Motrin is a nonsteroidal anti-inflammatory agent with analgesic properties used in the therapy of rheumatism and arthritis.
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Motrin is a nonsteroidal anti-inflammatory agent with analgesic properties used in the therapy of rheumatism and arthritis.
Active Ingredient: ibuprofen
Motrin (Ibubeta) as known as: Acatar zatoki, Actron, Acuilfem, Adax, Adex, Advel, Advil, Advil-mono, Advilcaps, Adviltab, Afebril, Ainex, Aktren, Alges-x, Algiasdin, Algidrin, Algifor, Algifor-l, Algofen, Algoflex, Algofren, Alidol f, Alindrin, Aliviol, Alivium, Alogesia, Altran, Anadvil, Anadvil rhume, Anafen, Anafidol, Anaflam, Analginakut, Analgion, Analper fem, Anco, Antalfort, Antalgil, Antalisin, Antarène, Antiflam, Antigrippine ibuprofen, Apirofeno, Apiron, Aprofen, Arafa, Ardinex, Arthrifen, Articalm, Artofen, Artril, Astefor, Atomo, Back pain, Balkaprofen, Baroc, Bediatil, Bestafen, Betagesic, Betaprofen, Bexistar, Biatain-ibu, Bifen, Blockten, Bolinet, Bonifen, Brafeno, Bren, Brufanic, Brufen, Brugesic, Brumed, Buburone, Bucoflam, Bufect, Bufen-sr, Buprex, Buprodol, Buprofen, Buprophar, Burana, Burana-c, Burana-caps, Buscofen, Butafen, Butidiona, Caldolor, Calmafen, Calmidol, Calmine, Cap-profen, Causalon ibu, Chemofen, Cibalgina, Cliptol, Combunox, Copiron, Cuprofen, Dadicil, Dadosel, Dalsy, Deep relief, Degiton, Deprofen, Deucodol, Dip rilif, Diprodol, Dismenol, Dismenol formel l, Diverin, Doctril, Dofen, Dolaraz, Dolgit, Dolin, Dolito, Dolo-puren, Dolo-spedifen, Dolobene, Dolobeneurin, Dolocanil, Dolocyl, Dolofast, Dolofen-f, Dolofin, Doloflam, Dolofor, Dolofort, Doloforte, Dologesic, Dolomate, Dolomax, Dolonet, Dolorac, Doloral, Doloraz, Dolorsyn, Dolorub, Doloxene, Dolprofen, Dolven, Doraplax, Dorival, Druisel, Duanibu, Ecoprofen, Edenil, Emflam, Emifen, Epsilon, Ergix douleur et fièvre, Erofen, Espasmovet, Espidifen, Esprenit, Esrufen, Ethifen, Eudorlin, Eufenil, Expanfen, Extrapan, Fabogesic, Factopan, Farsifen, Faspic, Febratic, Febricol, Febrifen, Febrolito, Femen, Femicaps, Feminalin, Femmex, Fenbid, Fenomas, Fenopine, Fenpic, Fenris, Fiedosin, Finalflex, Flamadol, Flamex, Flexistad, Fontol, Frenatermin, Gelobufen, Gelofeno, Gelopiril, Gélufène, Gerofen, Gineflor, Ginenorm, Grefen, Gyno-neuralgin, Hagifen, Haltran, Hapacol dau nhuc, Hémagène tailleur, I-pain, I-profen, Ib-u-ron, Ibalgin, Ibu, Ibuaid, Ibubenitol, Ibubeta, Ibubex, Ibucaps, Ibucare, Ibucler, Ibucod, Ibucodone, Ibuden, Ibudol, Ibudolor, Ibufabra, Ibufac, Ibufarmalid, Ibufen, Ibufix, Ibuflam, Ibuflamar, Ibugan, Ibugel, Ibugesic, Ibuhexal, Ibukem, Ibukey, Ibuklaph, Ibuleve, Ibulgan, Ibum, Ibumac, Ibumar, Ibumax, Ibumed, Ibumetin, Ibumousse, Ibumultin, Ibunate, Ibunovalgina, Ibupal, Ibupar, Ibuphil, Ibupirac, Ibupiretas, Ibupirol, Ibuprin, Ibuprof von ct, Ibuprofena, Ibuprofene, Ibuprofenix, Ibuprofeno, Ibuprofenum, Ibuprohm, Ibuprom, Ibuprovon, Ibuprox, Iburion, Ibusal, Ibuscent, Ibusi, Ibusifar, Ibusol, Ibuspray, Ibutan, Ibuten, Ibutenk, Ibutop, Ibux, Ibuxim, Ibuxin, Ibuzidine, Idyl, Imbun, Infibu, Infibutabletas, Inflam, Intafen, Intralgis, Ipren, Iproben, Iprofen, Ipronin, Iprox, Ipson, Ipufen, Irfen, Irufen, Junifen, Kin crema, Kontagripp sandoz, Kratalgin, Landelun, Lefebron, Lexaprofen, Liberat, Lisiprofen, Lumbax, Malafene, Marcofen, Matrix, Maxifen, Medafen, Medicol, Mediflam, Mediflam ninos, Medipren, Mejoral, Melfen, Menadol, Mensoton, Mestral, Metabel, Metorin, Migränin, Modafen, Mofen, Mogifen, Molargesico, Moment, Momentact, Motricit, Nagifen, Napacetin, Narfen, Neobrufen, Neofen, Neomeritine, Neoprofen, Neuralgin, Neurofen, Niofen, Nodolfen, Nonpiron, Norvectan, Novogeniol, Novogent, Nureflex, Nurofen, Nurofen rapid, Nurofenflash, Nurofentabs, Nurosolv, Oberdol, Oladol, Omafen, Optajun, Optalidon, Optalidon ibu, Optifen, Opturem, Ostarin, Oxibut, Ozonol, Pabiprofen, Paduden, Paidofebril, Painfree, Pakurat, Pamprin ib, Panafen, Pango, Parofen, Pedea, Pediaprofen, Pediatrin, Pedifen, Pelimed schmerz, Perdofemina, Perdophen pediatrie, Perfen, Perofen, Perviam, Pfeil, Phorpain, Pirexin, Pironal, Ponstil, Ponstil mujer, Ponstin, Ponstinetas, Probinex, Profen, Profinal, Proflex, Proris, Prosinal, Provin, Provon, Pymeprofen, Pyriped, Quadrax, Quimoral, Rafen, Ranfen, Ratiodol, Ratiodolor, Rebufen, Remofen, Renidon, Reprexain, Reufen, Reuprofen, Rhelafen, Ribunal, Rimofen, Robax platinum, Rufen, Rupan, Saetil, Saldeva, Salivia, Sapbufen, Sapofen, Sarixell, Schmerz-dolgit, Sconin, Serviprofen, Siflam, Sindol, Sine-aid ib, Siyafen, Smadol, Solpaflex, Solufen, Solvium, Spedifen, Spidifen, Spidufen, Spifen, Staderm, Subheron, Subitene, Sudafed sinus, Suprafen, Tabalon, Tatanol, Tenvalin, Teprix, Terbofen, Termalfeno, Termyl, Thermoflam, Tispol ibu-dd, Togal n, Tonal, Trauma-dolgit, Tri-profen, Tricalma, Trifene, Trosifen, Tussamag, Uniprofen, Unipron, Upfen, Upren, Urem, Urgo ibuprofen, Vargas, Vell, Verfen, Vesicum, Yariven, Zafen, Zatoprom, Zip-a-dol
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There is an additional general information about this medication active ingredient ibuprofen:Pharmacological action
NSAIDs, a derivative of phenylpropionic acid, ibuprofen has anti-inflammatory, analgesic and antipyretic effect.
The mechanism of action is associated with inhibition of COX activity - the main enzyme metabolism of arachidonic acid, which is a precursor of prostaglandins, which play a major role in the pathogenesis of inflammation, pain and fever. Analgesic effect is due to both peripheral (indirectly, through suppression of prostaglandin synthesis), and a central mechanism (due to inhibition of prostaglandin synthesis in the central and peripheral nervous system). Inhibits platelet aggregation.
For topical use anti-inflammatory and analgesic action. Reduces morning stiffness, increased the amount of motion in joints.
When oral administered ibuprofen almost completely absorbed from the gastrointestinal tract. Simultaneous food intake slows the rate of absorption. Metabolised in the liver (90%). T1 / 2 is 2-3 hours.
80% of the dose excreted in urine mainly as metabolites (70%), 10% - unchanged, 20% eliminated through the intestine in the form of metabolites.
Inflammatory, degenerative diseases of joints and spine (including rheumatic and rheumatoid arthritis, ankylosing spondylitis, osteoarthritis), articular syndrome in patients with acute gout, psoriatic arthritis, ankylosing spondylitis, tendonitis, bursitis, sciatica, traumatic inflammation of soft tissue and musculoskeletal apparatus. Neuralgia, myalgia, pain in infectious and inflammatory diseases of ENT organs, bursitis, algomenorrhea, headache and toothache. Fever in infectious and inflammatory diseases.Dosage and administration
Setting individually, depending on etiology of disease, severity of clinical manifestations. When administered rectally or adult single dose of 200-800 mg, the frequency of reception - 3-4; for children - 20-40 mg / kg in divided doses.
Topical applied within 2-3 weeks.
The maximum daily dose for adults when administered oral or rectally or is 2.4 g.
Oral, after a meal. Rheumatoid arthritis - by 0.8 g 3 times a day in osteoarthrosis and ankylosing spondylitis - by 0.4-0.6 g 3-4 times a day, in juvenile rheumatoid arthritis - at 30-40 mg / kg / day in several stages.
When soft tissue injuries, sprains - 1.6-2.4 g / day in divided doses.
At moderate pain syndrome - 1.2 g per day.
Digestive system: frequently - nausea, anorexia, vomiting, epigastric discomfort, diarrhea, possibly the development of erosive and ulcerative lesions of the gastrointestinal tract; rare - bleeding from the gastrointestinal tract, long-term use possible liver problems.
Central nervous system and peripheral nervous systems: frequently - headache, dizziness, sleep disturbances, agitation, visual impairment.
Hemopoietic system: long-term use may be anemia, thrombocytopenia, agranulocytosis.
Urinary tract: long-term use possible renal dysfunction.
Allergic reactions: often - skin rash, Quincke's edema, rarely - aseptic meningitis (usually in patients with autoimmune diseases), bronchospasm syndrome.
Local reactions: when topical used may be hyperemia of the skin, burning or tingling.
Erosive-ulcerative lesions in the gastrointestinal tract exacerbation, diseases of the optic nerve, "aspirin triad", hemodyscrasia, pronounced renal dysfunction and / or liver, children age (to 6 years), hypersensitivity to ibuprofen.Using during pregnancy and breastfeeding
Do not use ibuprofen in the III trimester of pregnancy. Application I and II trimesters of pregnancy is justified only in cases where the expected benefit to the mother than the possible harm to the fetus.
This medication ibuprofen in small amounts excreted in breast milk. Possible using in lactation for pain and fever. If necessary, prolonged use or use in high doses (800 mg / 24 h), should decide on the termination of breastfeeding.
Precautions are used with the attendant liver and kidney diseases, chronic heart failure, with dyspeptic symptoms before treatment, immediately after surgery, with indications of a history of gastrointestinal bleeding in diseases of the digestive tract, allergic reactions associated with NSAID intake.
In the course of treatment requires systematic monitoring of the liver and kidneys, peripheral blood picture.
It should not be applied externally to the damaged skin.
With simultaneous use of ibuprofen reduces the effect of antihypertensive agents (ACE inhibitors, beta-blockers), diuretics (furosemide, hypothiazide).
With the simultaneous use of anticoagulants may enhance their action.
With simultaneous application of SCS increases the risk of side effects from the gastrointestinal tract.
With the simultaneous application of ibuprofen may displace from compounds with plasma proteins indirect anticoagulants (acenocoumarol), derivatives of hydantoin (phenytoin), oral hypoglycemic drugs sulfonylurea derivatives.
With the simultaneous use of amlodipine may be a slight reduction of antihypertensive action of amlodipine, with acetylsalicylic acid - decreased concentration of ibuprofen in blood plasma, with baclofen - described a case of toxic gain of baclofen.
When applied simultaneously with warfarin may increase bleeding time, were also observed microhematuria, bruises with hydrochlorothiazide - perhaps a slight reduction of antihypertensive action of hydrochlorothiazide, captopril - may reduce antihypertensive effect of captopril, with cholestyramine - moderately decrease absorption of ibuprofen.
With simultaneous application of lithium carbonate increased the concentration of lithium in blood plasma.
With simultaneous application of magnesium hydroxide increases the initial absorption of ibuprofen, with methotrexate - increases the toxicity of methotrexate.
In case of overdose, call your local poison control center or emergency services.
Symptoms of overdose may include: dizziness; fast eye movements that you cannot control; slow breathing or short periods of time without breathing; blue color around the lips, mouth, and nose.
In a dry, protected from light place, at temperatures below 25°C. Expiration date for ibuprofen: 3 years.
PLEASE, BE CAREFUL!
Be sure to consult your doctor before taking any medication!
Ibuprofen is in a group of drugs called nonsteroidal anti-inflammatory drugs (NSAIDs). Ibuprofen works by reducing hormones that cause inflammation and pain in the body.
Ibuprofen is used to reduce fever and treat pain or inflammation caused by many conditions such as headache, toothache, back pain, arthritis, menstrual cramps, or minor injury.
Ibuprofen may also be used for other purposes not listed in this medication guide.Precautions
Taking an NSAID can increase your risk of life-threatening heart or circulation problems, including heart attack or stroke. This risk will increase the longer you use an NSAID. Do not use this medicine just before or after having heart bypass surgery (also called coronary artery bypass graft, or CABG).
NSAIDs can also increase your risk of serious effects on the stomach or intestines, including bleeding or perforation (forming of a hole). These conditions can be fatal and gastrointestinal effects can occur without warning at any time while you are taking an NSAID. Older adults may have an even greater risk of these serious gastrointestinal side effects.
Do not use this medication if you are allergic to ibuprofen, aspirin or other NSAIDs.
Before taking ibuprofen, tell your doctor if you are allergic to any drugs, or if you have:
If you have any of these conditions, you may need a dose adjustment or special tests to safely take ibuprofen.
FDA pregnancy category C. It is not known whether ibuprofen is harmful to an unborn baby. However, taking ibuprofen during the last 3 months of pregnancy may result in birth defects. Do not take ibuprofen during pregnancy unless your doctor has told you to.
It is not known whether ibuprofen passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.
Do not give this medicine to a child without the advice of a doctor.
Avoid taking ibuprofen if you are taking aspirin to prevent stroke or heart attack. Ibuprofen can make aspirin less effective in protecting your heart and blood vessels. If you must use both medications, take the ibuprofen at least 8 hours before or 30 minutes after you take the aspirin (non-enteric coated form).
Do not use any other over-the-counter cold, allergy, or pain medication without first asking your doctor or pharmacist. Many medicines available over the counter contain aspirin or other medicines similar to ibuprofen (such as ketoprofen or naproxen). If you take certain products together you may accidentally take too much of this type of medication. Read the label of any other medicine you are using to see if it contains aspirin, ibuprofen, ketoprofen, or naproxen.
Do not drink alcohol while taking ibuprofen. Alcohol can increase the risk of stomach bleeding caused by ibuprofen.
Avoid exposure to sunlight or artificial UV rays (sunlamps or tanning beds). Ibuprofen can make your skin more sensitive to sunlight and sunburn may result. Use a sunscreen (minimum SPF 15) and wear protective clothing if you must be out in the sun.Instructions
Seek emergency medical attention if you think you have used too much of this medicine. Overdose symptoms may include nausea, vomiting, stomach pain, drowsiness, black or bloody stools, coughing up blood, shallow breathing, fainting, or coma.
Since ibuprofen is sometimes taken as needed, you may not be on a dosing schedule. If you are taking the medication regularly, take the missed dose as soon as you remember. If it is almost time for the next dose, skip the missed dose and wait until your next regularly scheduled dose. Do not take extra medicine to make up the missed dose.Side effects
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Stop taking ibuprofen and seek medical attention or call your doctor at once if you have any of these serious side effects:
Less serious side effects may include:
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may report side effects to FDA at 1-800-FDA-1088.Interactions
Tell your doctor if you are taking an antidepressant such as citalopram (Celexa), duloxetine (Cymbalta), escitalopram (Lexapro), fluoxetine (Prozac, Sarafem, Symbyax), fluvoxamine (Luvox), paroxetine (Paxil), sertraline (Zoloft), or venlafaxine (Effexor). Taking any of these drugs with ibuprofen may cause you to bruise or bleed easily.
Before taking ibuprofen, tell your doctor if you are taking any of the following drugs:
This list is not complete and there may be other drugs that can interact with ibuprofen. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.Other Names
Advil, Advil Childrens, Advil Junior Strength, Advil Liquigel, Advil Migraine, Advil Pediatric, Childrens Ibuprofen Berry, Genpril, Haltran, IBU-200, Ibuprofen PMR, Midol IB, Midol Maximum Strength Cramp Formula, Motrin, Motrin Childrens, Motrin IB, Motrin Infant Drops, Motrin Junior Strength, Motrin Migraine Pain, NeoProfen, Nuprin, Pediacare Fever, Q-Profen, Rufen, Saleto-200, Saleto-400, Saleto-600, Saleto-800, ibuprofen, Ibu, Ibu-4, Ibu-6, Ibu-8, Ibu-Tab, Menadol, and Motrin PediatricDisclaimer
Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
Copyright 1996-2004 Cerner Multum, Inc. Version 2.05. Revision date 8/23/04
Last updated: April 19, 2016What is the most important information I should know about ibuprofen?
This medicine can increase your risk of life-threatening heart or circulation problems, including heart attack or stroke. This risk will increase the longer you use ibuprofen. Do not use this medicine just before or after having heart bypass surgery (also called coronary artery bypass graft, or CABG).
Seek emergency medical help if you have symptoms of heart or circulation problems, such as chest pain, weakness, shortness of breath, slurred speech, or problems with vision or balance.
This medicine can also increase your risk of serious effects on the stomach or intestines, including bleeding or perforation (forming of a hole). These conditions can be fatal and gastrointestinal effects can occur without warning at any time while you are taking ibuprofen. Older adults may have an even greater risk of these serious gastrointestinal side effects.
Call your doctor at once if you have symptoms of bleeding in your stomach or intestines. This includes black, bloody, or tarry stools, or coughing up blood or vomit that looks like coffee grounds.
Do not take more of this medication than is recommended. An overdose of ibuprofen can cause damage to your stomach or intestines. The maximum amount of ibuprofen for adults is 800 milligrams per dose or 3200 mg per day (4 maximum doses). Use only the smallest amount of ibuprofen needed to get relief from your pain, swelling, or fever.
Avoid taking ibuprofen if you are taking aspirin to prevent stroke or heart attack. Ibuprofen can make aspirin less effective in protecting your heart and blood vessels. If you must use both medications, take the ibuprofen at least 8 hours before or 30 minutes after you take the aspirin (non-enteric coated form).
Do not drink alcohol while taking ibuprofen. Alcohol can increase your risk of stomach bleeding caused by ibuprofen.Warning
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
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