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Sopamycetin

Category: Antibiotics

Description

Chloramphenicol is used for treating serious infections caused by certain bacteria.

Active Ingredient: chloramphenicol

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Other articles

Sopamycetin diseases

Chloramphenicol

(KLOR-am-FEN-ih-kahl) AK-Chlor, Chloromycetin Otic, Chloromycetin Sodium Succinate, Chloroptic S.O.P. Diochloram, Ophtho-Chloram, SopamycetinChloramphenicol Sodium SuccinateChloromycetin Sodium SuccinateChloramphenicol PalmitateChloromycetin PalmitateClass: Antibiotic

Action Interferes with or inhibits microbial protein synthesis.

IndicationsSystemic: Treatment of following types of infections caused by susceptible strains of specific microorganisms: serious systemic infections for which less potentially dangerous drugs are ineffective or contraindicated. Topical: Treatment of cystic fibrosis, superficial ocular infections, superficial infections involving external auditory canal, superficial skin infections; infection prophylaxis for minor cuts, wounds, burns and skin abrasions and for various gram-negative bacteria causing bacteremia and meningitis.

Oral use: Trivial infections (eg, colds, influenza, throat infections) or infections other than indicated; prophylaxis of systemic bacterial infections. Ophthalmic use: Epithelial herpes simplex keratitis; vaccinia; varicella; fungal disease of ocular structure; mycobacterial infections of eye; after uncomplicated removal of corneal foreign body. Otic use: Perforated tympanic membrane; when less potentially dangerous agents would be expected to be ineffective.

ADULTS: PO/IV 50 mg/kg/day in divided doses q 6 hr; may require up to 100 mg/kg/day initially for CNS infections. CHILDREN: PO/IV 50–75 mg/kg/day in divided doses q 6 hr; 50–100 mg/kg/day for meningitis. INFANTS & CHILDREN WITH IMMATURE METABOLIC PROCESSES: PO/IV 25 mg/kg/day. NEWBORNS: PO/IV Usually 25 mg/kg/day in 4 doses q 6 hr. NEONATES > 7 DAYS (> 2 KG): PO/IV 50 mg/kg/day in divided doses q 12 hr. NEONATES < 2 KG AND BIRTH-7 DAYS (> 2 KG): PO/IV 25 mg/kg qd.

ADULTS & CHILDREN: Ophthalmic 1–2 gtt q 15–30 min initially for acute infections; then reduce frequency as infection is controlled.

ADULTS & CHILDREN: Otic 2–3 gtt in ear tid.

ADULTS & CHILDREN: Topical Apply 1–4 times daily to affected area.

Anticoagulants: May enhance anticoagulation action. Barbiturates: May reduce effectiveness of chloramphenicol while barbiturate effects may be enhanced; effects may last days after barbiturates are withdrawn. Ferrous salts: May increase serum iron levels. Hydantoins (eg, phenytoin): May increase serum hydantoin levels, with possible toxicity; chloramphenicol levels may increase or decrease. Rifampin: May reduce chloramphenicol serum levels; effect may last days after rifampin is withdrawn. Sulfonylureas: May cause clinical manifestations of hypoglycemia. Vitamin B12: May decrease hematologic effects of vitamin B12 in patients with pernicious anemia.

Lab Test Interferences None well documented.

CNS: Headache; mental confusion; delirium; mild depression; optic neuritis; peripheral neuritis. DERM: Topical use: Itching or burning; urticaria; angioneurotic edema; dermatitis. GI: Diarrhea; nausea; vomiting; glossitis; stomatitis. HEMA: Bone marrow depression; aplastic anemia; hypoplastic anemia; thrombocytopenia; granulocytopenia. OTHER: Hypersensitivity reactions (eg, fever, rash, angioedema, urticaria, anaphylaxis); Gray syndrome. Topical use may produce same adverse reactions seen with systemic use.

Pregnancy: Pregnancy category undetermined. Lactation: Excreted in breast milk. Children: Use drug with caution and in reduced dosages in premature and term infants to avoid Gray syndrome toxicity (toxic and potentially fatal reaction in premature infants and newborns). Symptoms of Gray syndrome generally appear in this sequence: abdominal distention with or without emesis; progressive pallid cyanosis; vasomotor collapse, frequently accompanied by irregular respiration; death within a few hours of onset (death occurs in 40% of patients within 2 days of initial symptoms). Other initial symptoms of Gray syndrome may include refusal to suck, loose green stools, flaccidity, ashen gray color, decreased temperature and refractory lactic acidosis. Blood dyscrasias: Serious and fatal blood dyscrasias can occur. Inner ear infections: Use systemic antibiotic therapy. Ophthalmic ointment: May retard corneal epithelial healing. Renal or hepatic impairment: Excessive blood levels of drug may occur; dosage adjustment may be required. Preexisting liver dysfunction may be significant risk factor for Gray syndrome. Special risk patients: Use drug with caution in patients with acute intermittent porphyria or G-6-PD deficiency. superinfection: Use of antibiotics may result in bacterial or fungal overgrowth. Serious infections may need systemic treatment in addition to local treatment.


PATIENT CARE CONSIDERATIONS

  • Chloramphenicol sodium succinate is intended for IV use only; it is ineffective when given via IM route.
  • Give direct IV as 10% solution in Water for Injection or 5% Dextrose Injection over at least 1 min. Do not administer if cloudy. May also be diluted in 50–100 ml of D5W and administered over 30 min.
  • Substitute oral administration as soon as possible.
    • Administer orally in capsules and oral suspension with full glass of water on empty stomach at least 1 hr before or 2 hr after meals at evenly spaced intervals (q 6 hr) around clock.
    • Administer with food if GI upset occurs.
    • Have patient tilt head back. Place medication in conjunctival sac and close patient's eyes. Apply light finger pressure to lacrimal sac for 1 min after instillation.
    • Do not touch tip of cap to eye, fingers or other surface.
    • Avoid contact with eyes; for use in ear only.
    • If ear drops are kept refrigerated, hold container in hand for a few minutes to warm to near body temperature.
    • If drops are in suspension, shake well for 10 sec before using.
    • Have patient lie on side or tilt affected ear up for ease of administration. Allow drops to run in, and keep ear tilted for about 2 min.
    • Do not touch tip of cap to ear, fingers or other surface.
    • Do not use in eyes. Topical preparation is for external use only.
    • Cleanse affected area of skin prior to application unless otherwise instructed.
    • Cover with sterile bandage if needed.
    • Administer around clock at even intervals.
    • Obtain patient history, including drug history and any known allergies. Note any renal or hepatic impairment.
    • Determine baseline of infectious state: measure temperature; assess vital signs; examine appearance of wound, eye, ear, urine and stool; perform blood studies.
    • Confirm diagnosis from cultures prior to administration of drug.
    • Determine baseline CBC and platelet count and monitor every 2 days.
    • Avoid concurrent therapy with other drugs that suppress bone marrow.
    • Avoid repeat course of therapy if possible.
    • Monitor serum levels of medication weekly. Therapeutic level peak is 5–20 mcg/ml; if level is higher, notify physician.
    • If signs of anemia, leukopenia, reticulocytopenia or thrombocytopenia develop, notify physician.
    • Observe patient daily for signs of bone marrow depression (eg, fatigue, sore throat, bleeding, aplastic anemia, hypoplastic anemia, thrombocytopenia, agranulocytosis) and Gray syndrome in infants.
    • Discontinue drug at first sign of hematologic disorders attributable to chloramphenicol.
    OVERDOSAGE: SIGNS & SYMPTOMS Nausea, vomiting, unpleasant taste, diarrhea
    • Advise patient to take drug orally 1 hr before or 2 hr after meals. Explain that medication may be taken with food to avoid GI upset.
    • Instruct patient to complete entire regimen even if feeling better.
    • Emphasize importance of follow-up examinations because of possible complications from drug that can occur up to months after therapy is completed.
    • Caution patient about not sharing prescription medications because of danger of side effects.
    • Inform patient that ophthalmic solution may cause blurred vision or stinging for a few minutes after administration.
    • Instruct patient that bitter taste that occurs after IV administration will subside 2–3 min after injection.
    • Instruct patient to report these symptoms to physician: bleeding, fever, sore throat, itching, nausea, vomiting, diarrhea, bruising or numbness and weakness of hands or feet.
    • Advise parents to report these symptoms to physician if they occur in infants: failure to feed, abdominal distention, drowsiness, blue or gray skin color or any problems in breathing.
    • Instruct patient to report signs of further infection or worsening of current infection to physician.

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    Sonata - patient information, description, dosage and directions

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    Drugs and diseases reference index
    Drugs reference index «Sonata » Sonata

    Generic Name:Zaleplon (ZAL-e-plon)Brand Name: Sonata

    Sonata is used for:

    Short-term treatment of insomnia.

    Sonata is a hypnotic agent. It works by depressing the central nervous system (brain), causing drowsiness to aid in falling asleep.

    Do NOT use Sonata if:
    • you are allergic to any ingredient in Sonata
    • you are taking sodium oxybate (GHB)

    Contact your doctor or health care provider right away if any of these apply to you.

    Before using Sonata :

    Some medical conditions may interact with Sonata. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

    • if you are pregnant, planning to become pregnant, or are breast-feeding
    • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
    • if you have allergies to medicines, foods, or other substances, especially tartrazine dye or aspirin
    • if you have a history of depression or other mental illness, or alcohol or drug abuse; or if you are debilitated
    • if you have severe kidney or liver problems or a breathing disorder

    Some MEDICINES MAY INTERACT with Sonata. Tell your health care provider if you are taking any other medicines, especially any of the following:

    • Cimetidine or sodium oxybate (GHB) because an increase in sleep duration may occur
    • Carbamazepine, phenobarbital, phenytoin, or rifampin because they may decrease Sonata 's effectiveness

    This may not be a complete list of all interactions that may occur. Ask your health care provider if Sonata may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

    How to use Sonata :

    Use Sonata as directed by your doctor. Check the label on the medicine for exact dosing instructions.

    • Sonata comes with an extra patient information sheet called a Medication Guide. Read it carefully. Read it again each time you get Sonata refilled.
    • Take Sonata by mouth with or without food.
    • Do not take Sonata with or right after a high-fat or heavy meal. Doing so may delay when the medicine will begin to work.
    • Sonata works very quickly. It should be taken immediately before going to bed or after you have gone to bed and are having trouble falling asleep.
    • Do not take Sonata unless you will be able to get 4 or more hours of sleep before you must be active again.
    • If you miss a dose of Sonata. take it when you remember if you are still able to get at least 4 hours of sleep. If you are no longer able to get at least 4 hours of sleep when you remember, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

    Ask your health care provider any questions you may have about how to use Sonata .

    Important safety information:
    • Sonata may cause dizziness, drowsiness, or changes in vision. These effects may be worse if you take it with alcohol or certain medicines. Use Sonata with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it. Continue to use caution the morning after taking Sonata .
    • Do not drink alcohol or use medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) while you are using Sonata ; it may add to their effects. Ask your pharmacist if you have questions about which medicines may cause drowsiness.
    • Common side effects, such as dizziness, lightheadedness, coordination problems, and memory problems, occur most often within 1 hour after taking Sonata. Be sure to take Sonata right before you to go to bed or after you are already in bed. This will help to decrease these side effects.
    • Some patients taking Sonata have performed certain activities while they were not fully awake. These have included sleep-driving, making and eating food, making phone calls, and having sex. Patients often do not remember these events after they happen. Such an event may be more likely to occur if you use a high dose of Sonata. It may also be more likely if you drink alcohol or take other medicines that may cause drowsiness while you use Sonata. Tell your doctor right away if such an event happens to you.
    • Sonata may cause you to become sunburned more easily. Avoid the sun, sunlamps, or tanning booths until you know how you react to Sonata. Use a sunscreen or wear protective clothing if you must be outside for more than a short time.
    • If your symptoms do not get better within 7 days or if they get worse, check with your doctor.
    • Tell your doctor or dentist that you take Sonata before you receive any medical or dental care, emergency care, or surgery.
    • This product may contain tartrazine dye (FD & C Yellow No. 5). This may cause an allergic reaction in some patients. If you have ever had an allergic reaction to tartrazine, ask your pharmacist if your product has tartrazine in it.
    • Do NOT take more than the recommended dose or use for longer than prescribed without checking with your doctor.
    • You may experience trouble sleeping for 1 to 2 nights after you stop taking Sonata. If it continues, contact your doctor.
    • Use Sonata with caution in the ELDERLY; they may be more sensitive to its effects.
    • Sonata should be used with extreme caution in CHILDREN; safety and effectiveness in children have not been confirmed.
    • PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of taking Sonata while you are pregnant. Sonata is found in breast milk. Do not breast-feed while taking Sonata .

    When used for longer than a few weeks or at high doses, some people develop a need to continue taking Sonata. This is known as DEPENDENCE or addiction.

    If you stop taking Sonata suddenly, you may have WITHDRAWAL symptoms. These may include stomach and muscle cramps, vomiting, sweating, shakiness, and, rarely, seizures.

    Possible side effects of Sonata :

    All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

    Abnormal skin sensations; decreased sensitivity to touch; dizziness; drowsiness; incoordination; lightheadedness; muscle pain; short-term memory loss.

    Seek medical attention right away if any of these SEVERE side effects occur:

    Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); abnormal thinking; agitation; bizarre behavior; changes in personality, mood, or behavior; daytime drowsiness; hallucinations; memory loss; shortness of breath; suicidal thoughts; worsening of depression.

    This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch .

    If OVERDOSE is suspected:

    Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org ), or emergency room immediately. Symptoms may include coma; confusion; depression; drowsiness; lethargy; loss of consciousness; loss of coordination; low blood pressure; slow, shallow breathing; sluggishness.

    Proper storage of Sonata :

    Store Sonata between 68 and 77 degrees F (20 and 25 degrees C) in a tightly closed container. Protect from light, moisture, and heat. Do not store in the bathroom. Keep Sonata out of the reach of children and away from pets.

    General information:
    • If you have any questions about Sonata. please talk with your doctor, pharmacist, or other health care provider.
    • Sonata is to be used only by the patient for whom it is prescribed. Do not share it with other people.
    • If your symptoms do not improve or if they become worse, check with your doctor.

    This information is summary only. It does not contain all information about Sonata. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

    • Sonata Prescribing Information (FDA)
    • Sonata Consumer Overview
    • Sonata Detailed Consumer Information (PDR)
    • Sonata Advanced Consumer (Micromedex) - Includes Dosage Information
    • Zaleplon Prescribing Information (FDA)
    • Zaleplon Professional Patient Advice (Wolters Kluwer)
    See Also.

    Tanggapi komentar

    Oleh Anonymous (Min, 05/15/2011 - 00:55)

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