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Theodrip

Category: Allergies

Description

Quibron-T (Theophylline) is a bronchodilator used to treat the symptoms of asthma, chronic bronchitis, and emphysema.

Active Ingredient: Theophylline

Quibron-t (Theodrip) as known as: Accurbron, Aerobin, Afonilum, Alcophyllin, Aminophyllin, Ardephyllin, Asmanyl, Asmasolon, Bronchofyline, Bronchoretard, Bronkolin, Bronsolvan, Bufabron, Contiphyllin, Crisasma, Cylmin, Diffumal, Dilatrane, Drilyna, Duralyn, Durofilin, Egifilin, Elixifilin, Elixine, Elixophyllin, Etipramid, Eufilina, Euphyllin, Euphyllina, Euphylong, Flemphyline, Franol, Histafilin, Lasma, Liopect, Marex, Microphyllin, Nefoben, Neulin, New tedral, Nosma, Nuelin, Pediaphyllin pl, Pharmafil, Phylobid, Phyloday, Pirasmin, Pneumogéine, Pulmeno, Pulmophyllin, Pulmophylline, Pulmotractan, Quibron, Respicur, Retafyllin, Retaphyl, Sekiroid, Slo-phyllin, Sol-bid, Solosin, Sophafyllin, Spophyllin, Talofilina, Talotren, Tédralan, Telbans ds, Telin, Teobag, Teobid, Teofilina, Teofurmate, Teofylamin sad, Teokap, Teolin, Teolixir, Teolong, Teosona, Teotard, Terdan, Teromol, Theacitin, Theo, Theobid, Theobron, Theochron, Theocin, Theoday, Theodrip, Theodur, Theofol, Theolair, Theolin, Theolong, Theomol, Theoped, Theophar, Théophylline, Theophyllinum, Theoplus, Theospirex, Theostat, Theotard, Theotrim, Theovent, Theracap 131, Thioped, Thoin, Thromphyllin, Tromphyllin, Uni-dur, Unicon, Unicontin, Unifyl continus, Uniphyl, Uniphyllin, Unixan, Xanthium, Zepholin

H Kawai

H Kawai Publications
  1. Pharmacokinetic study of theophylline in dogs after intravenous administration with and without ethylenediamine

H Kawai
Omiya Research Laboratory, Nikken Chemicals Co, Ltd, Saitama, Japan
Methods Find Exp Clin Pharmacol 22:179-84. 2000

  • Usefulness and safety of theophylline injection form (Theodrip) for the treatment of acute asthma

    J Kojima
    Department of Medical Development, Nikken Chemicals Co, Ltd, Tokyo, Japan
    Methods Find Exp Clin Pharmacol 22:247-52. 2000

    Collaborators
    • J Kojima
    • H Fukui
    • H Katoh
    • A Ohnishi
    • K Onodera
    • T Taniguchi
    Detail Information Publications 2
    1. Pharmacokinetic study of theophylline in dogs after intravenous administration with and without ethylenediamine

    H Kawai
    Omiya Research Laboratory, Nikken Chemicals Co, Ltd, Saitama, Japan
    Methods Find Exp Clin Pharmacol 22:179-84. 2000

  • Usefulness and safety of theophylline injection form (Theodrip) for the treatment of acute asthma

    J Kojima
    Department of Medical Development, Nikken Chemicals Co, Ltd, Tokyo, Japan
    Methods Find Exp Clin Pharmacol 22:247-52. 2000

    Theodrip consists of 200 mg theophylline and 200 ml physiological saline in a plastic bag. Therefore, Theodrip, which does not contain ethylenediamine, is expected to have less adverse effects and be easier to handle than aminophylline.

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    Theodrip - Vasodilator Agents, Bronchodilator Agents, Respiratory Smooth Muscle Relaxants, ATC: R03DA04

    Theodrip Theodrip Brand names, Theodrip Analogs Theodrip Brand Names Mixture
    • Bronchyl Syrup (alcohol anhydrous + beechwood creosote + cocillana + eucalyptus + guaiacol oleate + ipecac + lobelia inflata + menthol + myroxylon balsamum + theophylline + white pine)
    • Choledyl Expectorant Elixir (guaifenesin + oxtriphylline)
    • Diuerb tab (oil of fleabane + theophylline + urea)
    • IDM Expectorant tab (guaifenesin + potassium iodide + pyrilamine maleate + theophylline)
    • IDM tab (potassium iodide + pyrilamine maleate + theophylline)
    • PMS-Oxtriphylline Elixir (alcohol anhydrous + oxtriphylline)
    • Pulmo Septol Sirop (beechwood creosote + cocillana + eucalyptus oil + guaiacol + ipecac + lobelia inflata + myroxylon balsamum + theophylline + white pine)
    • Ratio-theo-bronc (guaifenesin + potassium iodide + pyrilamine maleate + theophylline)
    • Tedral tab (l-ephedrine hydrochloride + phenobarbital + theophylline)
    • Theophylline 0.8mg and 5% dextrose inj (dextrose + theophylline)
    • Theophylline 0.8mg/ml in 5% dextrose inj (dextrose + theophylline)
    • Theophylline 1.6mg and 5% dextrose inj (dextrose + theophylline)
    • Theophylline 4mg and 5% dextrose inj (dextrose + theophylline)
    • Theophylline rougier elixir (alcohol anhydrous + theophylline)
    Theodrip Chemical_Formula Theodrip RX_link Theodrip fda sheet Theodrip msds (material safety sheet) Theodrip Synthesis Reference

    Traube, Ber. 33, (1940)

    Theodrip Molecular Weight Theodrip Melting Point Theodrip H2 O Solubility Theodrip State Theodrip LogP Theodrip Dosage Forms

    Capsule (sustained-release); Elixir; Liquid; Tablet; Tablet (extended-release)

    Theodrip Indication

    For the treatment of the symptoms and reversible airflow obstruction associated with chronic asthma and other chronic lung diseases, such as emphysema and chronic bronchitis.

    Theodrip Pharmacology

    Theophylline, an xanthine derivative chemically similar to caffeine and theobromine, is used to treat asthma and bronchospasm. Theophylline has two distinct actions in the airways of patients with reversible (asthmatic) obstruction; smooth muscle relaxation (i.e. bronchodilation) and suppression of the response of the airways to stimuli (i.e. non-bronchodilator prophylactic effects).

    Theodrip Absorption

    Theophylline is rapidly and completely absorbed after oral administration in solution or immediate-release solid oral dosage form.

    Theodrip side effects and Toxicity

    Symptoms of overdose include seizures, arrhythmias, and GI effects.

    Theodrip Patient Information

    Immediate Release Products

    The patient (or parent/care giver) should be instructed to seek medical advice whenever nausea, vomiting, persistent headache, insomnia or rapid heart beat occurs during treatment with theophylline, even if another cause is suspected. The patient should be instructed to contact their clinician if they develop a new illness, especially if accompanied by a persistent fever, if they experience worsening of a chronic illness, if they start or stop smoking cigarettes or marijuana, or if another clinician and a new medication or discontinues a previously prescribed medication. Patients should be instructed to inform all clinicians involved in their care that they are taking theophylline, especially when a medication is being added or deleted from their treatment. Patients should be instructed to not alter the dose, timing of the dose, or frequency of administration without first consulting their clinician. If a dose is missed, the patient should be instructed to take the next dose at the usually scheduled time and to not attempt to make up for the missed dose.

    This information is intended to aid in the safe and effective use of this medication. It is not a disclosure of all possible adverse or intended effects.

    The physician should reinforce the importance of taking only the prescribed dose and the time interval between doses. As with any controlled-release theophylline product, the patient should alert the physician of symptoms occur repeatedly, especially near the end of the dosing interval.

    When prescribing administration by the sprinkle method, details of the proper technique should be explained to patient

    Patients should be informed of the need to take this drug in the fasting state, and that drug administration should be 1 hour before or 2 hours after meals.

    Theodrip Organisms Affected

    Humans and other mammals

    Theodrip (Generic name - Theophylline) Online Information

    Theodrip - General Information: Theodrip - Pharmacology:

    Theodrip relaxes the smooth muscle of the bronchial airways and pulmonary blood vessels and reduces airway responsiveness to histamine, methacholine, adenosine, and allergen. Theodrip competitively inhibits type III and type IV phosphodiesterase (PDE), the enzyme responsible for breaking down cyclic AMP in smooth muscle cells, possibly resulting in bronchodilation. Theodrip also binds to the adenosine A2B receptor and blocks adenosine mediated bronchoconstriction.

    Theodrip for patients

    Immediate Release Products

    The patient (or parent/care giver) should be instructed to seek medical advice whenever nausea, vomiting, persistent headache, insomnia or rapid heart beat occurs during treatment with theophylline, even if another cause is suspected. The patient should be instructed to contact their clinician if they develop a new illness, especially if accompanied by a persistent fever, if they experience worsening of a chronic illness, if they start or stop smoking cigarettes or marijuana, or if another clinician and a new medication or discontinues a previously prescribed medication. Patients should be instructed to inform all clinicians involved in their care that they are taking theophylline, especially when a medication is being added or deleted from their treatment. Patients should be instructed to not alter the dose, timing of the dose, or frequency of administration without first consulting their clinician. If a dose is missed, the patient should be instructed to take the next dose at the usually scheduled time and to not attempt to make up for the missed dose.

    This information is intended to aid in the safe and effective use of this medication. It is not a disclosure of all possible adverse or intended effects.

    The physician should reinforce the importance of taking only the prescribed dose and the time interval between doses. As with any controlled-release theophylline product, the patient should alert the physician of symptoms occur repeatedly, especially near the end of the dosing interval.

    When prescribing administration by the sprinkle method, details of the proper technique should be explained to patient

    Patients should be informed of the need to take this drug in the fasting state, and that drug administration should be 1 hour before or 2 hours after meals.

    Theodrip Interactions

    Theophylline interacts with a wide variety of drugs. The interaction may be pharmacodynamic, i.e. alterations in the therapeutic response to theophylline or another drug or occurrence of adverse effects without a change in serum theophylline concentration. More frequently, however, the interaction is pharmacokinetic, i.e. the rate of theophylline clearance is altered by another drug resulting in increased or decreased serum theophylline concentrations. Theophylline only rarely alters the pharmacokinetics of other drugs.

    The drugs listed in TABLES 2A and 2B have the potential to produce clinically significant pharmacodynamic or pharmacokinetic interactions with theophylline. The information in the "Effect" column of TABLES 2A and 2B assumes that the interacting drug is being added to a steady-state theophylline regimen. If theophylline is being initiated in a patient who is already taking a drug that inhibits theophylline clearance (e.g., cimetidine, erythromycin), the dose of theophylline required to achieve a therapeutic serum theophylline concentration will be smaller. Conversely, if theophylline is being initiated in a patient who is already taking a drug that enhances theophylline clearance (e.g., rifampin), the dose of theophylline required to achieve a therapeutic serum theophylline concentration will be larger. Discontinuation of a concomitant drug that increases theophylline clearance will result in accumulation of theophylline to potentially toxic levels, unless the theophylline dose is appropriately reduced. Discontinuation of a concomitant drug that inhibits theophylline clearance will result in decreased serum theophylline concentrations, unless the theophylline dose is appropriately increased.

    The listing of drugs in TABLES 2A and 2B is current as of April 3, 1995. New interactions are continuously being reported for theophylline, especially with new chemical entities. The clinician should not assume that a drug does not interact with theophylline if it is not listed in TABLES 2A and 2B. Before addition of a newly available drug in a patient receiving theophylline, the package insert of the new drug and/or the medical literature should be consulted to determine if an interaction between the new drug and theophylline has been reported.

    TABLE 2A - Clinically significant drug interactions with theophylline*

    Type of Interaction

    ** Average effect on steady state theophylline concentration or other clinical effect for pharmacologic interactions. Individual patients may experience larger changes in serum theophylline concentration than the value listed.


    The Effect of Other Drugs on Theophylline Serum Concentration Measurements: Most serum theophylline assays in clinical use are immunoassays which are specific for theophylline. Other xanthines such as caffeine, dyphylline, and pentoxifylline are not detected by these assays. Some drugs (e.g.. cefazolin, cephalothin), however, may interfere with certain HPLC techniques. Caffeine and xanthine metabolites in neonates or patients with renal dysfunction may cause the reading from some dry reagent office methods to be higher than the actual serum theophylline concentration.

    Theodrip Contraindications

    This product is contraindicated in individuals who have shown hypersensitivity to its components. It is also contraindicated in patients with active peptic ulcer disease, and in individuals with underlying seizure disorders (unless receiving appropriate anti-convulsant medication).

    Indication, Mechanism Of Action, Food Interactions, Chemical, etc..

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