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Furoside

Category: Blood Pressure

Description

Furosemide is used for treating fluid build-up and swelling caused by congestive heart failure, liver cirrhosis, or kidney disease.

Active Ingredient: furosemide

Furosemide (Furoside) as known as: Apo-furosemide, Diurin, Froop, Frusemide, Frusid, Frusol, Furorese, Furosemida, Furosemidum, Furoside, Fusid, Impugan, Myrosemide, Novosemide, Rusyde, Seguril, Tenkafruse, Uritol

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Furoside Indications

Furoside is used for treating fluid build-up and swelling caused by congestive heart failure, liver cirrhosis, or kidney disease. It is also used in combination with other medicines to treat fluid build-up in the lungs. Furoside is a loop diuretic. Loop diuretics make the kidneys eliminate larger amounts of electrolytes (especially sodium and potassium salts) and water than normal (diuretic effect). Loop diuretics are useful for treating many conditions in which salt and water retention (eg, edema, swelling) is a problem.

Furoside Instructions

Use Furoside as directed by your doctor.

  • Do not take the medication in larger amounts, or take it for longer than recommended by your doctor. Follow the directions on your prescription label.
  • Your doctor may occasionally change your dose to make sure you get the best results from this medication.
  • Take Furoside by mouth with or without food.
  • To be sure Furoside is not causing harmful effects, your blood will need to be tested on a regular basis. Your kidney or liver function may also need to be tested. Do not miss any scheduled appointments.
  • If you are being treated for high blood pressure, keep using this medication even if you feel fine. High blood pressure often has no symptoms.
  • Furoside may increase the amount of urine or cause you to urinate more often when you first start taking it. To keep this from disturbing your sleep, try to take your dose before 6 pm.
  • If you miss a dose of Furoside, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Furoside.

Furoside Storage

Store Furoside at room temperature between 68 and 77 degrees F (20 and 25 degrees C) in a tightly closed container. Brief periods at temperatures of 59 to 86 degrees F (15 to 30 degrees C) are permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Furoside out of the reach of children and away from pets.

Do NOT use Furoside if:

  • you are allergic to any ingredient in Furoside
  • you are unable to urinate.

Contact your doctor or health care provider right away if any of these apply to you.

Some medical conditions may interact with Furoside. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have fluid in your abdomen, hearing impairment, liver disease, diabetes mellitus, low urine output, high blood uric acid levels, a blood disorder, kidney disease, or lupus; you have had a heart attack; or you are dehydrated.

Some medicines may interact with Furoside. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Nonsteroidal anti-inflammatory drugs (NSAIDs) (eg, ibuprofen, indomethacin) because they may decrease Furoside's effectiveness
  • Aminoglycosides (eg, gentamicin), angiotensin-converting enzyme (ACE) inhibitors (eg, captopril), ethacrynic acid, or salicylates (eg, aspirin) because serious side effects to the kidneys (decreased ability to urinate) and ears (hearing loss) may occur
  • Chloral hydrate because side effects, such as excessive sweating, rapid heart beat, and changes in blood pressure, may occur
  • Digoxin or lithium because the risk of their side effects may be increased by Furoside.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Furoside may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

Important Furoside Safety Information
  • Furoside may cause dizziness. These effects may be worse if you take it with alcohol or certain medicines. Use Furoside with caution. Do not drive or perform other possible unsafe tasks until you know how you react to it.
  • Furoside may cause dizziness, lightheadedness, or fainting; alcohol, hot weather, exercise, or fever may increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Sit or lie down at the first sign of any of these effects.
  • Diabetes patients - Furoside may affect your blood sugar. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine.
  • Blood pressure should be monitored when taking Furoside.
  • Your doctor may also prescribe a potassium supplement while you use Furoside. Check with your doctor before you use a salt substitute or other product that also has potassium in it.
  • Furoside may cause you to become sunburned more easily. Avoid the sun, sunlamps, or tanning booths until you know how you react to Furoside. Use a sunscreen or wear protective clothing if you must be outside for more than a short time.
  • Lab tests, including complete blood cell counts, may be performed while you use Furoside. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
  • Caution is advised when using Furoside in children; they may be more sensitive to its effects.
  • Pregnancy and breast-feeding: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Furoside while you are pregnant. Furoside is found in breast milk. If you are or will be breast-feeding while you use Furoside, check with your doctor. Discuss any possible risks to your baby.

All medicines may cause side effects, but many people have no, or minor, side effects.

Check with your doctor if any of these most common side effects persist or become bothersome:

Abnormal skin sensations; bladder spasm; blurred vision; constipation; cramping; dizziness; dizziness when rising from a seated or lying position; feeling of whirling motion; fever; headache; lightheadedness; mouth and stomach irritation; muscle spasm; nausea; redness; restlessness; ringing in the ears; seeing a yellow color; sensitivity to sunlight; vein inflammation.

Seek medical attention right away if any of these severe side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); confusion; diarrhea; drowsiness; dry mouth; excessive urination; hearing loss; loss of appetite; muscle pain/cramps/weakness; rapid or irregular heartbeat; restlessness; sudden joint pain; unusual bleeding or bruising; unusual thirst; unusual tiredness or weakness; vomiting; yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.

Other articles

Misdiagnosis of Medication Causes of Gout

Drug Causes of Gout Medication causes list: The list of possible medications or substances mentioned in sources as possibe causes of Gout includes:
  • Accure
  • Aldactazide
  • Amlodipine and Benazepril
  • Aspirin
  • Coversyl Plus
  • Cyclosporine - an immunosuppressant.
  • Dapa-Tabs
  • Diuretics
  • Dyazide
  • Edecril
  • Ethacrynic Acid
  • Indahexal
  • Indapamide
  • Insig
  • Isohexal
  • Isotretinoin
  • Isotrex
  • IsotrexGel
  • Levodopa - used for Parkinson's disease.
  • Lotrel
  • Maxzide
  • Maxzide-25
  • Moduretic
  • Nadide
  • Napamide
  • Natrilix
  • Niacin (vitamin B3) - excessive niacin can cause gout and high blood sugars.
  • Nicotinic acid
  • Oratane
  • Pyrazinamide
  • Pyrazynamide
  • Roaccutane
  • Salicylates
  • Salicylic acid
  • Spironazide
  • Spirozide
  • Zinamide
Drug interactions causing Gout:

When combined, certain drugs, medications, substances or toxins may react causing Gout.

The list below is incomplete and various other drugs or substances may cause your symptoms. Always advise your doctor of any medications or treatments you are using, including prescription, over-the-counter, supplements, herbal or alternative treatments.

  • Albert Furosemide and Cyclosporine interaction
  • Albert Furosemide and Sandimmune interaction
  • Apo-Furosemide and Cyclosporine interaction
  • Apo-Furosemide and Sandimmune interaction
  • Cyclosporine and Furosemide interaction
  • Cyclosporine and Lasix interaction
  • Fumide MD and Cyclosporine interaction
  • Fumide MD and Sandimmune interaction
  • Furocot and Cyclosporine interaction
  • Furocot and Sandimmune interaction
  • Furomide MD and Cyclosporine interaction
  • Furomide MD and Sandimmune interaction
  • Furose and Cyclosporine interaction
  • Furose and Sandimmune interaction
  • Furosemide and Cyclosporine interaction
  • Furosemide and Sandimmune interaction
  • Furosemide-10 and Cyclosporine interaction
  • Furosemide-10 and Sandimmune interaction
  • Furoside and Cyclosporine interaction
  • Furoside and Sandimmune interaction
  • Lasaject and Cyclosporine interaction
  • Lasaject and Sandimmune interaction
  • Lasimide and Cyclosporine interaction
  • Lasimide and Sandimmune interaction
  • Lasix and Cyclosporine interaction
  • Lasix and Sandimmune interaction
  • Lasix Special and Cyclosporine interaction
  • Lasix Special and Sandimmune interaction
  • Lo-Aqua and Cyclosporine interaction
  • Lo-Aqua and Sandimmune interaction
  • Luramide and Cyclosporine interaction
  • Luramide and Sandimmune interaction
  • Myrosemide and Cyclosporine interaction
  • Myrosemide and Sandimmune interaction
  • Neoral and Furosemide interaction
  • Neoral and Lasix interaction
  • Novo-Semide and Cyclosporine interaction
  • Novo-Semide and Sandimmune interaction
  • Ro-Semide and Cyclosporine interaction
  • Ro-Semide and Sandimmune interaction
  • Sandimmune and Furosemide interaction
  • Sandimmune and Lasix interaction
  • SangCya and Furosemide interaction
  • SangCya and Lasix interaction
  • SK-Furosemide and Cyclosporine interaction
  • SK-Furosemide and Sandimmune interaction
  • Uritol and Cyclosporine interaction
  • Uritol and Sandimmune interaction
About medication causes:

Another misdiagnosis possibility is that a particular medication or substance may be the real cause of the disease. Certain medications, chemicals, toxins or substances may possibly be underlying causes of Gout. Side effects of medications, or exposure to toxins, chemicals, or other substances may cause a symptom or condition. Hence, they become possible underlying causes of Gout but are often misdiagnosed or overlooked as a cause. For a general overview of this misdiagnosis issue, see Medication Underlying Cause Misdiagnosis.

Medical Tools & Articles:

Lasix drug category - ClairNava s blog


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Date: 20.05.2012
author: plemecin

lasix drug category


Image Collection (categories) Allergic Skin Disorders; Bacterial Skin Diseases. Furosemide (Lasix) is a drug (diuretic) prescribed for the treatment of edema (excess.

Lasix and Pregnancy - Blood Pressure Home Page


Furosemide Drug Information from Drugs.com. Includes. Apo-Furosemide 3; Bumex 1; Edecrin 2; Furoside 3; Lasix 3. Category: Diagnostic aid adjunct (renal disease)—Furosemide;
What other drugs will affect Lasix? If you take sucralfate (Carafate), take it at least 2. Pregnancy Category Risk cannot be ruled out. Approval History Tablet; Oral FDA.

Lasix - Senior Health

  • Lasix (Furosemide) Drug Information: Description, User Reviews.
    Furosemide Drug Information, Professional


    Lasix. From Marian Anne Eure, former About.com Guide. -This drug may make your skin more sensitive to. By Category
    furosemide (Lasix) - drug class, medical uses, medication side.
    It may not be safe to take Lasix during pregnancy, as the drug could cause harm to the. The FDA has classified Lasix as a pregnancy Category C medication, meaning the.
    Lasix Information from Drugs.com
    Learn about the prescription medication Lasix (Furosemide), drug uses, dosage, side effects, drug interactions, warnings, reviews and patient labeling.
    Image Collection (categories) Allergic Skin Disorders; Bacterial Skin Diseases. BRAND NAME: Lasix. DRUG CLASS AND MECHANISM: Furosemide is a potent diuretic (water.
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    lasix drug category Lasix (Furosemide) Drug Information: Description, User Reviews.

    The comments to this entry are closed.

  • Diuretics, Loop

    Category
    • Antihypercalcemic - Bumetanide; Ethacrynic Acid; Furosemide
    • Antihypertensive - Bumetanide; Ethacrynic Acid; Furosemide
    • Diagnostic aid adjunct, renal disease - Furosemide
    • Diuretic - Bumetanide; Ethacrynic Acid; Furosemide
    Description

    Loop diuretics are given to help reduce the amount of water in the body. They work by acting on the kidneys to increase the flow of urine.

    Furosemide is also used to treat high blood pressure (hypertension) in those patients who are not helped by other medicines or in those patients who have kidney problems.

    High blood pressure adds to the work load of the heart and arteries. If it continues for a long time, the heart and arteries may not function properly. This can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure. High blood pressure may also increase the risk of heart attacks. These problems may be less likely to occur if blood pressure is controlled.

    Loop diuretics may also be used for other conditions as determined by your doctor.

    This medicine is available only with your doctor's prescription, in the following dosage forms:
      Oral
    • Bumetanide
      • Tablets (U.S.)
    • Ethacrynic Acid
      • Oral solution (U.S. and Canada)
      • Tablets (U.S. and Canada)
    • Furosemide
      • Oral solution (U.S. and Canada)
      • Tablets (U.S. and Canada)
      Parenteral
    • Bumetanide
      • Injection (U.S.)
    • Ethacrynic Acid
      • Injection (U.S. and Canada)
    • Furosemide
      • Injection (U.S. and Canada)
    Brand Names

    Some commonly used brand names are:

    • Apo-Furosemide 3
    • Edecrin 2
    • Furoside 3
    • Lasix 3
    • Lasix Special 3
    • Novosemide 3
    • Uritol 3

    Med Surg Chapter 38 (Slides) flashcards

    Med Surg Chapter 38 (Slides) Like this study set? Create a free account to save it. Sign up for an account Create an account

    Stable plaque is a white, glistening, fibrous elevation that covers a lipid (primarily cholesterol) core.
    When stable plaque ruptures, thrombosis and vessel constriction obstruct the lumen, causing inadequate perfusion to distal tissues.

    Unstable plaque

    By contrast, unstable plaque has a liquid lipid core.
    Unstable plaque rupture causes more severe damage.
    the exposed underlying tissue causes platelet adhesion and rapid thrombus (clot) formation. The thrombus may suddenly block a blood vessel, resulting in ischemia and infarction (e.g. myocardial infarction).

    Risk Factors

    Genetic predisposition and diabetes
    Some pts have familial hyperlipidemia(an elevation of serum lipid levels). In these people, the liver makes excessive cholesterol and other fats. In some people with hereditary atherosclerosis, however, the blood cholesterol level is normal

    FUROSEMIDE, adverse effects, dosage, drug interactions

    Prescription is required

    THERAPEUTI C INDICATIONS
    Furosemide is a diuretic (which causes an increase in the removal of water by the kidneys) and is used to reduce edema associated with certain diseases of the heart, liver and kidney to control high blood pressure especially when the kidneys malfunctioning.

    USAGE
    The starting dose for treatment of edema is 20 to 80 mg, according to the effect, subsequent doses given every six hours should be maintained, reduced or increased. Subsequently, the maintenance dose is divided in one to three times a day. Often, this drug is given two to four days a week, then a few days off.

    For the treatment of hypertension, the first doses should be between 20 and 40 mg twice a day, if another medication is given to control hypertensi on, it is necessary to reduce the dose of other antihypertensive agent in half early treatment with furosemide, the doses of both drugs are then adjusted to achieve the best results.

    It is not advisable to exceed 40 mg 2 times per day furosemide to treat hypertension.

    The duration of action of furosemide is 4 to 6 hours (up to 8 hours), so it is advisable to take the last dose several hours before bed, otherwise you will have to get up at night to urinate.

    Within 1 or 2 weeks may be necessary before determining if this treatment is effective in lowering blood pressure.

    ADVERSE EFFECTS
    Laboratory experi ments show that furosemide may cause birth defects in children of mothers who took the drug during pregnancy, in fact, any woman of childbearing age and children should avoid furosemide.

    The complete cessation of renal function, manifested by a cessation of urine production, is a cons-strict indication for use of furosemide. On the other hand, people who have impaired liver function, diabetes, a history of gout or lupus, or pancreatitis may see their condition worsen or become more difficult to control during this treatment.

    The use of diuretics to lose weight is unnecessary and dangerous.

    POSSIBLE SIDE EFFECTS
    Furosemide is as dangerous as any other diuretics. In addition, as this drug works very quickly, it can easily cause severe dehydration and electrolyte imbalance in the blood, which is manifested by weakness, dizziness, lethargy, leg cramps, loss of appetite, vomiting and mental confusion.

    Especially when it is given intravenously, furosemide may cause fluid loss can lead to shock, with dramatic drop in blood pressure and risk of blood clots.

    Bizarre symptoms are sometimes reported following ingestion of the drug: the ringing in the ears, deafness or irreversible (especially when injected rapidly in large doses to patients with severe renal impairment), a loss of sensitivity to a body part and a sweet taste.

    DRUG INTERACTIONS
    Furosemide is dangerous when used in conjunction with certain other drugs:

    • The antibiotic cephloridine: risk of kidney damage;
    • Salicylates (aspirin) in high doses, toxicity is increased;
    • Cortisone: the risk of potassium deficiency is then increased;
    • Drugs against gout, oral hypoglycemic agents and insulin: their effectiveness is greatly diminished;
    • Other antihypertensive agents: their efficiency is increased;
    • Chloral hydrate, used for sleeping, can raise the pressure, quicken the pulse and cause hot flashes;
    • The indomethacide, used in arthritis, acts more as well and keeps the furosemide to act well;
    • Barbiturates, narcotics, phenothiazines, antidepressants may worsen hypotension;
    • Using clofibrate: the action of two drugs as well as their side effects are increased;
    • Theophylline: effects may be increased;
    • Phenytoin may decrease the absorption of furosemide;
    • Oral anticoagulants: the dosage must be adjusted after checking the prothrombin time;
    • Lithium: it becomes toxic and causes weakness, diarrhea, vomiting, lethargy and muscular incoordination.

    PRECAUTIONS
    The adjustment of the dosage of furosemide is difficult and requires close monitoring by the doctor, but must necessarily have recourse to certain laboratory tests before and during treatment, because these tests it is possible to avoid serious side effects.

    In particular, we must monitor the blood level of potassium: too much or too little potassium can cause various symptoms. When furosemide plus a patient takes the digital balance of its potassium may be a matter of life or death.

    If profuse diarrhea or vomiting occurs during this treatment, it is advisable to contact your doctor, because these two situations produce an imbalance in the balance of water and potassium and a high risk of side effects ondary serious.

    Alcohol consumption as well as physical violence and excessive heat can cause dizziness in people taking furosemide.

    OVERALL ASSESSMENT
    In hypertension, furosemide acts worse than thiazides, is much more dangerous and is generally more expensive. In fact, it should be reserved only for patients with kidney disease or those for whom thiazides are not suitable.

    Doctors often prescribe immediately after the main manufacturer has made a big promotional campaign, this is not a valid reason to justify the use of this drug.

    Diuretic side effects

    Diuretic side effects, types, and how to avoid the serious consequences
    June 17 2015 by Ray Sahelian, M.D.

    Diuretics, commonly called water pills, are a class of prescription medications that are used to treat high blood pressure, heart disease and certain kinds of kidney or liver disease. The drugs stimulate the kidneys to remove more water from the body, which is then passed through the urine. Loop diuretics are a strong type of diuretics. If you have an interest in treating high blood pressure naturally, see hypertension.

    Side effects, especially in the elderly
    The most common side effect of diuretics is increased urination. This occurs most frequently in people taking loop diuretics. People who take diuretics may also have too much potassium in their blood (hyperkalemia) if they take a potassium-sparing diuretic, or too little potassium in their blood (hypokalemia) if they take a thiazide diuretic. Other side effects of diuretics may include:

    Low sodium in your blood (hyponatremia).
    Increased blood sugar levels.
    Increased cholesterol levels.
    Weakness or fatigue, a feeling of lethargy.
    Dizziness or lightheadedness.

    Types of Diuretics availabe by prescription

    There are 3 types of diuretic medicines. Each type works a little differently, but they all lower the amount of salt and water in your body, which helps to lower your blood pressure.

    Thiazide diuretics
    Thiazide diuretics are used to treat high blood pressure by reducing the amount of sodium and water in the body. Thiazides are the only type of diuretic that dilates (widens) the blood vessels, which also helps to lower blood pressure.

    Commonly used brand names in the United States: Aquatensen (methyclothiazide), Diucardin (hydroflumethiazide), Diulo (metolazone), Diuril (chlorothiazide), Enduron (methyclothiazide), Esidrix (hydrochlorothiazide), Hydro-chlor (hydrochlorothiazide), Hydro-D (hydrochlorothiazide), HydroDIURIL (hydrochlorothiazide), Hydromox (quinethazone), Hygroton (chlorthalidone), Metahydrin (trichlormethiazide), Microzide (hydrochlorothiazide), Mykrox (metolazone), Naqua (trichlormethiazide), Naturetin (bendroflumethiazide), Oretic (hydrochlorothiazide), Renese (polythiazide), Saluron (hydroflumethiazide), Thalitone (chlorthalidone), Trichlorex (trichlormethiazide), Zaroxolyn (metolazone)

    Commonly used brand names in Canada: Apo-Chlorthalidone (chlorthalidone), Apo-Hydro (hydrochlorothiazide), Diuchlor H (hydrochlorothiazide), Duretic (methyclothiazide), HydroDIURIL (hydrochlorothiazide), Hygroton (chlorthalidone), Naturetin (bendroflumethiazide), Neo-Codema (hydrochlorothiazide), Novo-Hydrazide (hydrochlorothiazide), Novo-Thalidone (chlorthalidone), Uridon (chlorthalidone), Urozide (hydrochlorothiazide), Zaroxolyn (metolazone)

    Potassium-sparing diuretics
    Potassium-sparing diuretics are used to reduce the amount of water in the body. Unlike the other diuretic medicines, these medicines do not cause your body to lose potassium.

    Commonly used brand names in the United States: Aldactone (spironolactone), Dyrenium (triamterene), Midamor (amiloride)

    Commonly used brand names in Canada: Aldactone (spironolactone), Dyrenium (triamterene), Midamor (amiloride), Novospiroton (spironolactone)

    Loop-acting diuretics
    Loop-acting diuretics cause the kidneys to increase the flow of urine. This helps reduce the amount of water in your body and lower your blood pressure.
    Commonly used brand names in the United States: Bumex (bumetanide), Demadex (torsemide), Edecrin (ethacrynic acid), Lasix (furosemide), Myrosemide (furosemide)

    Commonly used brand names in Canada: Apo-Furosemide (furosemide), Edecrin (ethacrynic acid), Furoside (furosemide), Lasix (furosemide), Lasix Special (furosemide), Novosemide (furosemide), Uritol (furosemide)

    Diuretics and Heart Failure

    As the dosage of loop diuretics increases in patients with advanced heart failure, the risk of death also increases. Loop diuretics, especially when given at higher doses, activate a part of the nervous system known to increase the risk of death in heart failure patients. Loop diuretics, especially at higher doses, can also contribute to worsened kidney function and electrolyte abnormalities. Physicians should use loop diuretics at the lowest dose possible dose to relieve congestion but not to the point of keeping heart failure patients totally free of fluid in the lungs.

    Questions
    Is there any interaction between using a diuretic and taking the herb curcumin ?
    I don't see any clear interactions that would occur.

    DrugBank: Furosemide

    • Aminobenzenesulfonamide
    • Halobenzoic acid
    • 4-halobenzoic acid
    • 4-halobenzoic acid or derivatives
    • Aminobenzoic acid or derivatives
    • Aminobenzoic acid
    • Benzoic acid
    • Benzoic acid or derivatives
    • Phenylalkylamine
    • Substituted aniline
    • Benzoyl
    • Aralkylamine
    • Secondary aliphatic/aromatic amine
    • Halobenzene
    • Chlorobenzene
    • Aniline
    • Aryl halide
    • Aryl chloride
    • Heteroaromatic compound
    • Vinylogous amide
    • Aminosulfonyl compound
    • Sulfonyl
    • Sulfonic acid derivative
    • Sulfonamide
    • Furan
    • Oxacycle
    • Organoheterocyclic compound
    • Secondary amine
    • Monocarboxylic acid or derivatives
    • Carboxylic acid
    • Carboxylic acid derivative
    • Hydrocarbon derivative
    • Organosulfur compound
    • Organooxygen compound
    • Organonitrogen compound
    • Organochloride
    • Organohalogen compound
    • Carbonyl group
    • Amine
    • Aromatic heteromonocyclic compound

    Aromatic heteromonocyclic compounds

    For the treatment of edema associated with congestive heart failure, cirrhosis of the liver, and renal disease, including the nephrotic syndrome. Also for the treatment of hypertension alone or in combination with other antihypertensive agents.

    Furosemide, a sulfonamide-type loop diuretic structurally related to bumetanide, is used to manage hypertension and edema associated with congestive heart failure, cirrhosis, and renal disease, including the nephrotic syndrome.

    Mechanism of action

    Furosemide, a loop diuretic, inhibits water reabsorption in the nephron by blocking the sodium-potassium-chloride cotransporter (NKCC2) in the thick ascending limb of the loop of Henle. This is achieved through competitive inhibition at the chloride binding site on the cotransporter, thus preventing the transport of sodium from the lumen of the loop of Henle into the basolateral interstitium. Consequently, the lumen becomes more hypertonic while the interstitium becomes less hypertonic, which in turn diminishes the osmotic gradient for water reabsorption throughout the nephron. Because the thick ascending limb is responsible for 25% of sodium reabsorption in the nephron, furosemide is a very potent diuretic.

    60% absorbed in patients with normal renal function

    Volume of distribution

    This project is supported by the Canadian Institutes of Health Research (award #111062), Alberta Innovates - Health Solutions. and by The Metabolomics Innovation Centre (TMIC). a nationally-funded research and core facility that supports a wide range of cutting-edge metabolomic studies. TMIC is funded by Genome Alberta. Genome British Columbia. and Genome Canada. a not-for-profit organization that is leading Canada's national genomics strategy with $900 million in funding from the federal government. Maintenance, support, and commercial licensing is provided by OMx Personal Health Analytics, Inc.

    Furosemide (Furoside) Delivery

    You can order delivery of a Furosemide (Furoside) to the Austria, Norway, Japan or any other country in the world. Residents of the USA can order Furosemide (Furoside) to any city, to any address, for example to Denver, Torrance, Houston or Philadelphia.