Accutane is given to patients for treating severe acne that do not respond to other medicines.
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Accutane is given to patients for treating severe acne that do not respond to other medicines.
Active Ingredient: Isotretinoin
Accutane (Trecifan) as known as: Accuran, Accutin, Acnecutan, Acnemin, Acnetane, Acnetrex, Acnil, Acnogen, Acnotin, Aisoskin, Aknenormin, Aknesil, Amnesteem, Antibiotrex, Atlacne, Ciscutan, Claravis, Clarus, Curacne, Curakne, Curatane, Cuticilin, Decutan, Dercutane, Farmacne, Flexresan, Flitrion, Inotrin, Isdiben, Isoacne, Isocural, Isoderm, Isodermal, Isoface, Isogalen, Isogeril, Isoprotil, Isoriac, Isoskin, Isosuppra, Isosupra lidose, Isotane, Isotret, Isotret-hexal, Isotretin, Isotretinoina, Isotretinoinum, Isotrex, Isotrexin, Isotroin, Izotek, Lurantal, Lyotret, Neotrex, Nimegen, Noitron, Noroseptan, Novacne, Opridan, Oratane, Piplex, Policano, Procuta, Retinide, Retnol, Roaccutan, Roaccutane, Roacnetan, Roacutan, Sotret, Stiefotrex, Trecifan, Tretinac, Tretinak, Tretinex, Zonatian, Zoretanin
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There is an additional general information about this medication active ingredient isotretinoin:Pharmacological action
Isotretinoin is an pharmaceutical agent for the treatment of acne. Contributes to the normalization of terminal cell differentiation, inhibits the hyperproliferation of the epithelium of excretory ducts of the sebaceous glands, the formation of detritus and makes it easier to evacuate. Due to this reduced production of sebum and facilitates its isolation, normal structure, decreasing the inflammatory reaction around the glands. For external and systemic application isotretinoin has antiseborrhea, sebostatic, anti-inflammatory, keratitis and immunomodulatory actions, strengthens the processes of regeneration in the skin.Pharmacokinetics
When administered orally isotretinoin is absorbed from the gastrointestinal tract, absorption may increase when taken with food. Cmax plasma levels reached after 1-4 hours after ingestion.
Oral bioavailability is low which may be caused by parietal metabolism in the intestinal wall and the effect of "first passage" through the liver.
Isotretinoin is highly bound to plasma proteins. Metabolized in the liver with the formation of the main metabolite 4-oxo-isotretinoin, also there is some isomerization of isotretinoin in tretinoin.
Isotretinoin, tretinoin and its metabolites are enterohepatic recycling.
The end of T1/2 of tretinoin is 10-20 hours. An equivalent amount is determined in the feces, mostly unchanged, and urine in the form of metabolites.
For oral administration: severe nodular-cystic acne especially with the localization on the body.
For rectal administration: severe relapsing forms of acne, rashes associated with seborrheic process.
For external use: papule-pustular acne, seborrhea, rosacea, perioral dermatitis.
For oral administration initial dose is 500 mcg / kg / day; the maximum daily dose used for a limited time and is 1 mg / kg; the maintenance dose is 0.1-1 mg / kg / day; duration of treatment is 16 weeks, a second course conducted at intervals of 8 days. Isotretinoin is taken with meals in one or more receptions.
Rectal - 0.5-1 mg / kg / day, one time at night (in the supine position); course of treatment - 8-12 weeks, the intervals between courses - 1-2 months.
Ointment applied thinly to the affected areas of skin 2 times / day. Duration of treatment - 4-6 weeks.
Dermatological reactions: dry mucous membranes, skin rashes, dermatitis, pruritus, cheilitis, erythema (especially on the face), sweating, palmar-plantar desquamation and paronychia, nail dystrophy, increased proliferation of granulation tissue in the affected area, rarely - thinning hair, vasculitis, photosensitivity.
Senses: conjunctivitis, photophobia, decreased night vision, corneal opacity, weakening of the hearing.
CNS and peripheral nervous system: headache, rarely - depression, seizures, suicide, and in rare cases - intracranial hypertension.
Digestive system: nausea, rarely - colitis, bleeding from the gastrointestinal tract, transient elevation of liver transaminases and in rare cases - hepatitis.
Hematopoietic system: anemia, neutropenia, changes in platelet count, increased erythrocyte sedimentation rate.
Metabolism: increased concentrations of TG and glucose.
Musculoskeletal system: pain in muscles and joints, rarely - hyperostosis.
Other: nasal bleeding.
Rectal and topical using: 1-2 weeks of treatment may cause new eruptions, itching, swelling and redness.
Pregnancy, established and planned lactation, hypersensitivity to isotretinoin, the simultaneous use of tetracycline antibiotics.
For oral administration: severe liver and/or kidney damage, hypervitaminosis A, significantly elevated levels of lipids in blood plasma, neoplasms.
For rectal use - diseases of the rectum.
Isotretinoin has a pronounced teratogenic and embryotoxic action.
Contraindicated in established and planned pregnancy.
Contraindicated during lactation.
Rectally and topically applied with caution in liver disease, kidney disease, chronic pancreatitis, decompensation of heart function, chronic intoxication (including alcohol).
Rectal and external use in a pronounced exacerbation of the reaction (on 1-2-week treatment) is recommended to cancel the medication for a few days before its decline, then therapy can be resumed.
For oral administration requires regular monitoring of liver function and lipid levels in blood plasma before treatment, 1 month after initiation of therapy and then every 3 months.
In diabetes, obesity, alcoholism or lipid metabolism violations recommended more frequent monitoring of laboratory parameters. In diabetes mellitus or suspected it is necessary to strictly control glucose levels in plasma.
With prolonged use may develop symptoms of chronic hypervitaminosis A.
During treatment or within a certain time after its completion can not be donors for women of childbearing age.
During the treatment, patients should not be given UV treatment, patients should avoid direct exposure to sunlight.
In the course of treatment may occur intolerance of contact lenses.
Safety of children and prepubertal patients has not been established.
Should avoid the simultaneous use of isotretinoin and 19-nortestosterone derivatives, particularly in patients with gynecological / endocrine diseases.
Not recommended for concurrent use of other drugs with keratolytic or exfoliative properties (including other retinoids), and progesterone in the microdose (including drugs "mini-pilly").
The action of isotretinoin is weakened by the simultaneous application of progesterone in the microdose.
With the simultaneous application of isotretinoin and vitamin A may increase toxic effects.
With the simultaneous application of isotretinoin and aminoglycoside antibiotics is at risk of developing intracranial hypertension.
PLEASE, BE CAREFUL!
Be sure to consult your doctor before taking any medication!
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Accutane is a medicine prescribed for severe acne treatment. It should be used by patients who don't respond to other medications. It belongs to a class of drugs known as retinoids. It works by decreasing facial oil (sebum) production. High amounts of sebum can lead to severe acne.
You should consult with your doctor regarding your proper dosage. Take it with a full glass of water. Do not exceed your recommended dosage. The usual starting daily dose is 0.5 mg per kilogram of body weight taken daily for a period of 2 to 4 weeks. Isotretinoin should be taken as a single dose or in 2 divided doses during the day.
Before starting your treatment with Accutane discuss with your doctor all conditions you can have: allergy, diabetes, osteoporosis, asthma, heart disease, and kidney or liver problems, eating disorders (e.g. anorexia nervosa), alcohol abuse, pancreatitis. Do not use vitamin A, alcoholic beverages during the treatment. Middle aged people can be more sensitive to Accutane. Do not donate blood while you are taking isotretinoin and for at least 1 month after you stop taking it.
The patients with sensitivity to Accutane can't use the medicine. Do not take this medication if you: are breast-feeding, pregnant, are taking tetracycline antibiotics (e.g. tetracycline, doxycycline, minocycline), have excessively high blood cholesterol levels or excessively high levels of vitamin A.
Possible side effects
Headache, drowsiness, dizziness, constipation, vomiting, diarrhea, skin rashes, swelling of the eyelids or lips, crusty skin, nosebleeds, upset stomach, mental or mood changes, back, joint or muscle pain are common side effects. Serious side effects are very rare. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.
Accutane can interact with steroids(prednisone), tetracycline antibiotics, seizure medication (phenytoin), vitamin A-type drugs (e.g. acitretin, bexarotene), vitamin A. Interaction between two medications does not always mean that you must stop taking one of them. Tell your doctor or prescriber about all prescription, over-the-counter, and herbal medications you are taking.
Take the missed dose as soon as possible. If it is almost time of the next intake just skip it and go back to your schedule.
If you think you have overdosed the medicine seek emergency medical help immediately. The overdose symptoms are chest pain, nausea, irregular heartbeat, and feeling light-headed or fainting.
Store the medicine at room temperature between 68-77 degrees F (20-25 degrees C) away from light and moisture. Do not store your drugs in the bathroom. Keep all drugs away from reach of children and pets.
The information presented at the site has a general character. Note please this information cannot be used for self-treatment and self diagnosis. You should consult with your doctor or health care adviser regarding any specific instructions of your condition. The information is reliable, but we concede it could contain mistakes. We are not responsible for any direct, indirect, special or other damage caused by use of this information on the site and also for consequences of self-treatment.Customers Who Bought This Product Also Bought:
Despite the rise in reported cases, German Health Minister Daniel Bahr noted there is often a delay in the reporting time and the number of new infections are clearly going down, the AP reported. Timely, routine evaluation of research images by radiologists can result in identification of incidental findings in a substantial number of cases that can result in significant medical benefit to a small number of patients, they concluded.
The researchers found that women who have a family history of breast cancer or breast disease were about twice as likely to develop both benign breast disease and breast cancer than women with no family history of the disease.
Galanter said, The real serious drug problem is the painkillers -- Percocet, Vicodin, OxyContin. There are a notable number of young people getting seriously addicted. It's a noticeable statistic. Some of these drugs come from the family medicine cabinet but there are also people who get illicit prescriptions and then sell the drugs as dealers. We knew already that we can open up blocked vessels with the treatment, but now we have proof that patients have better outcomes, they actually benefit by being less disabled and less handicapped, said lead researcher Dr. Diederik Dippel, a neurologist at Erasmus M.C. University Medical Center in Rotterdam.
As our study shows, much of the increase can be attributed to the redefinition of what autism is and which diagnoses are reported, Hansen said. The increase in the observed autism prevalence is not due alone to environmental factors that we have not yet discovered.
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Accutane is given to patients for treating severe acne that do not respond to other medicines. Accutane is a retinoid. It works by reducing skin oil production, changing the characteristics of the skin oil, and preventing abnormal hardening of the skin.
Use Accutane as directed by your doctor.
Ask your health care provider any questions you may have about how to use Accutane.
Store Accutane at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store in a tightly closed container. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Accutane out of the reach of children and away from pets.
Active Ingredient: Isotretinoin.
Do NOT use Accutane if:
Contact your doctor or health care provider if any of these apply to you.
Some medical conditions may interact with Accutane. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
Some medicines may interact with Accutane. Tell your health care provider if you are taking any other medicines, especially any of the following:
This may not be a complete list of all interactions that may occur. Ask your health care provider if Accutane may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.
Important safety information:
All medicines may cause side effects, but many people have no, or minor, side effects.
Check with your doctor if any of these most common side effects persist or become bothersome:
Abnormal hair growth; abnormal skin sensations; bleeding and redness or swelling of the gums;changes in menstrual flow; chapped lips; decreased tolerance to contact lenses; dizziness; dry eyes and mouth; dry nose that may lead to nosebleeds; dry or peeling skin; fatigue; flushing; general body discomfort; hair thinning; headache; itching; lack of energy; nervousness; respiratory tract infection; sleeplessness; sweating; temporary worsening of acne; voice changes.
Seek medical attention right away if any of these severe side effects occur:
Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); bizarre, aggressive, or violent behavior; bowel pain; chest pain or pounding in the chest; dark urine; depression; difficult or painful swallowing; difficulty moving; excessive thirst or urination; fainting; fast heartbeat; fever; fractured or weak bones; hearing problems or ringing in the ears; increased pressure in the brain (pressure in the eye; nausea; vision changes; vomiting); joint or back pain; leg swelling; muscle weakness with or without pain; nausea; new or worsening heartburn; rectal bleeding; red patches or bruises on the legs; shortness of breath; seizures; severe birth defects; severe diarrhea; severe headache; skin infection; slurred speech; stomach pain or tenderness; stroke; stunted growth in children; sun sensitivity; swelling of the pancreas (fever; increased heartbeat; nausea; stomach tenderness; vomiting); swollen glands; thoughts of suicide; tightness in the lungs; vision changes; vomiting; weakness; yellowing of the skin or eyes.
Overdose symptoms may include headache, dizziness, vomiting, stomach pain, warmth or tingling under the skin, swelling of the lips, and loss of balance or coordination.
This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.
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