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Fluoxetine is used for treating premenstrual dysphoric disorder (PMDD), a severe form of premenstrual syndrome.

Active Ingredient: fluoxetine

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Lovan diseases


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See LOVAN. supra note 79 (noting the Sixth Edition changes position on the AMA Guides.

THE AMA GUIDES SIXTH EDITION TASK FORCE MEMBER REPORT (2008) (discussing the costly impact of the Sixth Edition's complexity on physicians, claimants, attorneys, and administrators); LOVAN. supra note 79, at 6-7 (reporting testimony from medical experts that fewer physicians would be willing to perform impairment ratings under the Sixth Edition due to its increased complexity).

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Lovan (Fluoxetine) dosage, side effects

Lovan, drug and medicine, pharmacy

Generic Name: Fluoxetine

Uses of Lovan:

Lovan (fluoxetine) belongs to the group of antidepressants known as SSRIs and is from the same drug (fluoxetine) as Prozac. Fluoxetine (Prozac) is used to treat depression, obsessive-compulsive disorder, some eating disorders, and panic attacks. Fluoxetine (Sarafem) is used to relieve the symptoms of premenstrual dysphoric disorder, including mood swings, irritability, bloating, and breast tenderness. Fluoxetine is in a class of medications called selective serotonin reuptake inhibitors (SSRIs). It works by increasing the amount of serotonin, a natural substance in the brain that helps maintain mental balance.

This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information.

How to Take Lovan:

Take this medicine as directed. It can be taken with or without food. Do not stop taking this medicine abruptly without consulting with your doctor. The usual adult dose of Lovan is between 20mg and 60mg per day.

Side Effects of Lovan:

Some common side effects reported with this medicine include:

  • Headache,
  • nervousness,
  • insomnia,
  • drowsiness,
  • fatigue or asthenia,
  • anxiety,
  • tremor
  • , dizziness or lightheadedness,
  • nausea,
  • dry mouth,
  • diarrhea,
  • anorexia,
  • excessive sweating.
  • Less frequently, rash, pruritus, weight loss, sexual dysfunction, convulsions.
Warnings and precautions for Lovan
  • Not to be used with an MAOI or within 14 days of discontinuing MAOI therapy. Allow at least 5 weeks after stopping Prozac before starting an MAOI. Do not administer thioridazine with Prozac or within 5 weeks after Prozac has been discontinued.
  • Tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking. Be sure to mention any of the following: alprazolam (Xanax); anticoagulants ('blood thinners') such as warfarin (Coumadin); antidepressants (mood elevators) such as amitriptyline (Elavil), amoxapine (Asendin), clomipramine (Anafranil), desipramine (Norpramin), doxepin (Adapin, Sinequan), imipramine (Tofranil), nortriptyline (Aventyl, Pamelor), protriptyline (Vivactil), and trimipramine (Surmontil); diazepam (Valium); digoxin (Lanoxin); flecainide (Tambocor); insulin or oral medications for diabetes; lithium (Eskalith, Lithobid); medications for anxiety and Parkinson's disease; medications for mental illness such as clozapine (Clozaril), haloperidol (Haldol), and pimozide (Orap); medications for seizures such as carbamazepine (Tegretol) and phenytoin (Dilantin); sedatives; sleeping pills; sumatriptan (Imitrex); tranquilizers; tryptophan; and vinblastine (Velban). Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
  • Precautions: Pregnancy, lactation, patients < 18 years of age, elderly patients. History of allergic reactions, seizures, suicidal tendency, activation of mania/hypomania, MI or unstable heart disease, diabetes, severe renal or hepatic impairment, hypokalemia (following self-induced vomiting), hyponatremia, altered platelet function.
  • You should know that fluoxetine may make you drowsy. Do not drive a car or operate machinery until you know how this medication affects you.
  • Remember that alcohol can add to the drowsiness caused by this medication.
  • tell your doctor and pharmacist if you are allergic to fluoxetine or any other medications.
What to do if you take Overdose of Lovan?

Seek medical attention immediately. For non emergencies, contact your local or regional poison control center.

What to do if you take Missed Dose of Lovan?

Take your next dose as soon as you remember. If it is time for your next dose, skip the missed dose and go back to your regular schedule. Do not take a double dose to make up for a missed one.

How to Store Lovan:

Keep this medication in the container it came in, tightly closed, and out of the reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Throw away any medication that is outdated or no longer needed. Talk to your pharmacist about the proper disposal of your medication.

Lovan is Supplied:

10mg, 20 mg capsules; 20 mg/5 mL of mint-flavored syrup, 120 mL bottles.

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Premenstrual dysphoric disorder - Psychology Wiki

Premenstrual dysphoric disorder

Premenstrual dysphoric disorder (PMDD) is an illness associated with the luteal phase of the menstrual cycle. It is characterized by severe irritability, anxiety and anger. It is similar to premenstrual syndrome (PMS), but differs from it in severity and in that it requires treatment, because it interferes in a woman's ability to function in her environment. It has been proposed as a disorder requiring further study by the American Psychiatric Association in the DSM-IV-TR.

Contents Causes Edit

The cause of PMDD is not known, but several theories exist. One theory suggests it is due to the lack of serotonin (a neurotransmitter in the brain) and mediated by the levels of the level of sex hormones (progesterone and estrogen ) in the luteal phase of the menstrual cycle. A common treatment for PMDD is selective serotonin reuptake inhibitors (SSRIs), specially fluoxetine (Sarafem, also known as Prozac).

Epidemiology Edit

The comdition is thought to afflicting 3% to 8% of women. [3] It is a diagnosis associated with the luteal phase of the menstrual cycle.

Symptoms Edit

Like less severe forms of PMS, premenstrual dysphoric disorder follows a predictable, cyclic pattern. Symptoms begin in the late luteal phase of the menstrual cycle (after ovulation) and end shortly after menstruation begins. [4]

Emotional symptoms are generally present, and in PMDD, mood symptoms are dominant. [4] Substantial disruption to personal relationships is typical for women with PMDD. [4] Anxiety, anger, and depression may also occur. The main symptoms, which can be disabling, include [5]

  • feelings of deep sadness or despair, possible suicide ideation
  • feelings of tension or anxiety
  • increased sensitivity to rejection or criticism
  • panic attacks
  • mood swings, crying
  • lasting irritability or anger, increased interpersonal conflicts; typically sufferers are unaware of the impact they have on those close to them
  • apathy or disinterest in daily activities and relationships
  • difficulty concentrating
  • fatigue
  • food cravings or binge eating
  • insomnia or hypersomnia; sleeping more than usual, or (in a smaller group of sufferers) being unable to sleep
  • feeling overwhelmed or feelings of being out of control
  • increase or decrease in sex drive
  • increased need for emotional closeness

Common physical symptoms include:

  • breast tenderness or swelling, heart palpitations, headaches, joint or muscle pain, swollen face and nose
  • an altered view of one's body - a sensation of 'bloating', feeling fat or actual weight gain.

Five or more of these symptoms may indicate PMDD. Symptoms occur during the 2 weeks before the menstrual cycle and disappear within a few days after the onset of the bleeding.

Genetic links and possible causes Edit

In 2007, the first significant genetic finding in premenstrual dysphoric disorder was reported. [6] [7] Variants in the estrogen receptor alpha gene that are associated with PMDD. Women with these genetic variants were more likely to suffer from PMDD. They also discovered that this association is seen only in women with a variant form of another gene, catechol—o—methyltransferase (COMT), which is involved in regulating the function of the prefrontal cortex, a critical regulator of mood.

Previously, research showed that women with PMDD have an abnormal response to normal hormone levels, and, thus, are differentially sensitive to their own natural hormone changes.

There is objective correlational evidence of a neurological connection for PMDD distress. The self-rated cardinal mood symptoms of women suffering premenstrual dysphoria was found to be significantly correlated with the concomitant worsening of their brain serotonin precursors, measured by positron emission tomography (PET). [8]

While the cause of PMDD has not been definitively established, a leading theory suggests it is due to the lack of serotonin (a neurotransmitter ) and mediated by the fluctuations of the levels of sex hormones (progesterone. estrogen. and testosterone ) in the luteal phase of the menstrual cycle. [8]

Supporting the hypothesized important role of serotonin. a number of selective serotonin reuptake inhibitors (SSRIs) have been shown in clinical trials to effectively treat the mood component of PMDD when taken during the dysphoric phase.

Women with PMDD but have never experienced major depressive disorder (MDD) have lower sensitivity and response to stress and pain than people with MDD. [9] This suggests that PMDD is a separate disease from MDD.

Unipolar depression. anxiety disorders. and other Axis I disorders are more common in women with premenstrual dysphoric disorder (PMDD) than in women without PMDD. [10]

Status and controversy Edit

Originally called late luteal phase dysphoric disorder (LLPDD), the disorder was renamed PMDD by the American Psychiatric Association in its May 1993 revision of the DSM-IV. It is not recognized as a disorder in the DSM-IV. PMDD was moved from a position the DSM-IV in the appendix of the manual to a "disorder requiring further study." [11] [12]

PMDD is accepted as an illness by the Food and Drug Administration (FDA) but has not as yet been listed as a separate disorder in the World Health Organization 's International Classification of Diseases. In 2003, the manufacturer of Prozac (fluoxetine) was required by the Committee for Proprietary Medicinal Products to remove PMDD from the list of indications for fluoxetine sold in Europe. [13] The committee found that. PMDD is not a well-established disease entity across Europe. There was considerable concern that women with less severe pre-menstrual symptoms might erroneously receive a diagnosis of PMDD resulting in widespread inappropriate short and long-term use of fluoxetine. [14]

Some commentators suggest that PMDD (along with heart disease. borderline high blood pressure. mild hypercholesterolemia. social anxiety disorder. restless leg syndrome. and female sexual dysfunction ) has been marketed by pharmaceutical companies in order to increase the demand for treatments. [16] Some psychiatrists and women's groups say that labeling this severe form of PMS as a psychiatric disorder, rather than a physical disorder, is stigmatizing. Psychologist Peggy Kleinplatz has criticized the diagnosis as part of a trend in medicalization of normal human behavior. [17]

Treatment Edit

The primary goal of treatment is to reduce the woman's suffering and the disruption to her social relationships.

Lifestyle changes such as regular exercise and a well balanced diet may ameliorate some of the effects of PMDD. There is some evidence that vitamin B6 can alleviate symptoms. [18]

Certain SSRIs provide relief as well. [19] The U.S. Food and Drug Administration (FDA) has approved four medications for the treatment of PMDD: Fluoxetine (available as generic or as Prozac or Sarafem ), sertraline (Zoloft), paroxetine (Paxil) and escitalopram oxalate (Lexapro).

L-tryptophan. a serotonin precursor, was found in two studies to provide significant relief when supplemented daily in a large dose. [20]

See also Edit References Edit
  1. ↑ Halbreich U (December 2004). The diagnosis of premenstrual syndromes and premenstrual dysphoric disorder--clinical procedures and research perspectives. Gynecol. Endocrinol. 19 (6): 320–34.
  2. ↑ Endicott J, McLaughlin TP, Grudzinski AN (December 2003). Comparison of managed care charges among patients treated with selective serotonin reuptake inhibitors for premenstrual dysphoric disorder. J Clin Psychiatry 64 (12): 1511–6.
  3. ↑ PMDD affects ". 3-8% of women of reproductive age. Assessment of published reports demonstrate that the prevalence of clinically relevant dysphoric premenstrual disorder is probably higher. 13-18% of women of reproductive age may have premenstrual dysphoric symptoms severe enough to induce impairment and distress, though the number of symptoms may not meet the arbitrary count of 5 symptoms on the PMDD list." PMID 12892987
  4. ↑ 4.0 4.1 4.2 Steiner, Pearlstein, et al. "Expert guidelines for the treatment of severe PMS, PMDD, and comorbidities: the role of SSRIs." J Womens Health (Larchmt). 2006 Jan-Feb;15(1):57-69 PMID 16417420
  5. ↑ Premenstrual Syndrome: "What is Premenstrual Dysphoric Disorder (PMDD?)"
  6. ↑ Huo L, Straub RE, Roca C, Schmidt PJ, Shi K, Vakkalanka R, Weinberger DR, Rubinow DR (October 2007). Risk for premenstrual dysphoric disorder is associated with genetic variation in ESR1, the estrogen receptor alpha gene. Biol. Psychiatry 62 (8): 925–33.
  7. ↑ "UNC Center for Women's Mood Disorders" http://www.med.unc.edu/psych/wmd/research/pmdd
  8. ↑ 8.0 8.1 Eriksson O, Wall A, Marteinsdottir I, et al. (March 2006). Mood changes correlate to changes in brain serotonin precursor trapping in women with premenstrual dysphoria. Psychiatry Res 146 (2): 107–16.
  9. ↑ Klatzkin RR, Lindgren ME, Forneris CA, Girdler SS (May 2010). Histories of major depression and premenstrual dysphoric disorder: Evidence for phenotypic differences. Biol Psychol 84 (2): 235–47.
  10. ↑ Kim DR, Gyulai L, Freeman EW, Morrison MF, Baldassano C, Dubé B (February 2004). Premenstrual dysphoric disorder and psychiatric co-morbidity. Arch Womens Ment Health 7 (1): 37–47.
  11. ↑ includeonly>Laurence, Leslie. "Psychiatric group scruitinzes categorizing form of PMS", Chicago Tribune. 1993-05-16.
  12. ↑ includeonly>Lehman, Betsy. "A little revision is creating a big furor", Boston Globe. 1993-05-10.
  13. ↑ Ray Moynihan (2004-02-14). Controversial disease dropped from Prozac product information. BMJ 328 (7436): 7436.
  14. ↑ European Agency for the Evaluation of Medicinal Products, Committee for Proprietary Medicinal Products. Summary Information. for Prozac and associated names.
  15. ↑ Sertraline (Zoloft), fluoxetine (Lovan, Prozac) for premenstrual dysphoric disorder (PMDD) National Prescribing Service Limited. (Australia)
  16. ↑ Mintzes B (April 2006). Disease mongering in drug promotion: do governments have a regulatory role. PLoS Med. 3 (4): e198.
  17. ↑ Offman A, Kleinplatz PJ (2004). Does PMDD Belong in the DSM? Challenging the Medicalization of Women's Bodies. The Canadian Journal of Human Sexuality. Vol. 13
  18. ↑ http://altmed.creighton.edu/pmdd/b6.htm
  19. ↑ Premenstrual Syndrome
  20. ↑ Steinberg S, Annable L, Young SN, Liyanage N (1999). A placebo-controlled study of the effects of L-tryptophan in patients with premenstrual dysphoria. Adv. Exp. Med. Biol. 467. 85–8.
External links Edit

Lovan - Uses, Dosage, Precautions, Drug Interactions and Side Effects

Brand Name: Fluox Other names: Afzot, Barozac, Dawnex, Depzac, Faxtin, Fludac, Flugen, Flunat, Flunil, Fluron Drug Class: serotonin Uptake Inhibitor, Antidepressant Uses of Lovan:

Lovan is an antidepressant belonging to the class of Serotonin Uptake Inhibitors (SSRIs) and is used in the treatment of stress, anxiety, depression, bulimia, narcolepsy, obsessive compulsive disorder, postpartum depression, premenstrual dysphoric disorder and fibromyalgia. It works by inhibiting the reuptake of the neurotransmitter serotonin at the synaptic cleft.


It is recommended to take this medicine as prescribed by your doctor. Do not stop taking Lovan abruptly as it may worsen your present condition. You can take it with or without food.

Warning and Precautions:

Do not take Lovan if you are hypersensitive to Fluoxetine.

Lovan should not be give to patients with severe kidney or liver disorder.

Do not give this medicine to patients taking mono amine oxidase inhibitors (MAOIs).

Tell your doctor if you have bee diagnosed with or have a history of unstable epilepsy, liver failure, renal impairment, cardiovascular disease or diabetes before taking Lovan.

Safety of this drug has not yet been established in pregnancy. Thus, you must not take it if you are pregnant or planning to become pregnant.

Drug Interactions:

Lovan can cause a transient shift in plasma concentration of protein bound drugs such as Warfarin and Digoxin resulting in adverse effects. It can prolong the half life of Diazepam. It Lovan is taken along with mono amine oxidase inhibitors (MAOIs), it can result in a serious reaction. Therefore, it is advised to start Lovan therapy only after 14 days of stopping MAOI therapy. When Lovan is combined with other antidepressants it leads to a two-fold increase in the plasma levels which can be very dangerous.

Side effects of Lovan:

Some of the most common side effects of the medication include nervousness, headache, insomnia, anxiety, tremor, drowsiness, dry mouth, nausea, vomiting, increased sweating, diarrhea, seizures, mania, hypomania or mixed manic states, hyponatraemia and the elevation of hepatic enzymes. Lovan can also cause vasculitis in patients with rash leading to lung, kidney and liver failure.

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Lovan Side Effects

Lovan Side Effects Track Your Side Effects

Note Your Observations

It is really important to keep track of your health symptoms, right from the time you start a new medicine. You can do it any way you prefer: in a notebook, in a computer file or using our online tool. You should also note down any other medicines you are taking at the same time, because there could be an interaction between these medicines.

Why Your Notes are Important

Your notes could be helpful in several ways:

  • You can use them to remind you of details that may alert your health care professional(s) to a problem
  • You will have a record to refer to in the future, in case you are ever prescribed the same medicine again

    You can use the following log form to write down important information, like the date and time you experienced a side effect and your symptoms, how strong the symptoms were, and any other medicines you were using.

    Medicine Name and Dosage:

    Other Medicine(s) or Treatment(s)

    Scale: 1 = very mild to 10 = very bad

    Side effects reports are analyzed to discover potential health product safety signals. Some important reactions may take an extremely long time to develop or occur infrequently. Continued monitoring of adverse reactions is thus essential to maintain a comprehensive safety and effectiveness profile of health products.

    You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

    Lovan reports list potential signals of serious risks and new safety information that were identified using the FDA Adverse Event Reporting System (FAERS).
    FAERS is a database that contains information on adverse event and medication errors reports submitted to FDA by healthcare professionals (such as physicians, pharmacists, nurses and others), consumers (such as patients, family members, layers and others) and manufacturers.

    Discuss Lovan Side Effects Did You Have a Lovan Side Effect? View Results How Effective is Lovan for You? View Results Lovan Safety Alerts, Active Ingredients, Usage Information

    Side Effects reported to FDA: 14

    Lovan safety alerts: No

    Reported deaths: 2

    Reported hospitalizations: 4

    Lovan Reviews

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    Czech exonyms — For exonyms in the Polish part of Cieszyn Silesia, see List of Czech exonyms for places in the Polish part of Cieszyn Silesia. The following is a list of Czech exonyms, that is to say names for places that do not speak Czech that have been… … Wikipedia

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