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Scopamin

Category: Pain Relief

Description

Anacin is a pain reliever intended for the temporary relief of minor aches and pains. Anacin is a combination salicylate and stimulant. It works by blocking several different chemical processes within the body that cause pain, inflammation, and fever. It also reduces the tendency for blood to clot.

Active Ingredient: aspirin caffeine

Anacin (Scopamin) as known as: Abdine, Abrol, Abrolet, Acamol, Acamoli, Ace-q-para, Acebel-p, Acecat, Acenol, Acephen, Aceralgin, Acertol, Acet, Aceta, Acetafen, Acetagen, Acetalgin, Acetalis, Acetamin, Acetaminofén, Acetamol, Acetazone forte, Acetolit, Aceval, Actadol, Actol, Adalgur, Adinol, Adol, Adolef, Adorem, Aeknil, Afebryl, Agurin, Alaxan, Aldolor, Algiafin, Algicalm, Algine, Alginox, Algisedal, Algocit, Algocod, Algodol, Algopirina, Algostase, Algotropyl, Alikal, Alivax, Alphamol, Alpiny, Alvedon, Amavita, Ametrex, Amfadol plus, Amifen, Amipar, Amol, Anadin, Analgan, Analgiplus, Analper, Ananty, Andox, Anexsia, Anhiba, Antidol, Antigriphine, Antigrippine, Antispa plus, Anyrume, Apap, Aphlogis, Apiret, Apiretal, Apo-acetaminophen, Aporex, Apotel, Apracur granulado, Apyrene, Arfen, Arthrifen plus, Atamel, Atasol, Atenemen, Atmiphen, Atralidon, Azur, Becetamol, Ben-u-ron, Benuron, Béres febrilin, Besemax, Besenol, Biocetamol, Biogesic, Biogrip-t, Biragan, Bivinadol extra, Bodrex, 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Transderm Scop - drug review: dosage, side effects, action, buy Transderm Scop

Transderm Scop


Transderm Scop. which is generically prescribed as scopolamine topical, is commonly used to relieve nausea. vomiting. and dizziness that is typically associated with motion sickness. Transderm Scop is a member of the family of medications known as anticholinergics, which decrease the secretion of fluids, dilate the pupils, and slow the stomach and intestine.

Transderm Scop is not appropriate for everyone. A thorough medical history should be assessed prior to prescribing this medication. Patients with a medical history which includes liver disease, enlarged prostate. kidney disease, bladder problems, glaucoma. and difficulty urinating may not be able to take this medication or may require careful monitoring while undergoing drug therapy with Transderm Scop, depending on the condition and the severity of the condition.

The American Food and Drug Administration rated Transderm Scop as a pregnancy risk category C. It has yet to be determined whether or not this medication will cause harm or birth defects to an unborn baby. It has yet to be determined whether or not Transderm Scop will pass through the mother’s breast milk and affect a nursing baby. The prescribing physician should avoid prescribing this medication to women who are pregnant, nursing, or who are likely to become pregnant.

There is a risk of side effects associated with Transderm Scop, some of which are severe. A patient suffering from a serious side effect or an allergic reaction should seek immediate emergency medical assistance. An allergic reaction will present with symptoms which include facial swelling. including swelling of the lips. mouth. tongue. or throat, hives. and difficulty breathing. Other serious side effects which require immediate emergency medical attention include insomnia which lasts for more than a few days and an irregular or fast heart rate accompanied by pain.

Other less serious side effects typically do not require emergency medical attention but should be reported to the prescribing physician. Patients should be encouraged to report all side effects. Less serious side effects include symptoms such as constipation. dry mouth, nose. or throat, drowsiness, restlessness, nervousness, excitability, insomnia, blurry vision, dizziness, nausea, loss of appetite. vomiting, fast heart rate, uneven heart rate, or difficulty urinating. Less serious side effects can often be reduced to a tolerable level by reducing the dosage of Transderm Scop. There is the possibility of a skin irritation from the patch site. This can be alleviated by placing the patches in various parts of the body when using them consecutively.

Transderm Scop should be taken exactly as directed by the physician. This medication is typically taken on an as needed basis, and thus missing a dose is not typically a problem. The patient should never take a double dose of this medication in an effort to derive more relief from symptoms than directed to avoid a potential overdose. If an overdose is suspected, the patient should seek immediate emergency medical attention. An overdose will present with symptoms which include seizures, dizziness, drowsiness, excitability, agitation, convulsions, hallucination, coma, or death.

There is a risk of negative drug interactions associated with Transderm Scop. A thorough medical history should be understood prior to prescribing this medication. Patients should be urged to inquire with the prescribing physician before taking any new medications, including over the counter medications and herbal remedies. Medications with a known interaction with Transderm Scop include antihistamines, decongestants, narcotic pain relievers, muscle relaxants, sedatives, antidepressants, alcohol, anxiety medications, and medications that are known to cause drowsiness.

Transderm scop has the following structural formula:

 Molecular formula of transderm scop is C17H21NO4
 Molecular weight is 303.353 g/mol
 Transderm scop available. 1.5mg patches

Generic name: Scopolamine

Brand name(s): Atrochin, Atroquin, Beldavrin, Buscopan, Euscopol, Hyosceine, Hyoscine, Hyosol, Hysco, Isoscopil, Kwells, L-Scopolamine, Oscine, Pamine, Scop, Scopamin, Scopoderm-Tts, Scopolaminhydrobromid, Scopos, Sereen, Skopolamin, Tranaxine, Transcop, Transderm-V, Triptone

MIN — Scopamin, general information, pharmacology, Scopamin for patients, Scopamin interactions, Scopamin contraindications, additional informat

Scopamin Scopamin - General Information

An alkaloid from Solanaceae, especially Datura metel L. and Scopola carniolica. Scopamin and its quaternary derivatives act as antimuscarinics like atropine, but may have more central nervous system effects. Among the many uses are as an anesthetic premedication, in urinary incontinence, in motion sickness, as an antispasmodic, and as a mydriatic and cycloplegic. [PubChem]

Pharmacology of Scopamin

Scopamin is a muscarinic antagonist structurally similar to the neurotransmitter acetylcholine and acts by blocking the muscarinic acetylcholine receptors and is thus classified as an anticholinergic. Scopamin has many uses including the prevention of motion sickness. It is not clear how Scopamin prevents nausea and vomiting due to motion sickness. The vestibular part of the ear is very important for balance. When a person becomes disoriented due to motion, the vestibule sends a signal through nerves to the vomiting center in the brain, and vomiting occurs. Acetylcholine is a chemical that nerves use to transmit messages to each other. It is believe that Scopamin prevents communication between the nerves of the vestibule and the vomiting center in the brain by blocking the action of acetylcholine. Scopamin also may work directly on the vomiting center. Scopamin must be taken before the onset of motion sickness to be effective.

Scopamin for patients Scopamin Interactions

The absorption of oral medications may be decreased during the concurrent use of scopolamine because of decreased gastric motility and delayed gastric emptying.

Scopolamine should be used with care in patients taking other drugs that are capable of causing CNS effects such as sedatives, tranquilizers, or alcohol. Special attention should be paid to potential interactions with drugs having anticholinergic properties; e.g. other belladonna alkaloids, antihistamines (including meclizine), tricyclic antidepressants, and muscle relaxants.

Laboratory Test Interactions

Scopolamine will interfere with the gastric secretion test.

Scopamin Contraindications

Transderm Scop is contraindicated in persons who are hypersensitive to the drug scopolamine or to other belladonna alkaloids, or to any ingredient or component in the formulation or delivery system, or in patients with angle-closure (narrow angle) glaucoma .

Additional information about Scopamin

Scopamin Indication: For the treatment of excessive salivation, colicky abdominal pain, bradycardia, sialorrhoea, diverticulitis, irritable bowel syndrome and motion sickness.
Mechanism Of Action: Scopamin acts by interfering with the transmission of nerve impulses by acetylcholine in the parasympathetic nervous system (specifically the vomiting center).
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Scopolamine
Synonyms: Not Available
Drug Category: Mydriatics; Adjuvants; Antimuscarinics; Antispasmodics
Drug Type: Small Molecule; Approved
Other Brand Names containing Scopolamine: Atrochin; Atroquin; Atroscine Hydrobromide; Beldavrin; Buscopan; Epoxytropine Tropate; Euscopol; Hydroscine Hydrobromide; Hyocine F Hydrobromide; Hyosceine; Hyoscine; Hyoscine Bromide; Hyoscine Hydrobromide; Hyoscyine Hydrobromide; Hyosol; Hysco; Isopto Hyoscine; Isoscopil; Kwells; L-Hyoscine Hydrobromide; L-Scopolamine; Methscopolamine Bromide; Oscine; SEE; Scop; Scopamin; Scopine Tropate; Scopoderm-Tts; Scopolamine Bromide; Scopolamine Hydrobromide; Scopolamine Hydrobromide Trihydrate; Scopolamine Hyoscine; Scopolaminhydrobromid; Scopolaminium Bromide; Scopolammonium Bromide; Scopos; Sereen; Skopolamin; Tranaxine; Transcop; Transderm-Scop; Transderm-V; Triptone; Tropic Acid, Ester with Scopine;
Absorption: Not Available
Toxicity (Overdose): Not Available
Protein Binding: Not Available
Biotransformation: Not Available
Half Life: Not Available
Dosage Forms of Scopamin: Solution Intravenous
Tablet Oral
Liquid Intravenous
Disc Transdermal
Solution Intramuscular
Chemical IUPAC Name: Not Available
Chemical Formula: C17H21NO4
Scopolamine on Wikipedia: http://en.wikipedia.org/wiki/Scopolamine
Organisms Affected: Humans and other mammals

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Scopamin diseases

PharmGKB contains no dosing guidelines for this. To report known genotype-based dosing guidelines, or if you are interested in developing guidelines, click here.

PharmGKB has no annotated drug labels with pharmacogenomic information for this. If you know of a drug label with PGx, send us a message.

PharmGKB contains no Clinical Variants that meet the highest level of criteria.

Disclaimer: The PharmGKB's clinical annotations reflect expert consensus based on clinical evidence and peer-reviewed literature available at the time they are written and are intended only to assist clinicians in decision-making and to identify questions for further research. New evidence may have emerged since the time an annotation was submitted to the PharmGKB. The annotations are limited in scope and are not applicable to interventions or diseases that are not specifically identified.

The annotations do not account for individual variations among patients, and cannot be considered inclusive of all proper methods of care or exclusive of other treatments. It remains the responsibility of the health-care provider to determine the best course of treatment for a patient. Adherence to any guideline is voluntary, with the ultimate determination regarding its application to be made solely by the clinician and the patient. PharmGKB assumes no responsibility for any injury or damage to persons or property arising out of or related to any use of the PharmGKB clinical annotations, or for any errors or omissions.

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Overview
  • Atrochin
  • Atroquin
  • Atroscine Hydrobromide
  • Beldavrin
  • Buscopan
  • Epoxytropine Tropate
  • Euscopol
  • Hydroscine Hydrobromide
  • Hyocine F Hydrobromide
  • Hyosceine
  • Hyoscine
  • Hyoscine Bromide
  • Hyoscine Hydrobromide
  • Hyoscyine Hydrobromide
  • Hyosol
  • Hysco
  • Isopto Hyoscine
  • Isoscopil
  • Kwells
  • L-Hyoscine Hydrobromide
  • L-Scopolamine
  • Methscopolamine Bromide
  • Oscine
  • SEE
  • Scop
  • Scopamin
  • Scopine Tropate
  • Scopoderm-Tts
  • Scopolamine Bromide
  • Scopolamine Hydrobromide
  • Scopolamine Hydrobromide Trihydrate
  • Scopolamine Hyoscine
  • Scopolaminhydrobromid
  • Scopolaminium Bromide
  • Scopolammonium Bromide
  • Scopos
  • Sereen
  • Skopolamin
  • Tranaxine
  • Transcop
  • Transderm-Scop
  • Transderm-V
  • Triptone
  • Tropic Acid, Ester with Scopine

Brand Mixture Names

PharmGKB Accession Id Type(s): Description

An alkaloid from Solanaceae, especially Datura metel L. and Scopola carniolica. Scopolamine and its quaternary derivatives act as antimuscarinics like atropine, but may have more central nervous system effects. Among the many uses are as an anesthetic premedication, in urinary incontinence, in motion sickness, as an antispasmodic, and as a mydriatic and cycloplegic.

Source: Drug Bank

Indication

For the treatment of excessive salivation, colicky abdominal pain, bradycardia, sialorrhoea, diverticulitis, irritable bowel syndrome and motion sickness.

Source: Drug Bank

Other Vocabularies

Information pulled from DrugBank has not been reviewed by PharmGKB.

Pharmacology, Interactions, and Contraindications Mechanism of Action

Scopolamine acts by interfering with the transmission of nerve impulses by acetylcholine in the parasympathetic nervous system (specifically the vomiting center).

Source: Drug Bank

Pharmacology

Scopolamine is a muscarinic antagonist structurally similar to the neurotransmitter acetylcholine and acts by blocking the muscarinic acetylcholine receptors and is thus classified as an anticholinergic. Scopolamine has many uses including the prevention of motion sickness. It is not clear how Scopolamine prevents nausea and vomiting due to motion sickness. The vestibular part of the ear is very important for balance. When a person becomes disoriented due to motion, the vestibule sends a signal through nerves to the vomiting center in the brain, and vomiting occurs. Acetylcholine is a chemical that nerves use to transmit messages to each other. It is believe that Scopolamine prevents communication between the nerves of the vestibule and the vomiting center in the brain by blocking the action of acetylcholine. Scopolamine also may work directly on the vomiting center. Scopolamine must be taken before the onset of motion sickness to be effective.

Source: Drug Bank

Absorption, Distribution, Metabolism, Elimination & Toxicity Route of Elimination

Scopamin diseases

Scopolamine hydrobromide Hot Products

1aH,5aH-Tropan-3a-ol, 6b,7b-epoxy-, (-)-tropate (ester), hydrobromide (8CI);Benzeneacetic acid, a-(hydroxymethyl)-, (1a,2b,4b,5a,7b)-9-methyl-3-oxa-9-azatricyclo[3.3.1.02,4]non-7-ylester, hydrobromide, (aS)- (9CI);Benzeneacetic acid, a-(hydroxymethyl)-, 9-methyl-3-oxa-9-azatricyclo[3.3.1.02,4]non-7-ylester, hydrobromide, [7(S)-(1a,2b,4b,5a,7b)]-;Scopolamine bromide (6CI);(-)-Hyoscinehydrobromide;(-)-Scopolamine bromide;(-)-Scopolamine hydrobromide;Beldavrin;Euscopol;Hydroscine hydrobromide;Hyocine F hydrobromide;Hyoscine bromide;Hyoscine hydrobromide;Hysco;Isoscopil;Kwells;Scopamin;Scopolaminehydrobromide;Scopolaminium bromide;Scopolammonium bromide;Scopos;Sea Legs;Sereen;Triptone;Wellcome Brand Scopolamine hydrobromide Injection;l-Hyoscinehydrobromide;l-Scopolamine hydrobromide;

Scopolamine hydrobromide Consensus Reports

Reported in EPA TSCA Inventory. EPA Genetic Toxicology Program.

Scopolamine hydrobromide Specification

The Hyoscine hydrobromide with the cas number 114-49-8, is also called (1)Scopolamine hydrobromide; (2) (-)-Hyoscine hydrobromide ; (3) (-)-Scopolamine bromide ; (4) (-)-Scopolamine hydrobromide ; (5) 1alphaH,5alphaH-Tropan-3-alpha-ol, 5beta,7beta-epoxy-, (-)-; (6)tropate (ester), hydrobromide ; (7) Beldavrin ; (8) Euscopol ; (9) Hyoscine bromide ; (10) Hyoscine hydrobromide ; (11) Hyosol ; (12) Hysco ; (13) Isoscopil ; (14) Kwells ; (15) NSC 61806 ; (16) Scopamin ; (17) Scopolamine bromide ; (18) Scopolamine hydrobromide ; (19) Scopolaminium bromide ; (20) Scopolammonium bromide ; (21) Scopos ; (22) Sereen ; (23) Tranaxine ; (24) l-Hyoscine hydrobromide ; (25) l-Scopolamine-hydrobromide

Uses of Hyoscine hydrobromide: Hyoscine hydrobromide, which is a type of medicine called an antimuscarinic (or anticholinergic), is alkaloid and has a strongest pharmacological effect, can be used to block the parasympathetic nerve, but also can be used as preparation for the central nervous system. Role of Hyoscine hydrobromide is similar to belladonna alkaloids. Though it has stronger curative effect, maintain relatively short time. Hyoscine hydrobromide can be used for anesthesia and analgesia, cough, motion sickness, also can be used for stiff and tremor symptom of parkinson's disease. Hyoscine hydrobromide is thought to prevent motion sickness by stopping the messages sent from the vestibular system from reaching an area of the brain called the vomiting centre. This area of the brain co-ordinates the vomiting reflex. Hyoscine blocks receptors called muscarinic (or cholinergic) receptors that are found in the vomiting centre. This prevents the vomiting centre from sending nerve messages to the stomach that would normally cause vomiting.

Preparation of The Hyoscine hydrobromide: The Hyoscine hydrobromide are the extraction of Hindu Datura Flower as raw materials. The Chinese traditional medicine flosdaturae preparations, which is anesthetic agents, derive from HuaTuo well-known mafeisan 2nd century A.D. The effective components extraction is scopolamine. Mixed Hindu Datura Flower powder with 50 ° c ethanol for percolation to obtain percolate without alkaloids. Percolate with reduced pressure distillation, recycle ethanol. Extractum is extracted with sulphuric acid. Add sodium carbonate to extract to pH9-10, then extracted by chloroform. Extraction, distillation and recycling to get tal alkaloid. And separation to get Hyoscine hydrobromide salt. Total yield is 0.15%.

You can still convert the following datas into molecular structure :
1. SMILES: Br.OC[C@H](c1ccccc1)C(=O)O[C@@H]2C[C@H]3N(C)[C@@H](C2)[C@@H]4O[C@H]34
2. InChI: InChI=1/C17H21NO4.BrH/c1-18-13-7-11(8-14(18)16-15(13)22-16)21-17(20)12(9-19)10-5-3-2-4-6-10;/h2-6,11-16,19H,7-9H2,1H3;1H/t11-,12-,13-,14+,15-,16+;/m1./s1

Hyoscine hydrobromide toxic data can be showed in the following sheet.

Anacin (Scopamin) Delivery

You can order delivery of a Anacin (Scopamin) to the Denmark, Austria, Japan or any other country in the world. Residents of the USA can order Anacin (Scopamin) to any city, to any address, for example to Knoxville, Tempe, Milwaukee or Houston.