Betnovate (Cortixyl depot)
Betnovate is used to help relieve redness, itching, swelling, or other discomfort caused by skin conditions.
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Betnovate is used to help relieve redness, itching, swelling, or other discomfort caused by skin conditions.
Active Ingredient: Betamethasone
Betnovate (Cortixyl depot) as known as: Akriderm, Alphatrex, Alpider, Anflavate, Antebate, Antroquoril, Asisone, Beben, Bectmiran, Bedicort g, Behealth, Beloderm, Belogent, Belosalic, Bemetson, Bemon, Benoson, Bentelan, Beprogel, Beprosone, Beprospen, Berbesolone, Besone, Bestflan, Beta cream, Beta micoter, Beta ointment, Béta septigen, Beta-micoter, Beta-val, Betabioptal, Betacap, Betacort, Betacorten, Betacream, Betacrem, Betaderm, Betadermic, Betafloroto, Betafoam, Betafusin, Betagalen, Betagentam, Betaject, Betalotio winthrop, Betam-ophtal, Betamatic, Betamed, Betamesol, Betameson, Betamet, Betametasona, Betametha, Betamethason, Bétaméthasone, Betamethasonum, Betamil, Betanoid, Betapred, Betariem, Betasalbe ksk, Betaselemin, Betasid, Betasin, Betason, Betasone, Betasone-g, Betatape, Betatopic, Betatrex, Betaval, Betaval-n, Betavate, Betavet, Betazon, Betesil, Betnelan, Betnelan v, Betnesalic, Betnesol, Betnesol-v, Betneval, Betnevate, Betnoval g, Betnovat, Betoblock, Betodermin, Betonate, Betopic, Betricin, Betsolan, Bettamousse, Bevalex, Bevason, Biorinil, Blacor, Blamy, Buccobet, Calamiraderon, Camnovate, Celesdepot, Celesemine, Célestamine, Celestan, Celestan biphase, Celestana, Célestène, Celestoderm, Celeston, Celeston valerat, Celestone, Celestonvalerat, Celestovet, Cevicort, Chlocodemin, Cidoten, Cidoten inyectable, Cidoten rapilento, Cidoten-v, Cilestoderme, Clotrasone, Coid, Colergis, Cordes beta, Coritex, Corsaderm, Cortamine, Corteroid, Cortibet, Cortiderma, Cortiflam, Cortimax, Cortispec, Cortival, Cortixyl, Cortixyl depot, Cremirit, Cronocorteroid, Cronolevel, Dacam, Daivobet, Debion-vg, Deflatop, Deltalaf, Dermabet, Dermabiolene, Dermasone, Dermesone, Dermizol, Dermosol, Dermosol-dp, Dermosone, Derzid, Dexacort depot, Dexan g, Dexan-vg, Digenta, Diprocel, Diproderm, Diprofast, Diproform, Diproforte, Diprofos, Diprogenta, Diprolen, Diprolene, Dipronova, Diprophos, Diprosalic, Diprosan, Diprosis, Diprosone, Diprosone depot, Diprospan, Diprostène, Diprotop, Diprovate, Disopranil, Dovobet, Dppollon, Ecoval, Egerian, Eleuphrat, Emperacin, Erispan, Exabet, Exabetin, Eye rinderon, Eyebet, Fidagenbeta, Floderm, Flogozyme, Flosteron, Fluororinil, Fubecot, Fucibet, Fucicort, Fucicream, Fuciderm, Fungolisin nf, Fusibact b, Fusibet, Futasone, Galinocort, Garamat, Garasone, Gentalyn, Gentamicin, Gentasone, Gentavet, Gentocin, Helpoderm, Hicort, Histablock, Hizubot, Ijilone v, Infanal, Inflacor, Inflacor retard, Isotic betaracin, Itisona, Kamelyn, Keligroll, Krimbeson, Kuterid, Kuterid g, Labosona, Lazar, Lenasone, Lenovate, Linolacort, Linolosal, Lotricomb, Luricul vg, Luxiq, Maxivate, Medobeta, Metaskin-n, Methasol, Methovate, Movithiol, Multiderm, Mytaderm, Nilacelin, Nisagon, Nolcot, Norbet, Ocuson, Oftasona p, Ophtamesone, Ophtasone, Opizole, Osmoran, Otomax, Oviskin, Persivate, Prevason, Prevex b, Propiochrone, Propioform, Proson, Psorcutan, Puradesmin, Quiacort, Ratio-topilene, Ratio-topisalic, Ratio-topisone, Repivate, Rinbeta pf, Rinderon, Rinderon-dp, Rinderon-v, Rinesteron, Saccortin, Salgen plus, Salibet, Sanbetason, Scanderma, Septon, Seroderm, Sinacort, Skilone, Skizon-n, Soderm, Solu-celestan, Soluderme, Solusone, Sonigen, Spel, Steromien, Steronema, Supraproct, Suprasone, Suprastene, Taclonex, Tanderil, Taro-sone, Tokuderm, Topagen, Topicasone, Topiderm, Topik, Topizone, Uciderm, Uniflex, Vabeta, Valbet, Valecort, Valederm, Valerpan, Valisone, Valnac, Verilona, Viltern, Vista-methasone, Walacort, Xamiol, Zensoderm, Zestam
Drug Development Phase: 1B
Dalazatide is a synthetic analog of a peptide isolated from a Caribbean sea anemone. It is a potent inhibitor of the Kv1.3 potassium channel and an important new pharmaceutical target due to its expression on effector memory T-cells. Effector memory T-cells are a subset of the T-cell family that cause inflammation and tissue damage in a broad range of autoimmune diseases. Dalazatide blocks activation of these cells without suppressing other T cell subtypes, potentially leaving intact the innate immune response and a majority of the adaptive immune response. As a result, dalazatide may not cause broad immune suppression in treated patients.
Dalazatide is being studied as a potential treatment for multiple autoimmune diseases including lupus, psoriasis, psoriatic arthritis, rheumatoid arthritis, multiple sclerosis, inflammatory bowel diseases, type 1 diabetes mellitus, atopic dermatitis, asthma, ANCA vasculitis and autoimmune uveitis.
Kineta is the first company to bring a Kv1.3 inhibitor into human clinical trials and has conducted two previous safety and tolerability studies of dalazatide in healthy volunteers. Additionally, dalazatide demonstrated clinical proof-of-concept in a Phase 1b Psoriasis Trial and is now ready for Phase II development. See Phase IB clinical trial results .
Note: This page contains information about the side effects of leuprolide. Some of the dosage forms included on this document may not apply to the brand name Lupron Depot.
Common side effects of Lupron Depot include weakness, signs and symptoms of injection site, dermatological reaction, edema, decreased testicular size, headache, depression, pain, vaginitis, increased lactate dehydrogenase, arthropathy, gastrointestinal disease, hot flash, urination disorder, diaphoresis, and emotional lability. Other side effects include respiratory tract disease, neuromuscular disease, dehydration, nausea and vomiting, prolonged partial thromboplastin time, myalgia, paresthesia, vertigo, dyspnea, impotence, sleep disorder, abnormal hepatic function tests, edema, increased serum alkaline phosphatase, increased serum aspartate aminotransferase, insomnia, and dizziness. See below for a comprehensive list of adverse effects.For the Consumer
Applies to leuprolide: kit, powder for solution, powder for suspension, powder for suspension 1 month, powder for suspension 3 month, powder for suspension 4 month, powder for suspension 6 month, solution
In addition to its needed effects, some unwanted effects may be caused by leuprolide (the active ingredient contained in Lupron Depot). In the event that any of these side effects do occur, they may require medical attention.
You should check with your doctor immediately if any of these side effects occur when taking leuprolide:For adultsLess common
Some of the side effects that can occur with leuprolide may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:For adultsMore common
Applies to leuprolide: intramuscular kit, intramuscular powder for injection, intramuscular powder for injection extended release, subcutaneous implant, subcutaneous kit, subcutaneous powder for injection extended release, subcutaneous solutionGeneral
The most commonly reported side effects were general pain, peripheral edema, hot flashes, hair loss, ECG changes, ischemia. [Ref ]Hypersensitivity
Postmarketing reports: Anaphylactoid reactions [Ref ]Genitourinary
Very common (10% or more): Vaginal dryness (37%), breast tenderness (up to 14%)
Common (1% to 10%): Urinary frequency/urgency, hematuria, urinary tract infection, ovarian hyperstimulation, testicular soreness/pain, breast soreness/tenderness, testicular atrophy, erectile dysfunction, penile disorder, reduced penis size, vaginal hemorrhage, gynecomastia, breast changes, breast enlargement, decrease in testicular size, impotence [Ref ]
Very common (10% or more): ECG changes (19%), ischemia (19%)
Common (1% to 10%): Hypertension, murmur, phlebitis, thrombosis, arrhythmias, angina, myocardial infarction [Ref ]
Very common (10% or more): Hot flashes (up to 91%)
Very rare (less than 0.01%): Pituitary apoplexy
Frequency not reported: Transient increase in serum testosterone concentrations during the first 2 days of therapy, 'flare' phenomenon [Ref ]
Common (1% to 10%): Depression, insomnia/sleep disorder, anxiety, nervousness, decreased libido, increased libido [Ref ]Nervous system
Common (1% to 10%): Dizziness/lightheadedness, headache [Ref ]Gastrointestinal
Common (1% to 10%): Constipation, nausea/vomiting, flatulence, dyspepsia, gastroenteritis/colitis, diarrhea, dysphagia, gastrointestinal bleeding, gastrointestinal disturbance, peptic ulcer, rectal polyps [Ref ]Dermatologic
Very common (10% or more): Hair loss (up to 18%)
Common (1% to 10%): Skin rash, acne, itching, dry skin, ecchymosis, pruritus, photosensitivity, clamminess, night sweats, increased sweating, skin pigmentation [Ref ]
Common (1% to 10%): Bone/joint pain, myalgia, ankylosing spondylosis, arthritis, blurred disc margins, bone fracture, muscle stiffness, muscle tenderness, pelvic fibrosis, spasms/cramps
Frequency not reported: Backache, muscle atrophy, limb pain
Postmarketing reports. Spinal fracture/paralysis, tenosynovitis-like symptoms [Ref ]
Common (1% to 10%): Anemia
Postmarketing reports: Decreased WBC
Frequency not reported: Decreased red blood cell count/hematocrit/hemoglobin [Ref ]
Common (1% to 10%): Dyspnea, sinus congestion, chest tightness, decreased breathing sounds, hemoptysis, pleuritic chest pain, pulmonary infiltrate, rales/rhonchi, rhinitis, strep throat, wheezing/bronchitis, pulmonary edema, pulmonary embolism [Ref ]Local
Frequency not reported: Erythema, ecchymosis, induration, abscess, pain, swelling, nodules, ulcers, irritation, necrosis at the site of injection [Ref ]Other
Very common (10% or more): General pain (up to 32.7%), peripheral edema (12.5%), asthenia (10%)
Common (1% to 10%): Tinnitus
Frequency not reported: Disturbance of smell/taste, vertigo
Postmarketing reports: Hearing disorder [Ref ]
Frequency not reported: Hepatitis, hepatomegaly
Postmarketing reports: Hepatic dysfunction [Ref ]
Common (1% to 10%): Anorexia
Frequency not reported: Weight gain/loss
Postmarketing reports: Diabetes [Ref ]
1. "Product Information. Lupron (leuprolide)." TAP Pharmaceuticals Inc, Deerfield, IL.
2. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
3. Cerner Multum, Inc. "Australian Product Information." O 0
Not all side effects for Lupron Depot may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.
Otsuka Pharmaceutical Co. Ltd. (Otsuka) and H. Lundbeck A/S (Lundbeck) today announced the European Medicines Agency's (EMA) acceptance of the submission of a marketing authorisation application (MAA) for the approval of aripiprazole depot formulation. The application of aripiprazole depot formulation is for the maintenance treatment of adult patients with schizophrenia.
"Our efforts to bring the aripiprazole depot formulation to market demonstrate our long-term commitment to discover, develop and champion treatments for the most challenging psychiatric diseases ," said William H. Carson, M.D. President and CEO, Otsuka Pharmaceutical Development & Commercialization, Inc. "If approved, more patients with schizophrenia will have access to the efficacy and safety profile of aripiprazole in a once-monthly formulation ."
"Long-acting therapies are moving to the forefront of treatment for psychiatric disorders, and I am very excited that we now also have submitted this product for approval in Europe, " says Executive Vice President Anders Gersel Pedersen, Head of Research & Development at Lundbeck, and continues: "If approved,aripiprazole depot formulationwill offer the clinical properties of oral aripiprazole, including its safety and efficacy profile, in a form that is suited to patients who may have difficulties consistently taking their medication ."
A ripiprazole depot formulation is the first dopamine D2 partial agonist submitted in Europe as a once-monthly injection. If approved, it will be a new treatment option to address the need for relapse prevention in patients with schizophrenia, a chronic and debilitating disease.
Results from the first clinical trial of aripiprazole depot formulation were presented in four poster presentations at the 2012 American Psychiatric Association (APA) Annual Meeting in May 2012 and have subsequently been published in the Journal of Clinical Psychiatry (Kane et al J Clin Psych, 2012). In December 2012, data from the second pivotal trial were presented at the 51 st Annual Meeting at the American College of Neuropsychopharmacology (ACNP) in Hollywood, Florida.
On 11 November 2011, Otsuka and Lundbeck announced an alliance to collaborate on the development and commercialisation of up to five early and late stage compounds in development. The two companies will co-commercialise aripiprazole depot formulation in the U.S. and will collaborate on the development and commercialisation of aripiprazole depot formulation in other markets worldwide. Aripiprazole depot formulation remains under review by the U.S. Food and Drug Administration (FDA).
About schizophrenia and disease relapse
Schizophrenia is a disease characterized by a distortion in the process of thinking and of emotional responsiveness. It most commonly manifests as hallucinations, paranoid or bizarre delusions, or disorganized speech and thinking, and is accompanied by significant social or occupational dysfunction. Onset of symptoms typically occurs in young adulthood, and the condition is chronic, often requiring life-long treatment to mitigate symptoms. It has been estimated that schizophrenia affects approximately 1% of the adult population in the U.S. and Europe, and approximately 24 million people worldwide  , . In the U.S. there are approximately 2.4 million adults with schizophrenia, prevalent equally in both genders  , . While there is no cure for the disease, symptoms and risk of relapse can be managed in most patients with appropriate antipsychotic treatment. However, when the disease is not managed, patients are at increased risk of disease relapse, which can cause the re-emergence or worsening of psychotic symptoms.
Relapses can occur during the natural course of schizophrenia . but the major driver of recurrent episodes is medication non-adherence  , . which may be as high as 50%. There are many reasons patients stop taking their medication and they include: poor insight about their illness, side effects from their current treatment, complicated medication regimens or lack of support from their family.
Recurrent relapses can result in function decline that may never return to pre-morbid levels 6,  , . The goals of long-term therapy in schizophrenia are therefor to prevent relapse, and to reduce the severity of side effects and residual symptoms  , .
About aripiprazole depot formulation
Aripiprazole depot formulation for extended-release injectable suspension, an intramuscular (IM) depot formulation of aripiprazole, is a sterile lyophilized powder that, when reconstituted with sterile water for injection, forms an injectable suspension that can be administered monthly.
After an initial injection of aripiprazole depot formulation along with an overlapping 14-day dosing of oral antipsychotic treatment, subsequent injections of aripiprazole depot formulation provide uninterrupted medication coverage for a month. Depot formulations of antipsychotic agents provide patients with stable concentrations of active drug that remain at a therapeutic range for an extended period of time and also allow psychiatrists to know when a patient does not return for a scheduled injection  , .
Financial guidance for 2012
The content of this release will have no influence on the Lundbeck Group's financial guidance for 2012, which was provided on 8 February 2012 in connection with the release of the financial results for 2011, and further specified in connection with the announcement of the restructuring plan on 14 June 2012.
About Otsuka Pharmaceutical Co. Ltd.
Founded in 1964, Otsuka Pharmaceutical Co. Ltd. is a global healthcare company with the corporate philosophy: 'Otsuka-people creating new products for better health worldwide.' Otsuka researches, develops, manufactures and markets innovative and original products, with a focus on pharmaceutical products for the treatment of diseases and consumer products for the maintenance of everyday health. Otsuka is committed to being a corporation that creates global value, adhering to the high ethical standards required of a company involved in human health and life, maintaining a dynamic corporate culture, and working in harmony with local communities and the natural environment.
Otsuka Pharmaceutical Co. Ltd. is a wholly owned subsidiary of Otsuka Holdings Co. Ltd. the holding company for the Otsuka Group. The Otsuka Group has business operations in 24 countries and regions around the world, with consolidated sales of approx. EUR 10.5 billion (JPY 1,154.6 billion or USD 14.0 billion) for fiscal year 2011. For more information, visit www.otsuka.co.jp/en.
H. Lundbeck A/S (LUN.CO, LUN DC, HLUYY) is an international pharmaceutical company highly committed to improving the quality of life for people suffering from brain disorders. For this purpose, Lundbeck is engaged in the research, development, production, marketing and sale of pharmaceuticals across the world. The company's products are targeted at disorders such as depression and anxiety, psychotic disorders, epilepsy and Huntington's, Alzheimer's and Parkinson's diseases.
Lundbeck was founded in 1915 by Hans Lundbeck in Copenhagen, Denmark. Today Lundbeck employs approximately 6,000 people worldwide. Lundbeck is one of the world's leading pharmaceutical companies working with brain disorders. In 2011, the company's revenue was DKK 16.0 billion (approximately EUR 2.1 billion or USD 3.0 billion). For more information, please visit www.lundbeck.com.
Safe Harbor/Forward-Looking Statements
The above information contains forward-looking statements that provide our expectations or forecasts of future events such as new product introductions, product approvals and financial performance.
Such forward-looking statements are subject to risks, uncertainties and inaccurate assumptions. This may cause actual results to differ materially from expectations and it may cause any or all of our forward-looking statements here or in other publications to be wrong. Factors that may affect future results include interest rate and currency exchange rate fluctuations, delay or failure of development projects, production problems, unexpected contract breaches or terminations, government-mandated or market-driven price decreases for Lundbeck's products, introduction of competing products, Lundbeck's ability to successfully market both new and existing products, exposure to product liability and other lawsuits, changes in reimbursement rules and governmental laws and related interpretation thereof, and unexpected growth in costs and expenses.
Certain assumptions made by Lundbeck are required by Danish Securities Law for full disclosure of material corporate information. Some assumptions, including assumptions relating to sales associated with product that is prescribed for unapproved uses, are made taking into account past performances of other similar drugs for similar disease states or past performance of the same drug in other regions where the product is currently marketed. It is important to note that although physicians may, as part of their freedom to practice medicine in the US, prescribe approved drugs for any use they deem appropriate, including unapproved uses, at Lundbeck, promotion of unapproved uses is strictly prohibited.
 National Institute of Mental Health (NIMH). Health Topics: Statistics. Available at http://www.nimh.nih.gov/statistics/1SCHIZ.shtml. Accessed July 19, 2012.
 World Health Organization (WHO). Schizophrenia Fact Sheet. 2010. Available at http://www.who.int/mental_health/management/schizophrenia/en/. Accessed July 16. 2012
 Regier, Darrel et al. The de Facto US Mental and Addictive Disorder Service System. Arch Gen Psychiatry. 1993; 50: 85-94.
 Topics-Statistics: Schizophrenia. 2010. Available at http://wwwapps.nimh.nih.gov/health/publications/the-numbers-count-mental-disorders-in-america.shtml#RegierServiceSystem. Accessed July 18, 2012.
 Wiersma D, Wanderling J, Dragomirecka E, et al. Social disability in schizophrenia: its development and prediction over 15 years in incidence cohorts in six European centres. Psychol Med 2000; 30 (5): 1155—1167
 Ascher-Svanum H, Zhu B, Faries D, et al. A prospective study of risk factors for nonadherence with antipsychotic medication in the treatment of schizophrenia. J Clin Psychiatry 2006; 67 (7): 1114—1123
 Robinson D, Woerner MG, Alvir JM, et al. Predictors of relapse following response from a first episode of schizophrenia or schizoaffective disorder. Arch Gen Psychiatry 1999; 56 (3): 241—247
 Ayuso-Gutiérrez JL, del Río Vega. Factors influencing relapse in the long-term course of schizophrenia. Schizophr Res 1997; 28: 199—206.
 Lieberman JA, Perkins D, Belger A, et al. The early stages of schizophrenia: speculations on pathogenesis, pathophysiology, and therapeutic approaches. Biol Psychiatry 2001; 50 (11): 884—897.
 Lehman AF, Lieberman JA, Dixon LB, et al; for the Work Group on Schizophrenia. Practice guideline for the treatment of patients with schizophrenia. 2 nd Edition. Arlington, VA: American Psychiatric Association; 2004. © American Psychiatric Association, 2010. Accessed at http://psychiatryonline.org/content.aspx?bookid=28§ionid=
1665359#45878. May 2012.
 Falkai P, Wobrock T, Lieberman J, et al. World Federation of Societies of Biological Psychiatry (WFSBP) guidelines for biological treatment of schizophrenia, Part 2: Long-term treatment of schizophrenia. World J Biol Psychiatry 2006; 7 (1): 5—40
 Patel MX, David AS. "Why aren't depot antipsychotics prescribed more often and what can be done about it?" Adv Psychiatr Treat, 2005; 11: 203-213.
 Kane, JM et al. "Guidelines for depot antipsychotic treatment in schizophrenia." Eur Neuropsychopharmacol, 1998; 8(1): 55-66.
Breakthrough in Eye Diseases
A team formed by HKUST biomaterial researchers develops the world’s first injectable hydrogel formulation that allows a long, sustainable release of protein therapeutics which can be used to treat eye diseases like macular degeneration and diabetic retinopathy. Nowadays, patients with these diseases have to be treated by monthly injection for years, which is far from an ideal treatment regime.
Team member Yu Yu, a postdoctoral fellow in Biomedical Engineering at HKUST, said: “Drugs formulated with our novel hydrogel material could be injectable as usual but release slowly from the depot, potentially providing effective long lasting treatment on patients.”
The hydrogel formulation is set to be injected only once per year, sparing patients from having to endure monthly injections. This helps cut down medical expenses and lower the risk associated with repeated injections, Prof. Ying Chau, Associate Professor form Biomedical Engineering at HKUST added.
Looking ahead, the team will move on to human clinical trials in three to four years. In the long run, the team targets to apply the medical treatment to underprivileged regions in China and many others, helping the needy patients get the medication at an affordable price.
The new development brought their company NovaMatrix Ltd. the third place at the fifth annual HKUST One Million Dollar Entrepreneurship Competition which aims to foster entrepreneurship and identify the best business plans.
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Betnovate is used to help relieve redness, itching, swelling, or other discomfort caused by skin conditions. This medicine is a corticosteroid (cortisone-like medicine or steroid).
Use Betnovate as directed by your doctor.
The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.
The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.
For redness, itching, and swelling of the skin:
Ask your health care provider any questions you may have about how to use Betnovate.
Store Betnovate at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Keep Betnovate out of the reach of children and away from pets.
Active Ingredient: Betamethasone.
Do NOT use Betnovate if:
Contact your doctor or health care provider right away if any of these apply to you.
Some medical conditions may interact with Betnovate. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
Some medicines may interact with Betnovate. Tell your health care provider if you are taking any other medicines, especially any of the following:
This may not be a complete list of all interactions that may occur. Ask your health care provider if Betnovate may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.
Important safety information:
If you suddenly stop taking Betnovate, you may have withdrawal symptoms, These may include unbalanced hormones (in both men and women).
All medicines may cause side effects, but many people have no, or minor, side effects.
Check with your doctor if any of these most common side effects persist or become bothersome:
Acne; clumsiness; dizziness; facial flushing; general body discomfort; headache; increased appetite; increased sweating; lightheadedness; nausea; nervousness; sleeplessness; upset stomach.
Seek medical attention right away if any of these severe side effects occur:
Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); black, tarry stools; changes in body fat; changes in menstrual periods; changes in skin color; chest pain; easy bruising or bleeding; irregular heartbeat; mental or mood changes (eg, depression); muscle pain, wasting, or weakness; seizures; severe nausea or vomiting; sudden severe dizziness or headache; swelling of feet or legs; symptoms of infection (eg, chills, fever, sore throat); tendon or bone pain; thinning of the skin; unusual skin sensation; unusual weight gain; vision changes or other eye problems; vomit that looks like coffee grounds.
This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.
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