Pills blog

Pradif

Category: Man's Health

Description

Flomax is used for treating enlarged prostate (benign prostatic hyperplasia).

Active Ingredient: Tamsulosin

Flomax (Pradif) as known as: Aclosan, Aglandin retard, Alna retard, Asoflon, Bazetham, Botam, Cepalux, Comadex, Contiflo, Controlpros, Damurgin, Espontal, Eupen, Expros, Flomaxtra, Flosin, Fokusin, Geroprostan, Gotely, Halonerol, Halthrow, Harnal, Harnal d, Harnal ocas, Harnalidge, Harnnat, Hartam, Josir, Lannatam, Lostam, Lura, Manfredol, Masulin, Maxrin, Mecir, Morvesin, Omexel, Omic, Omipro, Omix, Omnexel, Omnic, Omnic tocas, Omnistad, Omsal, Omsil, Palnac, Pradif, Prolosin, Proslosin, Prostacin, Prostacure, Prostadil, Prostalitan, Prostall, Prostam, Prostamnic, Prostazid, Provosal, Proximic, Ranlosin, Ranomax, Restream, Sebrane, Secotex, Stronazon, Sulix, Symlosin sr, Tabphyn, Tadin, Taflosin, Taliz, Tamictor, Tamik, Tamipro, Tamlic, Tamlosin, Tamnic, Tamsec, Tamsin, Tamslon, Tamsol, Tamsu, Tamsu-q, Tamsublock, Tamsudil, Tamsugen, Tamsukon, Tamsul, Tamsulek, Tamsulijn, Tamsulo-isis, Tamsulogen, Tamsulosiinhydrokloridi, Tamsulosina, Tamsulosine, Tamsulosinum, Tamsulozin, Tamsumedin, Tamsumin, Tamsuna, Tamsunar, Tamsunax, Tamsuprost, Tamurox, Tamzul, Tansiloprost, Tanyz, Totalprost, Uprox, Urimax, Uroflo, Urolosin, Urostad, Urosulol, Vetevel, Vi-uril

MIN — Omnic, general information, pharmacology, Omnic for patients, Omnic interactions, Omnic contraindications, additional information about Om

Omnic Omnic - General Information

Omnic is a selective antagonist at alpha-1A and alpha-1B-adrenoceptors in the prostate, prostatic capsule, prostatic urethra, and bladder neck. At least three discrete alpha1-adrenoceptor subtypes have been identified: alpha-1A, alpha-1B and alpha-1D; their distribution differs between human organs and tissue. Approximately 70% of the alpha1-receptors in human prostate are of the alpha-1A subtype. Blockage of these receptors causes relaxation of smooth muscles in the bladder neck and prostate.

Pharmacology of Omnic

Omnic, an alpha-adrenoceptor blocker with enhanced specificity for the alpha-adrenoceptors of the prostate, is commonly used to treat benign prostatic hyperplasia (BPH).

Omnic for patients

ABOUT FLOMAX CAPSULES

FLOMAX capsules are for use by men only. Flomax capsules are not indicated for use in women.

Please read this leaflet before you start taking FLOMAX capsules. Also, read it each time you renew your prescription, just in case new information has been added. Remember, this leaflet does not take the place of careful discussions with your doctor. You and your doctor should discuss FLOMAX capsules when you start taking your medication and at regular checkups.

Why your doctor has prescribed FLOMAX capsules?

Your doctor has prescribed FLOMAX capsules because you have a medical condition called benign prostatic hyperplasia or BPH. This occurs only in men.

Benign prostatic hyperplasia is an enlargement of the prostate gland. After age 50, most men develop enlarged prostates. The prostate is located below the bladder. As the prostate enlarges, it may slowly restrict the flow of urine. This can lead to symptoms such as:

ï a weak or interrupted urinary stream

ï a feeling that you cannot empty your bladder completely

ï a feeling of delay or hesitation when you start to urinate

ï a need to urinate often, especially at night

ï a feeling that you must urinate right away

Since cancer of the prostate may cause similar symptoms, you should be evaluated by your doctor to rule out prostate cancer. Your doctor will likely examine your prostate gland manually to detect abnormalities and may measure prostate-specific antigen (PSA) in your blood to help in evaluating for the presence of prostate cancer. FLOMAX capsules do not affect PSA levels.

Treatment Options for BPH

There are three main treatment options for BPH:

ï Program of monitoring or "Watchful Waiting". Some men have an enlarged prostate gland, but no symptoms, or symptoms that are not bothersome. If this applies, you and your doctor may decide on a program of monitoring, including regular checkups, instead of medication or surgery.

ï There are different kinds of medication used to treat BPH. Your doctor has prescribed FLOMAX capsules for you. See "What a FLOMAX capsule does to treat BPH" below.

ï Surgery. Some patients may need surgery. Your doctor can describe several different surgical procedures to treat BPH. Which procedure is best depends on your symptoms and medical condition.

What a FLOMAX capsule does to treat BPH

FLOMAX capsules act by relaxing muscles in the prostate and bladder neck at the site of the obstruction, resulting in improved urine flow and reduced BPH symptoms.

What you need to know while taking FLOMAX (tamsulosin HCI) capsules

ï You must see your doctorregularly .

While taking FLOMAX capsules, you must have regular checkups. Follow your doctor's advice about when to have these checkups.

ï It is important for you to recognize that FLOMAX capsules can cause a suddendrop in blood pressure especially following the first dose or when changing doses of FLOMAX capsules. Such a drop in blood pressure, although rare in occurrence, may be associated with fainting, dizziness. or lightheadedness. Therefore, get up slowly from a chair or bed at any time until you learn how you react to FLOMAX capsules. You should not drive or do any hazardous tasks until you are used to the side effects of FLOMAX capsules. If you begin to feel dizzy, sit down until you feel better. Although these symptoms are unlikely, you should avoid driving or hazardous tasks for 12 hours after the initial dose or after your doctor recommends an increase in dose. If you interrupt your treatment for several days or more, resume treatment at one capsule a day, after consulting with your physician. Other side effects may include sleeplessness, runny nose, or ejaculatory problems. In some cases, side effects may decrease or disappear when you continue to take FLOMAX capsules.

ï Extremely rarely, FLOMAX Capsules and similar medications have caused prolonged, painful erection of the penis, which is unrelieved by sexual intercourse or masturbation. This condition, if untreated, can lead to permanent inability to have an erection. If you have a prolonged erection, call your doctor or go to an Emergency Room as soon as possible.

You should discuss side effects with your doctor before taking FLOMAX capsules and anytime you think you are having a side effect.

How to take FLOMAX capsules

Follow your doctor's advice about how to take FLOMAX capsules. You should take it approximately 30 minutes following the same meal every day.

Do not share FLOMAX capsules with anyone else; it was prescribed only for you.

Do not crush, chew, or open capsules of FLOMAX capsules.

Keep FLOMAX capsules and all medicines out of reach of children.

FOR MORE INFORMATION ABOUT FLOMAX CAPSULES AND BPH, TALK WITH YOUR DOCTOR. IN ADDITION, TALK TO YOUR PHARMACIST OR OTHER HEALTHCARE PROVIDER.

Omnic Interactions

Drug-Drug Interactions . The pharmacokinetic and pharmacodynamic interactions between FLOMAX capsules and other alpha-adrenergic blocking agents have not been determined. However, interactions may be expected and FLOMAX capsules should NOT be used in combination with other alpha-adrenergic blocking agents.

The pharmacokinetic interaction between cimetidine and FLOMAX capsules was investigated. The results indicate significant changes in tamsulosin HCI clearance (26% decrease) and AUC (44% increase). Therefore, FLOMAX capsules should be used with caution in combination with cimetidine, particularly at doses higher than 0.4 mg.

Results from limited in vitro and in vivo drug-drug interaction studies between tamsulosin HCI and warfarin are inconclusive. Therefore, caution should be exercised with concomitant administration of warfarin and FLOMAX capsules.

Omnic Contraindications

Tamsulosin capsules are contraindicated in patients known to be hypersensitive to tamsulosin HCI or any component of tamsulosin capsules.

Additional information about Omnic

Omnic Indication: Used in the treatment of signs and symptoms of benign prostatic hyperplasia.
Mechanism Of Action: Omnic is a selective antagonist at alpha-1A and alpha-1B-adrenoceptors in the prostate, prostatic capsule, prostatic urethra, and bladder neck. At least three discrete alpha1-adrenoceptor subtypes have been identified: alpha-1A, alpha-1B and alpha-1D; their distribution differs between human organs and tissue. Approximately 70% of the alpha1-receptors in human prostate are of the alpha-1A subtype. Blockage of these receptors causes relaxation of smooth muscles in the bladder neck and prostate.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Tamsulosin
Synonyms: Not Available
Drug Category: Antineoplastic Agents
Drug Type: Small Molecule; Approved
Other Brand Names containing Tamsulosin: Flomax; Harnal; Omnic; Pradif; Tamsolusin; Tamsulosina [Inn-Spanish]; Tamsulosine [Inn-French]; Tamsulosinum [Inn-Latin];
Absorption: Absorption of tamsulosin HCI from capsules 0.4 mg is essentially complete (>90%) following oral administration under fasting conditions.
Toxicity (Overdose): LD50 = 650 mg/kg (in rats)
Protein Binding: 94%-99%
Biotransformation: Tamsulosin HCI is extensively metabolized by cytochrome P450 enzymes in the liver, however, the pharmacokinetic profile of the metabolites in humans has not been established.
Half Life: 5-7 hours
Dosage Forms of Omnic: Tablet, extended release Oral
Capsule, extended release Oral
Chemical IUPAC Name: 5-[(2R)-2-[2-(2-ethoxyphenoxy)ethylamino]propyl]-2-methoxybenzenesulfonamide
Chemical Formula: C20H28N2O5S
Tamsulosin on Wikipedia: http://en.wikipedia.org/wiki/Tamsulosin
Organisms Affected: Humans and other mammals

Other articles

Buy cheap Pradif 0, 2 mg for sale without a prescription

Buy cheap Pradif 0,2 mg for sale without a prescription

Often, advancefee fraud is referred to as Pradif 0,2 mg fraud, after the section of the Nigerian criminal code that outlaws such scams. The Western blot test can also be unclear, in which case Pradif 0,2 mg testing is done. Fine A, Patterson Eat three meals a day. Businesses are dropping or curtailing coverage because of increasing premiums, creating more uninsured and underinsured patients. Tobacco and a moist fruit preparation are placed below burning charcoal in the head of the contraption.

Other problems involve how you process information and your emotions. Some dermatologists were upset when the American Academy of Dermatology decided to use pharmaceutical company money to fund extra residency slots. He said the defense department is also evaluating programs that would train its medical officials in acupuncture - right down to medics in the field practicing acupuncture.

The experience immediately lifted their mood, and we saw a connection to fewer incidents of negative behavior. Sometimes just the way you feel (sad or happy) is a trigger. Because circulating neutrophils lack these receptors, the system is incredibly precise and targets only those immune cells that are actively contributing to inflammatory disease.

For instance, if you are lost and need to find your way, Pradif 0,2 mg of talking to lots of people at random, it is best to speak to a select few who have been in the neighborhood a while. Researchers from the Harvard School of Public Health say that a lower suicide risk is found in men drinking between 2 and 4 cups of coffee a day.

Doctors, particularly pediatricians, are worried that such an interpretation would impinge on their medical judgment and deter young patients from seeking necessary care for fear of being reported, the medical society said.

Osteoblasts are the cells primarily responsible for bone formation.

Further, it may give individuals a chance to inform potential surrogate decisionmakers of their wishes about organ donation or to enter their decision in a statebased organ donation registry.

Get emergency care if this situation occurs. Primary symptoms come from damage to the protective sheath around the nerves in your spine or brain. The more time zones a person crosses, the more severe jet lag can become. The numbers were released Aug. Do not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely. Sugar and a team got together to "virtually plan" the surgery to restore symmetry to Mr.

Pradif 0,2 mg - Tamsulosin

Cherries have been mentioned as having urate-lowering Pradif 0,2 mg inflammation-reducing properties, but there have been no rigorous studies of whether they can reduce the risk of gout attacks. High-fat meals may decrease the absorption of this medication. Learn more about Health Solutions, Ebix, Inc. Talk to your doctor about lifestyle changes that might benefit you.

  • They discovered that patient names, Social Security numbers and medical information had been displayed on an unsecured website for about 19 months.
  • The study authors theorized that bullies may have gained a boost in social status as children that in turn conferred a boost in physical health as adults.
  • That hold on claims officially lifted on June 18, meaning contractors could begin processing June claims at the reduced rate as soon as their systems had been tested to accept the change. What to Expect at Your Office VisitThe health care provider will perform a physical examination and look inside the ears.
Pradif 0,2 mg - With no prescription

Outlook (Prognosis)The problem goes away without treatment most of the time. Mens Health Switzerland this medication exactly as prescribed.

Ultimately, the growth factors produce an increase in the number of terminally differentiated cells of a particular lineage. Yuelong Shu, from the Chinese Center for Disease Control and Prevention in Beijing and co-author of the report. By David Glendinning, amednews Mens Health Switzerland. A mixture of secretions from sweat glands and the fatty byproduct of sebaceous glands, earwax is usually a wet yellow-brown wax or a dry white wax.

Since this kind of inflammation has been linked to a future risk of developing cardiovascular disease and type-2 diabetes, the researchers wanted to investigate whether eating often would cause more damage that might increase these risks in obese individuals.

The researchers analyzed the findings of seven studies that focused on the question of summer weight gain among children 5 to 17 years old.

This will keep your skin healthy and help your body absorb the medicine well. Use your crutches or walker for as long as you need them. Overuse injuries include the following: Carpal tunnel syndrome is caused by pressure on a nerve (median nerve) in the wrist. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline.

These pills are most commonly used by nursing mothers, women with pre-existing risks for blood clots, or other conditions that prevent them from taking estrogen.

Pradif Side Effects

Pradif Side Effects Track Your Side Effects

Note Your Observations

It is really important to keep track of your health symptoms, right from the time you start a new medicine. You can do it any way you prefer: in a notebook, in a computer file or using our online tool. You should also note down any other medicines you are taking at the same time, because there could be an interaction between these medicines.

Why Your Notes are Important

Your notes could be helpful in several ways:

  • You can use them to remind you of details that may alert your health care professional(s) to a problem
  • You will have a record to refer to in the future, in case you are ever prescribed the same medicine again

    You can use the following log form to write down important information, like the date and time you experienced a side effect and your symptoms, how strong the symptoms were, and any other medicines you were using.

    Medicine Name and Dosage:

    Other Medicine(s) or Treatment(s)

    Scale: 1 = very mild to 10 = very bad

    Side effects reports are analyzed to discover potential health product safety signals. Some important reactions may take an extremely long time to develop or occur infrequently. Continued monitoring of adverse reactions is thus essential to maintain a comprehensive safety and effectiveness profile of health products.

    You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

    Pradif reports list potential signals of serious risks and new safety information that were identified using the FDA Adverse Event Reporting System (FAERS).
    FAERS is a database that contains information on adverse event and medication errors reports submitted to FDA by healthcare professionals (such as physicians, pharmacists, nurses and others), consumers (such as patients, family members, layers and others) and manufacturers.

    Discuss Pradif Side Effects Did You Have a Pradif Side Effect? View Results How Effective is Pradif for You? View Results Pradif Safety Alerts, Active Ingredients, Usage Information

    Side Effects reported to FDA: 14

    Pradif safety alerts: No

    Reported deaths: 1

    Reported hospitalizations: 7

    Pradif Reviews

    No reviews, be a first to report a side effect via side effect reporting form

    © 2006-2016 PatientsVille.com

    Notice - The material on this site is for informational purposes only, and is not a substitute for medical advice, diagnosis or treatment provided by a qualified health care provider. Viewing and using of this information is subject to accepting Terms Of Use. PatientsVille.com does not provide medical advice, diagnosis or treatment. The information regarding adverse reports, reviews and polls contained on PatientsVille.com site has not been scientifically or otherwise verified as to a cause and effect relationship and cannot be used to estimate the incidence of side effects, adverse drug reactions or for establishing or changing of patient treatments. Thank you for visiting Patientsville.com!

  • DrugBank: Tamsulosin

    Tamsulosin is a selective antagonist at alpha-1A and alpha-1B-adrenoceptors in the prostate, prostatic capsule, prostatic urethra, and bladder neck. At least three discrete alpha1-adrenoceptor subtypes have been identified: alpha-1A, alpha-1B and alpha-1D; their distribution differs between human organs and tissue. Approximately 70% of the alpha1-receptors in human prostate are of the alpha-1A subtype. Blockage of these receptors causes relaxation of smooth muscles in the bladder neck and prostate.

    Structure for DB00706 (Tamsulosin)

    bryant ranch prepack

    Boehringer Ingelheim Pharmaceuticals, Inc.

    Physicians Total Care, Inc.

    A S Medication Solutions Llc

    Lake Erie Medical DBA Quality Care Products

    STAT Rx USA LLC

    Boehringer Ingelheim (Canada) Ltd Ltee

    Boehringer Ingelheim Pharmaceuticals, Inc.

    Boehringer Ingelheim (Canada) Ltd Ltee

    Jamp Pharma Corporation

    capsule (extended release)

    Mylan Pharmaceuticals Ulc

    Ranbaxy Pharmaceuticals Canada Inc.

    Teva Canada Limited

    Sandoz Canada Incorporated

    Sandoz Canada Incorporated

    Sandoz Tamsulosin CR

    Sandoz Canada Incorporated

    Sivem Pharmaceuticals Ulc

    Sanis Health Inc

    Pro Doc Limitee

    Teva Canada Limited

    Teva Canada Limited

    Triton Pharma Inc

    Generic Prescription Products

    Blenheim Pharmacal, Inc.

    Dispensing Solutions, Inc.

    Global Pharmaceuticals, Division of Impax Laboratories Inc.

    bryant ranch prepack

    Citron Pharma LLC

    American Health Packaging

    Contract Pharmacy Services Pa

    Blenheim Pharmacal, Inc.

    Proficient Rx LP

    Teva Pharmaceuticals USA Inc

    Aphena Pharma Solutions Tennessee, Llc

    Aurobindo Pharma Limited

    Sun Pharmaceutical Industries Limited

    Mc Kesson Contract Packaging

    Preferred Pharmaceuticals, Inc.

    capsule, gelatin coated

    Pd Rx Pharmaceuticals, Inc.

    Cadila Healthcare Limited

    Preferred Pharmaceuticals, Inc

    Physicians Total Care, Inc.

    Rebel Distributors Corp

    WOCKHARDT USA LLC

    St Marys Medical Park Pharmacy

    State of Florida DOH Central Pharmacy

    Northwind Pharmaceuticals, LLC

    Lake Erie Medical DBA Quality Care Products LLC

    Ncs Health Care Of Ky, Inc Dba Vangard Labs

    Mc Kesson Packaging Services A Business Unit Of Mc Kesson Corporation

    Golden State Medical Supply, Inc.

    Lake Erie Medical DBA Quality Care Products LLC

    Zydus Pharmaceuticals (USA) Inc.

    H.J. Harkins Company, Inc.

    Mylan Institutional Inc.

    Aidarex Pharmaceuticals LLC

    Mylan Pharmaceuticals Inc.

    Mc Kesson Packaging Services A Business Unit Of Mc Kesson Corporation

    Clinical Solutions Wholesale

    Avera Mc Kennan Hospital

    Carilion Materials Management

    Unit Dose Services

    STAT Rx USA LLC

    Actavis Elizabeth LLC

    Synthon Pharmaceuticals, Inc.

    Clinical Solutions Wholesale, Llc

    American Health Packaging

    Over the Counter Products

    Astellas Pharma Europe

    Dutasteride and Tamsulosin Hydrochloride

    Glaxo Smith Kline Llc

    Average: 408.512
    Monoisotopic: 408.171892706

    This compound belongs to the class of organic compounds known as amphetamines and derivatives. These are organic compounds containing or derived from 1-phenylpropan-2-amine.

    • Benzenesulfonamide
    • Amphetamine or derivatives
    • Phenylpropane
    • Methoxybenzene
    • Phenol ether
    • Anisole
    • Aralkylamine
    • Alkyl aryl ether
    • Aminosulfonyl compound
    • Sulfonyl
    • Sulfonic acid derivative
    • Sulfonamide
    • Secondary amine
    • Ether
    • Secondary aliphatic amine
    • Hydrocarbon derivative
    • Organosulfur compound
    • Organooxygen compound
    • Organonitrogen compound
    • Amine
    • Aromatic homomonocyclic compound

    Aromatic homomonocyclic compounds

    Used in the treatment of signs and symptoms of benign prostatic hyperplasia (reduction in urinary obstruction and relief of associated manifestations such as hesitancy, terminal dribbling of urine, interrupted or weak stream. etc.)

    Tamsulosin, a sulfamoylphenethylamine-derivative alpha-adrenoceptor blocker with enhanced specificity for the alpha-adrenoceptors of the prostate, is commonly used to treat benign prostatic hyperplasia (BPH). The drug is commercially available in a racemic mixture of 2 isomers, and is pharmacologically related to doxazocin, prazosin, and terazosin. However, unlike these drugs, tamsulosin has a higher affinity for the alpha-1A- adrenergic receptors, which are located in vascular smooth muscle. Studies show that tamsulosin has about 12 times greater affinity for alpha-1 adrenergic receptors in the prostate than those in the aorta, which may result in a reduced incidence of adverse cardiovascular effects.

    Mechanism of action

    Tamsulosin is a selective antagonist at alpha-1A and alpha-1B-adrenoceptors in the prostate, prostatic capsule, prostatic urethra, and bladder neck. At least three discrete alpha1-adrenoceptor subtypes have been identified: alpha-1A, alpha-1B and alpha-1D; their distribution differs between human organs and tissue. Approximately 70% of the alpha1-receptors in human prostate are of the alpha-1A subtype. Blockage of these receptors causes relaxation of smooth muscles in the bladder neck and prostate, and thus decreases urinary outflow resistance in men.

    Absorption of tamsulosin HCI from capsules 0.4 mg is essentially complete (>90%) following oral administration under fasting conditions.

    Volume of distribution

    • 16 L [intravenous administration to ten healthy male adults]
    Targets

    Kind Protein Organism Human Pharmacological action yes Actions antagonist General Function: Protein heterodimerization activity Specific Function: This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine(PE)-stimulated ERK signaling in cardiac myocytes. Gene Name: ADRA1A Uniprot ID: P35348 Molecular Weight: 51486.005 Da

    References
    1. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352 ]
    2. Abrams P, Speakman M, Stott M, Arkell D, Pocock R: A dose-ranging study of the efficacy and safety of tamsulosin, the first prostate-selective alpha 1A-adrenoceptor antagonist, in patients with benign prostatic obstruction (symptomatic benign prostatic hyperplasia). Br J Urol. 1997 Oct;80(4):587-96. [PubMed:9352698 ]
    3. Na YJ, Guo YL, Gu FL: Clinical comparison of selective and non-selective alpha 1A-adrenoceptor antagonists for bladder outlet obstruction associated with benign prostatic hyperplasia: studies on tamsulosin and terazosin in Chinese patients. The Chinese Tamsulosin Study Group. J Med. 1998;29(5-6):289-304. [PubMed:10503165 ]
    4. Lee E, Lee C: Clinical comparison of selective and non-selective alpha 1A-adrenoreceptor antagonists in benign prostatic hyperplasia: studies on tamsulosin in a fixed dose and terazosin in increasing doses. Br J Urol. 1997 Oct;80(4):606-11. [PubMed:9352700 ]
    5. Chapple CR, Wyndaele JJ, Nordling J, Boeminghaus F, Ypma AF, Abrams P: Tamsulosin, the first prostate-selective alpha 1A-adrenoceptor antagonist. A meta-analysis of two randomized, placebo-controlled, multicentre studies in patients with benign prostatic obstruction (symptomatic BPH). European Tamsulosin Study Group. Eur Urol. 1996;29(2):155-67. [PubMed:8647141 ]
    6. Schulman CC, Cortvriend J, Jonas U, Lock TM, Vaage S, Speakman MJ: Tamsulosin, the first prostate-selective alpha 1A-adrenoceptor antagonist. Analysis of a multinational, multicentre, open-label study assessing the long-term efficacy and safety in patients with benign prostatic obstruction (symptomatic BPH). European Tamsulosin Study Group. Eur Urol. 1996;29(2):145-54. [PubMed:8647140 ]
    7. Chen Y, Li H, Dong Q, Wang KJ: Blockade of alpha 1A-adrenoceptor: a novel possible strategy for male contraception. Med Hypotheses. 2009 Aug;73(2):140-1. doi: 10.1016/j.mehy.2009.02.022. Epub 2009 May 8. [PubMed:19427736 ]
    8. Michel MC, de la Rosette JJ: Efficacy and safety of tamsulosin in the treatment of urological diseases. Expert Opin Pharmacother. 2004 Jan;5(1):151-60. [PubMed:14680444 ]

    Kind Protein Organism Human Pharmacological action unknown Actions antagonist General Function: Alpha1-adrenergic receptor activity Specific Function: This alpha-adrenergic receptor mediates its effect through the influx of extracellular calcium. Gene Name: ADRA1D Uniprot ID: P25100 Molecular Weight: 60462.205 Da

    References
    1. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352 ]
    2. Noble AJ, Chess-Williams R, Couldwell C, Furukawa K, Uchyiuma T, Korstanje C, Chapple CR: The effects of tamsulosin, a high affinity antagonist at functional alpha 1A- and alpha 1D-adrenoceptor subtypes. Br J Pharmacol. 1997 Jan;120(2):231-8. [PubMed:9117115 ]
    3. Lowe FC: Summary of clinical experiences with tamsulosin for the treatment of benign prostatic hyperplasia. Rev Urol. 2005;7 Suppl 4:S13-21. [PubMed:16986050 ]
    4. Tomiyama Y, Tatemichi S, Tadachi M, Kobayashi S, Hayashi M, Kobayashi M, Yamazaki Y, Shibata N: [Effect of silodosin on intraurethral pressure increase induced by hypogastric nerve stimulation in dogs with benign prostatic hyperplasia]. Yakugaku Zasshi. 2006 Mar;126 Spec no.:225-30. [PubMed:16518087 ]
    5. Ishiguro M, Futabayashi Y, Ohnuki T, Ahmed M, Muramatsu I, Nagatomo T: Identification of binding sites of prazosin, tamsulosin and KMD-3213 with alpha(1)-adrenergic receptor subtypes by molecular modeling. Life Sci. 2002 Oct 11;71(21):2531-41. [PubMed:12270758 ]
    6. Taguchi K, Saitoh M, Sato S, Asano M, Michel MC: Effects of tamsulosin metabolites at alpha-1 adrenoceptor subtypes. J Pharmacol Exp Ther. 1997 Jan;280(1):1-5. [PubMed:8996174 ]
    7. Michel MC, de la Rosette JJ: Efficacy and safety of tamsulosin in the treatment of urological diseases. Expert Opin Pharmacother. 2004 Jan;5(1):151-60. [PubMed:14680444 ]

    Kind Protein Organism Human Pharmacological action unknown Actions antagonist General Function: Protein heterodimerization activity Specific Function: This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine (PE)-stimulated ERK signaling in cardiac myocytes. Gene Name: ADRA1B Uniprot ID: P35368 Molecular Weight: 56835.375 Da

    References
    1. Ishiguro M, Futabayashi Y, Ohnuki T, Ahmed M, Muramatsu I, Nagatomo T: Identification of binding sites of prazosin, tamsulosin and KMD-3213 with alpha(1)-adrenergic receptor subtypes by molecular modeling. Life Sci. 2002 Oct 11;71(21):2531-41. [PubMed:12270758 ]
    2. Michel MC, Hanft G, Gross G: Functional studies on alpha 1-adrenoceptor subtypes mediating inotropic effects in rat right ventricle. Br J Pharmacol. 1994 Feb;111(2):539-46. [PubMed:7911719 ]
    3. Taguchi K, Saitoh M, Sato S, Asano M, Michel MC: Effects of tamsulosin metabolites at alpha-1 adrenoceptor subtypes. J Pharmacol Exp Ther. 1997 Jan;280(1):1-5. [PubMed:8996174 ]
    4. Richardson CD, Donatucci CF, Page SO, Wilson KH, Schwinn DA: Pharmacology of tamsulosin: saturation-binding isotherms and competition analysis using cloned alpha 1-adrenergic receptor subtypes. Prostate. 1997 Sep 15;33(1):55-9. [PubMed:9294627 ]
    5. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352 ]
    6. Michel MC, de la Rosette JJ: Efficacy and safety of tamsulosin in the treatment of urological diseases. Expert Opin Pharmacother. 2004 Jan;5(1):151-60. [PubMed:14680444 ]
    Enzymes

    Kind Protein Organism Human Pharmacological action unknown Actions substrate General Function: Steroid hydroxylase activity Specific Function: Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It is involved in the metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic antidepressants. Gene Name: CYP2D6 Uniprot ID: P10635 Molecular Weight: 55768.94 Da

    References
    1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]

    Kind Protein Organism Human Pharmacological action unknown Actions substrate General Function: Vitamin d3 25-hydroxylase activity Specific Function: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiot. Gene Name: CYP3A4 Uniprot ID: P08684 Molecular Weight: 57342.67 Da

    References
    1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
    Carriers

    Kind Protein Organism Human Pharmacological action no General Function: Not Available Specific Function: Functions as transport protein in the blood stream. Binds various ligands in the interior of its beta-barrel domain. Also binds synthetic drugs and influences their distribution and availability in the body. Appears to function in modulating the activity of the immune system during the acute-phase reaction. Gene Name: ORM1 Uniprot ID: P02763 Molecular Weight: 23511.38 Da

    References
    1. Matsushima H, Watanabe T, Higuchi S: Effect of alpha(1)-acid glycoprotein on the pharmacokinetics of tamsulosin in rats treated with turpentine oil. J Pharm Sci. 2000 Apr;89(4):490-8. [PubMed:10737910 ]
    2. Hanada K, Tochikura N, Ogata H: Selective binding of tamsulosin to genetic variants of human alpha1-acid glycoprotein. Biol Pharm Bull. 2007 Aug;30(8):1593-5. [PubMed:17666829 ]
    3. Koiso K, Akaza H, Kikuchi K, Aoyagi K, Ohba S, Miyazaki M, Ito M, Sueyoshi T, Matsushima H, Kamimura H, Watanabe T, Higuchi S: Pharmacokinetics of tamsulosin hydrochloride in patients with renal impairment: effects of alpha 1-acid glycoprotein. J Clin Pharmacol. 1996 Nov;36(11):1029-38. [PubMed:8973992 ]

    This project is supported by the Canadian Institutes of Health Research (award #111062), Alberta Innovates - Health Solutions. and by The Metabolomics Innovation Centre (TMIC). a nationally-funded research and core facility that supports a wide range of cutting-edge metabolomic studies. TMIC is funded by Genome Alberta. Genome British Columbia. and Genome Canada. a not-for-profit organization that is leading Canada's national genomics strategy with $900 million in funding from the federal government. Maintenance, support, and commercial licensing is provided by OMx Personal Health Analytics, Inc.

    Medical Expulsive Therapy of Single Distal Ureteral Stones - Full Text View

    Medical Expulsive Therapy of Single Distal Ureteral Stones

    Further study details as provided by University of Zurich:

    Primary Outcome Measures:
    • Number of Participants With Stone Expulsion [ Time Frame: 21 days ] [ Designated as safety issue: No ]

    The primary end point was the number of patients per group experiencing stone expulsion until day 21, as confirmed by low-dose abdominal computed tomography (CT).

    Secondary Outcome Measures:
    • Time to Stone Passage [ Time Frame: 21 days ] [ Designated as safety issue: No ]

    The patient-defined time of stone expulsion was considered the event for time to stone passage. Patients with unnoticed stone expulsion were censored at the date of last positive stone status, and those who discontinued the therapy were censored at the date of last medication intake. Kaplan-Meier estimates were computed for time to stone passage.


  • Required Analgesics [ Time Frame: Until stone expulsion or up to 21 days ] [ Designated as safety issue: No ]

    Oral diclophenac (up to 3x50 mg pills) as first-line and oral metamizole (up to 8x 500mg pills)as second-line on-demand analgesics were prescribed. All patients were requested to record the required amount of pills per day


  • Maximum Daily Pain Score [ Time Frame: Until stone expulsion or up to 21 days ] [ Designated as safety issue: Yes ]

    All patients kept a diary to record the score of every painful episode on a 10-cm visual analogue scale (0= no pain at all; 10= strongest pain one can imagine).


  • Number of Participants Requiring Active Treatment [ Time Frame: 21 days ] [ Designated as safety issue: Yes ]

    The number of participants requiring active treatment was recorded. Shock wave lithotrypsy (SWL), ureterorenoscopy (URS) or insertion of an ureteral catheter were considered as active treatment.

    • patients with a single 2 to 7mm ureteral stone below the common iliac vessels
    • presence of multiple ureteral stones
    • renal insufficiency (glomerular filtration rate below 60 ml/min)
    • urinary tract infection
    • a solitary kidney
    • pregnancy
    • history of ureteral surgery or previous endoscopic procedure
    • hypersensitivity to tamsulosin
    • current alpha-blocker, calcium-antagonist or corticosteroid medication

    Contacts and Locations

    Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

    Please refer to this study by its ClinicalTrials.gov identifier: NCT00831701

    Department of Urology, University Hospital Zürich, Switzerland

    Zurich, Switzerland, 8091

    Sponsors and Collaborators

    University of Zurich

    01 Studienregister MasterAdmins


    Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):

    Räto T. Strebel, Department of Urology, University Hospital Zürich, switzerland

    Other Study ID Numbers:

    Study First Received:

    November 19, 2008

    Results First Received:

    January 11, 2010


    Keywords provided by University of Zurich:

    Adrenergic alpha antagonists
    drug therapy
    tamsulosin
    ureter


    Additional relevant MeSH terms:

    Ureteral Calculi
    Ureterolithiasis
    Calculi
    Pathological Conditions, Anatomical
    Ureteral Diseases
    Urinary Calculi
    Urolithiasis
    Urologic Diseases
    Tamsulosin
    Adrenergic Agents

    Adrenergic Antagonists
    Adrenergic alpha-1 Receptor Antagonists
    Adrenergic alpha-Antagonists
    Molecular Mechanisms of Pharmacological Action
    Neurotransmitter Agents
    Pharmacologic Actions
    Physiological Effects of Drugs
    Therapeutic Uses
    Urological Agents


    ClinicalTrials.gov processed this record on April 25, 2016

  • Pradif diseases

    • Product description
    • Safety information
    • Side effects
    • Flomax is used for treating enlarged prostate (benign prostatic hyperplasia [BPH]). Flomax is an alpha-blocker. It works by relaxing muscles in the prostate and bladder, which helps to improve urine flow and reduce symptoms of BPH.

      Use Flomax as directed by your doctor.

      • Take Flomax by mouth 30 minutes after eating the same meal each day.
      • Swallow Flomax whole. Do not break, crush, chew, or open capsules before swallowing.
      • If you miss a dose of Flomax, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once. If you miss more than 2 dose of Flomax, contact your doctor for instructions.

      Ask your health care provider any questions you may have about how to use Flomax.

      Store Flomax at 77 degrees F (25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Flomax out of the reach of children and away from pets.

      Active Ingredient: Tamsulosin.

      Do NOT use Flomax if:

      • you are allergic to any ingredient in Flomax
      • the patient is a woman or a child
      • you are taking another alpha-blocker (eg, prazosin).

      Contact your doctor or health care provider right away if any of these apply to you.

      Some medical conditions may interact with Flomax. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

      • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
      • if you have allergies to medicines or other substances
      • if you have had a severe allergic reaction (eg, severe rash, hives, difficulty breathing, dizziness) to any sulfonamide (sulfa) medicine, such as acetazolamide, celecoxib, certain diuretics (eg, hydrochlorothiazide), sulfonylureas (eg, glyburide), probenecid, sulfamethoxazole, valdecoxib, or zonisamide.
      • if you have a history of liver or kidney problems, or high or low blood pressure, or prostate cancer
      • if you will be having eye surgery.

      Some medicines may interact with Flomax. Tell your health care provider if you are taking any other medicines, especially any of the following:

      • Alpha-blockers (eg, prazosin) or phosphodiesterase inhibitors (eg, sildenafil) because symptoms of low blood pressure (eg, severe dizziness, lightheadedness, fainting) may occur
      • Azole antifungals (eg, ketoconazole), cimetidine, or serotonin specific reuptake inhibitors (eg, fluoxetine) because they may increase the risk of Flomax's side effects
      • Warfarin because the risk of side effects may be increased.

      This may not be a complete list of all interactions that may occur. Ask your health care provider if Flomax may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

      Important safety information:

      • Flomax may cause drowsiness, dizziness, blurred vision, lightheadedness, or fainting. These effects may be worse if you take it with alcohol or certain medicines. Use Flomax with caution. Do not drive or perform other possible unsafe tasks until you know how you react to it.
      • Flomax may cause dizziness, lightheadedness, or fainting; alcohol, hot weather, exercise, or fever may increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Sit or lie down at the first sign of any of these effects.
      • Do not drive or perform other possibly unsafe tasks for 12 hours after your first dose of Flomax or after any dose increase.
      • Tell your doctor or dentist that you take Flomax before you receive any medical or dental care, emergency care, or surgery.
      • Flomax may rarely cause a prolonged, painful erection. This could happen even when you are not having sex. If this is not treated right away, it could lead to permanent sexual problems such as impotence. Contact your doctor right away if this happens.
      • You will need to have regular check-ups with your doctor while you are using Flomax. Be sure to keep all doctor and lab appointments.
      • Flomax is for use by men only and should not be used by women.
    • All medicines may cause side effects, but many people have no, or minor, side effects.

      Check with your doctor if any of these most common side effects persist or become bothersome:

      Back pain; blurred vision; cough; decreased sexual ability; diarrhea; dizziness; drowsiness; lightheadedness; runny or stuffy nose; sinus inflammation; trouble sleeping; weakness.

      Seek medical attention right away if any of these severe side effects occur:

      Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); chest pain; fainting; fever, chills, or persistent sore throat; irregular heartbeat; prolonged, painful erection; severe of persistent dizziness.

      This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.

    Flomax (Pradif) Delivery

    Residents of the USA can order Flomax (Pradif) to any city, to any address, for example to Akron, New York, Portland or . You can order delivery of a Flomax (Pradif) to the Sweden, Israel, Denmark or any other country in the world.