonstrations given at the Royal Westminster Ophthalmic Hospital.

Reese, Algernon B. Tumors of the Eye. New York, Paul B. Hoeber, Inc. 1951. (2 nd edition 1963; 3 rd edition 1976.)

Dr. Reese worked at the Institute of Ophthalmology of the Presbyterian Hospital, and the Memorial Center for Cancer and Allied Diseases in New York. Working at these active institutions he collected a large series of patients with tumors of the eye and orbit. Although this is chiefly an oncology book, it had a profound influence on ophthalmic pathologists because there had not been a comparable book since Felix Lagrange in 1901. The book is organized with great clarity by tumor type and is well illustrated with Bethke and Quinlan drawings.

Friedenwald, Jonas S and Helenor Campbell Wilder, Edward Maumenee, Ted Sanders, John Keyes, Michael Hogan and W.C. & Ella Owens. Ophthalmic Pathology: an Atlas and Textbook. Philadelphia, Saunders, 1952.

This multi-authored book was characteristic of the collaborative tone of American ophthalmic pathology throughout the rest of the century. The book was a joint project of the American Academy of Ophthalmology and Otolaryngology, and the Armed Forces Institute of Pathology and its starting point was to combine Friedenwald’s text (Friedenwald, Jonas S. (1897-1955) Pathology of the Eye, NY, Macmillan, 1929) and General DeCoursey’s Atlas (DeCoursey, Elbert and Ash, J.E. Atlas of Ophthalmic Pathology, 1938; prepared at the Army Medical Museum, Office of the Surgeon General, U. S. Army, from material in the Registry of Ophthalmic Pathology, later to become the Armed Forces Institute of Pathology, and published by the AAO; 2 nd ed. 1939; 3 rd ed. 1942). This turned out to be the first edition of what was to become the definitive text of ophthalmic pathology.

Hogan, Michael J. and Zimmerman, Lorenz (eds). Pathology of the Eye. Philadelphia, Saunders, 1962.

This, the second edition became justly famous around the world and was perhaps the most influential ophthalmic pathology book of the century.

Spencer, William. OphthalmicPathology. Philadelphia, Saunders, 1985.

The third and fourth editions of this massive book were edited by Wm. Spencer, again under the sponsorship of the American Academy of Ophthalmology and the Armed Forces Institute of Pathology. (3rd edition 1985, three volumes; 4th edition 1996, four volumes, Saunders.) The illustrations in the 1985 3 rd edition place this three volume book well above its predecessors. As new techniques and new understanding became available the book continued to grow, so that the 1996 4 th edition, in four volumes, became a truly comprehensive and authoritative text. Pathologists working with other organs wish that they had a reference work of this quality in their area.

Hogan, Michael J. and Alvarado, Jorge A. Weddell, Joan E. Histology of the Human Eye. Philadelphia, Saunders, 1971.

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