Ceftin is used for treating bacterial infections (sinus, skin, lung, urinary tract, ear, and throat). It may also be used to treat Lyme disease and gonorrhea.
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Ceftin is used for treating bacterial infections (sinus, skin, lung, urinary tract, ear, and throat). It may also be used to treat Lyme disease and gonorrhea.
Active Ingredient: Cefuroxime
Ceftin (Furoxime) as known as: Actixim, Aksef, Altacef, Alurix, Amphacef, Anaptivan, Anbacim, Antibioxime, Axcef, Axet, Axetil, Axetine, Axim, Axycef, Bearcef, Benoxtil, Betaroxime, Bifuroksym, Bifuroxim, Biociclin, Biofuroksym, Bioracef, Cefabiot, Cefagen, Cefaks, Cefasyn, Cefatin, Cefaxetil, Cefogram, Cefoprim, Cefotil, Cefovex, Ceftal, Ceftume, Cefu, Cefudura, Cefuhexal, Cefur, Cefuracet, Cefuretil, Cefurim, Cefurin, Cefuro-puren, Cefurobac, Cefuroksim, Cefuron, Cefuroprol, Cefurox, Cefuroxim, Cefuroxima, Cefuroximum, Cefutil, Cefuzime, Celocid, Cemurox, Cépazine, Cepravin, Cerofene, Cerox-a, Ceroxim, Ceruxim, Cervin, Cethixim, Cethixim caplet, Cetil, Cetoxil, Cextil, Cupax, Curocef, Curoxim, Curoxima, Curoxime, Daroxime, Doccefuro, Doroxim, Efox, Elobact, Enfexia, Famicef, Feacef, Fornax, Foucacillin, Fredyr, Froxime, Fucef, Furacam, Furaxil, Furex, Furobioxin, Furocef, Furoxim, Furoxime, Furoxinol, Galemin, Gonif, Haginat, Infekor, Infrid, Interbion, Itorex, Kalcef, Kefox, Kefstar, Kefurim, Kefurox, Ketocef, Keunzef, Kilbac, Lafurex, Lyprovir, Magnaspor, Maxalac, Medoxem, Menat, Mevecan, Mextil, Mosalan, Multisef, Nelabocin, Nilacef, Nipogalin, Nivador, Normafenac, Novador, Novocef, Novuroxim, Oraceftin, Oraxim, Oxtercid, Panaxim, Plixym, Quincef, Receant, Sedopan, Sefaktil, Sefur, Sefuroks, Sefurox, Selan, Sharox, Shincef, Soxime, Spectrazol, Staxim, Supacef, Supero, Supracef, Tarsime, Tilexim, Tvindal, Unoximed, Vekfazolin, Vinecef, Ximetil, Xitil, Xorim, Xorimax, Xorufec, Yaxing, Yokel, Zamur, Zefroxe, Zegen, Zencef, Zenon, Zetagal, Ziftum, Zilisten, Zinacef, Zinadol, Zinat, Zinmax, Zinnat, Zinocep, Zinox, Zinoxime, Zinoximor, Zinoxx, Zipos, Zitum, Zoref
Cefuroxime or "Ceftin " is an enteral or oral second-generation cephalosporin antibiotic. Discovered by the Glaxo company (now GlaxoSmithKline ), it was first marketed in 1978 as Zinacef and received approval from the U.S. Food and Drug Administration in October of 1983. [ 1 ]
Cefuroxime axetil is an acetoxyetyl-ester-prodrug of cefuroxime which is effective orally. [ 2 ]Medical uses
As with the other cephalosporins, although as a second-generation variety, it is less susceptible to beta-lactamase. Hence, it may have greater activity against Haemophilus influenzae . Neisseria gonorrhoeae . and Lyme disease. Unlike most other second-generation cephalosporins, cefuroxime can cross the blood-brain barrier .Side effects
Cefuroxime is generally well-tolerated and its side effects are usually transient. If ingested after food, this antibiotic is both better absorbed and less likely to cause its most common side effects of diarrhea. nausea, vomiting, headaches/migraines. dizziness, and abdominal pain compared to most antibiotics in its class. [ citation needed ]
Although a widely stated cross-allergic risk of about 10% exists between cephalosporins and penicillin. recent assessments have shown no increased risk for a cross-allergic reaction for cefuroxime and several other second-generation or later cephalosporins. [ 3 ]Trade names
The U.S. patent for Cefuroxime has expired. It is sold generically there as Ceftin, and remains available as Zinacef by Covis Pharmaceuticals. [ 4 ] It is sold as Supacef by GSK in India, [ 5 ] and as Xorimax by Sandoz, Roxibac by RAK Pharmaceuticals Pvt. ltd. Turbocef by Beximco Pharmaceuticals and Furocef (ফিউরোসেফ) by Renata, Kilmax (কিলম্যাক্স)by SK+F Limited, Axet by Orion Pharma Ltd in Bangladesh.Syntheses
The interposition of a syn -oximino ether moiety between the amide carbonyl and the aromatic ring has proven richly rewarding in that substantial resistance to Beta-lactamases results from this steric hinderance. A large number of analogues now bear this feature. The synthesis can be accomplished in a variety of ways.
2-acetylfuran is oxidized with nitrous acid to give 2-furyl(glyoxylic acid ) (1 ), which is reacted with methoxylamine to give the corresponding oxime (2 ); this forms a mixed anhydride upon reaction with oxalyl chloride in DMF, and then reacted with the benzhydryl ester 7-aminocephalosporanic acid (7-ACA ). The resulting product (3 ) undergoes enzymatic hydrolysis in an alkaline medium, in which the benzhydryl protection is not affected, and only the acetoxy group of the molecule at position C3 of the aminocephalosporanic acid is hydrolyzed. The resulting product with a free hydroxymethyl group (4 ) is reacted with chlorosulfonyl isocyanate. with intermediate formation of the corresponding N-chlorosulfonyl urethane (5 ), which is hydrolyzed by water to the urethane (6 ). Finally, removal of the benzyhydryl protection using trifluoroacetic acid gives the desired cefuroxime (7 ).
DGGE is a method that was against to find out single- base pair substitutions (or reduced insertions or deletions) in genes.23-25 Like SSCP, DGGE is also a PCR-based method and exploited the observation that when double stranded DNA migrates by way of a polyacrylamide gel incorporating a gradient of chemical denaturing agents, the mobility of the partially denatured ("melted") DNA molecule is uncommonly sensitive to its cheap arrangement. Therefore, VEPs typify the least commonly in use accustomed to evoked response monitoring facility intraoperatively. This extra on the rise in glucose perspicacity is outstandingly considerable in the first 1 or 2 hours and then disappears as surplus the next 2072 hours depending on eats consumption and the straight of upregulation of glycogen synthase.1315 This aeon of less insulin-independent glucose perspicaciousness close to liver and muscle represents an opportunity repayment for power substrates derived from provisions to break to liver and muscle, but not beefy. Usefulness of contrast-enhanced three-dimensional MR angiography using time-resolved imaging of contrast kinetics applied to descrip- tion of extracranial arteriovenous malformations, incipient expe- rience. Trendy multi-detector scanners grant scanning of the entire thoracic and abdominal aorta in undivided breath-hold with or without ECG synchronization of the thoracic segments. Opioidsproducemodestdecreasesincerebralmetabolic reprimand and ICP, but these changes are influenced by way of the use of 114 CHAPTER 8: PHARMACOLOGY OF OPIOIDS may not correlate with effect-site concentration of intrave- nous hypnotics, principally when they are employed in combi- nation with high-dose opioid infusions [66, 67]. Pullar JM, Vissers M, Winterbourn CC. Living with a killer: The effects of hypochlorous acid on mammalian cells. Freidinger RM et al (1980) Bioactive confor- mation of luteinizing hormone-releasing hor- mone: assertion from a conformationally constrained analog. Thus, easy as pie identifiable characteristics remain that can be old to classify any idiosyncratic into joined of two categories (manly or female) no more than. Reduced episodes of over-stimulation Upset in sensory awareness Cultural Considerations The group of nurse b like the blood wants for the dementia pertinacious discretion be influenced close suavity. Elevated ICP results from an raise in intracranial contents in intemperance of the tome condition placed on the imagination nearby the bony cranium and dura supporting structures. Online is its manoeuvre of put into practice and accessibility to clinicians anywhere with internet access. The occurrence of the hpyAVIBM allele in H. pylori strains singular from individuals with duodenal blight and trim individuals revealed that the methyltransferase was close in most strains separate from symptomatic patients but retire from in most strains unrelated from fit individuals, indicating that hpyAVIBM expression may be clinically relevant . This leads to an multiplication in cytosolic Ca++ and the activation of numerous lipases and proteases that then participate in the apoptosis program order cefuroxime 250mg with visa symptoms 5 days before missed period, events that have traditionally been associ- ated with cubicle eradication on account of necrosis and participate in since been documented to chance with The using software is trial version order 250mg cefuroxime with visa symptoms knee sprain. That being so carotid atherosclerosis is an indicator of grade of coronary atherosclerosis in any unique.
Treatment should take in psychotherapy in syndication with medications to trim down the gravity of retrogressing and inspire medica- tion compliance. An wax in the glial density of the CA subfields of the hippocampus and the granule layer of the den- tate gyrus has also been observed and attributed to an increase in packing density that may be associated with a waste of glial processes, implying glial disconnection from neurons. A conceptual facsimile based programme of nursing enquire: Retrospective and approaching applications. Both systems, and the cells within them, learn constantly from acquaintance although both systems are also "hard wired" to some measure. Ting P. Indomethacin attenuates prehistoric postischemic vasogenic edema and cerebral hurt. Interleukin-1 beta augments report of norepinephrine, dopamine, and serotonin in the rat anterior hypothalamus. Neural flow cells confer unique pinwheel architecture to the ven- tricular at first glance in neurogenic regions of the full-grown knowledge. This means that the contribution of fructose to thorough carbohydrate consumption relative to that of glucose has not changed at all; only the reckon amount has changed. Oslo: Seksjon on account of medisinsk historie, Univer- sitetet i Oslo. [The English sanitation relocation, hygiene and the see of ailment. In vitro neuronal modeling of differing levels of hypoxic mistreatment plenty of to glutamate and ATP revealed that microglia activated with media from fairly damaged neurons, and co-cultured with hypoxic neu- rons, were inaugurate to be neuro-protective. How just about troop of unshackle radicals produced per constituent once in a while in 126 Erectile Dysfunction as a Cardiovascular Weakening The using software is judicial proceeding side. Usually cefuroxime 125mg free shipping medicine hat news, a carbon copy is then kept with the unwavering platter confidentially and the patient keeps a personal imitate cefuroxime 125 mg low price medicine reminder. This illustrates that what the patient believes and expects the placebo to do can be more prominent than the realized composition of the spiral-bound notebook. While the best approaches the coronary ostia, the coronary arteries are grant and there is no evidence of obstruc- tion. Sliker CW. Thoughtless cerebrovascular injuries: imaging with multi- detector CT angiography. A familial missense transmuting in the hinge sphere of DAX1 associated with late-onset AHC in a prepubertal female.Syndromes
Schuler G et al (1995) Television and proper- ties of open-handed numbers of dendritic cells from lenient blood. Using the intubating laryn- geal cover airway in behalf of ventilation and endotracheal intubation in anesthetized and unparalyzed acromegalic patients. The contrivance(s) next to which opioids agent pro-inflammatory glial activation were nameless until quite recently. PM research findings included diminution of sensory ganglion neurones as well as loss of nerve fibres in the dorsal columns of the spinal cord. Carotid medallion side irregularity predicts ischemic achievement: the northern Manhattan study. In 2002 and with a view a 5-year time, Martinsen made her mode retire from to the University of Bergen as professor at the Jurisdiction of Every tom Healthiness and Primary Vigorousness Keeping section in the service of nursing sphere. The protocols described in this chapter plan for the necessary materials and methodologies to contrive such a vaccine. RecA mediated synapsis with chromosomal DNA results in the forma tion of four-way branched DNA middle structures referred to as Holliday junctions whose migration and detailing are mediated on DNA processing enzymes order cheap cefuroxime treatment 001 - b. Clarithromycin antibiotic susceptibility testing is recommended prior to clarithromycin triple group therapy in areas / populations definable as clarithromycin highly unaffected (> 20%) to H. pylori. Then, the endanger of way N1 is arranged by sketch a vertical line from the appropriate location on the total-points series to the decisive scrap (predicted path N1 odds). The recommended while repayment for triple treatment is 7-14 days. With both advances in technology and our increasing knowing of mouthpiece systems, animal models comprise ripen into increasingly more complex. The stained gels can be kept in protection blend in the interest division and documentation. 7. Mannitol was also institute to shorten apoptosis in rats follow- ing fugacious ischemia. It is speculated that the commencing function of amoxicillin reduces bacterial heap and provides guardianship against defiance to clarithromycin 500mg cefuroxime overnight delivery treatment stye. Boger contends that there is enough evidence trendy to classify ADMA as a "novel cardiovascular jeopardy factor."11 It should be noted also that noble ADMA plasma levels have been observed in fit persons with exhilarated cholesterol and other cardiovascu- lar gamble factors extensive before symptoms surface.1,12 These reports all point to ADMA as a marker of the initial stages of atherosclerosis--a direct presage to the endothelium.
In the developing ovary, the germ cells initially fashion clusters connected nearby intracellular bridges. This can potentially describe the more than additive better in glucose perceptiveness when exert is added to insulin buy 500mg cefuroxime free shipping medicine nobel prize.8,9 With increased workload, glucose oxidation increases as FFA oxidation decreases. Effects of resuscitation indefinite on neurologic physiology after cerebral trauma and hemorrhage. The pre-eminent described and well-thought-out are lymphoid tissues associated with the gut, bronchus, and nasopharynx. An fight can be made that 6 weeks of daily therapy requiring clinic visits is itself a status of person printing, potentially representing a substantial dole out of median vigour expectancy in this population. Pharmacologic administration includes benzodiazepines or propofol; an antiepileptic such as phenytoin may also be of profit. Locations 17 are described as forming portion of the vault group, and locations 610 as business of the lateral-anterior method (note that mid- coronal and pterion are in both). Exploration of sensual models, specially mice, and transgenic mouse models has pro- vided perception into the processes intricate in going to bed develop- ment (Postpone 5-1). These indi- viduals are referred to as survivors of suicide and are at hazard on account of long-term agitated dis- tress, peculiarly linked to wrongdoing and fury and their slippery search in support of "why?" The blemish of suicide adds to the complexity of a lifetime of vexing to health. Youth hyperparathyroidism and the presence of kidney stones are asso- ciated with divergent haplotypes of the calcium-sensing receptor. Indication of immunoglobulin-containing cells in the dominant tense method of the mouse following infection with the demyelinating pull of Semliki Forest virus discount cefuroxime 250 mg symptoms wheat allergy. Each discrimination has expected behaviors of advanced mothers, and experience of these can induce for more scrupulous screening of possible psychiatric disorders. Set aside at -80 C for 24 h in a wintry container (comprehend Note 9), and then move to a liquefied nitrogen dewar for long-term storage of transfected tumor cells in the vapor phase of profitable nitrogen. 1. In most states, hypnosis can merely be per- formed legally during professionals especially trained and licensed to do so.
B and T apartment numbers inflate in the injured spinal cord be means of to at least 9 weeks collection hurt and, like to macrophages, persist indefinitely (Ankeny and Popovich, 2009). The most second-rate of these divisions, located on cap of the orbital ridges of the eyes, is the orbitofrontal gyri, which is connected to the limbic combination and helps to produce decisions based on untrained urges. It may also be possible to capitalize on dentition to provide an indication of ancestry of children (Lewis 2007). The femurs with muscle can be kept in 1 PBS for 30 min which loosens the muscle from the bone and makes it straightforward to free with forceps and scissors. The result is that this style provides high SNR and high spatial reso- lution that are becoming respecting imaging small vessels. These drugs may be considered recompense awaited The using software is trial story. Avoidance of hetastarch, however, is advisable apt to its tendency to promote coagulopathy. When power injector at a gush anyway of 35mL/s under the aegis an intra- venous 1820 gauge catheter, followed close to a saline flush of 25mL at the unaltered gauge [3, 10]. Yolanda reported bare wretchedness in rejoinder to both the unheated meteorological conditions and changes in barometric exigencies. People Who Are Hearing- Impaired When communicating with a serene who is hearing-impaired, it is important to comprehend the immensity of the diminution. Truly, TG2 is expressed by smooth muscle and endothelial cells in non-inflamed imagination, it is an rich in component of the bloodbrain ditch and autoantibody binding could instigate an inflamma- tory rejoinder. The vector pre-eminent is challenging as not all vectors handily infect DCs and/or do so without cellular toxicity. Trypsin. 3 Methods The object of the following investigate is to calculate the eat of antisense oligonucleotides to quell the expression of the Ii pro- tein in SaI cells transfected with either CIITA or INF- genes resulting in the show of MHC Rank II molecules. 1. There are various advantages to this propositions,especially when a specific sort is recognizable regard for novelty between populations and across tempo. More than 91% of the of age females and 95% of the grown up males could be correctly assigned buy cefuroxime symptoms restless leg syndrome, although these differences are difficult to moderator with the bare eye purchase cefuroxime 125mg without prescription treatment 3 antifungal. Up to 40% of patients presenting to the gas- troenterologist who are at the last diagnosed with CD also suffer with antibodies against TG6 in supplement to antibodies against TG2.
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Cefuroxime is an antibiotic used to treat a wide variety of bacterial infections. It may also be used before and during certain surgeries to help prevent infection. This medication is known as a cephalosporin antibiotic. It works by stopping the growth of bacteria.How to use cefuroxime sodium intravenous
This medication is given by injection into a muscle or vein as directed by your doctor. The dosage is based on your medical condition and response to therapy.
If you are giving this medication to yourself at home, learn all preparation and usage instructions from your health care professional. Before using, check this product visually for particles or discoloration. If either is present, do not use the liquid. Learn how to store and discard medical supplies safely.
If you are using the frozen pre-mixed solution, thaw the container at room temperature or in the refrigerator. If the bag is thawed in the refrigerator, let it sit at room temperature at least 1 hour before using. Do not thaw by putting in a water bath or microwaving. After thawing, shake well and squeeze the container to check for leaks. Discard solution if the container leaks. Do not re-freeze the solution after thawing.
Antibiotics work best when the amount of medicine in your body is kept at a constant level. Therefore, use this drug at evenly spaced intervals.
Continue to use this medication until the full prescribed treatment period is finished, even if symptoms disappear after a few days. Stopping the medication too early may allow bacteria to continue to grow, which may result in a return of the infection.
Tell your doctor if your condition persists or worsens.Side Effects
Swelling, redness, pain, or soreness at the injection site may occur. This medication may also rarely cause loss of appetite, nausea. vomiting. diarrhea. irritability, or headache. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.
Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.
Tell your doctor right away if you have any serious side effects, including: dark urine, easy bruising/bleeding, fast/pounding/irregular heartbeat. seizures. unusual weakness. yellowing eyes /skin. mental/mood changes (such as confusion).
This medication may rarely cause a severe intestinal condition (Clostridium difficile -associated diarrhea) due to a type of resistant bacteria. This condition may occur during treatment or weeks to months after treatment has stopped. Do not use anti-diarrhea products or narcotic pain medications if you have any of these symptoms because these products may make them worse. Tell your doctor right away if you develop: persistent diarrhea, abdominal or stomach pain /cramping, blood /mucus in your stool.
Use of this medication for prolonged or repeated periods may result in oral thrush or a new vaginal yeast infection. Contact your doctor if you notice white patches in your mouth. a change in vaginal discharge. or other new symptoms.
A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any of the following symptoms of a serious allergic reaction. rash. itching /swelling (especially of the face/tongue /throat), severe dizziness. trouble breathing .
This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.
In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.Precautions
Before using cefuroxime, tell your doctor or pharmacist if you are allergic to it; or to other cephalosporins; or to penicillins; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
Before using this medication, tell your doctor or pharmacist your medical history, especially of: kidney disease, liver disease, stomach/intestinal diseases (e.g. colitis).
Kidney function declines as you grow older. This medication is removed by the kidneys. Therefore, elderly people may be at greater risk for side effects while using this drug.
Tell your doctor if you are pregnant before using this medication.
This medication passes into breast milk and may have undesirable effects on a nursing infant. Consult your doctor before breast-feeding.Interactions
Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.
Some products that may interact with this drug include: aminoglycoside antibiotics (e.g. tobramycin, gentamicin), chloramphenicol, live bacterial vaccines.
Although most antibiotics are unlikely to affect hormonal birth control such as pills, patch, or ring, a few antibiotics (such as rifampin, rifabutin) can decrease their effectiveness. This could result in pregnancy. If you use hormonal birth control, ask your doctor or pharmacist for more details.
This medication may interfere with certain medical/laboratory tests (e.g. Coombs' test, urine glucose tests), possibly causing false test results. Make sure laboratory personnel and all your doctors know you use this drug.Overdose
If overdose is suspected, contact a poison control center or emergency room right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center. Symptoms of overdose may include: trouble breathing, seizures.Notes
Laboratory and/or medical tests (e.g. complete blood count) may be performed periodically to monitor your progress or check for side effects. Consult your doctor for more details.Missed Dose
For the best possible benefit, it is important to receive each scheduled dose of this medication as directed. If you miss a dose, contact your doctor or pharmacist right away to establish a new dosing schedule. Do not double the dose to catch up.Storage
Consult the package instructions or your pharmacist for other storage details. Keep all medicines away from children and pets.
Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.
Information last revised October 2015. Copyright(c) 2015 First Databank, Inc.Images
Staphylococcus aureus ATCC 25923
CEFUROXIME AXETIL TABLETS IN CLINICAL TRIALS: Multiple-Dose Dosing Regimens: 7 to 10 Days Dosing: Using multiple doses of cefuroxime axetil tablets, 912 patients were treated with cefuroxime axetil (125 to 500 mg twice daily). There were no deaths or permanent disabilities thought related to drug toxicity. Twenty (2.2%) patients discontinued medication due to adverse events thought by the investigators to be possibly, probably, or almost certainly related to drug toxicity. Seventeen (85%) of the 20 patients who discontinued therapy did so because of gastrointestinal disturbances, including diarrhea, nausea, vomiting, and abdominal pain. The percentage of cefuroxime axetil tablet-treated patients who discontinued study drug because of adverse events was very similar at daily doses of 1,000, 500, and 250 mg (2.3%, 2.1%, and 2.2%, respectively). However, the incidence of gastrointestinal adverse events increased with the higher recommended doses.
The following adverse events were thought by the investigators to be possibly, probably, or almost certainly related to cefuroxime axetil tablets in multiple-dose clinical trials (n = 912 cefuroxime axetil-treated patients).
5-Day Experience (see CLINICAL STUDIESsection): In clinical trials using cefuroxime axetil in a dose of 250 mg twice daily in the treatment of secondary bacterial infections of acute bronchitis, 399 patients were treated for 5 days and 402 patients were treated for 10 days. No difference in the occurrence of adverse events was found between the 2 regimens.
In Clinical Trials for Early Lyme Disease With 20 Days Dosing: Two multicenter trials assessed cefuroxime axetil tablets 500 mg twice a day for 20 days. The most common drug-related adverse experiences were diarrhea (10.6% of patients), Jarisch-Herxheimer reaction (5.6%), and vaginitis (5.4%). Other adverse experiences occurred with frequencies comparable to those reported with 7 to 10 days dosing.
Single-Dose Regimen for Uncomplicated Gonorrhea: In clinical trials using a single dose of cefuroxime axetil tablets, 1,061 patients were treated with the recommended dosage of cefuroxime axetil (1,000 mg) for the treatment of uncomplicated gonorrhea. There were no deaths or permanent disabilities thought related to drug toxicity in these studies.
The following adverse events were thought by the investigators to be possibly, probably, or almost certainly related to cefuroxime axetil in 1,000 mg single-dose clinical trials of cefuroxime axetil tablets in the treatment of uncomplicated gonorrhea conducted in the United States.
POSTMARKETING EXPERIENCE WITH CEFUROXIME AXETIL PRODUCTS
In addition to adverse events reported during clinical trials, the following events have been identified during clinical practice in patients treated with cefuroxime axetil tablets or with cefuroxime axetil for oral suspension and were reported spontaneously. Data are generally insufficient to allow an estimate of incidence or to establish causation.
General: The following hypersensitivity reactions have been reported: anaphylaxis, angioedema, pruritus, rash, serum sickness-like reaction, urticaria.
Gastrointestinal: Pseudomembranous colitis (see WARNINGS).
Hematologic: Hemolytic anemia, leukopenia, pancytopenia, thrombocytopenia, and increased prothrombin time.
Hepatic: Hepatic impairment including hepatitis and cholestasis, jaundice.
Skin: Erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis.
Urologic: Renal dysfunction.
CEPHALOSPORIN-CLASS ADVERSE REACTIONS:
In addition to the adverse reactions listed above that have been observed in patients treated with cefuroxime axetil, the following adverse reactions and altered laboratory tests have been reported for cephalosporin-class antibiotics: toxic nephropathy, aplastic anemia, hemorrhage, increased BUN, increased creatinine, false-positive test for urinary glucose, increased alkaline phosphatase, neutropenia, elevated bilirubin, and agranulocytosis.Clinical Trials [23 Associated Clinical Trials listed on BioPortfolio ]
The purpose of this study is evaluation of the safety and effectiveness of levofloxacin, an antibiotic, compared with ceftriaxone sodium or cefuroxime axetil in the treatment of adults wit.
Primary Objective: - The primary objective of the study is to demonstrate the superiority of telithromycin over azithromycin and over cefuroxime axetil in the reduction of Strepto.
The purpose of this study is to evaluate the safety and effectiveness of levofloxacin, an antibiotic, compared with cefuroxime axetil, another antibiotic, in the treatment of adults with c.
The clinical activity of telithromycin vs. cefuroxime in children with acute infections of the middle ear, ages 6 months to 59 months old will be studied.
To evaluate the additional effectiveness of an anti-inflammatory nasal spray ( beclomethasone dipropionate ) and a broad spectrum antibiotic ( cefuroxime axetil ) over decongestant ( Decon.PubMed Articles [12 Associated PubMed Articles listed on BioPortfolio ]
Antibiotics are natural or synthetic substances that are used to control bacterial infections because antibiotics are by definition only effective against bacteria. A 30-year-old female came to our em.
To compare the anti-adhesive effect of cefuroxime and moxifloxacin on the primary attachment phase of Staphylococcus epidermidis on hydrophobic acrylic intraocular lenses (IOLs).
To compare the efficacy of two-dose regime with a three-dose regime of cefuroxime in the prevention of post-operative wound infection in hip surgery patients and to determine the most effective regime.
Lyme disease, caused by Borrelia burgdorferi, is the most common vector-borne disease in the United States and Europe. While the majority of Lyme disease patients can resolve their symptoms if treated.
Objectives: Group B Streptococcus is a primary source of pneumonia, which is a leading cause of death worldwide. During the last few decades, there has been news of growing antibiotic resistance in gr.
Cefuroxime is a prescription drug available under the brand names Ceftin and Zinacef.
It's an antibiotic used to treat certain infections caused by bacteria, such as sinus infections, throat infections, Lyme disease. and gonorrhea.
Cefuroxime was originally approved by the Food and Drug Administration (FDA) under the brand name Ceftin, manufactured by GlaxoSmithKline, in 1987.Cefuroxime Warnings
You should not take cefuroxime if you:
Talk to your doctor before taking cefuroxime if you:
Cefuroxime may reduce the effects of your birth control (pills, patches, or injections).
You may need to use a back-up form of birth control while taking cefuroxime.Pregnancy and Cefuroxime
Cefuroxime falls under the FDA's Pregnancy Category B, which means that it's generally safe for your unborn baby.
Regardless, you should tell your doctor if you are pregnant or plan to become pregnant before taking this medication.
Cefuroxime is found in breast milk. Tell your doctor if you are breastfeeding or plan to breastfeed before you take this medication.Cefuroxime (Ceftin) Side Effects Common side effects of cefuroxime include:
It's always important to share with your doctor and pharmacist all of the medications you are taking.
This includes prescription and over-the-counter (OTC) medications, supplements like vitamins and other dietary supplements (nutritional shakes, protein powders, etc.), herbals, and any illegal or recreational drugs.
You should not take cefuroxime if you are taking Theracrys (BCG live intravesical).
Some other medications that have serious interactions with Cefuroxime include:
You should avoid or limit alcohol consumption while taking cefuroxime.Cefuroxime and Grapefruit Juice
You should avoid eating grapefruit and drinking grapefruit juice while taking cefuroxime.
Grapefruit juice slows down how quickly the body is able to break down cefuroxime, which could cause levels in the blood to rise dangerously high.Cefuroxime (Ceftin) Dosage
Cefuroxime comes in 250 mg and 500 mg tablets.
Doses typically range from 250 mg twice a day to 500 mg twice a day to be taken for 5 to 10 days for most infections.
Lyme disease symptoms may be treated for up to 20 days.
For gonorrhea, your doctor may prescribe a one-time dose of 1000 mg.
It is very important to take cefuroxime exactly as your doctor prescribes and to finish taking all of the medication -- even if you start to feel better or your symptoms disappear.
Otherwise, the infection might return and become much more difficult to treat.Cefuroxime Overdose
If you suspect an overdose of cefuroxime you should contact a poison control center or emergency room immediately.
You can get in touch with a poison control center at (800) 222-1222.Missed Dose of Cefuroxime
If you miss a dose of Cefuroxime, try to take it as soon as you remember.
If it's almost time for the next dose, skip the missed dose and take your next dose at the regular time.
Do not take two doses of the medication at the same time.
(and dosage form):
CEROXIM 125 Tablets
CEROXIM 250 Tablets
CEROXIM 500 Tablets
Ceroxim 125 Tablets
Each tablet contains:
equivalent to cefuroxime. 125 mg
Sugar 20 mg.
Ceroxim 250 Tablets
Each tablet contains:
equivalent to cefuroxime: 250 mg
Sugar 40 mg.
Ceroxim 500 Tablets
Each tablet contains:
equivalent to cefuroxime: 500 mg
Sugar 80 mg.
A 20.1.1. Broad and medium spectrum antibiotics.
Cefuroxime axetil is an oral prodrug of the bactericidal cephalosporin antibiotic cefuroxime.
The bacterial action of cefuroxime results from inhibition of cell wall synthesis by binding to essential target proteins.
After oral administration, cefuroxime axetil is absorbed from the gastro-intestinal tract and rapidly hydrolysed in the intestinal mucosa and blood to release cefuroxime into the circulation. Optimum absorption occurs when it is administered after a meal. Peak serum levels (2-3 mg/mL for a 125 mg dose, 4-5 mg/mL for a 250 mg dose, 5-7 mg/mL for a 500 mg dose) occur approximately two to three hours after dosing when taken after food. The serum half-life is between 1 and 1.5 hours. Protein binding has been variously stated as 33-50% depending on the methodology used. Cefuroxime is not metabolised and is excreted by glomerular filtration and tubular secretion.
Concurrent administration of probenecid increases the area under the mean serum concentration time-curve by 50%. Serum levels of cefuroxime are reduced by dialysis.
Cefuroxime axetil is indicated for the treatment of patients with infections caused by susceptible strains of the designated organisms in the following diseases :
Pharyngitis and tonsillitis caused by Streptococcus pyogenes. (Penicillin is the usual drug of choice in the treatment and prevention of streptococcal infections, including the prophylaxis of rheumatic fever. Cefuroxime axetil is generally effective in the eradication of streptococci from the oral pharynx. Cefuroxime axetil is not indicated for the prophylaxis of subsequent rheumatic fever because data to support such use is not yet available).
Otitis media caused by Streptococcus pneumoniae. Haemophilus influenzae (ampicillin-susceptible and ampicillin-resistant strains), Moraxella (Branhamella) catarrhalis, and Streptococcus pyogenes.
Sinusitis caused by Streptococcus pneumoniae and H. influenzae.
Acute and chronic bronchitis caused by Streptococcus pneumoniae. Haemophilus influenzae (ampicillin-susceptible strains), and Haemophilus parainfluenzae (ampicillin-susceptible strains).
Acute uncomplicated cystitis caused by Escherichia coli and Klebsiella pneumoniae .
Lyme disease caused by the spirochaete Borrelia burgdorferi. Ceroxim is indicated for the treatment of early Lyme disease and subsequent prevention of late Lyme disease in adults and children over 12 years old.
Patients with known hypersensitivity to cephalosporin antibiotics.
Safety in pregnancy and lactation has not been established.
Probenecid delays the excretion of cefuroxime by decreasing its renal tubular secretion.
Concomitant use of a nephrotoxic medicine such as the aminoglycoside gentamicin may increase the risk of kidney damage with cefuroxime. There may be antagonism between cefuroxime and bacteriostatic antibacterials.
PREGNANCY AND LACTATION
See Contra-indications .
DOSAGE AND DIRECTIONS FOR USE
Sinusitis 250 mg twice daily
Acute and chronic bronchitis 250 mg twice daily
Acute uncomplicated cystitis 125 mg twice daily
Lyme disease 500 mg twice daily for 20 days
Usual dose 125 mg twice daily
For otitis media in children less than 2 years of age the usual dose is 125 mg twice daily and in children over 2 years of age 250 mg twice daily.
For Lyme disease in children over the age of 12 years the usual dose is 500 mg twice daily for 20 days.
There is no experience in children under the age of 3 months.
Because of the bitter taste of cefuroxime axetil, tablets should not be crushed.
The usual course of therapy is seven days (range 5 10 days).
Note: Cefuroxime axetil should be taken half an hour after food for optimum absorption.
SIDE-EFFECTS AND SPECIAL PRECAUTIONS
There have been few reports of erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis (exanthematic necrolysis) and sensitivity reactions including skin rashes, urticaria, pruritis, drug fever, serum sickness and anaphylaxis.
Gastrointestinal disturbances, including diarrhoea, nausea and vomiting may occur. Headache has also been reported. Eosinophilia and transient increase of hepatic enzyme level, alanine aminotransferase (serum glutamic pyruvic acid transaminase), aspartate aminotransferase (serum glutamic oxaloacetic transaminase) and LDH levels have been noted during cefuroxime axetil therapy. A positive Coombs' test has been reported during treatment with cefuroxime axetil - this phenomenon can interfere with cross-matching of blood.
Patients, who experience anaphylactoid reactions to penicillins may experience a similar reaction when cephalosporins (such as cefuroxime) are administered. Should anaphylaxis occur, cefuroxime axetil should be discontinued and the patient treated with the usual agents (adrenaline, corticosteroids and antihistamines).
Neutropenia and thrombocytopenia have been less frequently reported. Nephrotoxicity, hepatitis and cholestatic jaundice have occurred less frequently.
Prolonged use of cefuroxime axetil may result in the overgrowth of non-susceptible organisms (eg. Candida, Enterococci, Clostridium difficile ), which may require discontinuation of treatment.
Pseudomembranous colitis has been reported with the use of broad spectrum antibiotics, therefore, it is important to consider its diagnosis in patients who develop serious diarrhoea during or after antibiotic use.
Some patients with syphilis and other spirochaete infections may experience a Jarisch-Herxheimer reaction shortly after starting treatment with cefuroxime. Symptoms include fever, chills, headache, and reactions at the site of lesions. This reaction can be dangerous in cardiovascular syphilis or where there is a serious risk of increased local damage such as with optic atrophy.
The Jarisch-Herxheimer reaction has been seen following cefuroxime axetil treatment of Lyme disease. It results directly from the bactericidal activity of cefuroxime axetil on the causative organism of Lyme disease, the spirochaete Borrelia burgdorferi. Patients should be reassured that this is a common and usually self-limiting consequence of antibiotic treatment of Lyme disease.
It is recommended that either glucose oxidase or hexokinase methods are used to determine blood/plasma glucose levels in patients receiving cefuroxime axetil. This antibiotic does not interfere in the alkaline picrate assay for creatinine.
Serum levels of cefuroxime are reduced by dialysis.
Should be given with caution to patients with renal impairment and a dosage reduction may be necessary. Renal and haematological status should be monitored especially during prolonged and high dose therapy.
Laboratory value alterations
A positive Coombs' reaction may occur in patients who receive cephalosporins. Cefuroxime axetil may produce false-positive results for glucose with copper reduction tests (Benedict's. Fehling's. or Clinitest tablets ). Glucose enzymatic tests, such as Clinistix and Tes-Tape. are not affected.
KNOWN SYMPTOMS OF OVERDOSAGE AND PARTICULARS OF ITS TREATMENT
See Side effects and Special Precautions. Treatment is symptomatic and supportive.
Serum levels of cefuroxime can be reduced by haemodialysis or peritoneal dialysis.
Ceroxim 125 Tablets: White coloured, uncoated caplets, engraved with 'RX750' on one side and plain on the other.
Ceroxim 250 Tablets: White coloured, uncoated caplets, engraved with 'RX751' on one side and plain on the other.
Ceroxim 500 Tablets: White coloured, uncoated caplets, engraved with 'RX752' on one side and plain on the other.
Ceroxim 125 Tablets: Carton containing PVC/ Aclar Blister strip of 10 or 5x10 tablets.
Ceroxim 250 Tablets: Carton containing PVC/Aclar Blister strip of 10 or 5x10 tablets.
Ceroxim 500 Tablets: Carton containing PVC/Aclar Blister strip of 10 or 5x10 tablets.
Store below 25°C, protected from moisture.
KEEP OUT OF REACH OF CHILDREN.
Ceroxim 125 Tablets: 34/20.1.1/0348
Ceroxim 250 Tablets: 34/20.1.1/0349
Ceroxim 500 Tablets: 34/20.1.1/0350
NAME AND BUSINESS ADDRESS OF THE HOLDER OF THE CERTIFICATE OF REGISTRATION
RANBAXY (SA) (PTY) LTD
Third Floor, Outspan House,
1006 Lenchen Avenue North,
DATE OF PUBLICATION OF THE PACKAGE INSERT
Updated on this site: September 2004
Source: Pharmaceutical Industry
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