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Mycasaal

Category: Muscle Relaxant

Description

Ponstel (Mefenamic Acid) is indicated for treating pain.

Active Ingredient: mefenamic acid

Ponstel (Mycasaal) as known as: Acide mefenamique, Acido mefenamico, Acidum mefenamicum, Acinic, Adsena, Aidol, Alfoxan, Algex, Algifemin, Algopress, Analspec, Apo-mefenamic, Aprostal, Asimat, Bafhameritin-m, Beafemic, Benostan, Calmin, Cetalmic, Corstanal, Coslan, Dogesic, Dolarac, Dolfenal, Dolmetine, Dolos, Dysman, Fenam, Fenamic, Fenamin, Fenamol, Fenaton, Fendol, Fensik, Flamic, Gardan, Gitaramin, Inflamyl, Laffed, Lapistan, Licostan, Lumental, Lysalgo, Mafepain, Masafen, Medicap, Mefac, Mefacit, Mefast, Mefenabene, Mefenacid, Mefenaminsäure, Méfénamique, Mefenan, Mefenax, Mefenix, Mefinal, Mefinter, Mefnac, Meftal, Meftan, Menin, Mephadolor, Molasic, Mycasaal, Namifen, Neuritorl c, Nichostan, Occorner, Omatan, Onemeday, Opistan, Pangesic, Parkemed, Pehastan, Pinalgesic, Ponac, Ponalar, Ponalgic, Poncofen, Pondex, Ponmel, Ponsamic, Ponsic, Ponstan, Ponstelax, Ponstyl, Pontacid, Pontal, Pontalon, Pontin, Revalan, Rolan, Sicadol, Spiralgin, Sportusal, Stanalin, Tanston, Teamic, Topgesic, Tran-mf, Tynostan, Vidan, Youfenam

Benzoicacid, 2- (2, 3-dimethylphenyl)amino - 61-68-7 properties reference

Benzoicacid, 2-[(2,3-dimethylphenyl)amino]-(CAS No. 61-68-7) Identification and Related Records

【Name】 Benzoicacid, 2-[(2,3-dimethylphenyl)amino]- 【Iupac name】 2-(2,3-dimethylanilino)benzoic acid 【CAS Registry number】 61-68-7 【Synonyms】 Anthranilicacid, N-2,3-xylyl- (8CI)
2-(2,3-Dimethylanilino)benzoic acid
2-[(2,3-Dimethylphenyl)amino]benzoic acid
2',3'-Dimethyl-N-phenylanthranilicacid
Bafameritin M
Baphameritin M
Bonabol
C.I. 473
CN 35355
Coslan
INF3355
In-M
Lysalgo
Mefacit
Mefenacid
Mefenamic acid
Mephenamic acid
N-(2,3-Dimethylphenyl)anthranilic acid
N-(2,3-Xylyl)-2-aminobenzoic acid
N-(2,3-Xylyl)anthranilic acid
NSC 94437
Namphen
Parkemed
Ponalar
Ponstan
Ponstel
Ponstil
Ponstyl
Pontal
Relafan
Tanston
Vialidon
【EINECS(EC#)】 200-513-1 【Molecular Formula】 C15H15 N O2 (Products with the same molecular formula) 【Molecular Weight】 241.2851 【Inchi】 InChI=1S/C15H15NO2/c1-10-6-5-9-13(11(10)2)16-14-8-4-3-7-12(14)15(17)18/h3-9,16H,1-2H3,(H,17,18) 【InChIKey】 HYYBABOKPJLUIN-UHFFFAOYSA-N 【Canonical SMILES】 CC1=C(C(=CC=C1)NC2=CC=CC=C2C(=O)O)C 【MOL File】
61-68-7.mol

Chemical and Physical Properties

【Appearance】 light yellow solid 【Density】 1.203 g/cm 3 【Melting Point】 230 °C 【Boiling Point】 398.8 °C at 760 mmHg 【Refractive Index】 1.639 【Flash Point】 195 °C 【Water】 insoluble 【Solubilities】 insoluble 【Color/Form】 CRYSTALS
WHITE TO OFF-WHITE, CRYSTALLINE POWDER 【Storage temp】 Refrigerator 【Spectral properties】 MAX ABSORPTION (0.1 N NAOH): 285 NM, 340 NM 【Computed Properties】 Molecular Weight:241.2851 [g/mol]
Molecular Formula:C15 H15 NO2
XLogP3:5.1
H-Bond Donor:2
H-Bond Acceptor:3
Rotatable Bond Count:3
Tautomer Count:4
Exact Mass:241.110279
MonoIsotopic Mass:241.110279
Topological Polar Surface Area:49.3
Heavy Atom Count:18
Formal Charge:0
Complexity:292
Isotope Atom Count:0
Defined Atom Stereocenter Count:0
Undefined Atom Stereocenter Count:0
Defined Bond Stereocenter Count:0
Undefined Bond Stereocenter Count:0
Covalently-Bonded Unit Count:1
Feature 3D Acceptor Count:2
Feature 3D Donor Count:1
Feature 3D Anion Count:1
Feature 3D Cation Count:1
Feature 3D Ring Count:2
Effective Rotor Count:3
Conformer Sampling RMSD:0.6
CID Conformer Count:11

Safety and Handling

【Hazard Codes】 Xn:Harmful 【Risk Statements】 R22 【Safety Statements 】 S22;S36/37 【Safety】

Safty information about Mefenamic acid (CAS NO.61-68-7) is:
Hazard Codes:?Xn
Risk Statements: 22-40-20/21/22?
R22:Harmful if swallowed.?
R40:Limited evidence of a carcinogenic effect.?
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed.
Safety Statements: 22-36
S22:Do not breathe dust.?
S36:Wear suitable protective clothing.
WGK Germany: 3
RTECS: CB4550000

【Formulations/Preparations】 CAPSULES: 250 MG. 【Specification】

Mefenamic acid. its cas register number is 61-68-7. It also can be called?Mefenamic acid [USAN:INN:BAN:JAN] ; 2-((2,3-Dimethylphenyl)amino)benzoic acid ; 2-Diphenylaminecarboxylic acid, 2',3'-dimethyl- ; Ac. mefenamico ; Ac. mefenamico [Italian] ; Acide mefenamique ; Acide mefenamique [French] ; Acide mefenamique [INN-French] ; Acido mefenamico ; Acido mefenamico [INN-Spanish] ; Acidum mefenamicum ; Acidum mefenamicum [INN-Latin] ; Anthranilic acid, N-2,3-xylyl- ; Bafhameritin-M ; Benzoic acid, 2-((2,3-dimethylphenyl)amino)- ; Benzoic acid, 2-(2,3-dimethylphenyl)amino- ; Bonabol ; Fenamin ; HL 1 ; Lysalgo ; Mefacit ; Mefedolo ; Mefenamate ; Mefenamic acid ; Mefenaminsaeure ; Mephenamic acid ; Mephenaminic acid ; Methenamic acid ; Mycasaal ; N-(2,3-Dimethylphenyl)anthranilic acid ; N-(2,3-Xylyl)-2-aminobenzoic acid ; N-2,3-Xylylanthranilic acid ; Namphen ; Parkemed ; Ponalar ; Ponstan ; Ponstan forte ; Ponstel ; Rolan ; Tamany Bonsan ; Tanston ; Vialidon. It is a?light yellow solid. Since?it plays a significant role in mefenamic acid elimination, patients with known liver deficiency may be prescribed lower doses. Kidney deficiency may also cause accumulation of the drug and its metabolites in the excretory system. Therefore patients suffering from renal conditions should not be prescribed mefenamic acid.

Use and Manufacturing

【Use and Manufacturing】

Methods of Manufacturing

PREPD BY COPPER-CATALYZED CONDENSATION OF O-CHLOROBENZOIC ACID & 2,3-DIMETHYLANILINE: WINDER. J PHARMACOL EXP THER 138, 405 (1962); BELG PATENT 605,302 (1961 TO PARKE, DAVIS).
O-CHLOROBENOZIC ACID IS CONDENSED WITH 2,3-XYLIDENE WITH AID OF POTASSIUM CARBONATE & RESULTING POTASSIUM SALT IS TREATED WITH MINERAL ACID TO LIBERATE DESIRED ACID. US PATENT 3,138,636.

【Usage】 Anti-inflammatory; analgesic.

Biomedical Effects and Toxicity

【Pharmacological Action】 - Anti-inflammatory agents that are not steroids. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions. They are used primarily in the treatment of chronic arthritic conditions and certain soft tissue disorders associated with pain and inflammation. They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects. Certain NSAIDs also may inhibit lipoxygenase enzymes or TYPE C PHOSPHOLIPASES or may modulate T-cell function. (AMA Drug Evaluations Annual, 1994, p 1814-5)
- Compounds or agents that combine with cyclooxygenase (PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES) and thereby prevent its substrate-enzyme combination with arachidonic acid and the formation of eicosanoids, prostaglandins, and thromboxanes. 【Therapeutic Uses】 Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase Inhibitors
MEFENAMIC ACID (PONSTEL). PROVIDES ANALGESIA IN MAN SIMILAR TO THAT PRODUCED BY ASPIRIN.
. INDICATED FOR RELIEF OF PAIN RESULTING FROM DENTAL EXTRACTIONS.
DRUG PREFERABLY SHOULD BE TAKEN WITH FOOD.
MEFENAMIC ACID SHOWED FAVORABLE RESULTS RELATIVE TO SOME ANALGESICS. 【Biomedical Effects and Toxicity】 CROSSES PLACENTAL BARRIER IN MONKEYS. EXCRETED IN URINE, BILE &/OR FECES.
ABSORBED SLOWLY FROM GI TRACT. HIGH PERCENTAGE. BOUND TO PLASMA PROTEINS. PEAK PLASMA LEVELS APPEAR IN 2 TO 4 HR. ANALGESIA MAY PERSIST FOR UP TO 6 HR. ABOUT 50%. IS EXCRETED IN URINE WITHIN 24 HR /HUMAN, ORAL/

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Mycasaal diseases

  • Product description
  • Safety information
  • Side effects
  • Ponstel (Mefenamic Acid) is in a group of drugs called nonsteroidal anti-inflammatory drugs (NSAIDs). Mefenamic acid works by reducing hormones that cause inflammation and pain in the body.

    Mefenamic acid is used to treat pain or inflammation caused by arthritis. It is also used to treat menstrual pain.

    Mefenamic acid may also be used for other purposes not listed in this medication guide.

    Take this medication exactly as it was prescribed for you. Do not take the medication in larger amounts, or take it for longer than recommended by your doctor. Follow the directions on your prescription label.

    If you take mefenamic acid for a long period of time, your doctor may want to check you on a regular basis to make sure this medication is not causing harmful effects. Do not miss any scheduled visits to your doctor.

    Take the medicine as directed by your doctor.

    Seek emergency medical attention if you think you have used too much of this medicine. Overdose symptoms may include nausea, vomiting, stomach pain, dizziness, drowsiness, black or bloody stools, coughing up blood, urinating less than usual or not at all, shallow breathing, fainting, or coma.

    Store mefenamic acid at room temperature, away from moisture, heat, and light.

    Active Ingredient: Mefenamic Acid

    This medicine can increase your risk of life-threatening heart or circulation problems, including heart attack or stroke. Do not use this medicine just before or after having heart bypass surgery (also called coronary artery bypass graft, or CABG).

    Seek emergency medical help if you have symptoms of heart or circulation problems, such as chest pain, weakness, shortness of breath, slurred speech, or problems with vision or balance.

    This medicine can also increase your risk of serious effects on the stomach or intestines, including bleeding or perforation (forming of a hole). These conditions can be fatal and gastrointestinal effects can occur without warning at any time while you are taking mefenamic acid. Older adults may have an even greater risk of these serious gastrointestinal side effects.

    Call your doctor at once if you have symptoms of bleeding in your stomach or intestines. This includes black, bloody, or tarry stools, or coughing up blood or vomit that looks like coffee grounds.

    Do not use any other over-the-counter cold, allergy, or pain medication without first asking your doctor or pharmacist.

    Do not drink alcohol while taking mefenamic acid. Alcohol can increase the risk of stomach bleeding.

    Important safety information:

    Tell your doctor if you are taking an antidepressant such as citalopram (Celexa), duloxetine (Cymbalta), escitalopram (Lexapro), fluoxetine (Prozac, Sarafem, Symbyax), fluvoxamine (Luvox), paroxetine (Paxil), sertraline (Zoloft), or venlafaxine (Effexor). Taking any of these drugs with mefenamic acid may cause you to bruise or bleed easily.

    Before taking mefenamic acid, tell your doctor if you are taking any of the following drugs:

    a blood thinner such as warfarin (Coumadin);

    a diuretic (water pill) such as furosemide (Lasix);

    cyclosporine (Gengraf, Neoral, Sandimmune);

    lithium (Eskalith, Lithobid);

    methotrexate (Rheumatrex, Trexall);

    steroids (prednisone and others); or

    aspirin or NSAIDs (non-steroidal anti-inflammatory drugs) such as diclofenac (Voltaren), etodolac (Lodine), fenoprofen (Nalfon), flurbiprofen (Ansaid), ibuprofen (Advil, Motrin), indomethacin (Indocin), ketoprofen (Orudis), ketorolac (Toradol), meclofenamate (Meclomen), meloxicam (Mobic), nabumetone (Relafen), naproxen (Aleve, Naprosyn), piroxicam (Feldene), and others.

    This list is not complete and there may be other drugs that can interact with mefenamic acid. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

    Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

    Stop taking mefenamic acid and seek medical attention or call your doctor at once if you have any of these serious side effects:

    chest pain, weakness, shortness of breath, slurred speech, problems with vision or balance;

    black, bloody, or tarry stools, coughing up blood or vomit that looks like coffee grounds;

    urinating less than usual or not at all;

    pain, burning, or bleeding when you urinate;

    nausea, stomach pain, low fever, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);

    fever, sore throat, and headache with a severe blistering, peeling, and red skin rash; or

    bruising, severe tingling, numbness, pain, muscle weakness.

    Less serious side effects may include:

    upset stomach, mild heartburn or stomach pain, diarrhea, constipation; bloating, gas;

    dizziness, headache, nervousness;

    skin itching or rash;

    increased sweating, runny nose;

    blurred vision; or

    ringing in your ears.

    This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

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Ponstel (Mycasaal) Delivery

Residents of the USA can order Ponstel (Mycasaal) to any city, to any address, for example to Houston, Chicago, Salt Lake City or Brooklyn. You can order delivery of a Ponstel (Mycasaal) to the Ireland, Austria, Puerto Rico or any other country in the world.